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右美托咪定静脉泵注在腰-硬联合麻醉剖宫产手术中对产妇止痛效果的影响

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罕少疾病杂志 2024年第4期31卷 80-81,94页

作者：庞波波刘秀杰洛阳市妇幼保健院麻醉科河南洛阳471000 洛阳市偃师人民医院麻醉科河南洛阳471900

目的分析并探究剖宫产手术中采用右美托咪定静脉泵注腰-硬联合麻醉后产妇的止痛效果。方法选择2021年2月至2023年2月进行剖宫产的98例产妇作为研究对象,对其随机分组后,参照组采用生理盐水与罗哌卡因进行麻醉,实验组通过罗哌卡因联合右... 详细信息

目的分析并探究剖宫产手术中采用右美托咪定静脉泵注腰-硬联合麻醉后产妇的止痛效果。方法选择2021年2月至2023年2月进行剖宫产的98例产妇作为研究对象,对其随机分组后,参照组采用生理盐水与罗哌卡因进行麻醉,实验组通过罗哌卡因联合右美托咪定进行静脉泵注麻醉,两组均采取腰-硬联合麻醉的方式。观察两组产妇不同时段[麻醉前(T1)、麻醉后5min(T2)、麻醉后20min(T3)、胎儿娩出时(T4)]血流动力学指标[心率(HR)、平均动脉压(MAP)]、产后各时段(6h、12h、24h、48h)疼痛程度(VAS评分)、新生儿分娩2min、5min后阿氏(Apgar)评分与产妇不良反应发生情况。结果两组产妇T1时段HR、MAP指标、T2时段MAP指标、产后6h的VAS评分、新生儿分娩后2min、5min的Apgar评分、不良反应发生率差异比较均不明显(P>0.05),但实验组产妇T2时段HR指标、T3、T4时段HR、MAP指标与参照组相比较高,产后12h、24h与48hVAS评分相较于参照组则较低,各组数值对比差异明显(P<0.05)。结论在剖宫产手术中产妇采用右美托咪定静脉泵注腰-硬联合麻醉,不但对产妇术中血流动力学影响较小,产后止痛效果良好,还不易引发不良反应,具有较高的麻醉安全性,适合用于临床推广。

关键词：右美托咪定静脉泵注腰-硬联合麻醉剖宫产手术止痛效果

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An Integrative Analysis of the Effects of Auxin on Jasmonic Acid Biosynthesis in Arabidopsis thaliana

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Journal of Integrative Plant Biology 2006年第1期48卷 99-103页

作者： Jun liu xiu-jie Wang Institute of Genetics and Development Biology the Chinese Academy of Sciences Beijing 100101 China

Auxin and jasmonic acid （JA） are two plant phytohormones that both participate in the regulation of many developmental processes. Jasmonic acid also plays important roles in plant stress response reactions. Although extensive investigations have been undertaken to study the biological functions of auxin and JA, little attention has been paid to the cross-talk between their regulated pathways. In the few available reports examining the effects of auxin on the expression of JA or JA-responsive genes, both synergetic and antagonistic results have been found. To further investigate the relationship between auxin and JA, we adopted an integrative method that combines microarray expression data with pathway information to study the behavior of the JA biosynthesis pathway under auxin treatment. Our results showed an overall downregulation of genes involved in JA biosynthesis, providing the first report of a relationship between auxin and the JA synthesis pathway in Arabidopsis seedlings.

关键词： Arabidopsis auxin biosynthesis jasmonic acid pathway.

