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数学学报（中文版） 2024年第2期67卷 347-356页

作者：刘建亚温婷婷吴杰山东大学数学学院济南250100 法国科学研究中心东巴黎大学分析与应用数学实验室克雷泰伊94010

Manin猜想预测了代数簇上的有理点分布规律.对给定的整系数本原正定二次型Q,方程x^(3)=Q(y)z表示一类奇异三次超曲面.本文主要介绍这类曲面上的Manin猜想,并概述其研究方法及相关结果.在最后一节,介绍几个推广结果.

关键词：奇异曲面有理点 Manin猜想

医保支付与医生薪酬的激励转化机制研究——DRG付费下的实验研究证据

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中国卫生政策研究 2024年第7期17卷 8-17页

作者：李星林兴刘文婷韩优莉首都医科大学公共卫生学院北京100069

目的:探究与DRG支付方式改革相适应的医生薪酬激励设计,为优化医保支付方式改革相关政策提供参考依据。方法:利用经济学实验,设计七种将DRG支付激励转化为薪酬激励的医生薪酬支付方式,招募210名医学生和65名医生作为被试人员,测试其在... 详细信息

目的:探究与DRG支付方式改革相适应的医生薪酬激励设计,为优化医保支付方式改革相关政策提供参考依据。方法:利用经济学实验,设计七种将DRG支付激励转化为薪酬激励的医生薪酬支付方式,招募210名医学生和65名医生作为被试人员,测试其在不同薪酬激励下为患者提供的医疗服务数量及相应患者健康效益。结果:向医生反馈DRG支付情况或将DRG支付结余与医生绩效工资挂钩均会将支付方式的激励传导给服务提供者,在此基础上,引入以质量为基础的按绩效支付,被试者提供的服务量与最优服务量之间的差值减小,患者健康效益损失比也降低。结论:在将DRG支付激励传导给服务提供者时,与以质量为基础的按绩效支付相结合的医生薪酬设计更有利于提高患者健康效益。

关键词：医保支付方式按疾病诊断相关分组付费医生行为实验研究

巧借现代多媒体技术突破小学低段看图写话教学重难点

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当代教研论丛 2024年第1期10卷 85-88页

作者：刘雯婷新疆乌鲁木齐八一中学附小新疆乌鲁木齐830000

小学低段看图写话是训练学生观察图画,然后用自己的语言说出来,并写下来。由于这一训练过程要有一定的层次和梯度,因此是小学低段写话教学的重难点问题。现代多媒体技术在突破这一教学重难点方面有着独特的优势。文章以部编版小学二年... 详细信息

小学低段看图写话是训练学生观察图画,然后用自己的语言说出来,并写下来。由于这一训练过程要有一定的层次和梯度,因此是小学低段写话教学的重难点问题。现代多媒体技术在突破这一教学重难点方面有着独特的优势。文章以部编版小学二年级上册语文园地七的看图写话教学为例,发挥现代多媒体教育技术优势去设置坡度,并基于学情,面向全体学生展开训练,做到分层指导、分层观察、分层呈现,从而创设一个师生多向立体交流互动的平台,让学生的表达能够有更广阔的平台,让学生习作的过程更加有趣。

关键词：多媒体技术小学低段看图写话

A novel de novo mutation of the Nipped-B-like gene in an isolated Chinese patient with Cornelia de Lange syndrome

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Chinese Medical Journal 2013年第1期126卷 191-192页

作者： XU Wei-zhen CHEN Chun-yue CHEN Xiao-ling ZHAO Yan liu wen-ting DU Zhen-fang ZHANG Xian-ning Institute of Cancer Zhejiang Cancer Hospital Hangzhou Zhejiang310022 China Department of Cell Biology and Medical Genetics NationalEducation Base for Basic Medical Sciences Institute of CellBiology Zhejiang University School of Medicine HangzhouZhejiang 310058 China Department of Reproductive Medicine Hangzhou Red CrossHospital Hangzhou Zhejiang 310003 China

Cornelia de Lange syndrome （CdLS; OMIM： 122470） is characterized by distinctive facial features, growthretardation, hirsutism, and upper limb reduction defects. Craniofacial features manifest as synophrys, arched eyebrows, long thick eyelashes, a small upturned nose, small widely-spaced teeth, and microcephaly. The intelligence quotient （IQ） is usually below the normal level. More phenotypes are frequently found, such as cardiac septal defects, gastrointestinal dysfunction, hearing loss, myopia, and cryptorchidism or hypoplastic genitalia.

