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Multichannel microneedle dry electrode patches for minimally invasive transdermal recording of electrophysiological signals

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Microsystems & Nanoengineering 2024年第3期10卷 119-136页

作者： Zhengjie liu xingyuan Xu shuang Huang xinshuo Huang Zhibo liu Chuanjie Yao Mengyi He Jiayi Chen Hui-jiuan Chen Jing liu xi xie State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologyGuangdong Province Key Laboratory of Display Material and TechnologySun Yat-Sen UniversityGuangzhouChina School of Biomedical Engineering Sun Yat-Sen UniversityGuangzhouChina The First Affiliated Hospital of Sun Yat-Sen University GuangzhouChina

The collection of multiple-channel electrophysiological signals enables a comprehensive understanding of the spatial distribution and temporal features of electrophysiological *** approach can help to distinguish the traits and patterns of different ailments to enhance diagnostic *** array electrodes,which can penetrate skin without pain,can lessen the impedance between the electrodes and skin;however,current microneedle methods are limited to single channels and cannot achieve multichannel collection in small ***,a multichannel(32 channels)microneedle dry electrode patch device was developed via a dimensionality reduction fabrication and integration approach and supported by a self-developed circuit system to record weak electrophysiological signals,including electroencephalography(EEG),electrocardiogram(ECG),and electromyography(EMG)*** microneedles reduced the electrode–skin contact impedance by penetrating the nonconducting stratum corneum in a painless *** multichannel microneedle array(MMA)enabled painless transdermal recording of multichannel electrophysiological signals from the subcutaneous space,with high temporal and spatial resolution,reaching the level of a single microneedle in terms of signal *** MMA demonstrated the detection of the spatial distribution of ECG,EMG and EEG signals in live rabbit models,and the microneedle electrode(MNE)achieved better signal quality in the transcutaneous detection of EEG signals than did the conventional flat dry electrode *** work offers a promising opportunity to develop advanced tools for neural interface technology and electrophysiological recording.

关键词： needle rabbit electrode

Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species

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Bio-Design and Manufacturing 2024年第1期7卷 14-30页

作者： xinshuo Huang Baoming Liang Shantao Zheng Feifei Wu Mengyi He shuang Huang Jingbo Yang Qiangqiang Ouyang Fanmao liu Jing liu Hui-jiuan Chen xi xie State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologyGuangdong Province Key Laboratory of Display Material and TechnologySun Yat-Sen UniversityGuangzhou 510006China School of Biomedical Engineering Sun Yat-Sen UniversityShenzhen 518107China Pazhou Lab Guangzhou 510330China The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510006China

Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in *** glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation,and the presence of reactive oxygen species(ROS)due to inflammationmay affect glucose *** technology is less invasive,yet microneedle adhesion with skin tissue is *** this work,we developed a microarrow sensor array(MASA),which provided enhanced skin surface adhesion and enabled simultaneous detection of glucose and H_(2)O_(2)(representative of ROS)in interstitial fluid in *** microarrows fabricated via laser micromachining were modified with functional coating and integrated into a patch of a three-dimensional(3D)microneedle *** to the arrow tip mechanically interlocking with the tissue,the microarrow array could better adhere to the skin surface after penetration into *** MASA was demonstrated to provide continuous in vivo monitoring of glucose and H_(2)O_(2) concentrations,with the detection of H_(2)O_(2) providing a valuable reference for assessing the inflammation ***,the MASA was integrated into a monitoring system using custom *** work provides a promising tool for the stable and reliable monitoring of blood glucose in diabetic patients.

关键词： Microarrow sensor array Glucose sensing Reactive oxygen species sensing Integrated system Continuous monitoring

Ultra-low frequency magnetic energy focusing for highly effective wireless powering of deep-tissue implantable electronic devices

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National Science Review 2024年第05期11卷 272-290页

作者： Yuanyuan Li Zhipeng Chen Yuxin liu Zijian liu Tong Wu Yuanxi Zhang Lelun Peng xinshuo Huang shuang Huang Xudong Lin xi xie Lelun Jiang Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-Sen University School of Mechanical and Electrical Engineering Guangzhou University State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information Technology Sun Yat-Sen University

The limited lifespan of batteries is a challenge in the application of implantable electronic devices. Existing wireless power technologies such as ultrasound, near-infrared light and magnetic fields cannot charge devices implanted in deep tissues, resulting in energy attenuation through tissues and thermal ***, an ultra-low frequency magnetic energy focusing(ULFMEF) methodology was developed for the highly effective wireless powering of deep-tissue implantable devices. A portable transmitter was used to output the low-frequency magnetic field(xisting wireless powering technologies. The ULFMEF is demonstrated to wirelessly power implantable micro-LED devices for optogenetic neuromodulation, and wirelessly charged an implantable battery for programmable electrical stimulation on the sciatic nerve. It also bypassed thick and tough protective shells to power the implanted devices. The ULFMEF thus offers a highly advanced methodology for the generation of wireless powered biodevices.

