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Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 299-310页

作者： liu Xiao-rong LI Shuo-fu MEI Wen-ya liu xiang-dan ZHOU Ri-bao College of Pharmacy Hunan University of Chinese MedicineChangsha(410208)China Department of Orthopaedics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(RA).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10,20 and 40µmol/L).Overexpression vectors for matrix metalloproteinase-2(MMP2)or MMP9 or SRC were transfected to explore their roles in isorhamnetin-mediated RA-FLS ***-FLS viability,migration,and invasion were ***,a collagen-induced arthritis(CIA)rat model was *** were randomly divided to sham,CIA,low-,medium-,and high-dosage groups using a random number table(n=5 in each group)and administed with normal saline or additional isorhamnetin[2,10,and 20 mg/(kg·day)]for 4 weeks,*** index was calculated and synovial tissue inflammation was determined in CIA *** levels of MMP2,MMP9,TNF-α,interleukin-6(IL-6),and IL-1β,as well as the phosphorylation levels of SRC,extracellular regulated kinase(ERK),and cyclic adenosine monophosphate response element-binding(CREB),were detected in RA-FLS and synovial *** docking was also used to analyze the binding of isorhamnetin to *** In in vitro studies,isorhamnetin inhibited RA-FLS viability,migration and invasion(P<0.05).Isorhamnetin downregulated the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1βin RA-FLS(P<0.05).The overexpression of either MMP2 or MMP9 reversed isorhamnetin-inhibited RA-FLS migration and invasion,as well as the levels of TNF-α,IL-6,and IL-1β(P<0.05).Furthermore,isorhamnetin bound to SRC and reduced the phosphorylation of SRC,ERK,and CREB(P<0.05).SRC overexpression reversed the inhibitory effect of isorhamnetin on RA-FLS viability,migration and invasion,as well as the negative regulation of MMP2 and MMP9(P<0.05).In in vivo studies,isorhamnetin decreased arthritis index scores(P<0.05)and alleviated synovial *** reduced the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1β,as well as the phosphorylation of SRC,ERK,and CRE

关键词： rheumatoid arthritis isorhamnetin SRC/ERK/CREB matrix metalloproteinase

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Monitoring of urinary iodine concentration in naval pilots:should iodine be supplemented or limited at coastal stations?

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Military Medical Research 2025年第1期12卷 154-156页

作者： Jia Zeng Qi Li xiang Lu dan-dan liu Rong-Guan Jiao Yan-Qing Jiang Yan-Bing liu Wan-Qing Xu Jun Ma Guo-Li Gu Department of Aeronautical Diseases Naval Medical CenterNaval Medical University of Chinese PLAShanghai 200052China No.92853 Station Troops Hospital of Chinese PLA Huludao 125000LiaoningChina Department of Intensive Care Unit Naval Medical CenterNaval Medical University of Chinese PLAShanghai 200052China Department III of Internal Medicine Naval Medical CenterNaval Medical University of Chinese PLAShanghai 200052China Department of General Surgery Air Force Medical CenterAir Force Medical University of Chinese PLABeijing 100142China

Dear Editor,In recent years,there has been a significant upward trend in the detection rate of thyroid diseases among military flight personnel[1].Thyroid diseases not only pose a serious threat to the health of flight personnel but also have negative impacts on the aviation safety and combat effectiveness of *** has been confirmed that the occurrence and progression of thyroid diseases are closely linked to dietary iodine *** have manifested that long-term excessive or insufficient iodine intake can lead to thyroid diseases[2,3].

关键词： Naval pilot Thyroid Urinary iodine

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Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li Jian xiang Lu Qiu Xiaohan Chen Yinkun Zhao Yujue Wang Qu Yue Taotao Gao Wenlong liu dan Xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu UniversityChengdu 610106SichuanChina School of Mechanical Engineering Chengdu UniversityChengdu 610106SichuanChina College of Food and Biological Engineering Chengdu UniversityChengdu 610106SichuanChina Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina College of Materials Science and Engineering Sichuan UniversityChengdu 610065SichuanChina

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries(AZIBs). These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose(Xylo) molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn^(2+)ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Aqueous Zn-ion battery Electrolyte additive Solvation structure Electrode/electrolyte interface Zn anode

