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Primary shunt hyperbilirubinaemia in a large four-generation family confirming autosomai dominant genetic disorder

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World Journal of Gastroenterology 2006年第19期12卷 3123-3125页

作者： Chun-Lian Wang Xiao-wei liu fang-Gen Lu Xiao-Ping Wu Chun-Hui Ouyang Dong-Ye Yang Department of Gastroenterology the Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China

AIM： To describe the pattern of inheritance and confirm the diagnostic criteda of primary shunt hyperbilirubinaemia （PSH）. METHODS： Forty members of a family pedigree across four generations were included in this study. All family members were interviewed and investigated by physical examination, hematology and liver function test and the pattern of inheritance was analyzed. RESULTS： Nine of the forty family members suffered primary shunt hyperbilirubinaemia. The mature erythrocytes of the propositus were irregular in shape and size. The pedigree showed transmission of the trait through four generations with equal distribution in male and female. No individual with a primary shunt hyperbilirubinaemia was born to unaffected parents. The penetrance was complete in adult. CONCLUSION： The pattern of inheritance is autosomal dominant. The abnormality of erythrocytes and decrease in white blood cell could be supplemented in the diagnosis of PSH. The PSH is a genetic disorder and could by renamed as hereditary shunt hyperbilirubinaemia.

关键词： Hyperbilirubinaemia Hereditary Shunt

Expression and significance of proapoptotic gene Bax in gastric carcinoma

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World Journal of Gastroenterology 1999年第1期5卷 20-22页

作者： liu Hai Feng, liu wei Wen, fang Dian Chun and MEN Rong Pu

AIM To study the expression of proapoptotic gene Bax in human gastric carcinoma and its significance. METHODS Using immunohistochemistry methods, the Bax protein expression in 57 specimens of gastric carcinoma and its relationship with clinical status and pathomorphological parameters were observed. RESULTS Thirty three (57 89%) cases were positive for Bax protein staining which was mainly located in the cytoplasm of tumor cells. The rate of Bax protein expression was not correlated with the tumor size, lymph node metastasis, depth of invasion, clinical stages of tumors and age and sex of patients ( P >0 05), but strongly associated with the morphological type and differentiation degree of tumors. It was significantly higher in intestinal type and well/moderately differentiated gastric carcinoma than in diffuse type and poorly differentiated gastric carcinoma ( P <0 05 and P <0 01). CONCLUSION The proapoptotic gene Bax is differentially expressed in most of gastric carcinoma and may take part in the modulation of apoptosis in gastric carcinoma. The expression of Bax might be associated with the occurrence of intestinal type gastric carcinoma and the differentiation of gastric carcinoma.

关键词： stomach neoplasms/pathology Bax gene gene expression immunohistochemistry

Expression of bcl-2 protein in gastric carcinoma and its significance

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World Journal of Gastroenterology 1998年第3期4卷 48-50页

作者： liu Hai Feng, liu wei Wen, fang Dian Chun and MEN Rong Pu

AIM To further study the role of bcl 2 protein expression in gastric carcinogenesis and tumor progression. METHODS Using immunohistochemical staining, the bcl 2 protein expression in 50 cases of gastric carcinoma and its relation to clinical status and pathomorphological parameters were observed. RESULTS Forty one (82%) cases were positive for bcl 2 protein staining which was located in the cytoplasm and nuclear membrane of tumor cells. The rate of bcl 2 protein expression was not correlated with the patient, sex, tumor size, lymph node status or clinical stages ( P >0 05). It was strongly associated with intestinal type tumors and poorly differentiated tumors ( P <0 05 and P <0 01). CONCLUSION Aberrant bcl 2 protein expression appears to be specifically associated with development of intestinal type gastric carcinoma, bcl 2 protein expression might play an important role in the early development/promotion and phenotypic differentiation of gastric carcinomas, but not in tumor progression.

关键词： stomach neoplasms/pathology bcl 2 protein gene expression immunohistochemical lymphatic metastasis

Metal-organic framework-derived porous carbon for the advanced aqueous zinc-ion hybrid capacitor

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Journal of Central South University 2024年第7期31卷 2268-2279页

作者： liu wei-fang HU Zi-han ZHANG Qi School of Chemistry and Chemical Engineering Hunan University of Science&TechnologyXiangtan 411201China Hunan Provincial Key Laboratory of Chemical Power Sources College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China

Aqueous zinc ion hybrid capacitors(ZIHCs)are considered one of the most promising electrochemical energy storage systems due to their high safety,environmental friendliness,low cost,and high power ***,the low energy density and the lack of sustainable design strategies for the cathodes hinder the practical application of ***,we design the N and O co-doped porous carbon cathode by annealing metal-organic framework(ZIF-8).ZIF-8 retains the original dodecahedral structure with a high specific surface(2814.67 m^(2)/g)and I_(G)/I_(D) ratio of 1.0 during carbonization and achieves self-doping of N and O *** defect sites are introduced into the porous carbon to provide additional active sites for ion adsorption after the activation of carbonized ZIF-8 by KOH *** ZIHCs assembled with modified ZIF-8 as the cathode and commercial zinc foil as the anode show an energy density of 125 W∙h/kg and a power density of 79 W/*** addition,this ZIHCs device achieves capacity retention of 77.8%after 9000 electrochemical cycles,which is attributed to the diverse pore structure and plentiful defect sites of ZIF-8-800(KOH).The proposed strategy may be useful in developing high-performance metal-ion hybrid capacitors for large-scale energy storage.