关键词： ultra-low frequency transcutaneous energy transmission electromagnetic generator implantable electronic device deep tissue

Semi-implantable device based on multiplexed microfilament electrode cluster for continuous monitoring of physiological ions

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Bio-Design and Manufacturing 2024年第1期7卷 88-103页

作者： shuang Huang Shantao Zheng Mengyi He Chuanjie Yao xinshuo Huang Zhengjie liu Qiangqiang Ouyang Jing liu Feifei Wu Hang Gao xi xie Hui-jiuan Chen State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringSun Yat-Sen UniversityShenzhen 518107China The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510080China Pazhou Lab Guangzhou 510335China Institute of Microelectronics of the Chinese Academy of Sciences Beijing 100029China

Modern medicine is increasingly interested in advanced sensors to detect and analyze biochemical *** sensors based on potentiometric methods are a promising platform for monitoring physiological ions in biological *** semi-implantable devices are mainly based on single-parameter *** semi-implantable electrodes for multiparameter sensing have more restrictions on the electrode size due to biocompatibility considerations,but reducing the electrode surface area could potentially limit electrode *** study developed a semi-implantable device system comprising a multiplexed microfilament electrode cluster(MMEC)and a printed circuit board for real-time monitoring of intra-tissue K^(+),Ca^(2+),and Na^(+)*** electrode surface area was less important for the potentiometric sensing mechanism,suggesting the feasibility of using a tiny fiber-like electrode for potentiometric *** MMEC device exhibited a broad linear response(K^(+):2–32 mmol/L;Ca^(2+):0.5–4 mmol/L;Na^(+):10–160 mmol/L),high sensitivity(about 20–45 mV/decade),temporal stability(>2weeks),and good selectivity(>80%)for the above *** vitro detection and in vivo subcutaneous and brain experiment results showed that the MMEC system exhibits good multi-ion monitoring performance in several complex *** work provides a platform for the continuous real-time monitoring of ion fluctuations in different situations and has implications for developing smart sensors to monitor human health.

关键词： Multiplexed microfilament electrode cluster Physiological ion sensing Subcutaneous and brain experiment Wearable platform for multi-ion detection Continuous real-time monitoring system

A flame-retardant binder with high polysulfide affinity for safe and stable lithium–sulfur batteries

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Science China Chemistry 2024年第3期67卷 1028-1036页

作者： Guowei Yu Guofeng Ye Cheng Wang Chenyang Wang Zhaoyun Wang Pu Hu Yu Li xi-xi Feng shuang-Jie Tan Min Yan Sen xin Zhitian liu Hubei Key Laboratory of Plasma Chemistry and Advanced Materials Hubei Engineering Technology Research Center of Optoelectronic and New Energy MaterialsSchool of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Lithium-sulfur(Li-S) batteries have shown promises for the next-generation, high-energy electrochemical storage, yet are hindered by rapid performance decay due to the polysulfide shuttle in the cathode and safety concerns about potential thermal runaway. To address the above challenges, herein, we show a flame-retardant cathode binder that simultaneously improves the electrochemical stability and safety of batteries. The combination of soft and hard segments in the polymer framework of binders allows high flexibility and mechanical strength for adapting to the drastic volume change during the Li(de)intercalation of the S cathode. The binder contains a large number of polar groups, which show the high affinity to polysulfides so that they help to anchor active S species at the cathode. These polar groups also help to regulate and facilitate the Li-ion transport, promoting the kinetics of polysulfide conversion reaction. The binder contains abundant phosphine oxide groups, which, in the case of battery's thermal runaway, decompose and release PO· radicals to quench the combustion reactions and stop the fire. Consequently, Li-S batteries using the new cathode binder show the improved electrochemical performance, including a low-capacity decay of 0.046% per cycle for 800 cycles at 1 C and favorable rate capabilities of up to 3 C. This work offers new insights on the practical realization of high-energy rechargeable batteries with stable storage electrochemistry and high safety.

