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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin liu Jian Zhang Ya Gao Shuyue Li Cui Chang xiang liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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“寒门贵子”是“补偿”还是“选拔”出来的?——对两所精英大学2018—2023年高校专项计划招生的追踪研究

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华东师范大学学报（教育科学版） 2025年第1期43卷 113-126页

作者：金文旺柳夕浪北京师范大学中国教育与社会发展研究院北京100875 山东师范大学教育学部济南250014

高校专项计划是我国促进高质量教育公平、破解农村学生上好大学难而出台的一项入学机会补偿政策。综合运用描述性统计方法,本研究对两所精英大学2018—2023年间高校专项计划的选录情况进行了持续追踪研究。从初审、降分、录取人数的总... 详细信息

高校专项计划是我国促进高质量教育公平、破解农村学生上好大学难而出台的一项入学机会补偿政策。综合运用描述性统计方法,本研究对两所精英大学2018—2023年间高校专项计划的选录情况进行了持续追踪研究。从初审、降分、录取人数的总体规模及变化趋势看,近几年高校专项计划政策力度不断加大,越来越多的寒门子弟进入精英高校。同时,精英大学高校专项计划实际招生呈现“补偿不均,选拔有余”的鲜明特点,经济欠发达、教育发展水平薄弱省域的农村学生和学校在该计划中并未获得更多优质高校入学机会的补偿,一个重要原因在于他们在高校自主选拔和高考选拔中处于劣势。为此,应调整高校专项计划招生办法及相关政策,确立“补偿为主,兼顾选拔”的价值导向并切实付诸实践,推进“实质的公平”。

关键词：高校专项计划补偿选拔教育公平精英大学

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Gamma-Ray Bursts Subset and Supernova Remnants Low Radio-Frequency Turnover

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Chinese Physics Letters 2000年第8期17卷 623-624页

作者： liu xiang Urumqi Astronomical Observatory National Astronomical ObservatoriesChinese Academy of SciencesUrumqi 830011

Durations of gamma-ray bursts(GRB's)are featured by>2s subset and<2s one,with initial corresponding energy ratio being 20:*** is found that supernova remants(SNR's)turnover frequencies peak at 100 and 500 *** assuming that GRB's originate from hypernova and making an analysis on the evolution of GRB's,we find that the initial energy of two GRB subsets leads to a different radio-frequency turnover of their remnant spectra,which accords positively with the turnover-frequency ratio of SNR's.

关键词： evolution supernova initial

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Prospects for Variable Gauge Rolling:Technology,Theory and Application

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Journal of Iron and Steel Research International 2011年第1期18卷 1-7页

作者： liu xiang-hua Northeastern University Shenyang 110004 Liaoning China

Variable gauge rolling （VGR） is a new technology to produce flat products with different thicknesses （FDT）, which could be used to replace conventional fiat products in order to save metals and reduce structure mass. The method of VGR was introduced for investigating new problems in rolling theory of VGR, and the new formulas for calculating parameters of VGR were proposed. Besides, some results of numerical simulation by finite elemen~ method were described. As an example, the products applications of FDT in bridge construction, ship building and auto manufacturing were presented. Finally, the prospects for VGR and FDT were discussed.

关键词： variable gauge rolling longitudinal profile plate tailor rolled blank

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Four-charm-quark matter from the CMS collaboration as a witness of the development of high-precision Hadron spectroscopy

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Science Bulletin 2024年第18期69卷 2802-2803页

作者： xiang liu School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu ProvinceLanzhou UniversityLanzhou 730000China Key Laboratory of Quantum Theory and Applications of MOE Lanzhou UniversityLanzhou 730000China MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China Research Center for Hadron and CSR Physics Lanzhou University and Institute of Modern Physics of CASLanzhou 730000China

Twenty years have passed since the observation of the Xe3872Tas the first XYZ charmonium-like *** the accumulation of experimental data,more and more new hadronic states have been discovered,inspiring extensive attention to exotic hadronic matter,including multiquarks,hybrid,and glueballs[1,2].Taking this opportunity,it is an appropriate time to build the“Particle Zoo2.0”version,which is the main task of the current study of hadron *** importantly,these joint experimental and theoretical efforts will further advance our understanding of the nonperturbative behavior of the strong interaction by these *** fact,representing the precision frontier of particle physics,hadron spectroscopy is entering the high-precision era.

关键词： spectroscopy state quark

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Review of dynamics and active control of large-scale space membrane antenna

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Astrodynamics 2024年第1期8卷 1-26页

作者： xiang liu Guoping Cai Department of Engineering Mechanics MOE Key Laboratory of HydrodynamicsChongqing Research InstituteShanghai Jiao Tong UniversityShanghai200240China

Large-scale space membrane antennas have significant potential in satellite communication,space-based early warning,and Earth *** of their large size and high flexibility,the dynamic analysis and control of membrane antenna are *** maintain the working performance of the antenna,the pointing and surface accuracies must be strictly ***,the accurate dynamic modeling and effective active control of large-scale space membrane antennas have great theoretical significance and practical value,and have attracted considerable interest in recent *** paper reviews the dynamics and active control of large-scale space membrane ***,the development and status of large-scale space membrane antennas are ***,the key problems in the dynamics and active control of large membrane antennas,including the dynamics of wrinkled membranes,large-amplitude nonlinear vibration,nonlinear model reduction,rigid-flexible-thermal coupling dynamic modeling,on-orbit modal parameter identification,active vibration control,and wave-based vibration control,are discussed in ***,the research outlook and future trends are presented.

