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基于纳管的Redis集群在线横向扩展的设计与实现

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电脑与电信 2024年第4期 102-105页

作者：刘晓强中国人民财产保险股份有限公司北京100022

随着企业生产系统规模的扩大,数据并发量及业务复杂度不断提升,通常采用Redis分布式集群的设计作为一层缓存来缓解调用数据库的压力,提升响应速度和服务水平。随着数据量的增加,最初上线的Redis集群的内存也会逐步达到整个集群的上限,... 详细信息

随着企业生产系统规模的扩大,数据并发量及业务复杂度不断提升,通常采用Redis分布式集群的设计作为一层缓存来缓解调用数据库的压力,提升响应速度和服务水平。随着数据量的增加,最初上线的Redis集群的内存也会逐步达到整个集群的上限,新增节点重新搭建集群需要停机,而纵向扩容单节点内存又会带来资源瓶颈,如何实现Redis集群的在线横向扩展,已经成为企业亟待解决的问题。对此,提出了一种Redis集群在线横向扩展的解决方案,并通过对Redis服务器的纳管将操作嵌入到具体管理系统中,实现一站式的检查、扩容和数据重分布,在业务不停机的前提下对Redis集群进行扩容。研究表明,该方案可协助企业及时、快速地进行Redis集群的在线横向扩展,避免纵向扩展带来的IO、CPU及内存资源瓶颈,减少运维的工作量,目前已经在金融企业核心系统得到实际应用,并取得了较好效果。

关键词： Redis集群横向扩展纵向扩展纳管

应对就业新形势构建工作新范式关于高校就业工作范式改革的思考

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中国大学生就业 2024年第3期 9-14,29页

作者：刘小强朱其昌中共江西省委教育工委江西省教育厅高等教育处

当前,高校毕业生就业工作面临“腹背受敌”“前后夹击”的严峻形势。一方面,高校毕业生就业规模持续增长并将继续保持增长若干年,另一方面,国内外环境变化带来了许多新的困难和挑战。但是与此同时,高校就业工作仍然延续的是一二十年前... 详细信息

当前,高校毕业生就业工作面临“腹背受敌”“前后夹击”的严峻形势。一方面,高校毕业生就业规模持续增长并将继续保持增长若干年,另一方面,国内外环境变化带来了许多新的困难和挑战。但是与此同时,高校就业工作仍然延续的是一二十年前的工作范式,呈现出“条块化”“点状化”“碎片化”“功利化”等明显特点,在新的就业形势下“左支右出”“力不从心”,疲于应付。做好高校毕业生就业工作,不仅需要各级党委政府的高度重视,更需要推动高校的就业工作范式转变,要树立“大就业”的工作理念,在体制机制上推动就业工作“体系化”,建设全员、全程、全方位的高校就业工作体系。

关键词：高校毕业生就业工作范式

Spatial Variability of Soil Chemical Properties in the Reclaiming Marine Foreland to Yellow Sea of China

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Agricultural Sciences in China 2009年第9期8卷 1103-1111页

作者： WEI Yi-chang BAI You-lu JIN Ji-yun ZHANG Fang ZHANG Li-ping liu xiao-qiang College of Resources and Environment North China University of Water Conservancy and Electric Power Zhengzhou 450011 P.R. China Institute of Agricultural Resourees and Regional Planning Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China

Precise information about the spatial variability of soil properties is essential in developing site-specific soil management, such as variable rate application of fertilizers. In this study the sampling grid of 100 m × 100 m was established to collect 1 703 soil samples at the depth of 0-20 cm, and examine spatial patterns including 13 soil chemical properties （pH, OM, NH4^＋, P, K, Ca, Mg, S, B, Cu, Fe, Mn, and Zn） in a 1 760 ha rice field in Haifeng farm, China, from 6th to 22nd of April, 2006, before fertilizer application and planting. Soil analysis was performed by ASI （Agro Services International） and data were analyzed both statistically and geostatistically. Results showed that the contents of soil OM, NH4^＋, and Zn in Haifeng farm were very low for rice production and those of others were enough to meet the need for rice cultivation. The spatial distribution model and spatial dependence level for 13 soil chemical properties varied in the field. Soil Mg and B showed strong spatial variability on both descriptive statistics and geostatistics, and other properties showed moderate spatial variability. The maximum ranges for K, Ca, Mg, S, Cu and Mn were all - 3 990.6 m and the minimum ranges for soil pH, OM, NH4^＋, P, Fe, and Zn ranged from 516.7 to 1 166.2 m. Clear patchy distribution of N, P, K, Mg, S, B, Mn, and Zn were found from their spatial distribution maps. This proved that sampling strategy for estimating variability should be adapted to the different soil chemical properties and field management. Therefore, the spatial variability of soil chemical properties with strong spatial dependence could be readily managed and a site-specific fertilization scheme for precision farming could be easily developed.

