检索结果-南通市图书馆

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第2期25卷 161-182页

作者： shen liu Xieping HUANG Xiangzhen KONG Qin FANG Center for Hypergravity Experiment and Interdisciplinary Research Zhejiang UniversityHangzhou310058China Institute of Geotechnical Engineering Zhejiang UniversityHangzhou310058China State Key Laboratory of Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of PLANanjing210007China

This paper presents a numerical study to improve the understanding of the complex subject of penetration and perforation of concrete targets impacted by low-velocity projectiles.The main focus is on the damage mechanisms and the major factors that account for the target resistance of the concrete.An improved continuous surface cap model recently proposed was employed.The model was first equipped with element erosion criteria and was adequately validated by comparisons with ballistic experiments.Comprehensive numerical simulations were carried out where the individual influence of tensile,shear,and volumetric behaviors(pore collapse)of a concrete target on its ballistic performance was investigated.Results demonstrated that cratering on the front face and scabbing on the rear face of the concrete target were mainly dominated by its tensile behavior.The major target resistance came from the second tunneling stage which was primarily governed by the shear and volumetric behaviors of the concrete.Particularly,this study captured the pore collapse-induced damage phenomenon during the high-pressure tunneling stage,which has been extensively reported in experiments but has usually been neglected in previous numerical investigations.

关键词： Penetration Perforation Damage mechanism Target resistance Projectile impact Pore collapse

Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第9期16卷 478-499页

作者： Yao Xiao Zaijin Tao Yufeng Ju Xiaolu Huang Xinshu Zhang Xiaonan liu Pavel A.Volotovski Chao Huang Hongqi Chen Yaozhong Zhang shen liu Department of Orthopaedics Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Tongji Hospital 389 Xincun RdShanghai 200065People’s Republic of China Key Laboratory for Thin Film and Microfabrication of Ministry of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Orthopedic Trauma Department Belarus Republic Scientific and Practical Center for Traumatology and OrthopedicsKizhevatova str.60/4220024 MinskBelarus Shanghai Haohai Biological Technology Limited Liability Company 1386 Hongqiao RdShanghai 200336People’s Republic of China Department of General Surgery Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Key Laboratory for High Temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Post-traumatic peritendinous adhesion presents a significant challenge in clinical medicine.This study proposes the use of diamond-like carbon(DLC)deposited on polylactic acid(PLA)membranes as a biophysical mechanism for anti-adhesion barrier to encase ruptured tendons in tendon-injured rats.The results indicate that PLA/DLC composite membrane exhibits more efficient anti-adhesion effect than PLA membrane,with histological score decreasing from 3.12±0.27 to 2.20±0.22 and anti-adhesion effectiveness increasing from 21.61%to 44.72%.Mechanistically,the abundant C=O bond functional groups on the surface of DLC can reduce reactive oxygen species level effectively;thus,the phosphorylation of NF-κB and M1 polarization of macrophages are inhibited.Consequently,excessive inflammatory response augmented by M1 macrophage-originated cytokines including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α)is largely reduced.For biocompatibility evaluation,PLA/DLC membrane is slowly absorbed within tissue and displays prolonged barrier effects compared to traditional PLA membranes.Further studies show the DLC depositing decelerates the release of degradation product lactic acid and its induction of macrophage M2 polarization by interfering esterase and PLA ester bonds,which further delays the fibrosis process.It was found that the PLA/DLC membrane possess an efficient biophysical mechanism for treatment of peritendinous adhesion.

关键词： Diamond-like carbon Reactive oxygen species scavenging Foreign body reaction Biodegradation Antioxidant Peritendinous adhesion

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting liu Shiqi Huang Xiangliang Chen shen liu Junshan Zhou Hongdong Zhao Ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion injury.Low-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s disease.However,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic stroke.To address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke models.First,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting analysis.We observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/reoxygenation.Second,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated virus.Low-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective phenotype.Finally,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte phenotype.These findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

量子认知的研究回溯、核心应用领域与未来展望

在线全文

学校读者我要写书评

暂无评论

自然辩证法通讯 2024年第4期46卷 41-48页

作者：刘燊安徽农业大学人文社会科学学院心理学系安徽合肥230036

量子认知是当代认知科学哲学体系中的一个新型的边缘分支学科,借助量子力学理论的数学方法对认知科学哲学领域中的现象构建模型,从而研究与描述人类认知,最为核心的应用领域是决策行为。近年来,一种基于量子理论的量子决策模型为解决传... 详细信息

量子认知是当代认知科学哲学体系中的一个新型的边缘分支学科,借助量子力学理论的数学方法对认知科学哲学领域中的现象构建模型,从而研究与描述人类认知,最为核心的应用领域是决策行为。近年来,一种基于量子理论的量子决策模型为解决传统决策模型难以解决的问题提供了新的思路。该模型打破了传统决策模型中经典概率理论的禁锢,为决策理论的发展指明了新的方向。然而,相较于其他较为成熟的认知科学哲学分支,量子认知的研究仍处于起步和发展阶段,还需要深入开展量子认知的基础理论研究、积极探索量子认知的神经生理基础、构建类量子贝叶斯网络以优化决策、发展量子博弈以拓宽量子认知疆域等。