关键词： Nipped-B-like gene Cornelia de Lange syndrome de novo mutation

基于HFMEA优化急诊救治流程对急性脑梗死患者急救时间及神经功能的影响

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罕少疾病杂志 2024年第6期31卷 11-12页

作者：彭雪芬刘文婷鹰潭市人民医院江西鹰潭335000

目的观察基于医疗失效模式与效应分析(HFMEA)优化急诊救治流程对急性脑梗死(ACI)患者急救时间及神经功能的影响。方法医院急诊自2022年4月开始实施基于HFMEA优化急诊救治流程,将实施前2020年8月至2022年3月期间急诊收治的ACI患者36例... 详细信息

目的观察基于医疗失效模式与效应分析(HFMEA)优化急诊救治流程对急性脑梗死(ACI)患者急救时间及神经功能的影响。方法医院急诊自2022年4月开始实施基于HFMEA优化急诊救治流程,将实施前2020年8月至2022年3月期间急诊收治的ACI患者36例纳入对照组,将2022年4月至2023年6月期间急诊收治的ACI患者3.6例纳入观察组。比较两组急救时间、神经功能及临床救治结局情况。结果与对.照组相比,观察组医生接诊、影像学检查出报告、溶栓、转诊时间短(P005)。结论基于HFMEA优化急诊救治流程可有效缩短ACI患者急救时间,降低神经功能损伤,改善临床救治结局。

关键词：急性脑梗死医疗失效模式与效应分析急诊救治神经功能

放牧对中小型土壤动物群落结构影响的Meta分析

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草地学报 2024年第4期32卷 1194-1203页

作者：孙彩彩安海涛杨晓霞吕卫东刘文亭董全民青海大学畜牧兽医科学院青海省畜牧兽医科学院/三江源区高寒草地生态教育部重点实验室/青海省高寒草地适应性管理重点实验室青海西宁810016

中小型土壤动物是地下生态系统重要的参与者,在地下生态系统物质循环和能量流动过程中均扮演着重要角色。本研究通过对40篇文献进行Meta分析,探讨放牧对中小型土壤动物群落结构变化的影响,结果表明:(1)放牧会提高中小型土壤动物丰度,但... 详细信息

中小型土壤动物是地下生态系统重要的参与者,在地下生态系统物质循环和能量流动过程中均扮演着重要角色。本研究通过对40篇文献进行Meta分析,探讨放牧对中小型土壤动物群落结构变化的影响,结果表明:(1)放牧会提高中小型土壤动物丰度,但会降低物种数和多样性指数。(2)放牧通过影响植物群落和土壤理化性质,进而间接影响中小型土壤动物的群落结构。(3)相关性分析表明,在围封处理下,中小型土壤动物丰度与土壤含水量、速效钾呈正相关;在放牧处理下,中小型土壤动物丰度与土壤含水量、速效钾、全磷呈显著正相关(P<0.01)。(4)结构方程模型结果显示,在围封处理下,土壤全氮对中小型土壤动物丰度产生显著正效应(标准化回归系数β=0.19,P<0.05)。综上所述,中小型土壤动物作为地下生态系统的重要参与者,其对放牧的响应方式,有利于为各地区制定更合理且科学的放牧方式。

关键词：放牧中小型土壤动物群落结构 Meta分析

Effects of Interaction of Soil Moisture and Organic Matter on Powdery Mildew Disease and Growth of Heracleum moellendorffii Hance

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Journal of Northeast Agricultural University(English Edition) 2021年第2期28卷 45-52页

作者： liu Zai-min Gao Xin-wen Zhang Meng-yao Li Kun liu wen-ting Jiang Xin-mei Yu Xi-hong Key Laboratory of Biology and Genetic Improvement of Horticulture Crops(Northeast Region) Ministry of Agriculture and Rural AffairsNortheast Agricultural UniversityHarbin 150030China College of Horticulture and Landscape Architecture Northeast Agricultural UniversityHarbin 150030China

Taking annual Heracl'eum moellendorffii Hance as the material,this research studied the epidemic dynamics of H.moellendorffii Hance powdery mildew and plant growth by using the interactive methods of soil moisture and soil organic matter.The results showed that the interaction of higher soil moisture content(60%-80%)and soil organic matter content(75-100 g•kg^(-1))had few diseases,dosease index and area under disease progression curve(AUDPC)compared with those of other treatments,thus could effectivley control powdery mildew disease.Moreover,higher soil moisture and organic matter content increased the yield,contents of soluble sugar,soluble protein,vitamin C and coumarin in H.moellendorffii Hance.

关键词： H.moellendorffii Hance irrigation and fertilizer management powdery mildew plant growth

In Situ Atomic Reconstruction Engineering Modulating Graphene-Like MXene-Based Multifunctional Electromagnetic Devices Covering Multi-Spectrum

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Nano-Micro Letters 2024年第9期16卷 247-261页

作者： ting‑ting liu Qi Zheng wen‑Qiang Cao Yu‑Ze Wang Min Zhang Quan‑Liang Zhao Mao‑Sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China Department of Physics Beijing Technology and Business UniversityBeijing 100048People’s Republic of China School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144People’s Republic of China

With the diversified development of big data,detection and precision guidance technologies,electromagnetic(EM)functional materials and devices serving multiple spectrums have become a hot topic.Exploring the multispectral response of materials is a challenging and meaningful scientific question.In this study,MXene/TiO_(2)hybrids with tunable conduction loss and polarization relaxation are fabricated by in situ atomic reconstruction engineering.More importantly,MXene/TiO_(2)hybrids exhibit adjustable spectral responses in the GHz,infrared and visible spectrums,and several EM devices are constructed based on this.An antenna array provides excellent EM energy harvesting in multiple microwave bands,with|S11|up to−63.2 dB,and can be tuned by the degree of bending.An ultra-wideband bandpass filter realizes a passband of about 5.4 GHz and effectively suppresses the transmission of EM signals in the stopband.An infrared stealth device has an emissivity of less than 0.2 in the infrared spectrum at wavelengths of 6-14μm.This work can provide new inspiration for the design and development of multifunctional,multi-spectrum EM devices.