In situ meso-tetra(4-carboxyphenyl)porphyrin ligand substitution in Hf-MOF for enhanced catalytic activity and stability in photoredox reactions

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Rare Metals 2024年第6期43卷 2682-2694页

作者： jie Hu Hong-Xin Lao xiu-Wu Xu Wei-Kang Wang Le-Le Wang Qin-Qin liu School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China College of Chemistry and Materials Engineering Research Center of Carbon NeutralityAnhui Normal UniversityWuhu 241002China Fujian Provincial Key Laboratory of Ecology-Toxicological Effects and Control for Emerging Contaminants Putian UniversityPutian 351100China

Though there are numerous intrinsic merits of metal-organic frameworks(MOFs),low charge separation efficiency has imposed heavy restrictions on their photocatalytic ***,in situ porphyrin ligand substitution,as a strategy for improving the charge separation efficiency and increasing the amounts of active sites,has been designed and realized in a Hf-biphenyl dicarboxylic acid(BPDC)***,a size and geometry matched meso-tetra(4-carboxyphenyl)porphyrin(TCPP)ligand was selected and doped into Hf-BPDC MOF by forming coordinating bonds with Hf centers,forming dualligand Hf-BPDC-TCPP *** resultant Hf-BPDC-TCPP MOF showed significantly improved activity and chemical stability in the photocatalytic H_(2)generation(261μmol·g^(-1)·h^(-1))and tetracycline(TC)degradation reactions(95.8%),which was 48 and 1.47 folds higher than that of the Hf-BPDC *** and electrochemical studies revealed that the introduction of porphyrin ligand could generate a stronger internal electric field for boosting the charge separation and transfer,increase the specific surface area for providing more active sites,and narrow the band gap to enhance the visible light *** in situ ligand substitution method provides a promising approach to build a tunable platform for constructing high-performance MOF photocatalysts.

关键词： Ligand substitution Metal organic frameworks Meso-tetra(4-carboxyphenyl)porphyrin Hydrogen evolution reaction Tetracycline degradation

Maternal weight and its association with risk of overweight in offspring:a trajectory analysis from a birth cohort in China

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World Journal of Pediatrics 2024年第5期20卷 496-505页

作者： Rui Deng Wei-Qin Li Xing-xiu Li liu-Mei Wei jie Hu Jun-Hong Leng Bin Dong Institute of Child and Adolescent Health School of Public HealthPeking University Health Science CenterNo.38 Xueyuan RdHaidian DistrictBeijing100191China Tianjin Women and Children’s Health Center No.96 Guizhou RdHeping DistrictTianjin300070China Menzies Health Institute Queensland Griffith UniversityNathanQLD4111Australia

Background Most studies on the association of maternal pregnancy weight with offspring weight trajectory have a short follow-up *** study aimed to explore the associations of maternal prepregnancy body mass index(BMI)and gestational weight gain(GWG)with childhood weight trajectories in a 7-year birth *** A total of 946 mother–child pairs(467 boys and 479 girls)from a longitudinal birth cohort in Tianjin City,China,were included in this study,ranging from pregnancy to offspring at 7 *** outcome variable was defined as overweight or not overweight in offspring at the last round.A group-based trajectory model was applied to identify childhood BMI trajectory *** Five discrete BMI trajectory groups were identified and characterized as constant underweight(25.2%),constant normal weight(42.8%),and high or increasing trajectory[at risk of overweight(16.9%),progressive overweight(11.0%)and progressive obesity(4.1%)].Maternal prepregnancy overweight was associated with 1.72(95%CI 1.14–2.60,P=0.01)to 4.02(95%CI 1.94–8.36,P<0.001)times the risk of all high or increasing trajectory groups,and excessive GWG was related to groups at risk of overweight[relative risk ratio(RRR)2.09,95%CI 1.27–3.46,P=0.004]and progressive obesity(RRR 3.33,95%CI 1.13–9.79,P=0.029).Children in all high or increasing trajectory groups were associated with greater overweight risk at the last round[risk ratios(RRs)ranged from 3.54(95%CI 2.53–4.95,P<0.001)to 6.18(95%CI 4.05–9.42,P<0.001)].Conclusion Maternal prepregnancy overweight and excessive gestational weight gain were associated with increasing or high-level childhood body mass index trajectories as well as a greater risk of overweight at 7 years.

