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Reconstruction of biomimetic ionic channels within covalent organic frameworks for ultrafast and selective uranyl capture

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Science China Chemistry 2024年第10期67卷 3423-3431页

作者： Cheng-rong Zhang xiao-Juan Chen Cheng-Peng Niu Cheng Meng Shun-Mo Yi Xin liu Jia-Xin Qi Qiu-Xia Luo Ru-Ping Liang Jian-Ding Qiu State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China College of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China

The efficient extraction of uranium,as the primary component of nuclear energy,holds significant *** inspiration from the charge interaction observed in biological ion channels,we encapsulated negatively charged polystyrene sulfonate(PSS)or sodium polystyrene carboxylate(PVBA)into the nanochannels of amidoxime functionalized covalent organic framework(COF-AO)in-situ to alter the cavity environment of *** synthesized COF-AO-PSS and COF-AO-PVBA are used for ultra-fast and highly selective uranium *** negatively charged PSS/PVBA was confined in the COF-AO channel providing the driving force for uranium transport and blocking other ions,thus creating a highly selective“uranium highway”.Additionally,introducing sulfonate groups or carboxyl groups into COF-AO offers supplementary coordination environments and weak interactions with *** to charge-assisted migration and various interaction mechanisms,both COF-AO-PSS and COF-AO-PVBA exhibit faster adsorption kinetics and higher selectivity compared to COF-AO *** adsorption capacities are 3.8 times and 2.4 times that of COF-AO alone respectively which highlights the necessity for constructing biomimetic ion channels in uranium adsorption *** work presents a bionic adsorbent based on covalent organic frameworks(COFs)for the first time,overcoming environmental and equipment limitations associated with traditional photocatalysis and electrocatalysis methods for uranium capture,opening up new avenues for designing multifunctional materials that mimic biological systems.

关键词： covalent organic frameworks Uranium biomimetic ion-channels adsorption

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Inhibition of viability of human retinal microvascular endothelial cells by vialinin A under high glucose condition

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1809-1815页

作者： Zhi-Gang Chen Gao-Qin liu Wei-Ming liu Pei-rong Lu Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Jiangsu Clinical Immunology Institute the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

AIM:To investigate the effects of vialinin A on viability of human retinal endothelial cells(HRECs)under high glucose condition and its potential ***:The HRECs were divided into four groups:normal glucose control group(NG,5 mmol/L D-glucose),high glucose group(HG,30 mmol/L D-glucose),HG+1μmol/L vialinin A group,and HG+5μmol/L vialinin A *** cell viabilities were measured with cell counting kit-8(CCK-8)assay for proliferation,with scratch assay for migration,and tube formation,for evaluation of the impact of vialinin A on cellular ***-time PCR and Western blotting were used to determine the expression level of vascular endothelial growth factor(VEGF).RESULTS:The proliferative capacity and migration of HRECs was reduced by 5μmol/L vialinin A in high glucose environment(both P<0.05).Vialinin A also inhibited highglucose-induced tube formation of *** expression level of VEGF and PI3K in HRECs was also significantly decreased by vialinin A(P<0.05).CONCLUSION:Vialinin A inhibits the cell viability of *** may serve as a potential target for anti-angiogenic therapy.

关键词： vialinin A vascular endothelial growth factor human retinal endothelial cells cell viability

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Visible-Light-Driven Four-Component Radical Relay Aminocarbonylation of Unactivated Alkenes

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Chinese Journal of Chemistry 2024年第9期42卷 990-996页

作者： Bin Lu Feng-Shuo Bao Zi-Wei He Wen-Jing xiao Jia-rong Chen Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction College of ChemistryCentralChina Normal University152 Luoyu RoadWuhanHubei 430079China Wuhan Institute of Photochemistry and Technology 7North Bingang RoadWuhanHubei 430083China Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province Gannan Normal UniversityGanzhouJiangxi 341000China

Catalytic four-component radical carbonylation of unactivated alkenes has recently been recognized as a robust protocol for rapid construction of various structurally diverse carbonyl *** the significance of fluorine-containing groups,this reaction class has been extensively applied to assembly of a variety of perfluoroalkyl carboxylic acid derivatives by transition metal ***,we report a visible-light-driven radical relay 1,2-perfluoroalkylation aminocarbonylation of unactivated alkenes using CO gas as carbonyl source and 4CzIPN as organic photocatalyst.A wide range of alkenes and amines were well tolerated,providing the valuableβ-perfluoroalkylated amides with generally good yields and high chemoselectivity.

