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Experimental study on the gas-stripping chamber of an E//B neutral particle analyzer

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Nuclear Science and Techniques 2024年第11期35卷 98-107页

作者： Long Ma De-Hao xie yan-Xi wang shuo wang Ji-Feng Han Wei-Ping lin Jian-li liu Xing-Quan liu yu-Guo liu xiao-bing Luo yuan Luo Guo-Feng Qu yu-Fan Qu Pei-Pei Ren Roy Wada lin-ge Zang Jing-Jun Zhu Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Southwestern Institute of Physics Chengdu 610218China Cyclotron Institute Texas A&M UniversityCollege StationTX 77843USA

Stripping units take a key role in the neutral particle analyzer(NPA).A renovated gas-stripping unit was constructed for the newly designed E//B *** H_(2)as the working gas,we measured the gas inlet pressure(P_(0))and vacuum chamber pressure(P_(3)).The pressure distribution inside the gas-stripping room was calculated with Ansys Fluent,using the measured P_(0)and P_(3)as boundary *** stripping efficiency of the stripping unit was then simulated utilizing the geant4 Monte Carlo code for the H and D *** pressure P_(0)=40 Pa,which is one-sixth of what found in the previous design and corresponds to a thickness of 1.27×10^(17)atoms∕cm^(2),was obtained as the optimum working pressure for the upgraded stripping *** 50 kV electron cyclotron resonance(ECR)ion source platform was designed and constructed for E//B NPA calibration,and its performance has been *** the ECR ion source platform,we measured the efficiency of the stripping unit through an inverse experiment with proton *** compared the current ratios of measurements with and without H_(2)gas to geant4 simulation *** found adequate agreement between the overall trends of the experiment and the *** significant deviation for incident energies below 20 keV may result from the scattering effects of low-energy protons,leading to reduced accuracy in single-scattering physics in geant4 *** the scattering corrections observed in the reverse experiments obtains more accurate stripping efficiencies for H and D atoms in the energy range of 20–200 keV and the global efficiency with the maximum values of 95.0%for H atoms and 78.9%for D atoms at 200 keV.

关键词： NPA Gas-stripping ECR ion source Stripping efficiency geant4

Recent progress in nuclear astrophysics research and its astrophysical implications at the China Institute of Atomic Energy

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Nuclear Science and Techniques 2024年第12期35卷 376-408页

作者： Wei-Ping liu bing Guo Zhu An Bao-Qun Cui xiao Fang Chang-Bo Fu bin-shui Gao Jian-Jun He yu-Chen Jiang Chong Lv Er-Tao li ge-Xing li yun-Ju li Zhi-hong li Gang lian Wei-Ping lin Yi-Hui liu Wei Nan Wei-Ke Nan yang-Ping Shen Na Song Jun Su liang-Ting Sun xiao-Dong Tang Luo-Huan wang shuo wang You-Bao wang Di Wu xiao-Feng Xi Sheng-Quan yan li-Yong Zhang China Institute of Atomic Energy Beijing 102413China Department of Physics Southern University of Science and TechnologyShenzhen 518055China Jinping Deep Underground Frontier Science and Dark Matter Key Laboratory of Sichuan Province Liangshan 615000China School of Physics Xi’an Jiaotong UniversityXi’an 710049China Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Key Laboratory of Nuclear Physics and Ion-beam Application(MoE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Joint Department for Nuclear Physics Institute of Modern PhysicsChinese Academy of Sciences and Lanzhou UniversityLanzhou 730000China CAS Key Laboratory of High Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 73000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Beam Technology of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhenChina Key Laboratory of Beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Mathematics and Physics Handan UniversityHandan 056005China Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space SciencesShandong UniversityWeihai 264209China State Key Laboratory of Nuclear Physics and Technology School of PhysicsCAPTPeking UniversityBeijing 100871China