关键词： large-scale space membrane antenna dynamicmodeling active control

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Photoluminescence properties of hexagonal indium tin oxide nanopowders prepared by solvothermal method

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Rare Metals 2018年第1期37卷 47-53页

作者： Fei Liang Jia-xiang liu The State Key Laboratory of Chemical Resource Engineering The Beijing Key Laboratory of Electrochemical Process and Technology for MaterialsCollege of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Hexagonal structure indium tin oxide（ITO）nanopowders were prepared by a solvothermal process at only 175 ℃ for 24 h and post-annealing at 400 ℃, using metal indium and SnCl4·5 H2 O as the raw materials. The morphology, crystal structures and structure defects of products were, respectively, analyzed by scanning electron microscopy（SEM）, X-ray diffraction（XRD） and confocal microprobe Raman system, the elemental state was investigated by X-ray photoelectron spectroscopy（XPS）, and the optical properties were carried out by ultraviolet-visible（UV-Vis） and photoluminescence（PL） spectrophotometers. The results show that the products are hexagonal structure with a particles size of 28-41 nm; the morphology of products consists of sphere and irregular *** pH values of solution increase, the content of oxygen vacancies increases and the optical band gap varies from3.59 to 3.78 eV. The products exhibit strong emission at417 nm with an excitation of 370 nm, and the PL intensity of samples increases with pH values increasing. Contrasting to cubic structure ITO powder, the hexagonal structure ITO has narrower optical band gap and higher PL intensity under the same excitation wavelength.

关键词： Hexagonal indium tin oxide Solvothermal Oxygen vacancies Optical band gap Photoluminescence

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An overview of XYZ new particles

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Chinese Science Bulletin 2014年第29期59卷 3815-3830页

作者： xiang liu School of Physical Science and Technology Lanzhou University

In the past decade,more and more charmoniumlike and bottomoniumlike states have been reported in experiments,which have led us to extensive discussions on the underlying structure of these *** this review,we briefly s... 详细信息

关键词：新粒子基础结构实验

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Removal of Cr(Ⅵ)by glutaraldehyde-crosslinked chitosan encapsulating microscale zero-valent iron:Synthesis,mechanism,and longevity

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Journal of Environmental Sciences 2024年第8期142卷 115-128页

作者： Yijun Duan Fang liu xiang liu Miao Li School of Environment Tsinghua UniversityBeijing 100084China Transportation Institute of Inner Mongolia University Hohhot 010070China

Microscale zero-valent iron(mZVI)has shown great potential for groundwater Cr(Ⅵ)***,low Cr(Ⅵ)removal capacity caused by passivation restricted the wide use of *** prepared mZVI/GCS by encapsulating mZVI in a porous glutaraldehydecrosslinked chitosan matrix,and the formation of the passivation layer was alleviated by reducing the contact between zero-valent iron *** average pore diameter of mZVI/GCS was 8.775 nm,which confirmed the mesoporous characteristic of this *** of batch experiments demonstrated that mZVI/GCS exhibited high Cr(Ⅵ)removal efficiency in a wide range of pH(2-10)and temperature(5-35℃).Common groundwater coexisting ions slightly affected m ZVI/*** material showed great reusability,and the average Cr(Ⅵ)removal efficiency was 90.41%during eight *** this study,we also conducted kinetics and isotherms ***-second-order model was the most matched kinetics *** Cr(Ⅵ)adsorption process was fitted by both Langmuir and Freundlich isotherms models,and the maximum Langmuir adsorption capacity of m ZVI/GCS reached243.63 mg/g,which is higher than the adsorption capacities of materials reported in most of the previous ***,the column capacity for Cr(Ⅵ)removal of a mZVI/GCS-packed column was 6.4 times higher than that of a mZVI-packed column in a 50-day ***,mZVI/GCS with a porous structure effectively relieved passivation problems of mZVI and showed practical application prospects as groundwater Cr(Ⅵ)remediation material with practical application prospects.

关键词： Chitosan Glutaraldehyde mZVI Cr(Ⅵ) Groundwater

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Borophene gas sensor

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Nano Research 2022年第3期15卷 2537-2544页

作者： Chuang Hou Guoan Tai Yi liu xiang liu The State Key Laboratory of Mechanics and Control of Mechanical Structures and Laboratory of Intelligent Nano Materials and Devices of Ministry of Education College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China

High-performance gas sensing devices have been extensively studied in industrial production,clinical medicine and environmental *** the materials used to fabricate gas sensors,two-dimensional(2D)materials are viewed as favorable candidate sensing materials because of their high surface-to-volume ratios,abundant surface activity,defect ***,gas sensors based on the previously reported 2D materials have some disadvantages such as poor air-stability and slow dynamic ***,borophene,as a unique 2D material,has been theoretically predicted to have excellent gas sensing characteristic,especially for nitrogen dioxide(NO_(2)).However,the gas sensing property of borophene has not been still reported ***,we report that a chemiresistive sensor device based on borophene shows high sensitivity,fast response,high selectivity,good flexibility and long-time *** is found that the sensor has a low experimental detection limit of around 200 ppb,a large detection range from 200 ppb to 100 ppm,and fast response time of 30 s and recovery time of 200 s at room temperature,which are remarkably superior to those of reported 2D *** underlying NO_(2) sensing mechanism of borophene is revealed by first-principles *** line with theoretical predication,it has also been confirmed experimentally that the borophene-based sensor has a unique selectivity to NO_(2) compared with other common ***,the sensor also displays superior flexibility and stability under different bending *** study shows excellent electronic and sensing characteristic of borophene,which indicates that it has great potential application value in high-performance sensing and detection in the future.

关键词： borophene gas sensor charge transfer wearable application density functional theory

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