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Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK

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International Journal of Oral science 2024年第3期16卷 471-485页

作者： Dexuan Zhuang Shuangshuang Wang Huiting Deng Yuxin shi Chang liu Xue Leng Qun Zhang Fuxiang Bai Bin Zheng Jing Guo Xun{2. Wu School and Hospital of Stomatology Cheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration&Shandong Provincial Clinical Research Center for Oral DiseasesJinanChina engineering Laboratory for Biomaterials and Tissue Regeneration Ningbo Stomatology HospitalSavaid Stomatology SchoolHangzhou Medical CollegeNingboChina Cedars-Sinai Cancer Institute Department of Biomedical SciencesCedars-Sinai Medical CenterLos AngelesCAUSA

The efficient clinical treatment of oral squamous cell carcinoma(OSCC)is still a challenge that demands the development of effective new *** has been shown to produce more potent anti-tumor activities than metformin on different tumors,however,not much is known about the influence of phenformin on OSCC *** found that phenformin suppresses OSCC cell proliferation,and promotes OSCC cell autophagy and apoptosis to significantly inhibit OSCC cell growth both in vivo and in ***-seq analysis revealed that autophagy pathways were the main targets of phenformin and identified two new targets DDIT4(DNA damage inducible transcript 4)and NIBAN1(niban apoptosis regulator 1).We found that phenformin significantly induces the expression of both DDIT4 and NIBAN1 to promote OSCC ***,the enhanced expression of DDIT4 and NIBAN1 elicited by phenformin was not blocked by the knockdown of AMPK but was suppressed by the knockdown of transcription factor ATF4(activation transcription factor 4),which was induced by phenformin treatment in OSCC ***,these results revealed that phenformin triggers endoplasmic reticulum(ER)stress to activate PERK(protein kinase R-like ER kinase),which phosphorylates the transitional initial factor eIF2.and the increased phosphorylation of eIF2.leads to the increased translation of *** summary,we discovered that phenformin induces its new targets DDIT4 and especially NIBAN1 to promote autophagic and apoptotic cell death to suppress OSCC cell *** study supports the potential clinical utility of phenformin for OSCC treatment in the future.

关键词： drugs treatment AMPK DDI

5,10,15,2.-Tetrakis(p-4-fluorobenzoyloxy)phenyl Porphyrin and Its Transition Metal Complexes

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Chemical Research in Chinese Universities 2006年第4期22卷 419-422页

作者： liu wei {2. Tong-shun liu Guo-fa college of materials {2. and engineering Shandong University of TechnologyZibo 255049 P. R. China college of Chemistry Jilin University Changchun 130023 P. R. China

The properties of porphyrins can be changed through the choice of peripheral substituents and inserted metal ions. To obtain porphyrin complexes with novel structures, 5,10, 15,2.-tetrakis（p-4-fluorobenzoyloxy） phenyl perphyrin（TFBOPPH2.） and its transition metal complexes {TFBOPPM [ M = Mn（ Ⅲ ）, Fe（ Ⅲ ）, Co（ Ⅱ ）, Ni（ Ⅱ ）, Cu（ Ⅱ ） and Zn（ Ⅱ ） ] } were synthesized and characterized by means of UV-Vis, IR photoacoustic speetrumetry, ^1H NMR, elemental analyses, molar conductance, and XPS methods. A structure is proposed, in which one porphyrln molecule is coordinated with a transition metal ion in a tetradentate fashion, while the chlorine ion is the balaneeable anion in Fe（ Ⅲ ） and Mn（ Ⅲ ） complexes.

