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Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC(CTONG1804):a multicenter open-label phase II study

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Signal Transduction and Targeted Therapy 2024年第1期9卷 249-258页

作者： Si-yang liu Song Dong xue-Ning yang Ri-Qiang Liao Ben-Yuan Jiang Qun Wang Xiao-Song Ben Gui-bin Qiao Jun-Tao Lin Hong-Hong yan Li-xu yan Qiang Nie Hai-yan Tu bin-Chao Wang Jin-Ji yang Qing Zhou Hong-Rui Li Ke liu Wendy Wu Si-yang Maggie liu Wen-Zhao Zhong Yi-Long Wu Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Thoracic Surgery Zhongshan HospitalFudan UniversityShanghaiChina Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Pathology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Fujian Key Laboratory of Advanced Technology for Cancer Screening and Early Diagnosis FuzhouChina Berry Oncology Corporation FuzhouChina Chinese Thoracic Oncology Group(CTONG) GuangzhouChina Department of Hematology The First Affiliated HospitalJinan UniversityGuangzhouChina

This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive(N)and nivolumab–chemotherapy(N/C)combinations based on PD-L1 *** patients exhibited resectable clinical stage IIA–IIIB(AJCC 8th edition)NSCLC without EGFR/ALK *** received either mono-nivolumab(N)or nivolumab+nabpaclitaxel+carboplatin(N/C)for three cycles based on PD-L1 *** primary endpoint was the major pathological response(MPR).Key secondary endpoints included the pathologic complete response(pCR),objective response rate(ORR),and event-free survival(EFS).Baseline PD-L1 expression and perioperative circulating tumor DNA(ctDNA)status were correlated with pCR and ***-two patients were enrolled,with 46 undergoing *** MPR was 50.0%(26/52),with 25.0%(13/52)achieving pCR,and 16.7%and 66.7%for patients with PD-L1≥50%in N and N/C groups,***(25.0%)patients experienced grade 3 or higher immune-related adverse events during neoadjuvant *** with post-neoadjuvant ctDNA negativity was more likely to have pCR(39.1%)compared with those remained positive(6.7%,odds ratio=6.14,95%CI 0.84-Inf,p=0.077).With a median follow-up of 25.1 months,the 18-month EFS rate was 64.8%(95%CI 51.9–81.0%).For patients with ctDNA–***+,the 18m-EFS rate was 93.8%vs 47.3%(HR,0.15;95%CI 0.04,0.94;p=0.005).Immunochemotherapy may serve as an optimal neoadjuvant treatment even for patients with PD-L1 expression≥50%.ctDNA negativity following neoadjuvant treatment and surgery could help identify superior pathological and survival benefits,which requires further confirmation in a prospective clinical trial(NCT04015778).

关键词： chemotherapy NSCLC treatment

Nickel-catalyzed carbonylative four-component 1,4-dicarbofunctionalization of 1,3-enynes

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Science China Chemistry 2024年第6期67卷 2029-2038页

作者： yan Zhao Qi-Chao Shan Hong Xin Pin Gao xu yang Xin-Hua Duan Li-Na guo Department of Chemistry School of ChemistryXi’an Key Laboratory of Sustainable Energy Material Chemistry and Engineering Research Center of Energy StorageMaterials and DevicesMinistry of EducationXi’an Jiaotong UniversityXi’an710049China School of Electrical Engineering Xi’an Jiaotong UniversityXi’an710049China

An efficient Ni-catalyzed four-component 1,4-carbocarbonylation of 1,3-enynes with activated alkyl halides and arylboronic acids under atmospheric pressure of CO is *** tuning the electronic and steric effects of alkyl radicals,both electronrich and electron-deficient 1,3-enynes were compatible with this *** protocol features mild conditions,broad substrate scope,excellent functional group compatibility and facile gram-scale synthesis,providing a practical approach to the quaternary carbon center-containing allenyl *** study revealed that the acyl-NiIIspecies plays an important role in both the coupling and the alkyl radical generation processes.