关键词： Visible light Photoredox catalysis Radical aminocarbonylation Multicomponent reaction Carbon monoxide Unactivated alkenes AmidesIReactionmechanisms

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GLP-1 receptor agonists and myocardial metabolism in atrial fibrillation

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Journal of Pharmaceutical Analysis 2024年第5期14卷 653-665页

作者： Jiani Zhong Hang Chen Qiming liu Shenghua Zhou Zhenguo liu Yichao xiao Department of Cardiovascular Medicine Second Xiangya HospitalCentral South UniversityChangsha410011China Xiangya School of Medicine Central South UniversityChangsha410008China Center for Precision Medicine and Division of Cardiovascular Medicine Department of MedicineSchool of MedicineUniversity of MissouriColumbiaMO65211USA

Atrial fibrillation(AF)is the most common cardiac *** medical conditions,including hypertension,diabetes,obesity,sleep apnea,and heart failure(HF),increase the risk for *** have unique metabolic characteristics to maintain adenosine triphosphate *** changes occur in myocardial metabolism in ***-like peptide-1 receptor agonists(GLP-1RAs)have been used to control blood glucose fluctuations and weight in the treatment of type 2 diabetes mellitus(T2DM)and ***-1RAs have also been shown to reduce oxidative stress,inflammation,autonomic nervous system modulation,and mitochondrial *** article reviews the changes in metabolic characteristics in cardiomyocytes in *** the clinical trial outcomes are unsatisfactory,the findings demonstrate that GLP-1 RAs can improve myocardial metabolism in the presence of various risk factors,lowering the incidence of AF.

关键词： Atrial fibrillation Glucagon-like peptide-1 receptor agonists Metabolism

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Association of Methionine Synthase rs1805087 Polymorphism With Arsenic-Related Skin Pigmentary Changes:A Population-Based Case-Control Study

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International Journal of Dermatology and Venereology 2024年第2期7卷 70-77页

作者： xiao-Yan Huang Yi xiao Dan-rong Jing Min-Xue Shen Li-Xia Lu Department of Pathology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Skin Cancer and Psoriasis Central South UniversityChangshaHunan 410008China Hunan Engineering Research Center of Skin Health and Disease Central South UniversityChangshaHunan 410008China Department of Social Medicine and Health Management Xiangya School of Public HealthCentral South UniversityChangshaHunan 410008China

Objective:Chronic arsenic exposure causes skin lesions including skin cancers,pigmentary changes,and *** polymorphism in arsenic metabolism may increase susceptibility to the development of arsenic-related skin *** study was performed to determine whether arsenic metabolism-related gene variants are associated with arsenic-related pigmentary ***:This case-control study involved 189 patients with arsenic-related pigmentary changes and 103 ***-eight polymorphisms in 10 genes determined by mass spectrometry assay served as candidate drivers of arsenic-induced pigmentary *** and plasma arsenic levels were determined by inductively coupled plasma mass *** arsenic concentrations were measured by nondispersive atomic fluorescence *** metabolites in urine were determined using high-performance liquid chromatography with inductively coupled plasma mass *** folate was measured using a folate radio assay *** of variance,nonparametric test,or the chi-square test was selected according to the data *** correlation analysis was used to determine the correlation between two *** regression was used to estimate the effect of single-nucleotide ***:The arsenic concentrations in urine,plasma,and hair and the urine arsenic species were not significantly different between patients and *** regression revealed that among the polymorphisms,the methionine synthase(MTR)rs1805087 polymorphism showed a protective effect against arsenic-related pigmentary *** the codominant model,the adjusted odds ratio for age,sex,and ethnicity was 0.41(95%confidence interval[CI],0.21-0.80;P=0.008)for the AG genotype and 0.11(95%CI,0.02-0.60;P=0.012)for the GG ***:MTR polymorphism showed a protective effect against arsenic-related pigmentary changes in the logistic regression *** effect of MTR rs1805087 might

关键词： methionine synthase arsenic-related pigmentary changes arsenic metabolism

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Eco-physiological characteristics of Tetracentron sinense *** in response to different light intensities

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Journal of Forestry Research 2024年第3期35卷 29-44页

作者： rong Wang Xueheng Lu Hongyan Han Xuemei Zhang Yonghong Ma Qinsong liu xiaohong Gan Key Laboratoryof Southwest Wildlife Resources Conservation Ministry of EducationChina West Normal UniversityNanchong 637009People's Republic of China Institute of Plant Adaptation and Utilization in Southwest Mountain China West Normal UniversityNanchong 637009People's Republic of China Office of the People's Government of Yuexi County Yuexi County 616650Liangshan Yi Autonomous PrefecturePeople's Republic of China