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Unraveling atomistic and electronic origins of multiaxial magnetic anisotropy

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Science China(Physics,Mechanics & Astronomy) 2025年第2期Mechanics & Astronomy) .卷 179-186页

作者： Boyu liu Xueyang Li Junsheng Feng Changsong Xu Hongjun xiang Key Laboratory of Computational Physical Sciences (Ministry of Education) Institute of Computational Physical SciencesState Key Laboratory of Surface Physics and Department of PhysicsFudan University Shanghai Qi Zhi Institute School of Physics and Material Engineering Hefei Normal University

Multiaxial magnetic anisotropy(MA) refers to the phenomenon that multiple axes of the magnetic crystal correspond to different energy minima. Compared with the common uniaxial magnetic anisotropy, multiaxial MA facilitates novel forms of applications in spintronics. Here, by combining the first-principles-based spin Hamiltonian and tight-binding(TB) method, we reveal the microscopic origins, instead of the common phenomenological understanding, of biaxial MA and triaxial MA. In the example system of NiO, it is found that the multiple minima result from the fourth-order and the sixth-order single ion interactions, while the difference between [110] and [1■0] directions originates from a second-order bond-dependent anisotropic pair interaction(i.e., the so-called Gamma interaction). Moreover, through the application of a newly developed general spin dependent TB approach, it is revealed that the triaxial MA arises from the special spin-orbital entangled Hund term, which is different from the orbital-independent Hund term in the usual Slater Koster TB method. Our work thus not only leads to a thorough understanding of the multiaxial MA in NiO, but also establishes a methodology that can be widely used to explore the microscopic origins of MA in different magnets.

关键词： multiaxial magnetic anisotropy origin of multiaxial magnetic mnisotropy effective spin Hamiltonian tight-binding model antiferromagnetism.

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Mesh-supported V2O5-WO3/TiO2 nanosheet array catalysts for efficient removal of NOx

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Tungsten 2025年第1期7卷 100-111页

作者： Zhi-Qi Zhang liu Yang Wen Luo Vladimir An Jing Li Bao-dan liu School of Materials Science and Engineering Northeastern University Foshan Graduate School of Innovation Northeastern University Kizhner Research Center School of Advanced Manufacturing Technologies Tomsk Polytechnic University

The design and synthesis of vanadium-based denitration catalysts with low-temperature activity pose significant challenges in the field of toxic gas *** this study,we have developed a novel approach to fabricate highly efficient V2O5-WO3/TiO2monolithic mesh catalysts for NOxreduction at low ***,TiO2nanosheets with strong adhesion and large surface area were grown on Ti mesh using plasma electrolytic oxidation technology and hydrothermal ***,super-small traces of WO3and V2O5active nano-species were subsequently deposited on TiO2nanosheets using the deposition-precipitation *** to traditional ceramic-based V2O5-WO3/TiO2catalysts,our V2O5-WO3/TiO2monolithic mesh catalyst exhibits superior mechanical performance,excellent thermal conductivity,lower pressure drop,higher utilization of active components,and stronger synergistic ***,the V2O5-WO3/TiO2monolithic mesh catalysts exhibited excellent low-temperature catalytic activity with 98% of NOxconversion at 220℃,and remarkable long-term SO2tolerance and water resistance in the selective catalytic reduction（SCR） of NOxwith *** SCR reaction of tiny V2O5and WO3active species supported on TiO2nanosheets directly demonstrated to follow the Eley-Rideal mechanism by in situ infrared spectra.

关键词： Low temperature activity Monolithic mesh catalysts NH3-SCR SO2 tolerance V2O5-WO3/TiO2

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Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang liu xiang Li Shen Du Ming Gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

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Effectiveness and safety of percutaneous nephrolithotomy with 3D mixed-reality guidance for renal calculi removal

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中华医学杂志(英文版) 2025年第2期138卷 2024 Nov 5页

作者： Yan Wei Guo danyang liu Yutong Qiao Ludong Du Zhen xiang Peng liu dan liu Yuexin Ping Hao Department of Urology Beijing Tongren Hospital Capital Medical University Beijing China

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Toward long-life Zn anode using highly polar electrolyte additives

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Journal of Energy Chemistry 2025年第2期101卷 651-660页

