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Dynamically lithium-compensated polymer artificial SEI to assist highly stable lithium-rich manganese-based anode-free lithium metal batteries

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Rare Metals 2024年第6期43卷 2527-2535页

作者： Ming-Ji Peng jin-Qiu Zhou Ting-Ting han yang Zhou Jie liu Na xu Zhen-Kang Wang Wen-bin lin Cheng-lin yan Key Laboratory of Core Technology of High Specific Energy Battery and Key Materials for Petroleum and Chemical Industry College of EnergySoochow UniversitySuzhou 215006China Light Industry Instituteof Electrochemical Power Sources Suzhou 215006China School of Chemistry and Chemical Engineering Nantong UniversityNantong 226019China e-mail:jliu93@*** State Key Laboratory of Space Power-Sources Technology Shanghai Institute of Space Power-SourcesShanghai 200245China Centre Energie Materiaux et TélécommunicationsInstitut National de la Recherche ScientifiqueVarennesQC J3X 1S2Canada Zhangjiagang Industrial Technologies Soochow UniversitySuzhou 215006China

Owing to the unique structure,anode-free lithium metal batteries(AFLMBs)have higher energy density and lower production cost than traditional lithium metal batteries(LMBs)or lithium-ion batteries(LIBs),However,AFLMBs suffer from an inherently finite Li reservoir and exhibit poor cycle stability,low Coulombic efficiency(CE)and severe dendrite *** this work,polydiallyl lithium disulfide(PDS-Li)was successfully synthesized and coated on Cu current collector by electrochemical *** PDS-Li acts as an additional lithium resource to compensate for the irreversible loss of lithium during *** addition,the special structure and lithiophilicity of PDS-Li contribute to lower nucleation overpotential and uniform lithium *** coupled with Li-rich manganese-based(LRM)cathode of Li1.2Mn0.54Ni0.13Co0.13O2,the anode-free full cell exhibits significantly improved cycle stability over 100 cycles and capacity retention of 63.3%and 57%after 80 and 100 cycles,*** believe that PDS-Li can be used to ensure stable cycling performance and high-energy-density in AFLMBs.

关键词： Anode-free Artificial solid electrolyte interphase(SEI) Lithium metal batteries Lithium-rich cathode Finite element simulation

Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC(CTONG1804):a multicenter open-label phase II study

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Signal Transduction and Targeted Therapy 2024年第1期9卷 249-258页

作者： Si-yang liu Song Dong xue-Ning yang Ri-Qiang Liao Ben-Yuan Jiang Qun Wang Xiao-Song Ben Gui-bin Qiao Jun-Tao lin Hong-Hong yan Li-xu yan Qiang Nie Hai-yan Tu bin-Chao Wang jin-Ji yang Qing Zhou Hong-rui Li Ke liu Wendy Wu Si-yang Maggie liu Wen-zhao Zhong yi-long Wu Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Thoracic Surgery Zhongshan HospitalFudan UniversityShanghaiChina Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Pathology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Fujian Key Laboratory of Advanced Technology for Cancer Screening and Early Diagnosis FuzhouChina Berry Oncology Corporation FuzhouChina Chinese Thoracic Oncology Group(CTONG) GuangzhouChina Department of Hematology The First Affiliated HospitalJinan UniversityGuangzhouChina

This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive(N)and nivolumab–chemotherapy(N/C)combinations based on PD-L1 *** patients exhibited resectable clinical stage IIA–IIIB(AJCC 8th edition)NSCLC without EGFR/ALK *** received either mono-nivolumab(N)or nivolumab+nabpaclitaxel+carboplatin(N/C)for three cycles based on PD-L1 *** primary endpoint was the major pathological response(MPR).Key secondary endpoints included the pathologic complete response(pCR),objective response rate(ORR),and event-free survival(EFS).Baseline PD-L1 expression and perioperative circulating tumor DNA(ctDNA)status were correlated with pCR and ***-two patients were enrolled,with 46 undergoing *** MPR was 50.0%(26/52),with 25.0%(13/52)achieving pCR,and 16.7%and 66.7%for patients with PD-L1≥50%in N and N/C groups,***(25.0%)patients experienced grade 3 or higher immune-related adverse events during neoadjuvant *** with post-neoadjuvant ctDNA negativity was more likely to have pCR(39.1%)compared with those remained positive(6.7%,odds ratio=6.14,95%CI 0.84-Inf,p=0.077).With a median follow-up of 25.1 months,the 18-month EFS rate was 64.8%(95%CI 51.9–81.0%).For patients with ctDNA–***+,the 18m-EFS rate was 93.8%vs 47.3%(HR,0.15;95%CI 0.04,0.94;p=0.005).Immunochemotherapy may serve as an optimal neoadjuvant treatment even for patients with PD-L1 expression≥50%.ctDNA negativity following neoadjuvant treatment and surgery could help identify superior pathological and survival benefits,which requires further confirmation in a prospective clinical trial(NCT04015778).

