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Successful treatment of latent autoimmune diabetes in adults with Traditional Chinese Medicine: a case report

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Journal of Traditional Chinese Medicine 2013年第6期33卷 766-769页

作者： Jiaxing Tian wenke liu Zhong Zhen Xiaolin Tong Department of Endocrinology Guang' anmen Hospital China Academy of Chinese Medical Sciences

INTRODUCTION： Latent autoimmune diabetes in adults （LADA） is regarded as one of the Insulin-de- pendent diabetes mellitus that progress slowly. It gradually became understood since 1970s. The on- set usually appears in adulthood, the islet autoanti- bodies are positive and the function of 13 cell is de- clined rapidly. The treatment is insulin injection. CASE PRESENTATION： The case reported followed is a 37-year-old male patient who was newly diag- nosed with type 2 diabetes. He abandoned oral hy- poglycemic agents since they caused stomach in- disposed. Before visiting, his islet autoantibodies were detected positive and he had never injected insulin before. We treated him with traditional Chi- nese herbals under the guidance of Traditional Chi- nese Medicine and differentiation, and achieved fine efficacy. CONCLUSION： Because the initial presentation of LADA is similar to Type 2 Diabetes Mellitus and ex- amination is not in common use, misdiagnosis isnot rare. Once LADA is diagnosed, the therapy must be adjusted. This case report indicated that Traditional Chinese Medicine might be an alterna- tive treatment for LADA.

关键词： Diabetes Mellitus, Type 2 Tripterygiumwilfordii Mianyi decoction

Improved root zone temperature buffer capacity enhancing sweet pepper yield via soil-ridged substrate-embedded cultivation in solar greenhouse

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International Journal of Agricultural and Biological Engineering 2018年第2期11卷 41-47页

作者： Guohai Fu Zonggeng Li wenke liu Qichang Yang Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences/Key Laboratory of Energy Conservation and Waste Management of Agricultural StructuresMinistry of AgricultureBeijing 100081China National Agricultural Technology Extension and Service Center Beijing 100125China

A novel soilless cultivation method,called as soil-ridged substrate-embedded cultivation(SSC)was invented,and an experiment was designed to investigate root zone temperature and production efficiency of sweet pepper cultivated by two SSC patterns,i.e.,SSC-P(polyethylene groove inserted)and SSC-W(wire-mesh groove inserted),and also other two cultivation methods,i.e.,soil ridge(SR)and naked polyethylene groove(PG).Results showed that PG,SSC-P and SSC-W increased the average minimal root zone temperature by 1.01℃,0.75℃,and 1.16℃ compared to SR(16.33℃)during March 16-20,*** June 1-5,SSC-P and SSC-W decreased the average maximal root zone temperature by 1.28℃ and 1.29℃ compared to SR(34.99℃),while PG increased it by 1.44℃.PG,SSC-P,and SSC-W decreased the differences of average daytime and night time temperatures by 1.34℃,2.13℃,and 2.88℃ compared to SR(4.56℃)during early ***,SSC-P and SSC-W decreased temperature differences of average daytime and night time by 0.9℃ and 1.07℃ compared to SR(0.95℃)during later stage,but PG improved by 2.85℃.Temperature difference of daytime and night time of SSC-W was minimal,and the temperature difference between the diurnal highest and the lowest temperature of SSC-W was also *** buffer capacity of SSC-W was slightly better than that of ***-W significantly improved the growth of sweet pepper compared to ***,fruit yield per square meter of sweet pepper cultivated on SSC-P and SSC-W improved by 21.24%and 50.33%,respectively compared to SR(3.06 kg/m^(2)),while PG lowered the yield by 13.72%.SSC-W was a better SSC pattern compared with SSC-P in terms of production efficiency.

关键词： soil cultivation SSC substrate cultivation solar greenhouse diurnal temperature difference root zone temperature

Efficacy of Shenzhuo formula on diabetic kidney disease:a retrospective study

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Journal of Traditional Chinese Medicine 2015年第5期35卷 528-536页

作者： Tian Jiaxing Zhao Linhua Zhou Qiang liu wenke Chen Xinyan Lian Fengmei Tong Xiaolin Department of Endocrinology Guang'anmen HospitalChina Academy of Chinese Medical Sciences Graduate School Beijing University of Chinese Medicine

OBJECTIVE:To observe the efficacy of a traditional Chinese medicine,Shenzhuo formula,on patients with diabetic kidney disease(DKD).METHODS:Eighty-eight outpatients with DKD were *** in estimated glomerular filtration rate(eGFR),creatinine clearance,serum creatinine,blood-urea-nitrogen,albuminuria,glycosylated hemoglobin(Hb_(A1C)),blood pressure,and lipid profile were measured and analyzed before and after intervention with Shenzhuo formula for 1,3,6,9,12,and 18 ***:Compared with the baseline amounts,serum creatinine decreased,and eGFR and creatinine clearance increased,significantly after intervention for 1,3,6,9,12,and 18 months(all P < 0.05).Mean eGFR increased by 2.11 mL/min per 1.73 m7 y after18-month *** protein at 24 h decreased significantly after 1,3,9,and 12 months(P < 0.05).Hb_(A1C) decreased significantly(P < 0.05) after 3,6,9,12,and 18 months,and systolic blood pressure decreased significantly(P < 0.05) after 1,3,and 6 *** cholesterol decreased significantly(P < 0.05) after 1,3,6,and 18 *** and low-density lipoprotein-cholesterol decreased significantly(P < 0.05) after 1 and 3 ***:Shenzhuo formula can improve eGFR and possibly slow DKD *** formula can also lower Hb_(A1C),lipid levels and blood pressure.