The regeneration of Tetracentron sinense *** poor in the understory and in open areas due to the charac-teristics of natural regeneration of the species on forest edges and in *** is unclear whether different light intensities in various habitats affect eco-physiological characteristics of saplings and their natural *** this study,the light intensity in *** habitats was simulated by artificial shading(L1:100%NS(natural sunlight)in the open;L2:50%NS in a forest gap or edge;L3:10%NS in understory)to investigate differences in morphology,leaf structure,physiology,and photosynthesis of 2-year-old sap-lings,and to analyze the mechanism of light intensity on sapling *** differences were observed in morphology(including leaf area,and specific leaf area)under different light *** to L1 and L3,chloroplast structure in L2 was *** increasing time,superoxide dismutase(SOD)and catalase(CAT)activities in L2 became gradually higher than under the other light intensities,while malondialdehyde(MDA)content was *** decreased osmoregulation substance contents of leaves but increased *** results suggest that light intensities significantly affect the eco-physiological characteristics of *** saplings and they would respond most favorably at intermediate levels of light by optimizing eco-physiological ***,50%natural sunlight should be created to promote saplings establishment and population recovery of *** during in situ conservation,including sowing mature seeds in forest edges or gaps and providing appropriate shade protection for seedlings and saplings in the open.

关键词： Chloroplast ultrastructure Eco-physiological characteristics Light intensities Sapling establishment Tetracentron sinense Oliv

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Optimal geometrical configuration and oxidation state of cobalt cations in spinel oxides to promote the performance of Li-O_(2) battery

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Nano Research 2024年第1期17卷 221-227页

作者： Yu Zhang Shuting Zhang Mengwei Yuan Yufeng Li rong liu Caiyun Nan Chen Chen Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua UniversityBeijing 100084China Beijing Key Laboratory of Energy Conversion and Storage Materials Institution College of ChemistryBeijing Normal UniversityBeijing 100875China X-ray diffraction Lab Analytical and Testing CenterBeijing Normal UniversityBeijing 100875China

Co_(3)O_(4) is considered as one of promising cathode catalysts for lithium oxygen(Li-O_(2))batteries,which contains both tetrahedral Co^(2+)sites(Co^(2+)Td)and octahedral Co^(3+)sites(Co^(3+)Oh).It is important to reveal the effect of optimal geometric configuration and oxidation state of cobalt ion in Co_(3)O_(4) to improve the performance of Li-O_(2) ***,through regulating the synthesis process,Co^(2+)and Co^(3+)sites in Co_(3)O_(4) were replaced with Zn and Al atoms to form materials with a unique Co *** Li-O_(2) batteries based on ZnCo_(2)O_(4) showed longer cycle life than that of CoAl_(2)O_(4),suggesting that in Co_(3)O_(4),the Co^(3+)Oh site is a relatively better geometric configuration than Co^(2+)Td site for Li-O_(2) *** calculations revealed that Co^(3+)Oh sites provide higher catalysis activity,regulating the adsorption energy of the intermediate LiO_(2) and accelerating the kinetics of the reaction in batteries,which further leads to the change of the morphology of the discharge product and ultimately improves the electrochemical performance of the batteries.

关键词： lithium oxygen(Li-O_(2))batteries geometrical configuration oxidation state lithium peroxide

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Immunomodulatory Function of Pien Tze Huang in T Cell-Mediated Anti-tumor Activity against B16-F10,MC38 and Hep1-6 Tumor Models

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Chinese Journal of Integrative Medicine 2024年第4期30卷 348-358页

作者： FU Yu-bing liu Chen-feng WANG Jin-jia JI xiao-lin TANG rong-han LIAO Kun-yu CHEN Ling-yue HONG Ya-zhen FAN Bin-bin WANG Shi-cong liu Wen-Hsien State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life ScienceXiamen UniversityXiamenFujian Province(361102)China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development ZhangzhouFujian Province(363000)China

Objective To investigate the anti-tumor effects of Pien Tze Huang(PZH)in mouse models of B16–F10 melanoma,MC38 colorectal cancer,Hep1-6 hepatocellular carcinoma and chemically induced hepatocellular carcinoma *** Various tumor models,including B16–F10,MC38 and Hep1-6 tumor hypodermic inoculation models,B16–F10 and Hep1-6 pulmonary metastasis models,Hep1-6 orthotopic implantation model,and chemically induced hepatocellular carcinoma model,were utilized to evaluate the anti-tumor function of *** growth was assessed by measuring tumor size and weight of solid tumors isolated from C57BL/6 *** cell proliferation and death of tumor cells in vitro,as well as T cell activation markers,cytokine production and immune checkpoints analysis,single-cell suspensions were prepared from mouse spleen,lymph nodes,and tumors after PZH *** PZH demonstrated significant therapeutic efficacy in inhibiting tumor growth(P0.05).Nevertheless,PZH exhibited a remarkable ability to enhance T cell activation and the production of interferon gamma,tumor necrosis factor alpha,and interleukin 2 in CD4^(+)T cells in vitro(P<0.01 or P<0.05).Importantly,PZH substantially inhibited T cell exhaustion and boosted cytokine production by tumor-infiltrating CD8^(+)T cells(P<0.01 or P<0.05).Conclusion This study has confirmed a novel immunomodulatory function of PZH in T cell-mediated anti-tumor immunity,indicating that PZH holds promise as a potential therapeutic agent for cancer treatment.

