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Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 299-310页

作者： liu xiao-rong LI Shuo-fu MEI Wen-ya liu Xiang-dan ZHOU Ri-bao College of Pharmacy Hunan University of Chinese MedicineChangsha(410208)China Department of Orthopaedics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(RA).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10,20 and 40µmol/L).Overexpression vectors for matrix metalloproteinase-2(MMP2)or MMP9 or SRC were transfected to explore their roles in isorhamnetin-mediated RA-FLS ***-FLS viability,migration,and invasion were ***,a collagen-induced arthritis(CIA)rat model was *** were randomly divided to sham,CIA,low-,medium-,and high-dosage groups using a random number table(n=5 in each group)and administed with normal saline or additional isorhamnetin[2,10,and 20 mg/(kg·day)]for 4 weeks,*** index was calculated and synovial tissue inflammation was determined in CIA *** levels of MMP2,MMP9,TNF-α,interleukin-6(IL-6),and IL-1β,as well as the phosphorylation levels of SRC,extracellular regulated kinase(ERK),and cyclic adenosine monophosphate response element-binding(CREB),were detected in RA-FLS and synovial *** docking was also used to analyze the binding of isorhamnetin to *** In in vitro studies,isorhamnetin inhibited RA-FLS viability,migration and invasion(P<0.05).Isorhamnetin downregulated the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1βin RA-FLS(P<0.05).The overexpression of either MMP2 or MMP9 reversed isorhamnetin-inhibited RA-FLS migration and invasion,as well as the levels of TNF-α,IL-6,and IL-1β(P<0.05).Furthermore,isorhamnetin bound to SRC and reduced the phosphorylation of SRC,ERK,and CREB(P<0.05).SRC overexpression reversed the inhibitory effect of isorhamnetin on RA-FLS viability,migration and invasion,as well as the negative regulation of MMP2 and MMP9(P<0.05).In in vivo studies,isorhamnetin decreased arthritis index scores(P<0.05)and alleviated synovial *** reduced the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1β,as well as the phosphorylation of SRC,ERK,and CRE

关键词： rheumatoid arthritis isorhamnetin SRC/ERK/CREB matrix metalloproteinase

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湘西丧俗“大葬”考证

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怀化学院学报 2024年第3期43卷 45-52页

作者：刘晓蓉怀化学院湖南怀化418008

自清雍正年间改土归流后,湘西广大地区在保有本地区原有丧葬习俗的基础上,与中原丧葬文化逐渐融合,形成了独具地方特色的丧葬习俗。丧葬期间,孝家门上贴“当大事”三字,灵柩停于堂屋中央,三至九天不等。当地俗称出殡前一天为“大葬”,... 详细信息

自清雍正年间改土归流后,湘西广大地区在保有本地区原有丧葬习俗的基础上,与中原丧葬文化逐渐融合,形成了独具地方特色的丧葬习俗。丧葬期间,孝家门上贴“当大事”三字,灵柩停于堂屋中央,三至九天不等。当地俗称出殡前一天为“大葬”,举行最隆重的丧仪,陪伴亡人最后一程。“大葬”一词在湘西盛行已久,但词义颇费理解。利用民间宝卷写本、历史典籍,结合当地方言语音,探赜索隐,发现“大葬”实乃“大赞”之讹。

关键词：湘西丧俗大葬大赞方言民间写本

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Cs/O沉积Na_(2)KSb光电阴极表面的第一性原理研究

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物理学报 2024年第8期73卷 341-349页

作者：王麒铭张益军王兴超王亮金睦淳任玲刘晓荣钱芸生南京理工大学电子工程与光电技术学院南京210094 北方夜视科技(南京)研究院有限公司南京211106

Na_(2)KSb光电阴极在光电倍增管、图像增强器、真空电子源等领域具有重要应用.为指导高灵敏度Na_(2)KSb光电阴极的制备,采用第一性原理计算方法,研究不同表面取向和原子终止面的Na_(2)KSb表面模型,获得稳定且最有利于电子发射的表面结构... 详细信息

Na_(2)KSb光电阴极在光电倍增管、图像增强器、真空电子源等领域具有重要应用.为指导高灵敏度Na_(2)KSb光电阴极的制备,采用第一性原理计算方法,研究不同表面取向和原子终止面的Na_(2)KSb表面模型,获得稳定且最有利于电子发射的表面结构.基于该表面进一步研究了不同覆盖度下的Cs原子沉积和Cs/O原子共沉积对Na_(2)KSb表面电子结构和光学性质的影响.对比表面能、吸附能和吸附前后的功函数结果表明,Na_(2)KSb(111)K表面具有优越的电子发射能力以及良好的稳定性.当Na_(2)KSb(111)K表面吸附2/4单层的Cs原子和1/4单层O原子时,获得最大功函数下降量0.16 eV.表面吸附Cs/O原子有利于电荷往表面上方转移,并产生电荷累积,能形成有效表面偶极矩.通过分析能带结构和态密度,发现吸附Cs原子对导带底存在额外的能带贡献,且引入O原子吸附后价带发生上移.此外,吸附Cs/O原子有利于增强表面近红外光吸收,但是会导致表面紫外和可见光吸收变差.