关键词： soil property spatial variability geostatistcs site-specific fertilization precision farming

Energetic Opportunities of Solid Composite Propellants Containing Some Hypothetic Furazano-[3,4-d]-pyridazine-based Derivatives

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火炸药学报 2016年第5期39卷 28-34页

作者： LEMPERT David B. DOROFEENKO Ekaterina M. SHU Yuan-jie JIANG Wei-dong WU Zong-kai WANG Ke liu xiao-qiang Institute of Problems of Chemical Physics Russian.Academy of Sciences(IPCP RAS)Moscow 142432 Russia Xi'an Modern Chemistry Research Institute Xi'an 710065China School of Chemistry and Environmental Engineering Sichuan.University of Science and EngineeringZigong Sichuan.643000China

Six furazano-[3,4-d]-pyridazine-based derivatives as main compounds in solid composite propellants have been investigated.It was shown that the use of some furazano-[3,4-d]-pyridazine-based derivatives as main compounds in solid composite propellants can considerably increase ballistic parameters compared with HMX if the compounds under consideration contain difluoramine groups.And the use of the compounds under consideration may be successful only in the presence of an active binder and 10%-30% of AP or ADN as additional oxidizers.

关键词： solid composite propellant furazano-[3,4-d]-pyridazine-based derivative energetic specific impulse

CDH13 Genetic Polymorphisms, Adiponectin and Ischemic Stroke： a Chinese Family-based Sib-pair Study

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Biomedical and Environmental Sciences 2017年第1期30卷 35-43页

作者： CHEN Li SUN Ke Xin JUAN Juan FANG Kai liu Kuo WANG Xue Yin WANG Ling YANG Chao liu xiao qiang LI Jing TANG Xun WU Yi Qun QIN Xue Ying WU Tao CHEN Da Fang HU Yong Hua Department of Epidemiology and Biostatistics Peking University Health Science Center Beijing 100191 China Beijing Center for Disease Prevention and Control Beijing 100013 China Department of Epidemiology & Biostatistics Capital Medical University Beijing 100069 China Pingshan New District Center for Disease Control and Prevention Shenzhen 518118 Guangdong China Shilou Township Hospital Beijing 102422 China

Objective To understand the relationships between CDH13（T-cadherin） genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors. Methods We recruited 342 Chinese ischemic stroke sib pairs. We genotyped rs4783244 and rs7193788 on CDH13 using time-of-flight mass spectrometry genotyping technology and measured total and high-molecular weight（HMW） adiponectin levels. We investigated associations between SNPs and ischemic stroke, and interactions between SNPs and other risk factors using multi-level mixed-effects regression model. Results In individuals without ischemic stroke, CDH13 rs4783244 was associated with total adiponectin levels（per T： Coef =-0.257, P = 0.001）. CDH13 rs7193788 was associated with total adiponectin levels（per A： Coef =-0.221, P = 0.001） and HMW adiponectin levels（per A： Coef =-0.163, P = 0.003）. rs7193788 was significantly associated with ischemic stroke（GA/AA vs. GG： OR = 1.55, 95% CI： 1.07 to 2.24, P = 0.020） after Bonferroni correction（α = 0.025）. There was an interaction between rs7193788 and diabetes（P = 0.036）. Compared to diabetes-free individuals with rs7193788 GG genotype, diabetes patients with rs7193788 GA/AA genotypes had higher risks for ischemic stroke（OR = 2.64, 95% CI： 1.58-4.40, P 〈 0.001）. Conclusion CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke.

关键词： Family correction cadherin SNPs genotype transformed preserving false trained burden

Non-contact and full-field online monitoring of curing temperature during the in-situ heating process based on deep learning

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Advances in Manufacturing 2024年第1期12卷 167-176页

作者： qiang-qiang liu Shu-Ting liu Ying-Guang Li Xu liu xiao-Zhong Hao College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing210016People’s Republic of China School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing211816People’s Republic of China

Online monitoring of the curing temperature field is essential to improving the quality and efficiency of the manufacturing process of composite parts.Traditional embedded sensor-based technologies have difficulty monitoring the full temperature field or have to introduce heterogeneous items that could have an undesired impact on the part.In this paper,a non-contact,full-field monitoring method based on deep learning that predicts the internal temperature field of composite parts in real time using surface temperature measurements of auxiliary materials is proposed.Using the proposed method,an average temperature monitoring accuracy of 97%is achieved in various heating patterns.In addition,this method also demonstrates satisfying feasibility when a stronger thermal barrier covers the part.This method was experimentally validated during the self-resistance electric heating process,in which the monitoring accuracy reached 93.1%.This method can potentially be applied to automated manufacturing and process control in the composites industry.