关键词： Pien Tze Huang metastasis anti-tumor immunity T cell activation T cell exhaustion immune checkpoints Chinese medicine

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Etching-free pixel definition in InGaN green micro-LEDs

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Light(Science & Applications) 2024年第8期13卷 1655-1665页

作者： Zhiyuan liu Yi Lu Haicheng Cao Glen Isaac Maciel Garcia Tingang liu xiao Tang Na xiao Raul Aguileta Vazquez Mingtao Nong xiaohang Li Advanced Semiconductor Laboratory Electrical and Computer Engineering ProgramCEMSE DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia

The traditional plasma etching process for defining micro-LED pixels could lead to significant sidewall *** near sidewall regions act as non-radiative recombination centers and paths for current leakage,significantly deteriorating device *** this study,we demonstrated a novel selective thermal oxidation(STO)method that allowed pixel definition without undergoing plasma damage and subsequent dielectric *** annealing in ambient air oxidized and reshaped the LED structure,such as p-layers and InGaN/GaN multiple quantum ***,the pixel areas beneath the pre-deposited SiO_(2)layer were selectively and effectively *** was demonstrated that prolonged thermal annealing time enhanced the insulating properties of the oxide,significantly reducing LED leakage ***,applying a thicker SiO_(2)protective layer minimized device resistance and boosted device efficiency *** the STO method,InGaN green micro-LED arrays with 50-,30-,and 10-μm pixel sizes were manufactured and *** results indicated that after 4 h of air annealing and with a 3.5-μm SiO_(2)protective layer,the 10-μm pixel array exhibited leakage currents density 1.2×10^(-6)A/cm^(2)at-10 V voltage and a peak on-wafer external quantum efficiency of~6.48%.This work suggests that the STO method could become an effective approach for future micro-LED manufacturing to mitigate adverse LED efficiency size effects due to the plasma etching and improve device ***-LEDs fabricated through the STO method can be applied to micro-displays,visible light communication,and optical interconnect-based *** planar pixel geometry will provide more possibilities for the monolithic integration of driving circuits with ***,the STO method is not limited to micro-LED fabrication and can be extended to design other III-nitride devices,such as photodetectors,laser diodes,high-electron-mobility transistors

关键词： annealing protective quantum

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Preparation of NiTip/Al composites with controllable phase transformation and damping behavior by friction stir processing

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Science China(Technological Sciences) 2024年第2期67卷 597-607页

作者： WU xiao JIANG HongJie LI WangYun liu ChongYu HUANG HongFeng liu ShuHui WEI LiLi School of Material Science and Engineering Guilin University of Technology Guilin 541004China Key Laboratory of New Processing Technology for Nonferrous Metal&Materials Ministry of EducationGuilin University of Technology Guilin 541004China School of Mechanical and Electrical Engineering Guilin University of Electronic TechnologyGuilin 541004China

The NiTip/1060Al composites were prepared using a pre-aging and friction stir method(FSP)to enhance the low-temperature damping performance of the aluminum alloy and accommodate various service *** bonding between NiTi particles and the 1060Al matrix is well established after FSP,and no new phases are formed in the *** phasetransformation peak temperature of NiTip/1060Al composites gradually shifts to lower temperatures with increased aging temperature of NiTi *** room temperature,the 550℃-NiTip/1060Al composite exhibits superior damping performance,with an internal friction value 144%higher than that of the FSP-1060Al ***,at-91℃,the 650℃-NiTip/1060Al composite demonstrates better damping performance,with an internal friction value 158%higher than that of the FSP-1060Al *** NiTip/1060Al composites exhibit the internal friction peak of NiTi phase-transformation in the temperature range from-91℃to 60℃.This characteristic results in significantly better damping performance compared to the FSP-1060Al alloy and other high-damping aluminum matrix composites.

关键词： NiTi particle aluminum matrix composites phase transformation damping behavior friction stir processing

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