Nuclear astrophysics is a rapidly developing interdisciplinary feld of research that has received extensive attention from the scientifc community since the midtwentieth ***,it uses the laws of extremely small atomic nuclei to explain the evolution of the *** to the complexity of nucleosynthesis processes and our limited understanding of nuclear physics in astrophysical environments,several critical astrophysical problems remain *** achieve a better understanding of astrophysics,it is necessary to measure the cross sections of key nuclear reactions with the precision required by astrophysical *** measurement of nuclear reaction cross sections is an important method of investigating how nuclear reactions infuence stellar *** the challenges involved in measuring the extremely low crosssections of nuclear reactions in the Gamow peak and preparing radioactive targets,indirect methods,such as the transfer reaction,coulomb dissociation,and surrogate ratio methods,have been developed over the past several *** are powerful tools in the investigation of,for example,neutron-capture(n,r)reactions with short-lived radioactive ***,direct measurement is still preferable,such as in the case of reactions involving light and stable *** an essential part of stellar evolution,these low-energy stable nuclear reactions have been of particular interest in recent *** overcome the diffculties in measurements near or deeply within the Gamow window,the combination of an underground laboratory and high-exposure accelerator/detector complex is currently the optimal ***,underground experiments have emerged as a new and promising direction of *** addition,to better simulate the stellar environment in the laboratory,research on nuclear physics under laser-driven plasma conditions has gradually become a frontier *** recent years,the CIAE team conducted a series of distinctive nuclea

关键词： Nuclear astrophysics Indirect method Underground laboratory Direct measurement Lowenergy nuclear reaction

Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng Zhao Dong li Shao-lin Xiong yan-Qiu Zhang yang Su Wei Chen Yi Zhao xiao-Bo li Jia-Cong liu Wen-Xi Peng Rui Qiao Xin-Qiao li Xiang-yang Wen li-Ming Song Shi-Jie Zheng Xin-Ying Song xiao-yun Zhao yue Huang shuang-Nan Zhang shuo xiao Ce Cai Zheng-Hua An Can Chen Gang Chen Wei Chen yan-Qi Du Min Gao Ke Gong Dong-Ya Guo Zhi-Wei Guo Jian-Jian He bin li Chao li Chao-yang li Gang li Jian-Hui li Lu li Qing-Xin li yan-Guo li Jing liang xiao-Hua liang Jin-yuan liao xiao-Jing liu Ya-Qing liu Qi Luo Xiang Ma bin Meng ge Ou Dong-li Shi Jing-yan Shi Gong-Xing Sun Xi-Lei Sun You-li Tuo Chen-Wei wang Hui wang Jin wang Jin-Zhou wang Ping wang Wen-shuai wang hong Wu Sheng-Lun xie yan-bing Xu yu-Peng Xu wang-Chen Xue Sheng yang Min Yao Jian-Ying Ye Qi-bin Yi Chao-yue Zhang Da-li Zhang Fan Zhang Fei Zhang hong-Mei Zhang Kai Zhang Peng Zhang xiao-Lu Zhang Zhen Zhang Guo-Ying Zhao Shi-Yi Zhao Chao Zheng Xing Zhou yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(geCAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1651-1664页

作者： Xiong xie Qiaoshuai Lan Jinyi Zhao Sulin Zhang Lu liu yumin Zhang Wei Xu Maolin Shao Jingjing Peng shuai Xia yan Zhu Keke Zhang Xianglei Zhang Ruxue Zhang jian li Wenhao Dai Zhen ge shulei Hu Changyue yu Jiang wang Dakota Ma Mingyue Zheng Haitao yang gengfu xiao Zihe Rao Lu Lu Leike Zhang Fang Bai Yao Zhao Shibo Jiang hong liu Drug Discovery and Design Center State Key Laboratory of Drug ResearchCAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghai 200032China Shanghai Institute for Advanced Immunochemical Studies and School of life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China School of Chinese Materia Medica Nanjing University of Chinese Medicine138 Xian Lin RoadJiangsu 210023 NanjingChina School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China National Clinical Research Center for Infectious Disease Shenzhen Third People's HospitalShenzhen 518112China

Respiratory disease caused by coronavirus infection remains a global health *** several SARS-CoV-2-specific vaccines and direct-acting antivirals are available,their effcacy on emerging coronaviruses in the future,including SARS-CoV-2 variants,might be ***-targeting antivirals provide preventive and therapeutic strategies to overcome resistance and manage future outbreak of emerging *** L(CTSL)and calpain-1(CAPN1)are host cysteine proteases which play crucial roles in coronaviral entrance into cells and infection-related immune ***,two peptidomimetic a-ketoamide compounds,14a and 14b,were identified as potent dual target inhibitors against CTSL and *** X-ray crystal structures of human CTSL and CAPN1 in complex with 14a and 14b revealed the covalent binding of a-ketoamide groups of 14a and 14b to C25 of CTSL and C115 of *** showed potent and broad-spectrum anticoronaviral activities in vitro,and it is worth noting that they exhibited low nanomolar potency against SARS-CoV-2 and its variants of concern(VOCs)with ECso values ranging from 0.80 to 161.7 nM in various *** mechanistic exploration indicated that they exhibited anticoronaviral activity through blocking viral ***,14a and 14b exhibited good oral pharmacokinetic properties in mice,rats and dogs,and favorable safety in *** addition,both 14a and 14b treatments demonstrated potent antiviral potency against SARS-CoV-2 XBB 1.16 variant infection in a K18-hACE2 transgenic mouse *** 14b also showed effective antiviral activity against HCoV-OC43 infection in a mouse model with a final survival rate of 60%.Further evaluation showed that 14a and 14b exhibited excellent antiinflammatory effects in Raw 264.7 mouse macrophages and in mice with acute *** together,these results suggested that 14a and 14b are promising drug candidates,providing novel insight into developing pan-coronavirus inhibitors with anti