关键词： Body-weight trajectory Child Gestational weight gain Overweight Pregnancy

A short review of antibacterial Cu-bearing stainless steel:antibacterial mechanisms,corrosion resistance,and novel preparation techniques

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Journal of Iron and Steel Research(International) 2024年第1期31卷 24-45页

作者： Shuai liu Han-jie Guo School of Artificial Intelligence Beijing Technology and Business UniversityBeijing100048China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials University of Science and Technology BeijingBeijing100083China

Cu-bearing stainless steel is widely used in the fields of food,medical and household sanitary equipment because of its surface finish and corrosion ***,the growth of bacteria on stainless steel leads to the formation of biofilms,which causes ***,the antibacterial property of stainless steel is a worthy research *** of breakthroughs in the field of corrosion resistance and antimicrobial properties are still ***,due to the scarcity of publications on the antibacterial mechanisms and processing methods of antibacterial Cu-bearing stainless steel,we review the current state of relevant research and *** toxicity of Cu,corrosion resistance mechanism of stainless steel,and antibacterial mechanism and preparation method of antibacterial stainless steel are *** addition,alloying,surface modification and other methods are found to have limitations in balancing the toxicity and antibacterial properties of copper and the relationship between the antibacterial properties and corrosion resistance of Cu-bearing stainless steel.A new preparation method of antibacterial stainless steel associated with selective laser melting(SLM)is *** is becoming a powerful additive manufacturing technology that can be used to manufacture customized and complex *** research status of SLM applied in antibacterial stainless steel preparation is ***,the future research direction of Cu-bearing antibacterial stainless steel is discussed.

关键词： Cu-bearing stainless steel Antibacterial Processing Additive manufacturing Corrosion resistance

Mg-doped,carbon-coated,and prelithiated SiO_(x) as anode materials with improved initial Coulombic efficiency for lithium-ion batteries

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Carbon Energy 2024年第3期6卷 204-214页

作者： Bin liu jie liu Cheng Zhong Wenbin Hu Key Laboratory of Advanced Ceramics and Machining Technology(Ministry of Education) School of Materials Science and EngineeringTianjin UniversityTianjinChina Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjinChina Joint School of National University of Singapore and Tianjin University TianjinChina International Campus of Tianjin University Binhai New CityFuzhouChina

Silicon suboxide(SiO_(x),x≈1)is promising in serving as an anode material for lithium-ion batteries with high capacity,but it has a low initial Coulombic efficiency(ICE)due to the irreversible formation of lithium silicates during the first *** this work,we modify SiO_(x) by solid-phase Mg doping reaction using low-cost Mg powder as a reducing *** show that Mg reduces SiO_(2) in SiO_(x) to Si and forms MgSiO_(3) or Mg_(2)SiO_(4).The MgSiO_(3) or Mg_(2)SiO_(4) are mainly distributed on the surface of SiO_(x),which suppresses the irreversible lithium-ion loss and enhances the ICE of SiO_(x).However,the formation of MgSiO_(3) or Mg_(2)SiO_(4) also sacrifices the capacity of SiO_(x).Therefore,by controlling the reaction process between Mg and SiO_(x),we can tune the phase composition,proportion,and morphology of the Mg-doped SiO_(x) and manipulate the *** obtain samples with a capacity of 1226 mAh g^(–1) and an ICE of 84.12%,which show significant improvement over carbon-coated SiO_(x) without Mg *** the synergistical modification of both Mg doping and prelithiation,the capacity of SiO_(x) is further increased to 1477 mAh g^(–1) with a minimal compromise in the ICE(83.77%).

关键词： initial Coulombic efficiency lithium-ion batteries magnesium doping prelithiation silicon suboxide

Experimental Investigation on Vertical Hydraulic Transport of Ores in Deepsea Mining

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China Ocean Engineering 2024年第1期38卷 42-53页

