检索结果-南通市图书馆

Metabolic restraining of epigenetic modifications promotes cardiomyocyte proliferation

在线全文

学校读者我要写书评

暂无评论

Life Metabolism 2024年第1期3卷 4-6页

作者： xiuxiu liu Bin Zhou New Cornerstone Science Laboratory State Key Laboratory of Cell BiologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

The metabolic state of a cell is closely related to its structure and function in adult mammalian *** adult cardiomyocytes primarily use fatty acids as an energy substrate to support heart ***,Li and his colleagues reported that inhibiting fatty acid oxidation in cardiomyocytes keeps them in an immature *** influences epigenomic modifications and ultimately increases the proliferation capacity of the cardiomyocytes.

关键词： state. restrain primarily

The Neurovascular Unit Dysfunction in the Molecular Mechanisms of Epileptogenesis and Targeted Therapy

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第5期40卷 621-634页

作者： xiuxiu liu Ying Zhang Yanming Zhao Qian Zhang Feng Han Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases Ministry of EducationNanjing211166China International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical UniversityNanjing211166China Institute of Brain Science The Affiliated Brain Hospital of Nanjing Medical UniversityNanjing211166China Gusu School Nanjing Medical UniversitySuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou210019China

Epilepsy is a multifaceted neurological syndrome characterized by recurrent,spontaneous,and synchronous *** pathogenesis of epilepsy,known as epileptogenesis,involves intricate changes in neurons,neuroglia,and endothelium,leading to structural and functional disorders within neurovascular units and culminating in the development of spontaneous *** current research on epilepsy treatments primarily centers around anti-seizure drugs,it is imperative to seek effective interventions capable of disrupting *** this end,a comprehensive exploration of the changes and the molecular mechanisms underlying epileptogenesis holds the promise of identifying vital biomarkers for accurate diagnosis and potential therapeutic *** early diagnosis and timely intervention is paramount,as it stands to significantly improve patient prognosis and alleviate the socioeconomic *** this review,we highlight the changes and molecular mechanisms of the neurovascular unit in epileptogenesis and provide a theoretical basis for identifying biomarkers and drug targets.

关键词： Epileptogenesis Neurovascular unit Molecular mechanisms Drug targets

Milk-derived exosomes as a promising vehicle for oral delivery of hydrophilic biomacromolecule drugs

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2023年第2期18卷 137-149页

作者： Yuting Li Liyun Xing Lingling Wang Xi liu Licheng Wu Mingjie Ni Zhou Zhou Lian Li xiuxiu liu Yuan Huang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Exosomes,as promising vehicles,have been widely used in the research of oral drug delivery,but the generally low drug loading efficiency of exosomes seriously limits its application and *** this study,we systematically investigated the effects of drug loading methods and physicochemical properties(lipophilicity and molecular weight)on drug loading efficiency of milk-derived exosomes to explore the most appropriate loading *** finding revealed that the drug loading efficiency of exosomes was closely related to the drug loading method,drug lipophilicity,drug molecular weight and exosome/drug *** note,we demonstrated the universality that hydrophilic biomacromolecule drugs were the most appropriate loading drugs for milk-derived exosomes,which was attributed to the efficient loading capacity and sustained release ***,milk-derived exosomes could significantly improve the transepithelial transport and oral bioavailability of model hydrophilic biomacromolecule drugs(octreotide,exendin-4 and salmon calcitonin).Collectively,our results suggested that the encapsulation of hydrophilic biomacromolecule drugs might be the most promising direction for milk exosomes as oral drug delivery vehicles.

关键词： Milk-derived exosomes Loading efficiency Drug lipophilicity Molecular weight Drug release Oral delivery

Protective effect of Tongdu Tiaoshen acupuncture combined with Xiaoxuming decoction(小续命汤)on dopaminergic neurons in Parkinson’s disease model

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2023年第3期43卷 484-493页

作者： WU Haiyang WANG Ying HAN Wei LI Huihui JI Haisheng liu xiuxiu Department of encephalopathy the Second Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230061China Deparment of acupuncture and Moxibustion The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Department of acupuncture and massage Anhui University of Chinese MedicineHefei 230061China