关键词： chemotherapy NSCLC treatment

NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1421-1436页

作者： Yu-Jie xu Ya-Chang Huo Qi-Tai zhao jin-yan liu yi-Jun Tian Lei-Lei yang yi Zhang Biotherapy Center and Cancer Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Oncology Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhou 450003Henan ProvinceChina

BACKGROUND Metabolic reprogramming plays a key role in cancer progression and clinical outcomes;however,the patterns and primary regulators of metabolic reprogramming in colorectal cancer(CRC)are not well *** To explore the role of nicotinamide adenine dinucleotide phosphate oxidase 4(NOX4)in promoting progression of *** We evaluated the expression and function of dysregulated and survival-related metabolic genes using Gene Ontology and Kyoto Encyclopedia of Genes and *** clustering was used to cluster CRC based on dysregulated metabolic genes.A prediction model was constructed based on survival-related metabolic *** formation,migration,invasion,proliferation,apoptosis and clone formation was used to evaluate the biological function of NOX4 in *** sequencing was utilized to explore the alterations of gene expression NOX4 over-expression tumor *** vivo subcutaneous and lung metastasis mouse tumor model was used to explore the effect of NOX4 on tumor *** We comprehensively analyzed 3341 metabolic genes in CRC and identified three clusters based on dysregulated metabolic *** these genes,NOX4 was highly expressed in tumor tissues and correlated with worse *** vitro,NOX4 overexpression induced clone formation,migration,invasion,and stemness in CRC ***,RNA-sequencing analysis revealed that NOX4 overexpression activated the mitogen-activated protein kinase-MEK1/2-ERK1/2 signaling ***,a MEK1/2 inhibitor,abolished the NOX4-mediated tumor *** vivo,NOX4 overexpression promoted subcutaneous tumor growth and lung metastasis,whereas trametinib treatment can reversed the *** Our study comprehensively analyzed metabolic gene expression and highlighted the importance of NOX4 in promoting CRC metastasis,suggesting that trametinib could be a potential therapeutic drugs of CRC clinical therapy targeting NOX4.

关键词： Colorectal cancer Metabolic reprogramming Metastasis Nicotinamide adenine dinucleotide phosphate oxidase 4 Mitogen-activated protein kinase signaling

XOR spin logic operated by unipolar current based on field-free spin-orbit torque switching induced by a lateral interface

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Rare Metals 2024年第8期43卷 3868-3875页

作者： yan-ru Li Mei-yin yang Guo-Qiang Yu Bao-Shan Cui jin-Biao liu Yong-Liang Li Qi-Ming shao Jun Luo Key Laboratory of Microelectronic Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of Sciences(IMECAS)Beijing 100029China University of Chinese Academy of Sciences(UCAS) Beijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Institute of Physics Chinese Academy of SciencesBeijing 100190China Key Laboratory for Magnetism and Magnetic Materials of Ministry of Education Lanzhou UniversityLanzhou 730000China Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China

Spin logics have emerged as a promising avenue for the development of logic-in-memory *** particular,the realization of XOR spin logic gates using a single spin-orbit torque device shows great potential for low-power stateful logic circuits in the next *** this study,we successfully obtained the XOR logic gate by utilizing a spin-orbit torque device with a lateral interface,which was created by local ion implantation in the Ta/Pt/Co/Ta Hall device exhibiting perpendicular magnetic *** angle of the lateral interface is set at 45°relative to the current direction,leading to the competition between symmetry breaking and current-driven Néel-type domain wall ***,the field-free magnetic switching reversed is realized by the same sign of current amplitude at this *** on this field-free magnetic switching behavior,we successfully proposed an XOR logic gate that could be implemented using only a single spin-orbit torque Hall *** study provides a potentially viable approach toward efficient spin logics and in-memory computing architectures.