关键词： Porphyrin Synthesis Transition metal Complex

CEPC Technical Design Report

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Radiation Detection technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen {2.qiang Chen Tianlu Chen wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of science and technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced science and {2. Beijing china Institute of Atomic Energy Beijing china Jiliang University HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china University of Geosciences Beijing china University of Geosciences WuhanHubei china University of Mining and technology XuzhouJiangsu china West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china University Of science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.15)and the Conceptual Design Report(CDR,2.18),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

中国塑性成形技术和装备30年的重大突破与进展

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塑性工程学报 2024年第4期31卷 2-45页

作者：林忠钦黄庆学苑世剑赵国群华林易幼平詹梅李淑慧刘伟王宝雨陈军王涛李宏伟黄亮何祝斌钟掘上海交通大学上海市复杂薄板结构数字化制造重点实验室上海200240 太原理工大学机械与运载工程学院山西太原030024 哈尔滨工业大学金属精密热加工国家级重点实验室黑龙江哈尔滨150001 山东大学材料科学与工程学院山东济南250061 武汉理工大学汽车工程学院湖北武汉430070 中南大学轻合金研究院湖南长沙410083 西北工业大学材料学院陕西西安710072 北京科技大学机械工程学院北京100083 上海交通大学材料科学与工程学院上海200240 华中科技大学材料科学与工程学院湖北武汉430074 大连理工大学机械工程学院辽宁大连116023

1994以来的30年,在国家重大需求的强劲牵引下,我国塑性成形技术与装备取得举世瞩目的巨大成就,研制出一大批世界第一的成形装备,实现了三大技术跨越,形成了规模最大的研究队伍,我国塑性成形技术总体水平进入世界先进国家行列,多个单项... 详细信息

1994以来的30年,在国家重大需求的强劲牵引下,我国塑性成形技术与装备取得举世瞩目的巨大成就,研制出一大批世界第一的成形装备,实现了三大技术跨越,形成了规模最大的研究队伍,我国塑性成形技术总体水平进入世界先进国家行列,多个单项技术和装备达到国际领先水平。选择了其中8项最具代表性成果,并介绍其在塑性工程理论和技术上取得的重大突破以及对国家重大装备研制的突出贡献,分析了我国塑性成形技术与国际领先水平的差距。最后对我国塑性成形技术发展将呈现出的“三超两高”五大发展趋势进行了展望。

关键词：金属成形技术装备塑性

Review of pre-processing technologies for ice cores

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Journal of Mountain science 2018年第9期15卷 1950-1960页

作者： DU Wen-tao KANG shi-chang QIN Xiang SUN wei-jun ZHANG Yu-lan {2. Yu-shuo CHEN Ji-zu Qilian Shan Station of Glaciology and Ecologic Environment State Key Laboratory of Cryospheric ScienceNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China CAS Center for Excellence in Tibetan Plateau Earth sciences Beijing 100101China University of Chinese Academy of sciences Beijing 100049China college of Population Resources and EnvironmentShandong Normal UniversityJinan 250014China

High-resolution ice core records covering long time spans enable reconstruction of the past climatic and environmental conditions allowing the investigation of the earth system's evolution. Preprocessing of ice cores has direct impacts on the data quality control for further analysis since the conventional ice core processing is time-consuming, produces qualitative data, leads to ice mass loss, and leads to risks of potential secondary pollution. However, over the past several decades, preprocessing of ice cores has received less attention than the improvement of ice drilling, the analytical methodology of various indices, and the researches on the climatic and environmental significance of ice core records. Therefore, this papers reviews the development of the processing for ice cores including framework, design as well as materials, analyzes the technical advantages and disadvantages of the different systems. In the past, continuous flowanalysis(CFA) has been successfully applied to process the polar ice cores. However, it is not suitable for ice cores outside polar region because of high level of particles, the memory effect between samples, and the filtration before injection. Ice core processing is a subtle and professional operation due to the fragility of the nonmetallic materials and the random distribution of particles and air bubbles in ice cores, which aggravates uncertainty in the measurements. The future developments of CFA are discussed in preprocessing, memory effect, challenge for brittle ice, coupling with real-time analysis and optimization of CFA in the field. Furthermore, non-polluting cutters with many different configurations could be designed to cut and scrape in multiple directions and to separate inner and outer portions of the core. This system also needs to be coupled with streamlined operation of packaging, coding, and stacking that can be implemented at high resolution and rate, avoiding manual intervention. At the same time, information

关键词： Ice core Alpine region Polar region Pre-processing Innovation

Single-atomic tungsten-doped Co_(3)O_(4) nanosheets for enhanced electrochemical kinetics in lithium–sulfur batteries

