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BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang Qing-Rong Li Lei Xu Zi-Chun Yuan xiao liu Mao-Ju Tang Man Luo xiao-Wu Zhong Qiang Ma xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

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Experimental Study of Irregular Wave Reflection by a Perforated Caisson Breakwater Under Wave Overtopping Conditions

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Journal of Ocean University of China 2022年第4期21卷 926-934页

作者： liu xiao liu Yong Shandong Provincial Key Laboratory of Ocean Engineering Ocean University of ChinaQingdao 266100China

The characteristics of irregular wave reflection by a perforated caisson breakwater under wave overtopping conditions were investigated using physical model *** effects of various parameters,especially the mean overtopping discharge that was mainly determined by the relative crest freeboard,on the reflection coefficient of perforated caisson breakwater were analyzed using experimental *** results showed that the wave overtopping occurrence had no appreciable effect on the reflection coefficient when the mean overtopping discharge was less than 0.2 m^(3)(m s)^(−1).Under the wave overtopping condition,the reflection coefficient of the perforated caisson breakwater in this study was reduced by 20%-50% compared with that of the non-perforated caisson breakwater.A predictive formula of the reflection coefficient for perforated caisson breakwaters in terms of relative water depth,relative chamber width,and porosity of the caisson front wall,was developed for practical engineering design.

关键词： perforated caisson model test reflection coefficient wave overtopping predictive formula

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A novel optimal data fusion algorithm and its application for the integrated navigation system of missile

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Chinese Journal of Aeronautics 2022年第5期35卷 53-68页

作者： Di liu Xiyuan CHEN xiao liu Key Laboratory of Micro-Inertial Instrument and Advanced Navigation Technology Ministry of Education School of Instrument Science and EngineeringSoutheast UniversityNanjing 210096China School of Electronic and Information Engineering(Department of Physics) Qilu University of TechnologyJinan 250353China

For Inertial Navigation System(INS)/Celestial Navigation System(CNS)/Global Navigation Satellite System(GNSS)integrated navigation system of the missile,the performance of data fusion algorithms based on the Cubature Kalman Filter(CKF)is seriously degraded when there are non-Gaussian noise and process-modeling errors in the system ***,a novel method is proposed,which is called Optimal Data Fusion algorithm based on the Adaptive Fading maximum Correntropy generalized high-degree CKF(AFCCKF-ODF).First,the Adaptive Fading maximum Correntropy generalized high-degree CKF(AFCCKF)is proposed and used as the local filter for the INS/GNSS and INS/CNS subsystems to improve the robustness of local state ***,the local state estimation is fused based on the minimum variance principle and highdegree cubature criterion to get the globally optimal ***,the experimental results verify that the proposed algorithm can significantly improve the robustness of the missile-borne INS/CNS/GNSS integrated navigation system to non-Gaussian noise and process modeling error and obtain the global optimal navigation information.

关键词： Data fusion High-degree cubature Kalman filter Integrated navigation Non-Gaussian noise Process-modeling error

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内冲击激发式安全雷管的研制与适配性测试

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火工品 2025年第1期 1-6页

作者：邓小娟代鹏举董金龙刘晓娟王爱上海鲲程电子科技有限公司上海201100 广东宏大民爆集团有限公司广东广州510000 湖南湘科控股集团有限公司湖南长沙410000 江西新余国泰特种化工有限责任公司江西新余338000 湖南神斧集团湘南爆破器材有限责任公司湖南永州425000

针对工业雷管在使用过程中因起爆药感度高而引发的安全事故和环境污染问题,研制了一种新型内冲击激发式安全雷管(简称“IID雷管”),并开展其与不同点火药的适配性测试。通过采用猛炸药作为主要装药,以及设计激发组件,实现了高效有序的... 详细信息

针对工业雷管在使用过程中因起爆药感度高而引发的安全事故和环境污染问题,研制了一种新型内冲击激发式安全雷管(简称“IID雷管”),并开展其与不同点火药的适配性测试。通过采用猛炸药作为主要装药,以及设计激发组件,实现了高效有序的起爆和传爆过程;通过与不同点火药的适配测试,以及对起爆能力、延期精度等关键功能的全面评估,验证了IID雷管在与LTNR和K-K等药剂适配时,各项性能均满足行业标准。此外,IID雷管结构工艺简单、安全环保,具有广泛的应用前景。

关键词：安全雷管数码电子雷管内冲击激发无起爆药雷管激发组件

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A Two-Stage Service Replica Strategy for Business Process Efficiency Optimization in Community Cloud

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Chinese Journal of Electronics 2017年第1期26卷 80-87页

作者： LUO Haoyu liu Jin liu xiao State Key Laboratory of Software Engineering School of Computer Wuhan University School of Information Technology Deakin University

Business process that facilitates the organization cooperation and resource sharing plays an important role in Community cloud(Comc). The nature of applications and decentralized infrastructure in Comc make it a big challenge in ensuring the execution efficiency of business process, especially when the business requests are in high concurrency. We present a two-stage service replica strategy to improve the execution efficiency of business process by shortening the response time of request to single service and reducing interaction time among distributed services. We initially utilize the social network property of services to pre-allocate the replicas of key services. After that, queueing model is adopted to determine the required additional replicas according to the quantity and frequency of user requests, then schedule service replicas and requests dynamically. Experiments demonstrate the effectiveness of the proposed strategy.