作者： liu Lei liu Jian-cheng LI Xin XU Li-xin ZHANG xiu-zhan State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Sanya Yazhou Bay Institution of Deep-sea Sci-Tech Shanghai Jiao Tong UniversitySanya 572000China China Merchants Marine And Offshore Research Institute Co. Ltd.Shenzhen 518067China China Merchants Deepsea Research Institute(Sanya)Co. Ltd.Sanya 572000China School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Deepsea mining has been proposed since the 1960s to alleviate the lack of resources on *** hydraulic transport of collected ores from the seabed to the sea surface is considered the most promising method for industrial *** the present study,an indoor model test of the vertical hydraulic transport of particles was conducted.A noncontact optical method has been proposed to measure the local characteristics of the particles inside a vertical pipe,including the local concentration and particle *** hydraulic gradient of ore transport was evaluated with various particle size distributions,particle densities,feeding concentrations and mixture flow *** transport,the local concentration is larger than the feeding concentration,whereas the particle velocity is less than the mixture *** qualitative effects of the local concentration and local fluid velocity on the particle velocity and slip velocity were *** local fluid velocity contributes significantly to particle velocity and slip velocity,whereas the effect of the local concentration is marginal.A higher feeding concentration and mixture flow velocity result in an increased hydraulic *** effect of the particle size gradation is slight,whereas the particle density plays a crucial role in the transport.

关键词： deepsea mining vertical hydraulic transport experiment flow characteristics

Analysis of large datasets for identifying molecular targets in intestinal polyps and metabolic disorders

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BIOCELL 2024年第3期48卷 415-429页

作者： SHAN OU YUN XU QINGLAN liu TIANWEN YANG WEI CHEN xiu YUAN XIN ZUO PENG SHI jie YAO Department of Gastroenterology The First Affiliated Hospital of Chongqing Medical and Pharmaceutical CollegeChongqingChina

Background:The interrelation between intestinal polyps,metabolic syndrome(MetS),and colorectal cancer(CRC)is a critical area of *** research focuses on pinpointing potential molecular targets to understand the link between intestinal polyp formation,metabolic irregularities,and CRC ***:We examined clinical samples from patients with intestinal polyps coexisting with MetS and compared them with samples from patients with standard intestinal *** sequencing and public database analysis were employed to identify significant pathways and *** targets were then validated through immunohistochemistry(IHC).Following the RNA interference of key target expression,a series of experiments,including the cell counting kit-8 assay,colony formation,wound healing,and Transwell assays,were ***:Comparative analysis revealed 75 up-regulated and 61 down-regulated differentially expressed genes(DEGs)in the MetS polyp group *** *** encyclopedia of genes and genomes(KEGG)pathway enrichment suggested these DEGs were primarily associated with cell cycle and *** with comparative toxicogenomics database(CTD)and the cancer genome atlas(TCGA)databases highlighted 44 key CRC-related *** interaction networks indicated connections of purkinje cell protein 4(PCP4),olfactomedin 1(OLFM1),fibronectin 1(FN1),and transforming growth factor beta 3(TGF-β3)with the mitogen-activated protein kinase(MAPK)*** correlation studies suggested higher risk associations with FN1,PCP4,and TGF-β3,while OLFM1 was identified as a lower risk *** analysis revealed a decrease in OLFM1 in MetS-associated intestinal *** interference with OLFM1 in polyp epithelial cells,there was a significant enhancement in cell proliferation,colony formation,and cell migration and invasion ***:Our study highlights a significant decrease in OLFM1 expression in MetS-associated intestinal

关键词： Colorectal cancer Metabolic syndrome Intestinal polyp OLFM1 Exosome

Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy:a precise construction of structurally diverse azaspiro polycyclic scaffolds

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Science China Chemistry 2024年第2期67卷 576-586页

作者： Xiao-Bao Wu Jun-xiu Shi Yi-Ming Ou Hua-jie Jiang Yi-Jun Fang Qi-Ming Wang Quan Gao jie Yu Department of Applied Chemistry Anhui Province Engineering Laboratory for Green Pesticide Development and ApplicationAnhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Agricultural UniversityHefei230036China

A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic *** diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results(up to 99:1 e.r.,>95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(Ⅲ) complexes.

关键词： asymmetric catalysis post-Ugi transformation anionic stereogenic-at-cobalt(Ⅲ)complex azaspiro polycyclic scaffold one-pot synthesis