关键词：量子认知量子决策类量子贝叶斯网络量子心灵量子博弈

Meta-heuristic optimization inspired by proton-electron swarm

在线全文

学校读者我要写书评

暂无评论

The Journal of China Universities of Posts and Telecommunications 2020年第3期27卷 42-52,72页

作者： liu Yongli liu shen School of Computer Science and Technology Henan Polytechnic UniversityJiaozuo 454000China

While solving unimodal function problems,conventional meta-heuristic algorithms often suffer from low accuracy and slow convergence.Therefore,in this paper,a novel meta-heuristic optimization algorithm,named proton-electron swarm(PES),is proposed based on physical rules.This algorithm simulates the physical phenomena of like-charges repelling each other while opposite charges attracting in protons and electrons,and establishes a mathematical model to realize the optimization process.By balancing the global exploration and local exploitation ability,this algorithm achieves high accuracy and avoids falling into local optimum when solving target problem.In order to evaluate the effectiveness of this algorithm,23 classical benchmark functions were selected for comparative experiments.Experimental results show that,compared with the contrast algorithms,the proposed algorithm cannot only obtain higher accuracy and convergence speed in solving unimodal function problems,but also maintain strong optimization ability in solving multimodal function problems.

关键词： meta-heuristic proton electron swarm

在线全文

学校读者我要写书评

暂无评论

基于空化时空分布特征的调节阀空蚀风险预测

华中科技大学学报(自然科学版) 2024年第6期52卷 71-79页

作者：张雨佳刘秀梅李贝贝刘申中国矿业大学机电工程学院

针对煤液化工程中的关键设备高压差调节阀耐空蚀能力差、使用寿命短的问题，利用高速相机拍摄获取调节阀空化流场图像，提出空隙率λ表征气相体积分数、空隙率变化速率β表征空蚀风险指标，实现了调节阀空蚀破坏的准确预测．结果表明：... 详细信息

针对煤液化工程中的关键设备高压差调节阀耐空蚀能力差、使用寿命短的问题，利用高速相机拍摄获取调节阀空化流场图像，提出空隙率λ表征气相体积分数、空隙率变化速率β表征空蚀风险指标，实现了调节阀空蚀破坏的准确预测．结果表明：空隙率数值与气相体积分数正相关；随着入口压力的增大，阀芯头部和喉部对应空隙率数值增大，空化得到充分发展向扩张段延伸并溃灭，调节阀内空化呈初生、发展、脱落和溃灭的周期性变化趋势．当空隙率变化速率β<0时，表示空泡处于溃灭状态，据此可以判断该处存在空蚀风险；随着入口压力的增加，附着型空泡溃灭位置较为固定在调节阀头部，是阀芯发生空蚀破坏的主要原因．游离型空化损伤区域随着入口压力增加逐渐向调节阀下游延伸，调节阀流道上方和下方空化损伤区域为非对称结构，下方的空化损伤区域整体超前于上方．

关键词：空化调节阀空隙率空蚀破坏风险预测

Improved HHO algorithm based on good point set and nonlinear convergence formula

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The Journal of China Universities of Posts and Telecommunications 2021年第2期28卷 48-67页

作者： Guo Hairu Meng Xueyao liu Yongli liu shen School of Computer Science and Technology Henan Polytechnic UniversityJiaozuo 454000China

Harris hawks optimization(HHO)algorithm is an efficient method of solving function optimization problems.However,it is still confronted with some limitations in terms of low precision,low convergence speed and stagnation to local optimum.To this end,an improved HHO(IHHO)algorithm based on good point set and nonlinear convergence formula is proposed.First,a good point set is used to initialize the positions of the population uniformly and randomly in the whole search area.Second,a nonlinear exponential convergence formula is designed to balance exploration stage and exploitation stage of IHHO algorithm,aiming to find all the areas containing the solutions more comprehensively and accurately.The proposed IHHO algorithm tests 17 functions and uses Wilcoxon test to verify the effectiveness.The results indicate that IHHO algorithm not only has faster convergence speed than other comparative algorithms,but also improves the accuracy of solution effectively and enhances its robustness under low dimensional and high dimensional conditions.