关键词： Ni catalysis four-component 1 4-carbocarbonylation 1 3-enynes

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A New Excess Free Energy Mixing Rule for Representing Vapor-Liquid Equilibria of Mixed Refrigerants

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Journal of Thermal Science 2024年第3期33卷 1161-1173页

作者： YE Gongran FANG Yibo yan Yuhao liu Ying OUyanG Hongsheng guo Zhikai HAN Xiaohong Key Laboratory of Refrigeration and Cryogenic Technology of Zhejiang Province Institute of Refrigeration and CryogenicsZhejiang UniversityHangzhou310027China State Key Lab for Fluorine Greenhouse Gases Replacement and Control Treatment Zhejiang Research Institute of Chemical IndustryHangzhou310014China Zhejiang Key Laboratory of Clean Energy and Carbon Neutrality Zhejiang UniversityHangzhou310027China

A suitable mixing rule is important for vapor liquid equilibrium(VLE)investigations for mixed *** this work,a new excess free energy mixing rule(MRv)was proposed at zero pressure based on the linear relationship between dimensionless parameter 1/(u-1)and *** mixing rule was explicit adopted variable liquid molar *** applicable temperature range of MRv could be extended by means of an empirical method to estimate the liquid molar volume for components at high *** mixing rules modified Huron-Vidal mixing rule(MHV1),Wong-Sandler mixing rule(WS),and MRv at two reference pressures were used to compare the VLE data in the calculation of 37 mixed *** demonstrated that MRv had a relatively similar accuracy to MHV1 and WS for component and pressure ***,the average excess Gibbs free energy using the MRv mixing rule for the 37 selected mixed refrigerants(0.0013)was much lower than those using the MHV1(0.0078)and WS(0.0809)mixing rules,which was very valuable for the design and optimization of thermodynamic systems using mixed refrigerants.

关键词： mixed refrigerant vapor liquid equilibrium(VLE) mixing rule reproducibility

A Model for Detecting Fake News by Integrating Domain-Specific Emotional and Semantic Features

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Computers, Materials & Continua 2024年第8期80卷 2161-2179页

作者： Wen Jiang Mingshu Zhang xu’an Wang Wei bin Xiong Zhang Kelan Ren Facheng yan College of Cryptography Engineering Engineering University of People’s Armed PoliceXi’an710086China Key Laboratory of Network and Information Security Engineering University of People’s Armed PoliceXi’an710086China Key Laboratory of CTC&Information Engineering Engineering University of People’s Armed PoliceMinistry of EducationXi’an710086China

With the rapid spread of Internet information and the spread of fake news,the detection of fake news becomes more and more *** detection methods often rely on a single emotional or semantic feature to identify fake news,but these methods have limitations when dealing with news in specific *** order to solve the problem of weak feature correlation between data from different domains,a model for detecting fake news by integrating domain-specific emotional and semantic features is *** method makes full use of the attention mechanism,grasps the correlation between different features,and effectively improves the effect of feature *** algorithm first extracts the semantic features of news text through the Bi-LSTM(Bidirectional Long Short-Term Memory)layer to capture the contextual relevance of news ***-BiLSTM is then used to extract emotional features and predict the probability of positive and negative emotions in the *** then uses domain features as an enhancement feature and attention mechanism to fully capture more fine-grained emotional features associated with that ***,the fusion features are taken as the input of the fake news detection classifier,combined with the multi-task representation of information,and the MLP and Softmax functions are used for *** experimental results show that on the Chinese dataset Weibo21,the F1 value of this model is 0.958,4.9% higher than that of the sub-optimal model;on the English dataset FakeNewsNet,the F1 value of the detection result of this model is 0.845,1.8% higher than that of the sub-optimal model,which is advanced and feasible.