关键词： calpain overcome entrance

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin liu yue Huang Guang-Cheng xiao Qing-Cui Bu Jin-Lu Qu shu Zhang shuang-Nan Zhang shu-Mei Jia Fang-Jun Lu Xiang Ma lian Tao Wei Zhang li Chen li-Ming Song Ti-Pei li yu-Peng Xu Xue-Lei Cao Yong Chen Cong-Zhan liu Ce Cai Zhi Chang Gang Chen Tian-Xiang Chen Yi-Bao Chen yu-Peng Chen Wei Cui Wei-Wei Cui Jing-Kang Deng Yong-Wei Dong yuan-yuan Du Min-Xue Fu Guan-Hua Gao He Gao Min Gao Ming-yu ge yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-Wei Han Jia Huo Lu-Hua Jiang Wei-Chun Jiang Jing Jin Yong-Jie Jin ling-Da Kong bing li Cheng-Kui li Gang li Mao-shun li Wei li Xian li xiao-Bo li Xu-Fang li yang-Guo li Zheng-Wei li xiao-Hua liang Jing-yuan liao Bai-Sheng liu Guo-Qing liu hong-Wei liu xiao-Jing liu Yi-Nong liu Bo Lu Xue-Feng Lu Qi Luo Tao Luo bin Meng Yi Nang Jian-Yin Nie ge Ou Na Sai Ren-Cheng Shang Xin-Ying Song liang Sun Ying Tan You-li Tuo Chen wang Guo-Feng wang Juan wang ling-Jun wang Weng-shuai wang yu-Sa wang Xiang-yang Wen Bai-yang Wu Bo-bing Wu Mei Wu shuo xiao Shao-lin Xiong He Xu Jia-Wei yang Sheng yang yan-Ji yang Yi-Jung yang Qi-bin Yi Qian-Qing Yin yuan You Ai-Mei Zhang Cheng-Mo Zhang Fan Zhang hong-Mei Zhang Juan Zhang Tong Zhang Wan-Chang Zhang Wen-Zhao Zhang Yi Zhang Yi-Fei Zhang Yong-Jie Zhang yuan-Hang Zhang yue Zhang Zhao Zhang Zhi Zhang Zi-liang Zhang Hai-Sheng Zhao xiao-Fan Zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou Jian-Feng Zhou yu-Xuan Zhu Ren-lin Zhuang yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

Expert consensus on clinical standardized application of high-flow nasal cannula oxygen therapy in adults

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Chinese Medical Journal 2020年第11期133卷 1322-1324页