关键词： Graphene-like MXene hybrids Multi-spectral response Multi-function antenna Ultra-wideband bandpass filter Electromagnetic device

BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway

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Current Medical Science 2024年第2期44卷 333-345页

作者： Jun-li ZHAO Lin ZHAO Qiu-nan ZHAN Miao liu ting ZHANG wen-wen CHU Department of Nephrology Shanghai University of Medicine&Health Sciences Ailiated Zhoupu HospitalShanghai 201318China Orthopedic Department Guangming Traditional Chinese Medicine Hospital of Pudong New AreaShanghai 201399China

Objective:Peritoneal fibrosis(PF)is the main cause of declining efficiency and ultrafiltration failure of the peritoneum,which restricts the long-term application of peritoneal dialysis(PD).This study aimed to investigate the therapeutic effects and mechanisms of bone marrow mesenchymal stem cells-derived exosomes(BMSC-Exos)on PF in response to PD.Methods:Small RNA sequencing analysis of BMSC-Exos was performed by second-generation sequencing.C57BL/6J mice were infused with 4.25%glucose-based peritoneal dialysis fluid(PDF)for 6 consecutive weeks to establish a PF model.A total of 36 mice were randomly divided into 6 groups:control group,1.5%PDF group,2.5%PDF group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment group.Reverse transcription quantitative polymerase chain reaction(RT-qPCR)was performed to measure the expression level of miR-27a-3p in BMSC-Exos and peritoneum of mice treated with different concentrations of PDF.HE and Masson staining were performed to evaluate the extent of PF.The therapeutic potential of BMSC-Exos for PF was examined through pathological examination,RT-qPCR,Western blotting,and peritoneal function analyses.Epithelial-mesenchymal transition(EMT)of HMrSV5 was induced with 4.25%PDF.Cells were divided into control group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment group.Cell Counting Kit-8 assay was used to measure cell viability,and transwell migration assay was used to verify the capacity of BMSC-Exos to inhibit EMT in HMrSV5 cells.Results:Small RNA sequencing analysis showed that miR-27a-3p was highly expressed in BMSC-derived exosomes compared to BMSCs.The RT-qPCR results showed that the expression of miR-27a-3p was upregulated in BMSC-Exos,but decreased in PD mice.We found that PF was glucose concentration-dependently enhanced in the peritoneum of the PD mice.Compared with the control mice,the PD mice showed high solute transport and decreased ultrafiltration volume as well as an obvious fibroproliferative response,with markedly increas

关键词： peritoneal fibrosis bone marrow mesenchymal stem cell-derived exosomes miR-27a-3p TP53 epithelialmesenchymal transition

Visualization analysis of research hotspots and trends on gastrointestinal tumor organoids

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2826-2841页

作者： Gang Wang Tao liu wen-ting He School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Digestive System Tumor Prevention and Treatment and Translational Medicine Engineering Innovation Center of Lanzhou University Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Digestive System Tumor Translational Medicine Engineering Research Center of Gansu Province Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The Second Hospital&Clinical Medical School Lanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKGROUND Gastrointestinal tumor organoids serve as an effective model for simulating cancer in vitro and have been applied in basic biology and preclinical research.Despite over a decade of development and increasing research achievements in this field,a systematic and comprehensive analysis of the research hotspots and future trends is lacking.AIM To address this problem by employing bibliometric tools to explore the publication years,countries/regions,institutions,journals,authors,keywords,and references in this field.METHODS The literature was collected from Web of Science databases.CiteSpace-6.2R4,a widely used bibliometric analysis software package,was used for institutional analysis and reference burst analysis.VOSviewer 1.6.19 was used for journal cocitation analysis,author co-authorship and co-citation analysis.The‘online platform for bibliometric analysis(https://***/app)’was used to assess the total number of publications and the cooperation relationships between countries.Finally,we employed the bibliometric R software package(version R.4.3.1)in R-studio,for a comprehensive scientific analysis of the literature.RESULTS Our analysis included a total of 1466 publications,revealing a significant yearly increase in articles on the study of gastrointestinal tumor organoids.The United States(n=393)and Helmholtz Association(n=93)have emerged as the leading countries and institutions,respectively,in this field,with Hans Clevers and Toshiro Sato being the most contributing authors.The most influential journal in this field is Gastroenterology.The most impactful reference is"Long term expansion of epithelial organs from human colon,adenoma,adenocarcinoma,and Barrett's epithelium".Keywords analysis and citation burst analysis indicate that precision medicine,disease modeling,drug development and screening,and regenerative medicine are the most cutting-edge directions.These focal points were further detailed based on the literature.CONCLUSION This bibliometric study offers an objective and quantitative analysis

关键词： Gastrointestinal tumor organoids Bibliometric analysis Drug development and screening Model CiteSpace