关键词： lithium–sulfur battery polymer binder polysulfide affinity flame retardancy

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关于降低ST型缓冲器阻抗力的研究

北京交通大学学报 2006年第1期30卷 87-90页

作者：刘喜双谢基龙北京交通大学机械与电子控制工程学院北京100044

通过构建ST型缓冲器力学结构模型,在对ST型缓冲器进行理论分析的基础上,提出了从缓冲器结构到工艺的综合改进建议,并得到了试验验证,解决了ST型缓冲器阻抗力超限问题.

关键词：缓冲器阻抗力摩擦

浸种催芽模式对水培花生芽胚根发育及标准化生产的影响

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湖北农业科学 2024年第10期63卷 64-67,73页

作者：夏全杰赵滢梅博杰陈镇刘双喜高长清彭裕超汪新胜刘华曙孝感市农业科学院湖北孝感432000

为了探索水培花生芽最适宜胚根发育的浸种催芽条件,设置不同梯度的温度、浸种时间和催芽时间组合,对花生种子进行培养,统计胚根发育情况。结果表明,当温度设置在25~27℃,浸种时间为3~4 h,催芽32~36 h时,花生芽胚根发育较好,最适宜花生... 详细信息

为了探索水培花生芽最适宜胚根发育的浸种催芽条件,设置不同梯度的温度、浸种时间和催芽时间组合,对花生种子进行培养,统计胚根发育情况。结果表明,当温度设置在25~27℃,浸种时间为3~4 h,催芽32~36 h时,花生芽胚根发育较好,最适宜花生芽上穴盘生长,收获的花生芽商品率最高。

关键词：浸种催芽水培花生芽标准化生产胚根发育影响

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Impacts of multi-foulings on salinity gradient energy conversion process in negatively charged conical nanochannels

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Science China(Technological Sciences) 2024年第6期67卷 1714-1726页

作者： MAO RuiJie CHEN xi ZHOU RuHong LONG Rui liu ZhiChun liu Wei School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan430074China China-EU Institute for Clean and Renewable Energy Huazhong University of Science and TechnologyWuhan430074China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan430074China

Membrane fouling inevitably occurs during nanofluidic reverse ***,the impact of multi-fouling on the energy conversion performance of negatively charged conical nanochannels under asymmetrical configurations is systematically *** results reveal that in Configuration I,where a high-concentration solution is applied at the tip side,at small concentration ratios,multiple foulings reduce the electric *** Configuration II,where a low-concentration solution is applied at the tip side,multiple foulings near the base side contribute to the electric *** fouling that formed near the lowconcentration entrance diminished the electric power and energy conversion ***-fouling lowered the electrical power consumption by 69.27%and 99.94%in Configurations I and II,*** Configuration I,the electric power first increased with increasing fouling surface charge density,reached its maximum value,and thereafter *** Configuration II,the electric power first decreased with increasing fouling surface charge density,reached its minimum value,and thereafter *** negative or positive charge densities of fouling contribute to the electric power and energy conversion efficiency.

关键词： conical nanochannel fouling nanofluidic reverse electrodialysis salinity gradient energy

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基于DSP的永磁同步电机控制系统研究

煤炭技术 2013年第11期32卷 68-70页

作者：刘喜双黑龙江科技大学电气与信息工程学院哈尔滨150027 黑龙江财经学院计算机与信息工程系哈尔滨150025

分析了永磁同步电动机转子磁链定向矢量控制原理,采用电压空间矢量脉冲宽度调制(SVPWM)技术,设计了以DSP为核心的交流永磁同步电机控制系统。对该控制系统的硬件电路和软件进行了分析与设计。实验结果表明,该系统能够实现对永磁同步电... 详细信息

分析了永磁同步电动机转子磁链定向矢量控制原理,采用电压空间矢量脉冲宽度调制(SVPWM)技术,设计了以DSP为核心的交流永磁同步电机控制系统。对该控制系统的硬件电路和软件进行了分析与设计。实验结果表明,该系统能够实现对永磁同步电动机电流和电压的双闭环控制,具有实际应用价值。

关键词：永磁同步电动机矢量控制 DSP 空间矢量脉冲宽度调制(SVPWM)