关键词： Filed-free magnetic switching Spin-orbit torque XOR logic gate Lateral interface

Root-derived long-distance signals trigger ABA synthesis and enhance drought resistance in Arabidopsis

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Journal of Genetics and Genomics 2024年第7期51卷 749-761页

作者： Qian-Qian liu jin-Qiu Xia Jie Wu yi han Gui-Quan Zhang Ping-Xia zhao Cheng-bin Xiang Division of Life Sciences and Medicine Division of Molecular&Cell BiophysicsHefei National Science Center for Interdisciplinary Sciences at the MicroscaleUniversity of Science and Technology of ChinaThe Innovation Academy of Seed DesignChinese Academy of SciencesHefeiAnhui 230027China College of Life Sciences Anhui Agricultural UniversityHefeiAnhui 230036China College of Agronomy South China Agricultural UniversityGuangzhouGuangdong 510642China School of Biology and Basic Medical Sciences Soochow UniversitySuzhouJiangsu 215123China

Vascular plants have evolved intricate long-distance signaling mechanisms to cope with environmental stress,with reactive oxygen species(ROS)emerging as pivotal systemic signals in plant stress ***,the exact role of ROS as root-to-shoot signals in the drought response has not been *** this study,we reveal that compared with wild-type plants,ferric reductase defective 3(frd3)mutants exhibit enhanced drought resistance concomitant with elevated NINE-CIS-EPOXYCAROTENOID DIOXYGENASE 3(NCED3)transcript levels and abscisic acid(ABA)contents in leaves as well as increased hydrogen peroxide(H_(2)O_(2))levels in roots and *** experiments distinctly illustrate that drought resistance can be conferred by the frd3 rootstock regardless of the scion genotype,indicating that long-distance signals originating from frd3 roots promote an increase in ABA levels in ***,the drought resistance conferred by the frd3 mutant rootstock is weakened by the CAT2-overexpressing scion,suggesting that H_(2)O_(2)may be involved in long-distance ***,the results of comparative transcriptome and proteome analyses support the drought resistance phenotype of the frd3 *** together,our findings substantiate the notion that frd3 root-derived long-distance signals trigger ABA synthesis in leaves and enhance drought resistance,providing new evidence for root-to-shoot long-distance signaling in the drought response of plants.

关键词： frd3 Drought resistance Root-to-shoot long-distance signals Reactive oxygen species(ROS) H_(2)O_(2) Iron ABA

Interface defect induced upgrade of K-storage properties in KFeSO4Fcathode: From lowered Fe-3d orbital energy level to advancedpotassium-ion batteries

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Green Energy & Environment 2024年第11期9卷 1724-1733页

作者： yan liu Zhen-yi Gu Yong-Li Heng jin-Zhi Guo Miao Du Hao-Jie Liang Jia-lin yang Kai-yang Zhang Kai Li Xing-long Wu MOE Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal UniversityChangchunJilin130024China Faculty of Chemistry Northeast Normal UniversityChangchunJilin130024China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China

KFeSO_(4)F(KFSF)is considered a potential cathode due to the large capacity and low ***,the inferior electronic conductivity leads to poor electrochemical *** engineering can facilitate the electron/ion transfer by tuning electronic structure,thus providing favorable electrochemical ***,through the regulation of surface defect engineering in reduced graphene oxide(rGO),the Fe–C bonds were formed between KFSF and *** Fe–C bonds formed work in regulating the Fe-3d orbital as well as promoting the migration ability of K ions and increasing the electronic conductivity of ***,the KFSF@rGO delivers a high capacity of 119.6 mAh g^(-1).When matched with a graphite@pitch-derived S-doped carbon anode,the full cell delivers an energy density of 250.5 Wh kg^(-1) and a capacity retention of 81.5%after 400 *** work offers a simple and valid method to develop high-performance cathodes by tuning defect sites.