作者： Jian-Qiao Xu Long-Xiang Su Peng yan Xing-shuo Hu Ruo-Xuan Wen Kun xiao hong-Jun Gu Jin-gen Xia bing Sun Qing-Tao Zhou yu-Chao Dong Jia-lin liu Pin-Hua Pan hong Luo Qi li li-Qiang Song Si-Cheng Xu yan-Ming li Dao-Xin wang Dan li Qing-yuan Zhan li-Xin xie 无 Departm ent of Pulmonary&Critical Care Medicine Chinese People Liberation Army(PLA)General HospitalBeijing 100853China Department of Critical Care Medicine Peking Union Medical College HospitalBeijing 100005China Department of Pulmonary&Critical Care Medicine China and Japan Friendship HospitalBeijing 100029China Department of Pulmonary&Critical Care Medicine Beijing Chaoyang Hospital affiliated to Capital Medical UniversityBeijing 100020China Department of Pulmonary&Critical Care Medicine Peking University Third HospitalBeijing 100191China Department of Respiratory Medicine Changhai HospitalShanghai 200433China Department of Respiratory Medicine Ruijin Hospital Affiliated to the Shanghai Jiao Tong University Medical SchoolShanghai 200025China Department of Respiratory Medicine XiangYa HospitalCentral South UniversityChangshaHunan 410008China Department of Pulmonary&Critical Care Medicine XiangYa Second Hospital of Central South UniversityChangshaHunan 410011China Department of Pulmonary&Critical Care Medicine Xinqiao Hospital of the Third Military Medical UniversityChongqing 400037China Department of Pulmonary&Critical Care Medicine Xijing Hospital of Fourth Military Medical UniversityXi'anShaanxi 710032China Department of Respiratory Medicine The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830000China Department of Pulmonary&Critical Care Medicine Beijing HospitalBeijing 100730China Department of Respiratory Medicine The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Respiratory Medicine The First Bethune Hospital of Jilin UniversityChangchunJilin 130021China Pulmonary&Critical Care Medicine Group of Chinese Thoracic Society/Pulmonary&Critical Care Medicine Committee of Chinese Association of Chest Physician

High-flow nasal cannula oxygen therapy(HFNC)is a novel respiratory support technology and has been extensively applied in clinics in recent *** therapeutic equipment mainly includes an air-oxygen blender,an active humidifier,a high-flow nasal cannula,and a connecting inspiratory *** provides patients a humidified high-flow gas(8-80 L/min)with relatively stable oxygen concentration(21-100%),temperature(31-37℃)and performs oxygen therapy via a nasal cannula,which is very comfortable.

关键词： flow connecting high

Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients

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Chinese Medical Journal 2013年第12期126卷 2276-2280页

作者： ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING xiao-qiang yu Xue-qing liN hong-li liu Jian xie Ru-juan wang li-ning NI Zhao-hui liu Fu-you YIN Ai-ping XING Chang-ying wang li SHI Wei liu Jian-she HE Ya-ni DING Guo-hua li Wen-ge WU Guang-li MIAO li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI yun-kai LUO Hui-min liN Shan CHEN Meng-hua GONG li yanG Yi-bin yanG xiao-ping li Ying WAN Jian-xin wang Nian-song li Hai-ying XI Chun-sheng HAO li XU yan FANG Jing-ai liu Bi-cheng li Rong-shan wang Rong ZHANG Jing-hong wang Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng liu Zhi-hong yuAN Wei-jie SUN Shi-ren ZHANG ling ZHOU Chun-hua CHEN Qin-kai JIA shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian Zhong liang-bao Department of Nephrology State key Laboratory of Kidney Disease Chinese PLA General Hospital Beijing 100853 China Nephrology Institute of the Chinese People's liberation Army Chinese People's Liberation Army Key Laboratory of Nephrology Beijing 100853 China Department of Nephrology West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Nephrology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China Department of Nephrology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Nephrology First Affiiated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of Nephrology First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Nephrology First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Nephrology First Afftiated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Nephrology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China Department of Nephrology Second Xiangya Hospital Central South University Changsha Hunan 410000 China Department of Nephrology First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Nephrology First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) Nanjing Jiangsu 210029 China Department of Nephrology Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China Department of Nephrology Guangdong Provincial People's Hospital Guangzhou Guangdong 510030 China Department of Nephrology Affliated Xiehe Hospital Tongji Medical College Huazhong Science and Technology University Wuhan Hubei 430022 China Department of Nephrology Daping Hospital Third Military Medi

Background Data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease （CKD） patients are *** aim of the present study was to investigate the prevalence,awareness,treatment,and control of hypertension in the non-dialysis CKD patients through a nationwide,multicenter study in *** The survey was performed in 61 tertiary hospitals in 31 provinces,municipalities,and autonomous regions in China （except hong Kong,Macao,and Taiwan）.Trained physicians collected demographic and clinical data and measured blood pressure （BP） using a standardized *** was defned as systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg,and/or use of antihypertensive *** 〈140/90 mmHg and 〈130/80 mmHg were used as the 2 thresholds of hypertension *** multivariate logistic regression with adjustment for sex and age,we analyzed the association between CKD stages and uncontrolled hypertension in non-dialysis CKD *** The analysis included 8927 non-dialysis CKD *** prevalence,awareness,and treatment of hypertension in non-dialysis CKD patients were 67.3%,85.8%,and 81.0%,*** hypertensive CKD patients,33.1% and 14.1% had controlled BP to 〈140/90 mmHg and 〈130/80 mmHg,*** successive CKD stages,the prevalence of hypertension in non-dialysis CKD patients increased,but the control of hypertension decreased （P〈0.001）.When the threshold of BP 〈130/80 mmHg was considered,the risk of uncontrolled hypertension in CKD 2,3a,3b,4,and 5 stages increased 1.3,1.4,1.4,2.5,and 4.0 times compared with CKD 1 stage,respectively （P〈0.05）.Using the threshold of 〈140/90 mmHg,the risk of uncontrolled hypertension increased in advanced stages （P〈0.05）.Conclusions The prevalence of hypertension Chinese non-dialysis CKD patients was high,and the hypertension control was *** successive CKD stages,the risk of uncontrolled hypertension increased.