关键词： Na_(2)KSb 光电阴极 Cs/O沉积功函数偶极矩

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长期大量施用污泥堆肥显著提升华北地区粮食作物产量和土壤碳汇效应

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植物营养与肥料学报 2024年第5期30卷 899-908页

作者：姚海刘晓荣李海洋李浩杨文彬李颖杜新忠安妙颖刘宏斌北京市排水集团有限责任公司北京100044 北京林业大学水土保持学院北京100083 辽宁省盐碱地利用研究所辽宁盘锦124010 北方干旱半干旱耕地高效利用全国重点实验室/农业农村部面源污染控制重点实验室/北京昌平土壤质量国家野外科学观测研究站/中国农业科学院农业资源与农业区划研究所北京100081 菏泽金正大生态工程有限公司山东菏泽274000

【目的】阐明长期不同用量质量达标的污泥堆肥配施化肥对华北地区冬小麦-夏玉米轮作体系作物产量,以及耕层土壤有机碳储量(SOCS)和全氮(TN)、全磷(TP)、全钾(TK)含量的影响,为污泥高效资源化利用及农业绿色可持续发展提供理论依据。【... 详细信息

【目的】阐明长期不同用量质量达标的污泥堆肥配施化肥对华北地区冬小麦-夏玉米轮作体系作物产量,以及耕层土壤有机碳储量(SOCS)和全氮(TN)、全磷(TP)、全钾(TK)含量的影响,为污泥高效资源化利用及农业绿色可持续发展提供理论依据。【方法】于北京市昌平区,开展污泥堆肥(SW)与化肥配施定位试验(2008—2020年),种植制度为冬小麦-夏玉米轮作,试验设置5个处理:100%尿素(N)、50%WS+50%尿素(0.5SW+0.5N)、100%SW+50%尿素(SW+0.5N)、200%SW+50%尿素(2SW+0.5N)、400%SW+50%尿素(4SW+0.5N)处理。小麦、玉米收获后,调查籽粒和秸秆产量,0—20 cm土层土壤有机质和氮磷钾含量,并计算土壤固碳效率。【结果】随着污泥堆肥用量的增加,小麦和玉米籽粒和秸秆产量逐渐增加,与N处理相比,0.5SW+0.5N处理小麦、玉米籽粒和秸秆多年平均产量无显著差异,SW+0.5N、2SW+0.5N和4SW+0.5N处理下小麦籽粒产量分别增加了6.97%、14.88%和17.94%,玉米籽粒产量分别增加了8.43%、11.77%和15.38%。土壤中有机碳储量、全氮、全磷、全钾含量在0.5SW+0.5N、SW+0.5N、2SW+0.5N和4SW+0.5N处理下较N处理明显提升。同时,土壤中有机碳储量、全氮、全磷和全钾含量随污泥堆肥用量的增加而显著增加(P<0.05)。N、0.5SW+0.5N、SW+0.5N、2SW+0.5N和4SW+0.5N处理下,土壤全氮含量多年平均值分别为1.07、1.26、1.56、1.93和2.73 g/kg,全磷含量分别为1.19、1.67、2.37、3.27、4.11 g/kg,全钾含量分别为18.60、19.06、19.85、20.07、21.19 g/kg。【结论】与单施尿素相比,以质量达标的污泥堆肥替代50%尿素(0.5SW+0.5N)不会影响小麦、玉米籽粒和秸秆产量,而且可以提升土壤肥力。在尿素用量减半条件下,增加污泥堆肥用量可显著提高小麦、玉米籽粒产量和土壤肥力,特别是在污泥堆肥氮用量为尿素氮用量的4倍时,小麦和玉米可稳定增产15%~18%,并且由于高量污泥堆肥的长期施用极大地提升了土壤中有机碳、全氮、全磷和全钾的储量,保证了产量的可持续性和土壤的碳汇效应。