作者： Nengbin Cai Hongming Chen Busheng Zhang Zijing liu Xinbo He dan Zhou Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology Beijing Shunde Innovation School University of Science and Technology Beijing School of Textile Science and Engineering Wuyi University

Unstable Zn interface caused by rampant dendrite growth and parasitic side reactions always hinders the practical application of aqueous zinc metal batteries（AZMBs）,Herein,tyrosine（Tyr） with high molecular polarity was introduced into aqueous electrolyte to modulate the interfacial electrochemistry of Zn *** AZMBs,the positively charged side of Tyr can be well adsorbed on the surface of Zn anode to form a water-poor layer,and the exposed carboxylate side can be easily coordinated with Zn2+,favoring inducing uniform plating of Zn2+and inhibiting the occurrence of water-induced side *** in turn enable the achievement of highly stable Zn ***,the Zn anodes achieve outstanding cyclic stability(3000 h at 2 mA cm-2,2 mA h cm-2and 1300 h at 5 mA cm-2,5 mA h cm-2),high average Coulombic efficiency（99.4% over 3200 cycles）,and high depth of discharge（80% for 500 h）.Besides,the assembled Zn‖NaV3O8·1.5H2O full cells deliver remarkable capacity retention and ultra-long lifetime(61.8% over 6650 cycles at 5 A g-1) and enhanced rate capability(169 mA h g-1at 5 A g-1).The work may promote the design and deep understanding of electrolyte additives with high molecular polarity for high-performance AZMBs.

关键词： AZMBs Electrolyte additives Highly stable Zn anode Interfacial electrochemistry Tyr

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Laser image refractive index sensor based on the combination of a coreless optical fiber and a digital camera

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Optoelectronics Letters 2025年第2期21卷 65-68页

作者： GUO Jingzhong LAN Feng CHEN xiang liu Haifeng Xi'an Institute of Space Radio Technology Key Laboratory of Optoelectronic Sensor and Sensing Network Technology College of Electronic Information and Optical Engineering Nankai University

As a laser passes through a scattering medium,the light interacts with the irregular reflections within the medium,resulting in light scattering and the formation of *** this paper,an image sensor based on the combination of a coreless optical fiber and a digital camera is proposed for liquid refractive index sensing *** coreless fiber is used as a sensing unit,and the change in the speckle pattern is measured using the digital correlation method to detect the magnitude of the liquid's refractive *** experimental results indicate that the laser image sensing technique is capable of effectively distinguishing liquid samples with refractive indices ranging from 1.332 8 to1.390 8,with a sensing sensitivity of-1.306 ***,the laser image sensing technique,with its advantages of high experimental reproducibility,simple system design,remote over-control,holds great research significance and potential application in laser communication and sensor integration.

关键词： A

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Achieving further refinement of grain structure and improvement of mechanical properties in Al-12Si-4Cu-2Ni-1Mg alloy by Al-Ti-C-B master alloy addition and deep cryogenic treatment

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China Foundry 2025年第1期22卷 75-82页

作者： Lin-fei Xia Wen-bo Li Zuo-shan Wei Yu-ying Wu xiang-fa liu China Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China Shandong Key Laboratory of Advanced Aluminum Materials and Technology Binzhou Institute of TechnologyBinzhou 256600ShandongChina

Near-eutectic Al-Si alloys are widely used in automotive manufacturing due to their superior wear resistance and high temperature *** of high Si content,the grain refinement of near-eutectic Al-Si alloy has been a problem for many *** this study,the effect of deep cryogenic treatment(DCT)on the microstructure and mechanical properties of Al-12Si-4Cu-2Ni-Mg alloy with addition of Al-Ti-C-B master alloy was fully *** show that the average grain size of the alloy is greatly reduced from 0.92 mm to 0.50 mm,and the eutectic Si and Al7Cu4Ni precipitates are spheroidized and refined in Al-12Si-4Cu-2Ni-Mg after DCT for 24 h and aging *** these changes of microstructures result in a significant increment of about 22.5%in elongation and a slight enhancement of about 6.8%in tensile ***,the refinement of microstructure also significantly improves the fatigue life of the alloy.

关键词： deep cryogenic treatment near-eutectic Al-Si master alloy microstructure mechanical properties

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