关键词： Fake news detection domain-related emotional features semantic features feature fusion

A comprehensive review on surface modifications of black phosphorus using biological macromolecules

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Frontiers of Materials Science 2024年第2期18卷 37-59页

作者： Chaiqiong guo xuhong He xuanyu liu Yuhui Wang yan Wei Ziwei Liang Di Huang Department of Biomedical Engineering Research Center for Nano-biomaterials&Regenerative MedicineCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China

Black phosphorus(BP),a novel two dimensional material,exhibits remarkable photoelectric characteristics,ultrahigh photothermal conversion efficiency,substantial specific surface area,high carrier mobility,and tunable band gap *** attributes have positioned it as a promising candidate in domains such as energy,medicine,and the ***,its vulnerability to light,oxygen,and water can lead to rapid degradation and loss of crystallinity,thereby limiting its synthesis,preservation,and ***,BP has demonstrated cytotoxic tendencies,substantially constraining its viability in the realm of ***,the imperative for surface modification arises to bolster its stability and biocompatibility,while concurrently expanding its utility *** macromolecules,integral components of living organisms,proffer innate advantages over chemical agents and polymers for the purpose of the BP *** review comprehensively surveys the advancements in utilizing biological macromolecules for the modifications of *** doing so,it aims to pave the way for enhanced stability,biocompatibility,and diversified applications of this material.

关键词： blackphosphorus tumor therapy biocompatibility surface modification biomacromolecule

Lonicera Japonica Caulis Ameliorates LPS and TNF-α-Induced HT-29 Cell Injury by Inhibiting the MAPK/ERK/JNK/p38 Pathway

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Biomedical and Environmental Sciences 2024年第7期37卷 805-810页

作者： Hanxiu Lu Wei yan Xiao Yuan Yongbo Kang Zhongjian liu Qiang guo Faculty of Life science and Technology Kunming University of Science and TechnologyKunming 650031YunnanChina School of medicine Kunming University of Science and TechnologyKunming 650031YunnanChina Department of Gastroenterology The First People’s Hospital of Yunnan ProvinceKunming 650032YunnanChina Department of Gastroenterology The First People’s Hospital of Yuxi CityYuxi 653100YunnanChina Institute of Basic and Clinical Medicine The First People’s Hospital of Yunnan ProvinceKunming 650032YunnanChina

Inflammatory bowel disease(IBD)is characterized by chronic inflammation of the intestinal tract,and shows a high rate of *** have accumulated extensive experience in the treatment of IBD,with biologics and small molecule drugs having greatly expanded the therapeutic scope of IBD in recent ***,such treatments involve a high price and a single target of drug action.

关键词： drugs treatment p38

Methanol steam reforming for hydrogen production driven by an atomically precise Cu catalyst

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Green Energy & Environment 2024年第7期9卷 1079-1084页

作者： Weigang Hu Haoqi liu Yuankun Zhang Jiawei Ji Guangjun Li Xiao Cai xu liu Wen Wu xu Weiping Ding yan Zhu School of Chemistry and Chemical Engineering Nanjing University School of Physical Science and Technology Ningbo University

Plasmon-induced hot-electron transfer from metal nanostructures is being intensely pursed in current photocatalytic research,however it remains elusive whether molecular-like metal clusters with excitonic behavior can be used as light-harvesting materials in solar energy utilization such as photocatalytic methanol steam *** this work,we report an atomically precise Cu13cluster protected by dual ligands of thiolate and phosphine that can be viewed as the assembly of one top Cu atom and three *** Cu13H10（SR）3（PR’3）7(SR=2,4-dichlorobenzenethiol,PR’3=P（4-FC6H4）3) cluster can give rise to highly efficient light-driven activity for methanol steam reforming toward H2production.