OBJECTIVE:To explore the possible mechanism of Tongdu Tiaoshen acupuncture combined with Xiaoxuming decoction(小续命汤,XXMD)in the treatment of Parkinson’s disease(PD).METHODS:C57BL/6 mice were randomly divided into eight groups(n=12),including blank group,model group,medication group,acupuncture group,high-dose XXMD group(XXMD-H),low-dose XXMD group(XXMD-L),acupuncture combined with high-dose XXMD group(A+H),and acupuncture combined with low-dose XXMD group(A+L).After treatment for 6 weeks,dopamine(DA)neurons and the pathological changes of tyrosine hydroxylase(TH)positive cells were *** enzyme-linked immunosorbent assay(ELISA)was used to measure the content of DA and the level of interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-10(IL-10)and tumor necrosis factor alpha(TNF-α).The m RNA level of PINK1 and Parkin and the protein expression of Nix,PINK1 and Parkin in the substantia nigra were also ***:Combination treatment effectively ameliorated the symptoms of *** with model group,combined treatment significantly up-regulated the protein expression of Nix,Parkin and PINK1 and the m RNA levels of PINK1 and Parkin in the substantia nigra(P<0.0001,P<0.001,P<0.01 or P<0.05).Furthermore,the levels of pro-inflammation cytokines were obviously decreased after combination therapy,while IL-10 content was increased remarkably(P<0.01).CONCLUSION:Compared with each treatment alone,combination therapy improved the pathological damage of DA neurons of PD mice more *** possible mechanism may be attributed to the up-regulated level of mitochondrial autophagy and improved mitochondrial *** results provide fresh insight into the mechanism of co-treatment with Tongdu Tiaoshen acupuncture and XXMD for PD.

关键词： Parkinson disease acupuncture dopaminergic neurons Tongdu Tiaoshen Xiaoxuming decoction mitochondrial autophagy

Centromere inactivation in a dicentric rice chromosome during sexual reproduction

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2013年第33期58卷 4602-4607页

作者： GONG ZhiYun XUE Chao liu xiuxiu ZHANG MingLiang ZHOU Yong YU HengXiu GU MingHong Key Laboratory of Crop Genetics and Physiology of Jiangsu Province/Key Laboratory of Plant Functional Genomics of Ministry of Education Yangzhou University

T0135 is a variant selected from the progeny of a rice line telotrisomic for the short arm of chromosome 11(2n+11S·).Fluorescent in situ hybridization(FISH)results indicated that T0135 contained two telocentric chromosomes,which have two centromere-specific molecular markers(5S rDNA)for chromosome 11;thus T0135 is a newly-described rice chromosome variant with two dicentric chromosomes,named 22+11L·+11L·+11S·11S·+11S·11S·(22 represents the 22 chromosomes excluding chromosome 11 in the rice genome,"·"represents the centromere).To investigate the genetic stability of the rice dicentric chromosomes during sexual reproduction,we observed the chromosome types in the ***-four percent of the progeny had the same chromosome type as the parental *** result indicates that the dicentric chromosomes are mostly stable during mitosis and *** analysis for centromere specific histone H3(CENH3)revealed that only one centromere is active and the other centromere is inactivated in the rice dicentric chromosomes.

关键词： 1号染色体着丝粒繁殖过程遗传稳定性水稻品系失活免疫荧光分析分子标志物

同方期刊数据库

The Rational Solutions and the Interactions of the N-Soliton Solutions for Boiti-Leon-Manna-Pempinelli-Like Equation

在线全文

学校读者我要写书评

暂无评论

Journal of Applied Mathematics and Physics 2017年第3期5卷 700-714页

作者： xiuxiu liu Huanhe Dong Yong Zhang Xin Chen Department of Mathematics and Systems Science Shandong University of Science and Technology Qingdao China

These rational solutions which can be described a kind of algebraic solitary waves which have great potential in applied value in atmosphere and ocean. It has attracted more and more attention recently. In this paper, the generalized bilinear method instead of the Hirota bilinear method is used to obtain the rational solutions to the (2 + 1)-dimensional Boiti-Leon-Manna-Pempinelli-like equation (hereinafter referred to as BLMP equation). Meanwhile, the (2 + 1)-dimensional BLMP-like equation is derived on the basis of the generalized bilinear operators D3,x D3,y and D3,t. And the rational solutions to the (2 + 1)-dimensional BLMP-like equation are obtained successively. Finally, with the help of the N-soliton solutions of the (2 + 1)-dimensional BLMP equation, the interactions of the N-soliton solutions can be derived. The results show that the two soliton still maintained the original waveform after happened collision.