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Carbon Energy 2023年第8期5卷 31-41页

作者： Sangni Wang Riming Hu Ding Yuan Lei Zhang Chao Wu Tianyi Ma wei Yan Rui Wang Liang liu Xuchuan Jiang Hua Kun liu shi Xue Dou Yuhai Dou Jiantie Xu National engineering Laboratory for VOCs Pollution Control technology and Equipment Guangdong Provincial Key Laboratory of Atmospheric EnvironmentPollution Control School of Environment and EnergySouth China University of TechnologyGuangzhouChina shandong Institute of Advanced technology JinanChina School of materials science and {2. Institute for Smart Materials&EngineeringUniversity of JinanJinanChina Institute of Energy materials science University of Shanghai for Science and TechnologyShanghaiChina Institute for Superconducting and Electronic materials University of WollongongWollongongAustralia School of science RMIT UniversityMelbourneVictoriaAustralia State Key Laboratory for Modification of Chemical Fibers and Polymer materials College of Materials Science and EngineeringDonghua UniversityShanghaiChina

The practical application of lithium–sulfur batteries(LSBs)is severely hindered by the undesirable shuttling of lithium polysulfides(LiPSs)and sluggish redox kinetics of sulfur ***,a series of ultrathin singleatomic tungsten-doped Co_(3)O_(4)(Wx-Co_(3)O_(4))nanosheets as catalytic additives in the sulfur cathode for LSBs are rationally designed and *** from the enhanced catalytic activity and optimized electronic structure by W doping,the Wx-Co_(3)O_(4) not only reduces the shuttling of LiPSs but also decreases the energy barrier of sulfur redox reactions of sulfur species,leading to accelerated electrode *** a result,LSB cathodes with the use of 5.0 wt%W0.02.Co_(3)O_(4) as the electrocatalyst show the high reversible capacities of 12.7.0 and 558.6 mAh g^(-1) at 0.2.and 5.0 C,respectively,and maintain a high reversible capacity of 644.6 mAh g^(-1) at 1.0 C(1.0 C=1675 mA g^(-1))after 500 *** a high sulfur loading of 5.5 mg cm^(-2. and electrolyte–electrode ratio of 8μL_(electrolyte) mg_(sulfur)^(-1),the 5.0 wt%W_(0.02.-Co_(3)O_(4)-based sulfur cathode also retains a high reversible areal capacity of 3.86 mAh cm^(-2. at 0.1 C after 50 cycles with an initial capacity retention of 84.7%.

关键词： catalytic additives lithium-sulfur batteries single-atomic dopant sluggish redox kinetics

The mitigation of pitch-derived carbon with different structures on the volume expansion of silicon in Si/C composite anode

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Journal of Energy Chemistry 2023年第9期84卷 292-302页

作者： Xin Xue Xiao liu Bin Lou Yuanxi Yang Nan shi FuShan Wen Xiujie Yang Dong liu State Key Laboratory of Heavy Oil Processing China University of PetroleumQingdao 266580ShandongChina Department of Chemical engineering University college London Torrington Place London WC1E7JEUK

The microstructures of carbon precursors significantly affect the electrochemical performance of Si/C composite ***,the interaction between Si and carbon materials with different structures is still ***-based materials undergoing different thermal treatments are superior sources for synthesizing carbons with different ***,different types of mesophase pitch(domain,flow-domain and mosaic structure) obtained from controllable thermal condensation are utilized to prepare Si/C composite materials and the corresponding models are established through finite element simulation to explore the correlation between the lithium storage properties of Si/C composites and the structures of carbon *** results indicate that the flow-domain texture pitch P2.has a better ability to buffer the volume expansion of silicon particles for its highly ordered arrangement of carbon crystallites inside could disperse the swelling stress uniformly alongside the particle *** sample Si@P2.exhibits the highest capacity of 132. mA h/g after 2.0 cycles at a current density of 0.1 A/g as well as the best rate performance and *** sample Si@P3 in which the mosaic texture pitch P3 composed of random orientation of crystallites undergoes the fastest capacity *** findings suggest that highly ordered carbon materials are more suitable for the synthesis of Si/C composite anodes and provide insights for understanding the interaction between carbon and silicon during the charging/discharging process.