关键词： Diabetic nephropathies Creatinine Estimated glomerularfiltration rate Shenzhuoformula

Effect of Space Law on Space Activities

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Aerospace China 1994年第2期 32-34页

作者： liu wenke,Chen Shushi

In recent years, people have made increasing studies and discussions on the relationship between the law and space activity. Some famous space law scholars in the world have put forward the opinions of "impact of the development of space technology on the law of outer space" and "development of space law as a result of astronautical technology", which show the fact that space activity and law infiltrate and influence each other. Space technology has played a leading role in the generation and development of space law. The paper quite agrees with the above mentioned opinions, but tries to

关键词： legal discussions outer engaged mentioned obligation seriously regulate normalized formal

Choroid plexus CCL2‒CCR2 signaling orchestrates macrophage recruitment and cerebrospinal fluid hypersecretion in hydrocephalus

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Acta Pharmaceutica Sinica B 2024年第10期14卷 4544-4559页

作者： Qiguang Wang Fei liu Yue Li Huan Zhang Xin Qi Ke Wu Yi Zhang Shenglan You wenke liu Xuhui Hui Hanmei Li Lei Zhu Huile Gao Jian Cheng Department of Neurosurgery West China HospitalSichuan UniversityChengdu 610041China Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Institute of Thoracic Oncology West China HospitalSichuan UniversityChengdu 610041China Institutes for Systems Genetics Frontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China Institute of Rare Diseases West China Hospital of Sichuan UniversityChengdu 610041China Research Core Facility of West China Hospital Sichuan UniversityChengdu 610041China Key Laboratory of Coarse Cereal Processing School of Food and Biological EngineeringChengdu UniversityChengdu 610106China

The choroid plexus(ChP)serves as the principal origin of cerebrospinal fluid(CSF).CSF hypersecretion due to ChP inflammation has emerged as an important pathogenesis of hydrocephalus ***,the precise mechanisms of ChP inflammation and the ensuing CSF hypersecretion in hydrocephalus remain *** the present study,we elucidate the critical role of macrophages in the pathogenesis of ChP ***,we identify the chemokine CCL2,released by ChP epithelial cells,recruits CCR2+monocytes to the ChP thereby inciting hydrocephalus *** accumulated ChP macrophages increase the inflammation in ChP epithelial cells through TNF-α/TNFR1/NF-κB signaling cascade,thereby leading to CSF ***,augmentation of ChP‒CCL2 using an adeno-associated viral approach(AAV)exacerbates macrophage recruitment,activation,and ventriculomegaly in rat PHH *** application of Bindarit,a specific CCL2 inhibitor,significantly inhibits ChP macrophage infiltration and activation and reduces CSF secretion ***,the administration of CCR2 antagonist(INCB 3284)reduces ChP macrophage accumulation and *** study not only unveils the ChP CCL2‒CCR2 signaling in the pathophysiology of hydrocephalus but also unveils Bindarit as a promising therapeutic choice for the management of posthemorrhagic hydrocephalus.

关键词： Hydrocephalus Macrophages CCL2 CCR2 Choroid plexus Epithelial cells Crosstalk Cerebrospinal fluid hypersecretion

Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Oncology Research 2025年第1期33卷 67-81页

作者： XIANG LI wenke JIN LIFENG WU HUAN WANG XIN XIE WEI HUANG BO liu State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical TechnologyChengdu University of Traditional Chinese MedicineChengdu611137China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China

Background:Triple-negative breast cancer(TNBC),characterized by its lack of traditional hormone receptors and HER2,presents a significant challenge in oncology due to its poor response to conventional *** is an important process for maintaining cellular homeostasis,and there are currently autophagy biomarkers that play an effective role in the clinical treatment of *** contrast to targeting protein activity,intervention with proteinprotein interaction(PPI)can avoid unrelated crosstalk and regulate the autophagy process with minimal interference ***:Here,we employed Naive Bayes,Decision Tree,and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC,aiming to uncover novel therapeutic ***,the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay,and the interaction relationship was verified by molecular docking and CO-IP experiments after *** formation,cellular immunofluorescence,cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)tests were used to predict the clinical therapeutic effects of manipulating candidate ***:By developing three PPI classification models and analyzing over 13,000 datasets,we identified 3733 previously unknown autophagy-related *** network analysis revealed the central role of Beclin 2 in autophagy regulation,uncovering its interactions with 39 newly identified ***,the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1,which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay ***,in vitro investigations showed that overexpressing Beclin 2 increased Ubiquilin 1,promoted autophagy-dependent cell death,and inhibited proliferation and metastasis in MDA-MB-231 ***:This study not