关键词： Rational Solution Generalized Bilinear Method BLMP-Like Equation N-Soliton Solution

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

互联网公益的发展生态及其治理

国家行政学院学报 2018年第5期 158-163,192,193页

作者：刘秀秀中共北京市委党校北京100044

互联网公益作为新兴的公益形式,是"互联网+"国家战略中的重要组成部分。在互联网公益随着技术进步发展迅猛的同时,也呈现出不平衡的发展生态:一是在网络社会中占据不同位置的公益组织发展状况参差不齐;二是互联网公益领域的不规范操作频... 详细信息

互联网公益作为新兴的公益形式,是"互联网+"国家战略中的重要组成部分。在互联网公益随着技术进步发展迅猛的同时,也呈现出不平衡的发展生态:一是在网络社会中占据不同位置的公益组织发展状况参差不齐;二是互联网公益领域的不规范操作频发,公益运作效果良莠不齐。这种生态状况与公益行动者的分散与聚合、技术使用的效度与限度、制度建设的道与术,这几对互构式机制密切相关。随着公益领域的技术支持愈发智能,公益组织的结构日益多样,亟需更具创新性的治理思路。营造清朗的网络空间,生产正向的互联网逻辑,促进公益行动者进一步共享技术红利,并在多方参与的形式下加快制度建设的步伐,将有利于推动互联网公益走向平衡的健康生态。

关键词：互联网公益发展生态技术红利公益行动者

网络化时代的信息主义精神——来自互联网公益领域的经验

在线全文

学校读者我要写书评

暂无评论

江海学刊 2019年第6期 111-117,254,255页

作者：刘秀秀中共北京市委党校(北京行政学院)校刊编辑部

在卡斯特的信息时代三部曲中,"信息主义精神"是一个极具学术生命力,但尚未引起足够重视的概念。它既可以从韦伯的经典历史概念"资本主义精神"中汲取营养,又能够在当下鲜活的经验事实中找到抓手。互联网公益发展的二十余年中,有两个绵亘... 详细信息

在卡斯特的信息时代三部曲中,"信息主义精神"是一个极具学术生命力,但尚未引起足够重视的概念。它既可以从韦伯的经典历史概念"资本主义精神"中汲取营养,又能够在当下鲜活的经验事实中找到抓手。互联网公益发展的二十余年中,有两个绵亘较久且悬而未决的论争--技术是否向善和公益是否向右,拆解其中涉及的结构、行动者、技术、认同等要素,有利于解码信息主义精神。技术至上主义在文化符码的嬗变中上升又跌落,是由于信息主义精神植根于社会结构之中,偏向性的情感认同、拉锯中的网络信任、纠葛中的价值归属是其流变的一波三折;而互动中的意义之争是信息主义精神的存在形式,层级化的行动者在其中争夺"互动者"的位置。作为网络化社会中的核心价值,信息主义精神研究还有很长的路要走:识别传统有助于锚定信息主义精神的位置,而重建理论则是技术迷思中的重要救赎。

关键词：信息主义精神互联网公益技术向善公益向右

在线全文

学校读者我要写书评

暂无评论

论朝鲜李朝与中国明朝外交中的辞赋唱和

西南民族大学学报（人文社会科学版） 2022年第12期43卷 171-177页

作者：刘秀秀山东大学儒学高等研究院山东济南250100

在朝鲜李朝与中国明朝的宗藩交聘活动中,两朝使臣除诗歌唱和外,辞赋唱和也很频繁。其辞赋唱和的主题,大体分为平壤祭吊箕子、途中纪述游览、汉城宴游登临三类。这些赋作在文学上发扬了中华辞赋次韵唱酬的形式,接受并延续了“祖骚宗汉”... 详细信息

在朝鲜李朝与中国明朝的宗藩交聘活动中,两朝使臣除诗歌唱和外,辞赋唱和也很频繁。其辞赋唱和的主题,大体分为平壤祭吊箕子、途中纪述游览、汉城宴游登临三类。这些赋作在文学上发扬了中华辞赋次韵唱酬的形式,接受并延续了“祖骚宗汉”的中华赋学观,提高了朝鲜汉文赋的艺术成就。在文化上具有彰显本国物情和颂宣明朝上德两重意涵:前者呈现出“尚实”的特点,后者则既展示“事大”之诚,又表现为对中华文明的服膺和认同,并导扬其“衣冠文物,一同中华”的民族自信,涵盖了多重表意功能。

关键词：朝鲜李朝中国明朝外交辞赋唱和主题文学特点文化意涵