关键词： Nanocluster Photocatalysis Methanol steam reforming Atomically precise Copper catalyst

Co_(3)S_(4)-pyrolysis lotus fiber flexible textile as a hybrid electrocatalyst for overall water splitting

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Journal of Energy Chemistry 2024年第2期89卷 336-344,I0008页

作者： Qiulan Zhou Zhen liu xuxu Wang Yaqian Li Xin Qin Lijuan guo Liwei Zhou Weijian xu Academician Workstation Changsha Medical UniversityChangsha 410219HunanChina College of Chemistry and Chemical Engineering Hunan UniversityChangsha 410082HunanChina College of Environmental Science and Engineering Hunan UniversityChangsha 410082HunanChina School of Basic Medicine Changsha Medical UniversityChangsha 410219HunanChina

Electrocatalytic overall water splitting(OWS),a pivotal approach in addressing the global energy crisis,aims to produce hydrogen and ***,most of the catalysts in powder form are adhesively bounding to the electrodes,resulting in catalyst detachment by bubble generation and other uncertain interference,and eventually reducing the OWS *** surmount this challenge,we synthesized a hybrid material of Co_(3)S_(4)-pyrolysis lotus fiber(labeled as Co_(3)S_(4)-p LF)textile by hydrothermal and hightemperature pyrolysis processes for electrocatalytic *** to the natural LF textile exposing the uniformly distributed functional groups(AOH,ANH_(2),etc.)to anchor Co_(3)S_(4)nanoparticles with hierarchical porous structure and outstanding hydrophily,the hybrid Co_(3)S_(4)-p LF catalyst shows low overpotentials at 10 m A cm^(-2)(η_(10,HER)=100 m Vη_(10,OER)=240 mV)alongside prolonged operational stability during electrocatalytic *** calculations reveal that the electron transfer from p LF to Co_(3)S_(4)in the hybrid Co_(3)S_(4)-p LF is beneficial to the electrocatalytic *** work will shed light on the development of nature-inspired carbon-based materials in hybrid electrocatalysts for OWS.

关键词： Overall water splitting Hybrid electrocatalyst Textile Lotus fiber Co_(3)S_(4)nanoparticles

Oil-soluble polymer brushes-functionalized nanoMOFs for highly efficient friction and wear reduction

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Friction 2024年第7期12卷 1499-1511页

作者： Jianxi liu Yong QIAN Dongsheng LI Wei WU Mengchen ZHANG Jie yan bin LI Feng ZHOU State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an 710072China Shaanxi Engineering Research Center of Special Sealing Technology Xi'an Aerospace Propulsion InstituteXi'an 710100China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

Nanomaterials as lubricating oil additives have attracted significant attention because of their designable composition and structure,suitable mechanical property,and tunable surface ***,the poor compatibility between nanomaterials and base oil limits their further *** this work,we demonstrated oil-soluble poly(lauryl methacrylate)(PLMA)brushes-grafted metal-organic frameworks nanoparticles(nanoMOFs)as lubricating oil additives that can achieve efficient friction reduction and anti-wear *** were synthesized by free-radical polymerization,which was coordinatively grafted onto the surface of the UiO-67 ***,PLMA brushes were grown on the macroinitiator-modified UiO-67 by surface-initiated atom transfer radical polymerization,which greatly improved the lipophilic property of the UiO-67 nanoparticles and significantly enhanced the colloidal stability and long-term dispersity in both non-polar solvent and base *** adding UiO-67@PLMA nanoparticles into the 500 SN base oil,coefficient of friction and wear volume reductions of 45.3%and 75.5%were achieved due to their excellent mechanical properties and oil ***,the load-carrying capacity of 500 SN was greatly increased from 100 to 500 N by the UiO-67@PLMA additives,and their excellent tribological performance was demonstrated even at a high friction frequency of 65 Hz and high temperature of 120℃.Our work highlights oil-soluble polymer brushes-functionalized nanoMOFs for highly efficient lubricating additives.

关键词： MOFs polymer brushes surface modification tribological properties friction reduction anti-wear