关键词： Online monitoring Curing temperature field Deep learning(DL) In-situ heating

Pyruvate kinase M in germ cells is essential for sperm motility and male fertility but not spermatogenesis

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Asian Journal of Andrology 2024年第2期26卷 212-219页

作者： Gao-Qing Qian xiao-Chen Wang Xi Zhang Bin Shen qiang liu State Key Laboratory of Reproductive Medicine and Offspring Health Nanjing Medical UniversityNanjing 211166China Shanghai Key Laboratory of Reproductive Medicine Department of HistoembryologyGenetics and Developmental BiologyShanghai Jiao Tong University School of MedicineShanghai 200025China State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China

Male germ cells employ specific metabolic pathways throughout their developmental stages.In a previous study,we discovered heightened expression of pyruvate kinase M(PKM),a pivotal glycolytic enzyme,in spermatogonia and spermatids.To gain deeper insights into PKM's roles in spermatogenesis,sperm function,and male fertility,we engineered a conditional-knockout mouse model(Pkm-vkO mice)to selectively disrupt the Pkm gene within germ cells.Despite maintaining regular testicular histology and sperm morphology,the male Pkm-vko mice were infertility,characterized by significant impairments in sperm motility and adenosine triphosphate(ATP)generation.In addition,Pkm-null spermatozoa exhibited similar deficits in protein tyrosine phosphorylation linked to capacitation,as well as compromised performance in in vitro fertilization experiments.To conclude,PKM's presence is not obligatory for the entirety of spermatogenesis in male germ cells;however,it emerges as a critical factor influencing sperm motility and overall male fertility.

关键词： glycolysis male fertility pyruvate kinase M sperm motility spermatogenesis

洛索洛芬钠胶囊溶出曲线研究方法的建立及实践

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中国药物经济学 2024年第3期19卷 101-104页

作者：陈雨蕉付金凤许直刘晓强常州市食品药品纤维质量监督检验中心江苏常州213102

目的摸索并建立洛索洛芬钠胶囊溶出曲线研究方法。方法分别采用方法a.篮法,以水900 ml为溶出介质,转速为100转/min,方法b.篮法,以水900ml为溶出介质,转速为50转/min,以及方法c.桨法,以水900ml为溶出介质,转速为50转/min,经5、10、15、20... 详细信息

目的摸索并建立洛索洛芬钠胶囊溶出曲线研究方法。方法分别采用方法a.篮法,以水900 ml为溶出介质,转速为100转/min,方法b.篮法,以水900ml为溶出介质,转速为50转/min,以及方法c.桨法,以水900ml为溶出介质,转速为50转/min,经5、10、15、20、30、45、60 min时,取溶出液滤过,取续滤液作为供试品溶液进行预实验,采用高效液相色谱法进行溶出量分析。结果选择方法c为溶出条件,3家企业的洛索洛芬钠胶囊在4种介质中的溶出速率均较快,但达到平台期前各取样时间点溶出量批内差异较大。3家企业的洛索洛芬钠胶囊在介质pH1.0盐酸溶液中溶出量均受限。结论建议上述各生产企业进一步优化处方与工艺,缩小达到平台期前各取样时间点溶出量批内差异。

关键词：洛索洛芬钠胶囊体外溶出曲线溶出方法 4种溶出介质

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甘肃省新型基础测绘技术标准体系建设研究

中国标准化 2024年第11期 130-133页

作者：李克恭刘小强赵伟山于东海甘肃省测绘工程院甘肃省应急测绘技术工程中心自然资源部测绘标准化研究所

为了实现甘肃省新型基础测绘实体编码、数据生产、整合建库、数据更新和质量控制等在技术方面的标准化,建立科学、规范和高效的甘肃省新型基础测绘技术标准体系,本文开展了对现行国家、行业、部分试点省市新型基础测绘相关技术标准成果... 详细信息

为了实现甘肃省新型基础测绘实体编码、数据生产、整合建库、数据更新和质量控制等在技术方面的标准化,建立科学、规范和高效的甘肃省新型基础测绘技术标准体系,本文开展了对现行国家、行业、部分试点省市新型基础测绘相关技术标准成果调研,采用系统工程法对甘肃省新型基础测绘技术标准体系建设的层次和架构进行论证,运用文献研究、专家咨询和问卷调查等方法,对技术体系构成的标准框架和内容进行系统性研究,通过研究,完成了甘肃省新型基础测绘技术标准体系建设,该成果为全面推进甘肃新型基础测绘奠定了技术基础。

关键词：标准体系标准编制关键技术新型基础测绘系统工程法

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