关键词： Si/C composite materials Mesophase pitch Finite element simulation Volume expansion

Understanding the roles of Ti on the structure and electrochemical performances of Li2.u1-xTixO3 cathode materials for Li-ion batteries

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Journal of Energy Chemistry 2019年第6期28卷 9-16页

作者： Hu Zhao Yanchao shi Li Xue Yingzhi Cheng Zhongbo Hu Xiangfeng liu college of materials {2. and Optoelectronic technology University of Chinese Academy of SciencesBeijing 100049China Inner Mongolia Synthetic Chemical Institute Hohhot 010072Inner MongoliaChina School of Chemical engineering Shandong University of TechnologyZibo 255049ShandongChina

The lattice doping has been widely used to improve the electrochemical performances of Li-rich cathode materials but the roles of the introduced foreign atoms are still not very ***,a series of Li2.u1-xTixO3 solid solutions have been synthesized and the roles of Ti doping on the structural and electrochemical properties of Li2.uO3 have been comprehensively *** Rietveld refinement exhibits that the interlayer spacing gradually shortens with increasing Ti *** shrinkage is favorable to the layered structure stability but increases the lithium diffusion *** measurements show that Li2.u0.8Ti0.2.3 possesses the best cyclability with 196.9 and 196.1 m Ah g-1for charge and discharge capacity retaining after 90 cycles,*** voltammetry scanning indicates that Ti dopant promotes the formation of more peroxo-or superoxo-like species but reduces the initial coulumbic *** of electrochemical impedance spectroscopy display that Ti doping reduces the charge transfer impedance,which facilitates the lithium-ion diffusion across the electrolyteelectrode interface and improves the electronic ***2.u0.8Ti0.2.3exhibits the best electrochemical performance owing to the balance among all the factors discussed *** study also offers some new insights into optimizing the electrochemical performances of Li-rich cathode materials through the lattice doping.

关键词： Lithium-ion battery Li-rich cathode Ti doping Rietveld refinement

CoS_(2.nanowires supported graphdiyne for highly efficient hydrogen evolution reaction

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Journal of Energy Chemistry 2021年第9期30卷 272-278页

作者： Wangjing Xie Kang liu Guodong shi Xinliang Fu Xiaojie Chen Zixiong Fan Min liu Mingjian Yuan Mei Wang Key Laboratory of Marine Chemistry Theory and technology (Ministry of Education)College of Chemistry and Chemical EngineeringOcean University of ChinaQingdao 266100China Key Laboratory of Advanced Energy materials Chemistry (Ministry of Education)Renewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai University300071 TianjinChina School of Physics and Electronics State Key Laboratory of Powder MetallurgyCentral South UniversityChangsha 410083China college of science Henan University of TechnologyZhengzhou 450001China

Transition metal sulfides are an important category for hydrogen evolution reaction(HER).However,only few edge unsaturated sulfurs functionalize as catalytic sites,which has dramatically limited the catalytic activity and *** this work,planar unsaturated sulfurs in(2.1)plane of the CoS_(2.nanowires have been successfully activated through constructing Graphdiyne-CoS_(2.heterojunction *** corresponding electrons transfer energy barriers for these planar unsaturated sulfurs have been significantly diminished,which are induced by the synergetic effects of the sp~1 hybridized carbons and unsaturated planar *** addition,DFT simulations reveal the synergetic effects of the sp~1 hybridized carbons and unsaturated planar sulfurs can promote electron transfer kinetics of the key step,VolmerHeyrovsky step,of the *** expected,the Graphdiyne-CoS_(2.heterojunction nanocomposites exhibit superior HER catalytic performance with low overpotential of 97 mV at 10 mA cm^(-2.,and the Tafel slope of 56 mV dec^(-1).Furthermore,the heterojunction shows outstanding stability as well due to the pr tection of the Graphdiyne(GDY).The approach thus paves the way for the further efficient transition metal disulfides catalyst manufactures.

关键词： Graphdiyne Electrocatalysts Hydrogen evolution reaction DFT simulation 2. carbon material