关键词：污泥堆肥土壤肥力小麦玉米作物产量产量可持续性

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Atomic layer deposition in advanced display technologies:from photoluminescence to encapsulation

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International Journal of Extreme Manufacturing 2024年第2期6卷 65-82页

作者： rong Chen Kun Cao Yanwei Wen Fan Yang Jian Wang xiao liu Bin Shan State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiPeople’s Republic of China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiPeople’s Republic of China

Driven by the growing demand for next-generation displays,the development of advanced luminescent materials with exceptional photoelectric properties is rapidly accelerating,with such materials including quantum dots and phosphors,***,the primary challenge preventing the practical application of these luminescent materials lies in meeting the required durability *** layer deposition(ALD)has,therefore,been employed to stabilize luminescent materials,and as a result,flexible display devices have been fabricated through material modification,surface and interface engineering,encapsulation,cross-scale manufacturing,and *** addition,the appropriate equipment has been developed for both spatial ALD and fluidized ALD to satisfy the low-cost,high-efficiency,and high-reliability manufacturing *** strategic approach establishes the groundwork for the development of ultra-stable luminescent materials,highly efficient light-emitting diodes(LEDs),and thin-film ***,this significantly enhances their potential applicability in LED illumination and backlighted displays,marking a notable advancement in the display industry.

关键词： atomic layer deposition display luminescent encapsulation

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Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis

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Neural Regeneration Research 2024年第3期19卷 671-679页

作者： Chunyun liu Shangde Guo rong liu Minfang Guo Qing Wang Zhi Chai Baoguo xiao Cungen Ma Institute of Brain Science Shanxi Datong UniversityDatongShanxi ProvinceChina The Key Research Laboratory of Benefiting Qi for Acting Blood Cireulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine/Research Center of Neurobiology Shanxi University of Chinese MedicineTaiyuanShanxi ProvinceChina Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina

Multiple sclerosis is characterized by demyelination and neuronal loss caused by inflammatory cell activation and infiltration into the central nervous *** polarization plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis,a traditional experimental model of multiple *** study investigated the effect of Fasudil on macrophages and examined the therapeutic potential of Fasudil-modified macrophages in experimental autoimmune *** found that Fasudil induced the conversion of macrophages from the pro-inflammatory M1 type to the anti-inflammatory M2 type,as shown by reduced expression of inducible nitric oxide synthase/nitric oxide,interleukin-12,and CD16/32 and increased expression of arginase-1,interleukin-10,CD14,and CD206,which was linked to inhibition of Rho kinase activity,decreased expression of toll-like receptors,nuclear factor-κB,and components of the mitogen-activated protein kinase signaling pathway,and generation of the pro-inflammatory cytokines tumor necrosis factor-α,interleukin-1β,and ***,Fasudil-modified macrophages effectively decreased the impact of experimental autoimmune encephalomyelitis,resulting in later onset of disease,lower symptom scores,less weight loss,and reduced demyelination compared with unmodified *** addition,Fasudil-modified macrophages decreased interleukin-17 expression on CD4^(+)T cells and CD16/32,inducible nitric oxide synthase,and interleukin-12 expression on F4/80^(+)macrophages,as well as increasing interleukin-10 expression on CD4^(+)T cells and arginase-1,CD206,and interleukin-10 expression on F4/80^(+)macrophages,which improved immune regulation and reduced *** findings suggest that Fasudil-modified macrophages may help treat experimental autoimmune encephalomyelitis by inducing M2 macrophage polarization and inhibiting the inflammatory response,thereby providing new insight into cell immunotherapy for m

关键词： anti-inflammatory experimental autoimmune encephalomyelitis Fasudil macrophage multiple sclerosis pro-inflammatory Rho kinase

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Rational design of superior catalysts from topological semimetals with nontrivial energy window

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Rare Metals 2024年第5期43卷 1956-1964页

作者： Min Zhao Li-rong Wang Wei liu Ming-Hang Li Ying liu Xue-Fang Dai Guo-Dong liu xiao-Ming Zhang Key Laboratory of Reliability and Intelligence of Electrical Equipment School of Materials Science and Engineering ManufacturingHebei University of TechnologyTianjin 300130China

Materials featuring topological energy bands and nontrivial surface states hold significant promise in unlocking unprecedented opportunities for innovating electrocatalytic ***,it remains a challenge to realize superior topological catalysts which can carry both high catalytic activity and excellent catalytic ***,we propose that a family of Ni-based binary materials hosting fantasying topological conjunct-nodalpoint state and a large nontrivial energy window(NEWD)represents an ideal choice for such superior topological catalysts in hydrogen evolution *** presence of conjunct-nodal-points ensures long Fermi arcs on the surface,thereby enabling an extremely high catalytic *** NEWD plays a crucial role in stabilizing the high catalytic activity against external perturbations,such as strain and electron/hole *** roles for conjunctnodal-points and NEWD are substantiated by the observable weakening of catalytic performance during topological phase transitions,which result in the removal of the conjunct-nodal-points,NEWD and their corresponding long Fermi *** work unveils a hidden mechanism and opens a feasible route for developing superior quantum catalysts from novel topology point of view.