关键词： HHO algorithm local optimum good point set nonlinear formula multi-dimension

右美托咪定对腹腔镜供肝获取术供者苏醒期恢复质量的影响

在线全文

学校读者我要写书评

暂无评论

四川大学学报（医学版） 2024年第3期55卷 693-698页

作者：崔凌利邹毅张梁刘珅薛富善首都医科大学附属北京友谊医院麻醉科北京100050

目的观察术中输注右美托咪定(dexmedetomidine, DEX)对行活体肝移植腹腔镜供肝获取术供者术后苏醒质量的影响。方法前瞻性纳入择期行活体肝移植腹腔镜供肝切取术供肝脏者56例,随机分为两组(n=28):DEX组和对照组。DEX组患者入室后静脉... 详细信息

目的观察术中输注右美托咪定(dexmedetomidine, DEX)对行活体肝移植腹腔镜供肝获取术供者术后苏醒质量的影响。方法前瞻性纳入择期行活体肝移植腹腔镜供肝切取术供肝脏者56例,随机分为两组(n=28):DEX组和对照组。DEX组患者入室后静脉泵注DEX 1μg/kg 15 min,随后以0.4μg/(kg·h)输注至供肝肝门静脉阻断后停止;对照组患者采用等容积0.9%生理盐水,输注速度和停药时间同DEX组。主要观察指标为苏醒期躁动(emergence agitation, EA)的发生率,苏醒期躁动依据AFPS(Aono's four-point scale)评分进行评估。次要观察指标包括术中麻醉和手术情况、术后自主呼吸恢复时间、苏醒时间、拔管时间、Ramsay镇静评分、寒战发生率、数字评分法(numeric rating scale, NRS)疼痛评分、拔管期血压以及心率等。结果 DEX组和对照组术后苏醒期躁动发生率分别为10.7%和39.3%,DEX组躁动发生率低于对照组(P=0.014)。DEX组供者APFS躁动评分[中位数(四分位间距)]较对照组更低[1(1,1)分vs. 2(1,3)分,P=0.005]。DEX组术中丙泊酚和瑞芬太尼的用量明显减少(P0.05)。结论 DEX能够降低活体肝移植供者苏醒期躁动发生率,改善苏醒期恢复质量,且不影响术后苏醒和拔管时间。

关键词：苏醒期躁动右美托咪定活体供者肝切除术随机对照试验

在线全文

学校读者我要写书评

暂无评论

肌腱病疼痛发生机制研究进展

中华创伤杂志 2024年第1期40卷 80-86页

作者：熊英宏刘申徐大启中南大学湘雅医院运动医学科湖南省器官损伤衰老与再生医学重点实验室国家老年疾病临床医学研究中心长沙410008

肌腱在运动系统中发挥重要作用,但这一结构损伤后会导致疼痛和功能下降,被称为肌腱病,其中疼痛是最早出现的症状,严重影响患者的生活和工作。尽管目前有多种方法用于治疗肌腱病疼痛,但治疗周期长且效果不佳,其主要原因在于肌腱病疼痛发... 详细信息

肌腱在运动系统中发挥重要作用,但这一结构损伤后会导致疼痛和功能下降,被称为肌腱病,其中疼痛是最早出现的症状,严重影响患者的生活和工作。尽管目前有多种方法用于治疗肌腱病疼痛,但治疗周期长且效果不佳,其主要原因在于肌腱病疼痛发生机制仍尚未完全明确。因此,明确肌腱病疼痛的发生机制,对寻找新的治疗策略有重要价值。为此,笔者从组织结构改变、疼痛介质、中枢调控等方面就肌腱病疼痛发生机制的研究进展进行综述,为肌腱病疼痛的机制研究和临床治疗提供参考。

关键词：肌腱病运动损伤疼痛中枢可塑性

在线全文

学校读者我要写书评

暂无评论

马铃薯蛋白组成、性质及其改性应用研究进展

食品工业科技 2024年第9期45卷 36-44页

作者：孙莹周斌王龙刘申朱秀清哈尔滨商业大学旅游烹饪学院黑龙江哈尔滨150028 哈尔滨商业大学食品工程学院黑龙江哈尔滨150028

我国马铃薯加工业的快速发展可以归因于马铃薯主食工业化战略的实施。马铃薯蛋白以其高营养价值和功能而闻名,具有特殊的溶解度,并含有大量在其他植物蛋白中缺乏的酪氨酸。因此,马铃薯蛋白在各种市场应用上具有巨大的潜力。本文对马铃... 详细信息

我国马铃薯加工业的快速发展可以归因于马铃薯主食工业化战略的实施。马铃薯蛋白以其高营养价值和功能而闻名,具有特殊的溶解度,并含有大量在其他植物蛋白中缺乏的酪氨酸。因此,马铃薯蛋白在各种市场应用上具有巨大的潜力。本文对马铃薯蛋白的组成、功能性质、改性方法和改性应用进行了全面的综述。马铃薯蛋白具有良好的溶解性、发泡化和乳化特性、凝胶性和抗氧化活性。目前,酶法和微生物发酵是马铃薯蛋白改性研究的重点。此外,本文还概述了马铃薯蛋白中普遍存在的主要问题,并根据目前的研究进展提出了未来的发展前景。未来,应深入研究马铃薯蛋白分子结构与其功能活性的联系;马铃薯蛋白与其他植物蛋白的综合利用;酶法和微生物发酵可作为未来改性方向,利用微生物资源降低改性成本。

关键词：马铃薯蛋白组成功能性质蛋白改性应用