关键词： Triple-negative breast cancer(TNBC) Autophagy Protein-protein interactions(PPI) Artificial intelligence(AI) Beclin 2 Ubiquilin 1

Interpretation of the Traditional Chinese Medicine portion of the diagnosis and treatment protocol for corona virus disease 2019(Trial Version 7)

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Journal of Traditional Chinese Medicine 2020年第3期40卷 497-508页

作者： Song Ping Zhao Linhua Li Xiuyang Su Jiansen Jiang Zhaoyuan Song Bin liu wenke Tang Shuang Lei Ye Ding Qiyou Yang Ze Lin Jiaran Wei Yu Tong Xiaolin International Cooperation Division China Academy of Chinese Medical SciencesBeijing 100700China Department of Endocrinology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Tianjin Tasly Medical&Healthcare Investment Co.Ltd.Tianjin 300410China The Third Affiliated Hospital of Zunyi Medical University Zunyi 563099China Beijing University of Chinese Medicine Beijing 100029China Department of Endocrinology and Metabolism the Second Affiliated Hospital of Shaanxi University of Traditional Chinese MedicineXianyang 712000China

The TCM protocol in the Diagnosis and Treatment Protocol for corona virus disease 2019(COVID-19)(Trial Version 7) has been updated from previous versions. The protocol was formulated under the direct leadership of the National Administration of Traditional Chinese Medicine, based on the experience of a panel of experts, supported by evidence from fever clinics and from the outcomes of emergency(EM) observation rooms and inpatients throughout China(especially in Wuhan, Hubei Province) in combination with the latest scientific research results and data. The present interpretation of the TCM protocol is based on an overall understanding of the revised content, and aims to guide and standardize its clinical application to provide a reference for clinicians.

关键词： Medicine Chinese traditional Corona virus disease 2019 Protocol interpretation

Exposing vertebral artery from lateral to medial under the guide of peri-vertebral artery fat pad in far lateral approach

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Chinese Medical Journal 2022年第4期135卷 468-470页

作者： Jiuhong Li Linlin Song Zhigang Lan wenke liu Yuekang Zhang Xuhui Hui Jianguo Xu Xuesong liu Department of Neurosurgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Ultrasound West China HospitalSichuan UniversityChengduSichuan 610041China

Far lateral approach(FLA),together with its modified approaches,is a fundamental surgical approach for surgical resection of lesions located at the ventral or ventrolateral side of the foramen magnum.[1,2,3,4,5]The key procedure in FLA is exposing the vertebral artery(VA)especially the V3 segment.[1,5,6]When performing an FLA,most neurosurgeons choose to expose the suboccipital triangle(formed by the rectus capitis posterior major,the superior oblique,and the inferior oblique)as a key anatomical landmark initially and then expose the V3 segment.[1,2,5,6,7]However,on the one hand,this muscular anatomical landmarks-suboccipital triangle varies in depth,morphology,and location in different patients,which increases the risk of VA injury during surgery.[3]On the other hand,this procedure could lead to exposing difficulty due to the obstruction of overlying layers of muscles and the distribution of blood vessels,which could prolong the time for craniotomy *** course of VA could vary,such as looping backward and bulge posteriorly between the lips of the suboccipital triangle,where it could be damaged if one expects it to be found in the depth of the suboccipital triangle.[3]Thus,neurosurgeons have the potential for VA injury and a rather prolonged time to successfully expose VA.

关键词： vertebral medial triangle

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习近平关于国际传播工作重要论述研究

马克思主义研究 2023年第10期 113-121页

作者：刘文科云南大学民族政治研究院云南昆明650091

党的十八大以来,习近平总书记关于国际传播工作的重要论述,全面阐述了“为什么要加强和改进国际传播工作”“加强和改进什么样的国际传播工作”等新时代中国特色社会主义国际传播的根本问题,具有丰富的理论内涵。习近平关于国际传播工... 详细信息

党的十八大以来,习近平总书记关于国际传播工作的重要论述,全面阐述了“为什么要加强和改进国际传播工作”“加强和改进什么样的国际传播工作”等新时代中国特色社会主义国际传播的根本问题,具有丰富的理论内涵。习近平关于国际传播工作重要论述系统说明了国际传播工作的传播主体、传播渠道、传播对象、传播内容以及传播效能等新时代中国特色社会主义国际传播的基本内容,强调了加强国际传播能力建设,形成同我国综合国力和国际地位相匹配的国际话语权等新时代中国特色社会主义国际传播的目标方向,并指出明确的实践路径。

关键词：国际传播工作中国特色社会主义国际传播习近平文化思想