关键词： First-principles modeling Topological semimetal Nontrivial surface states Hydrogen evolution reaction

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Empirical likelihood for spatial cross-sectional data models with matrix exponential spatial specification

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 125-139页

作者： liu Yan rong Jian-rong QIN Yong-song Nanning University Nanning 530200China Center for Applied Mathematics of Guangxi and College of Mathematics and Statistics Guangxi Normal UniversityGuilin 541004China

In this paper,we study spatial cross-sectional data models in the form of matrix exponential spatial specification(MESS),where MESS appears in both dependent and error *** empirical likelihood(EL)ratio statistics are established for the parameters of the MESS *** is shown that the limiting distributions of EL ratio statistics follow chi-square distributions,which are used to construct the confidence regions of model *** experiments are conducted to compare the performances of confidence regions based on EL method and normal approximation method.

关键词： MESS empirical likelihood con dence region

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Surgically treating a rare and asymptomatic intraductal papillary neoplasm of the bile duct:A case report

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World Journal of Clinical Cases 2024年第2期12卷 367-373页

作者： Shen-Zhen Zhu Zhao-Feng Gao xiao-rong liu xiao-Guang Wang Fei Chen Department of General Surgery Jiaxing Second HospitalJiaxing 314000Zhejiang ProvinceChina Department of Hepatobiliary Surgery Jiaxing Second HospitalJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Intraductal papillary neoplasms of the bile duct(IPNBs)are rare and characterized by papillary growth within the bile duct *** is similar to obstructive biliary *** this report,we present an unexpected case of asymptomatic IPNB and consolidate our findings with the relevant literature to augment our understanding of this *** relevant literature contributes to a more comprehensive understanding of the *** SUMMARY A 66-year-old Chinese male patient was admitted to our hospital for surgical intervention after gallstones were discovered during a routine physical *** imaging revealed a lesion on the left side of the liver,which raised the suspicion of IPNB.A laparoscopic left hemihepatectomy was performed,and subsequent histopathological examination confirmed the diagnosis of *** the 3-mo postoperative follow-up,the patient reported good recovery and no *** can manifest both latently and *** surgical resection is the most effective treatment for *** Hepatic and biliary masses,should be considered to diagnose *** surgery and vigilant follow-up are crucial in determining prognosis.

关键词： Intraductal papillary neoplasm of the bile duct Tumor Surgical treatment Prognosis Case report

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Comprehensive analysis of the potential pathogenesis of COVID-19 infection and liver cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 436-457页

作者： Yao rong Ming-Zheng Tang Song-Hua liu xiao-Feng Li Hui Cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND A growing number of clinical examples suggest that coronavirus disease 2019(COVID-19)appears to have an impact on the treatment of patients with liver cancer compared to the normal population,and the prevalence of COVID-19 is significantly higher in patients with liver ***,this mechanism of action has not been *** sets for COVID-19(GSE180226)and liver cancer(GSE87630)were obtained from the Gene Expression Omnibus *** identifying the common differentially expressed genes(DEGs)of COVID-19 and liver cancer,functional enrichment analysis,protein-protein interaction network construction and scree-ning and analysis of hub genes were ***,the validation of the differential expression of hub genes in the disease was performed and the regulatory network of transcription factors and hub genes was *** Of 518 common DEGs were obtained by screening for functional *** hub genes including aurora kinase B,cyclin B2,cell division cycle 20,cell division cycle associated 8,nucleolar and spindle associated protein 1,etc.,were further identified from DEGs using the“cytoHubba”*** enrichment analysis of hub genes showed that these hub genes are associated with P53 signalling pathway regulation,cell cycle and other functions,and they may serve as potential molecular markers for COVID-19 and liver ***,we selected 10 of the hub genes for in vitro expression validation in liver cancer *** Our study reveals a common pathogenesis of liver cancer and *** common pathways and key genes may provide new ideas for further mechanistic studies.

关键词： COVID-19 Liver cancer Differentially expressed genes Hub genes Pathogenesis

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