关键词： non-dialysis chronic kidney disease chronic kidney disease stages hypertension epidemiology

Dark matter direct search sensitivity of the PandaX-4T experiment

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Science China(Physics,Mechanics & Astronomy) 2019年第3期62卷 49-57页

作者： hongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen yunHua Chen XiangYi Cui binbin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani linHui Gu Xuyuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji Yonglin Ju Shaoli li Yao li Heng lin HuaXuan liu JiangLai liu yuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing wang Cheng wang hongWei wang Meng wang Qiuhong wang SiGuang wang Xiuli wang XuMing wang Zhou wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao xiao PengWei xie binbin yan JiJun yang Yong yang ChunXu yu JuMin yuan JianFeng yue Dan Zhang Tao Zhang li Zhao Qibin Zheng JiFang Zhou Ning Zhou xiaoPeng Zhou Shanghai Key Laboratory for Particle Physics and Cosmology Institute of Nuclear and Particle Physics (INPC) (INPC) and School of Physics and AstronomyShanghai Jiao Tong University School of Physics and Technology Xinjiang University Shanghai Key Laboratory for Particle Physics and Cosmology Institute of Nuclear and Particle Physics (INPC) and School of Physics and AstronomyShanghai Jiao Tong University Yalong River Hydropower Development Company Ltd. Shanghai Institute of Applied Physics Chinese Academy of Sciences School of Mechanical Engineering Shanghai Jiao Tong University School of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE)(MOE) Shandong University School of Physics Nankai University Tsung-Dao Lee Institute School of Physics Peking University Department of Physics University of Maryland College Park School of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong University Center of High Energy Physics Peking University School of Medical Instrument and Food Engineering University of Shanghai for Science and Technology

The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 ge V/c^2.

关键词： dark matter WIMPs direct detection xenon

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20年前后正常人肺组织51种元素含量比较

光谱学与光谱分析 2008年第5期28卷 1153-1156页

作者：曾静欧阳荔王小燕刘雅琼解清诸洪达武权樊体强王京宇北京大学公共卫生学院北京100083 北京大学医药卫生分析中心生命元素组学实验室北京100083 中国医学科学院中国协和医科大学放射医学研究所天津300192

采用电感耦合等离子体质谱仪(ICP-MS)、发射光谱仪(ICP-AES)及石墨炉原子吸收光谱(GFAAS)对采自1982-83年及2004-05年的正常男性肺样品中的51种元素含量进行了测定及比较。样品经微波消解及敞开式酸法消解。结果显示,2004-05年样品相比... 详细信息

采用电感耦合等离子体质谱仪(ICP-MS)、发射光谱仪(ICP-AES)及石墨炉原子吸收光谱(GFAAS)对采自1982-83年及2004-05年的正常男性肺样品中的51种元素含量进行了测定及比较。样品经微波消解及敞开式酸法消解。结果显示,2004-05年样品相比于1982-83年样品,Na,Mg,P,K,As,Mo,Ag,Ba,Bi及除Sc外的所有被测稀土共23种元素的含量显著降低,Zn,Ga,ge,Se,Au和Zr六种元素含量显著增加。这种变化可能与20年前后外界环境的改变及生活、饮食习惯等的改变有关,如20年前肺中稀土的高含量可能由于当时大量的稀土农用引起,而20年后某些微量有益元素(Zn和Se)明显上升与近年来健康意识提高有关,此外近年样品Pb,Cd,Cr和Ni等重金属元素含量的增加则有可能与空气质量恶化等因素有关。一半以上被测元素含量发生显著改变,故基于元素含量的正常值范围有必要在不同时期做出相应的调整。

关键词：正常人肺组织元素含量比较