关键词： zinc ion hybrid capacitor cathode metal-organic framework(ZIF-8) KOH activation

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui liu Xingxing fang Liangming Zhang Bin liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

Clinical significance of Fas antigen expression in gastric carcinoma

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World Journal of Gastroenterology 1999年第1期5卷 95-96页

作者： liu Hai Feng 1, liu wei Wen 1, fang Dian Chun 1, liu Feng Xian 2 and HE Guang You 2

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关键词： stomach neoplasms/pathology Fas antigen lymphatic metastasis prognosis immunohistochemistry

Frequency Response of Modulated Electroluminescence of Light-Emitting Diodes

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Chinese Physics Letters 2011年第10期28卷 244-247页

作者： FENG Lie-Feng LI Yang LI Ding WANG Cun-Da ZHANG Guo-Yi YAO Dong-Sheng liu wei-fang XING Peng-Fei Department of Applied Physics Tianjin UniversityTianjin 300072 Research Center for Wide-band Gap Semiconductors School of PhysicsPeking UniversityBeijing 100871

Frequency responses of modulated electroluminescence(EL)of light-emitting diodes were measured using a testing *** increasing frequency of the ac signal,the relative light intensity(RLI)clearly ***,a peculiar asynchrony between the RLI and ac small-signal is *** frequencies higher than 10 kHz,the RLI clearly lags behind the ac signal and the absolute value of the lagging angle is nearly proportional to the signal *** the classical recombination model of light-emitting diodes under ac small-signal modulation,these abnormal characteristics of modulated EL can be clearly explained.

关键词： diodes absolute testing

Upcycling of polyethylene terephthalate to1,4-cyclohexanedimethanol in water

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Science China Chemistry 2025年

作者： Shuhui fang Zhiwen Gao Xinrui Shi Min Zhang wei Zhang Yue liu State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University Engineering Center for Sustainable Carbon Science and Technology East China Normal University Institute of Eco-Chongming

The recycling of waste polyethylene terephthalate（PET）, an extensively used polymer as plastic and fiber materials, has become an urgent topic due to the rapid generation and accumulation of plastic waste into the environment. Current chemical recycling approaches to depolymerize and convert PET into 1,4-cyclohexanedimethanol（CHDM）, an important chemical in the production of advanced polyesters, predominantly use organic solvents, such as alcohols or dioxane. Herein, we developed an environmentally friendly and economically viable pathway for converting PET to CHDM using water as the solvent. In this process, PET is sequentially hydrolyzed in water, hydrogenated to 1,4-cyclohexane dicarboxylic acid（CHDA）, and then reduced to CHDM. The PET conversion rate is self-enhanced in aqueous medium via acid-catalyzed hydrolysis by the generated CHDA intermediate. A Pd-based catalyst（e.g., Pd/C） selectively hydrogenates the arene ring of the PET monomer, terephthalic acid intermediate, and a Ru-Sn/C bimetallic catalyst reduces its COOH to CH2OH group. At optimized reaction conditions, a complete conversion of PET and 80.1% yield of CHDM are obtained. Alternatively, this approach can also efficiently produce CHDA from PET, with a yield up to 86.4%.

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过敏性肺炎的高分辨率CT表现

中国实用内科杂志 2019年第2期39卷 107-110页

作者：刘韦芳刘敏北京大学医学部中日友好临床医学院北京100029 中日友好医院放射诊断科北京100029

过敏性肺炎(HP)是由于吸入各种抗原性有机物粒子而引起的弥漫性肉芽肿性间质性肺疾病(ILD)。HP传统上分为急性期、亚急性期和慢性期。长期暴露于抗原可导致疾病发展为不可逆纤维化。对于HP,高分辨率CT(HRCT)是最敏感的检查,作为慢性HP与... 详细信息

过敏性肺炎(HP)是由于吸入各种抗原性有机物粒子而引起的弥漫性肉芽肿性间质性肺疾病(ILD)。HP传统上分为急性期、亚急性期和慢性期。长期暴露于抗原可导致疾病发展为不可逆纤维化。对于HP,高分辨率CT(HRCT)是最敏感的检查,作为慢性HP与ILD鉴别诊断的关键手段,特别是在临床上不能进行肺活检的情况下HRCT可以提供重要线索。文章总结HP的HRCT典型表现,希望可以为临床提供早期诊断线索。

关键词：过敏性肺炎高分辨率计算机断层扫描奶酪头征气体陷闭