关键词： Community cloud(Comc) Business process Execution efficiency Service replica Queueing theory

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Enhanced release of the poorly soluble drug itraconazole loaded in ordered mesoporous silica

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Science China Chemistry 2015年第3期58卷 400-410页

作者： xiao liu Shunai Che State Key Laboratory of Metal Matrix Composites School of Chemistry and Chemical Engineering Shanghai Jiao Tong University

It is known that the energy of the amorphous state of itraconazole loaded in ordered mesoporous materials is high relative to that of the crystalline state and is responsible for enhanced solubility and dissolution rate. We investigated the effects of particle size(0.7–5μm), mesostructure(2D p6 mm, cubic Ia-3d and cubic Fm-3m) and pore size(2.2–15.4 nm) of mesoporous silicas on the release performance of itraconazole. Results indicated that the release performance was not influenced by the particle sizes tested here, that the release performance increased with increasing pore diameter due to the lower probability of drug molecules colliding to recrystallize in large pores, and that the release performance was decreased in the cage-type pore structure(Fm-3m) compared to that in the cylindrical pore structures(p6mm and Ia-3d) because of the small entrance to the cagelike pores that retards the drug release.

关键词： itraconazole poorly soluble enhanced release mesoporous silica

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Possible modulation of migrating diurnal tide by latitudinal gradient of zonal wind observed by SABER/TIMED

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Science China Earth Sciences 2016年第2期59卷 408-417页

作者： liu MoHan XU JiYao liu HanLi liu xiao State Key Laboratory of Space Weather Center for Space Science and Applied Research Chinese Academy of Sciences College of Earth Science University of Chinese Academy of Sciences High Altitude Observatory National Center for Atmospheric Research College of Mathematics and Information Science Henan Normal University

Temperature data from SABER/TIMED and Empirical Orthogonal Function （EOF） analysis are taken to examine possible modulations of the temperature migrating diurnal tide （DW1） by latitudinal gradients of zonal mean zonal wind （ ζ ）. The result shows that ζ increases with altitudes and displays clearly seasonal and interannual variability. In the upper meso- sphere and lower thermosphere （MLT）, at the latitudes between 20°N and 20°S, when ζ strengthens （weakens） at equinoxes （solstices） the DW1 amplitude increases （decreases） simultaneously. Stronger maximum in March-April equinox occurs in both ζ and the DW1 amplitude. Besides, a quasi-biennial oscillation of DW1 is also found to be synchronous with ζ. The resembling spatial-temporal features suggest that ζ in the upper tropic MLT probably plays an important role in modulating semiannual, annual, and quasi-biennial oscillations in DW1 at the same latitude and altitude. In addition, ζ in the meso- sphere possibly affects the propagation of DW1 and produces SAO of DW1 in the lower thermosphere. Thus, SAO of DW1 in the upper MLT may be a combined effect of ζ both in the mesosphere and in the upper MLT, which models studies should determine in the future.

关键词： Migrating diurnal tide Temporal variations Latitudinal gradient of zonal wind Mesosphere and lower thermo- sphere

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Rodent biology and management: Current status, opinion and challenges in China

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Journal of Integrative Agriculture 2019年第4期18卷 830-839页

作者： liu xiao-hui State Key Laboratory for Biology of Plant Diseases and Insect Pests Key Laboratory of Weed and Rodent Biology and Management Institute of Plant Protection Chinese Academy of Agricultural Sciences

China experiences serious agricultural damages from rodents, and, correspondingly, researchers in China are actively studying rodent biology and management. Following the popularization of ecologically-based rodent pest management and extension of the basic state policy of Ecological Civilization Construction in China, recent efforts in rodent control technologies are mainly focused on eliminating side effects of rodenticides and developing environmentally friendly techniques. Considering ecological functions of rodents to test their interaction with the environment is a promising design for understanding rodent populations in local ecosystems and for developing ecologically-based rodent management. Using ecological phenotypes and applying advanced techniques of molecular biology, genetics, and epigenetics might be useful for illustrating the deep regulatory mechanisms of fluctuations in rodent populations. However, facing the dual characteristics of rodents as pests and their roles as keystone species in many ecosystems, it is still a challenge to establish reasonable local thresholds to balance rodent management with the negative effects of rodent control on the environment in the future.

关键词： rodent rodent management rodent biology

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Testing conditional independence with data missing at random

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Applied Mathematics(A Journal of Chinese Universities) 2018年第3期33卷 298-312页

作者： liu Yi liu xiao-hui College of Science China University of Petroleum (East China) School of Statistics Jiangxi University of Finance and Economics Research Center of Applied Statistics Jiangxi University of Finance and Economics

It is known that conditional independence is a quite basic assumption in many fields of statistics. How to test its validity is of great importance and has been extensively studied by the literature. Nevertheless, all of the existing methods focus on the case that data are fully observed, but none of them seems having taken into account of the scenario when missing data are present. Motivated by this, this paper develops two testing statistics to handle such a situation relying on the idea of inverse probability weighted and augmented inverse probability weighted techniques. The asymptotic distributions of the proposed statistics are also derived under the null hypothesis. The simulation studies indicate that both testing statistics perform well in terms of size and power.

关键词： conditional independence cumulative sum process of residuals missing at random inverse probability weighting re-sampling

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Nighttime anomaly of ionospheric electron density

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Science China Earth Sciences 2016年第7期59卷 1517-1518页

作者： XU JiYao liu xiao State Key Laboratory of Space Weather National Space Science Center Chinese Academy of Sciences School of Mathematics and Information Science Henan Normal University

The ionosphere is composed of a large number of electrons and ions, which are produced by the photoionization effect of the solar radiation on the neutral atmosphere. The altitude range of ionosphere is about 60–1000 km and varies with local time and other factors （e.g., solar and geomagnetic activity）. Although the ionosphere varies over multiply timescales, the diurnal variation is in the dominant position due to the sun’s photoionization effect.

关键词： anomaly altitude neutral multiply latitude winter seasonal diurnal magnitude hemisphere

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