关键词： Potassium-ion batteries Cathode Defect chemistry KFeSO4F Fe–C bond

Lignin-reinforced PVDF electrolyte for dendrite-free quasi-solid-state Li metal battery

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Rare Metals 2024年第3期43卷 1006-1016页

作者： Xin-yang Chen xue-Jie Gao han-yan Wu Yu-long liu Xiao-Fei yang run-Cang Sun Center for Lignocellulosic Chemistry and Biomaterials College of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian116034China Division of Energy Storage Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China School of Chemistry Northeast Normal UniversityChangchun130024China

Quasi-solid-state lithium metal batteries(QSSLMBs)assembled with polyvinylidene fluoride(PVDF)are a promising class of next-generation rechargeable batteries due to their safety,high energy density,and superior interfacial ***,PVDF has a series of inherent drawbacks such as low ionic conductivity,ease of crystallization,and hydrophobic character that leading to poor cell *** tackle these issues,a lignin-reinforced PVDF electrolyte is proposed in this work to solve these drawbacks of PVDF and enhance the comprehensive performance of *** lithophilic polar groups of lignin can promote uniform deposition of Li on the *** with the improved mechanical properties can efficiently prevent Li dendrites penetration through the *** addition,more active sites provided by lignin can also enhance Li^(+)transport and lead to a faster electrochemical reaction *** from the ingenious design,Li symmetric cells with 5%lignin-PVDF quasi-solid-state electrolyte can operate for 900 h at a high current density/capacity of 5 mA·cm^(-2)/5 mAh·cm^(-2),while shortcircuiting occurs after 56 h for the counterpart(pure PVDF).Moreover,a full cell of Li/5%lignin-PVDF/LFP cell demonstrates a high capacity of 96.2 mAh·g^(-1)after 2000 cycles at 10 *** work is expected to open up promising opportunities to develop other high-energy/power-density QSSLMBs.

关键词： Quasi-solid-state electrolyte Lignin PVDF Dendrite-free Li metal battery

Turbulent Image Restoration in Atmosphere with Cyclopean Processing via binocular Fusion

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Chinese Physics Letters 2024年第8期41卷 33-38页

作者： han Yao jin-yan lin Li-Bang Chen yi-Kun liu Jian-ying Zhou State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-Sen UniversityGuangzhou 510275China Guangdong Provincial Key Laboratory of Quantum Metrology and Sensing School of Physics and AstronomySun Yat-Sen University(Zhuhai Campus)Zhuhai 519082China

The outstanding issue to overcoming atmospheric turbulence on distant imaging is a fundamental interest and technological *** propose a novel scenario and technique to restore the optical image in turbulent environmental by referring to Cyclopean image with binocular *** human visual intelligence,image distortion resulting from the turbulence is shown to be substantially *** simulation results taking into account of the atmospheric turbulence,optical image system,image sensors,display and binocular vision perception are presented to demonstrate the robustness of the image restoration,which is compared with a single channel planar optical imaging and *** involving binocular telescope,image recording and the stereo-image display is conducted and good agreement is obtained between the simulation with perceptive experience.A natural extension of the scenario is to enhance the capability of anti-vibration or anti-shaking for general optical imaging with Cyclopean image.

关键词： image turbulence shaking

Engineering CuMn Prussian blue analog-shelled nanobox for efficient electrochemical reduction of nitrate to ammonia

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Tungsten 2024年第4期6卷 833-844页

作者： Zi-yi yang Yu-Dong Li Dan liu mao-Sen Song yang Gao Qing-Ping Wu En-Shan han yan-Zhen He Xiao-Hui yang School of Chemical Engineering and Technology Hebei University of Technology Key Laboratory of Bio-Based Material Science and Technology Northeast Forestry University Institute of Electrochemical Energy Storage Helmholtz-Zentrum Berlin für Materialien und Energie Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences

Electrocatalytic nitrate reduction reaction（ENRR） for ammonia synthesis is a promising strategy to relieve nitration contamination,as well as an alternative to the Haber-Bosch *** blue analogs（PBAs） are expected to be an electrocatalytic material with superior performance owing to their abundant active sites and open channel ***,most reported PBA materials possess low nitrate conversion and ammonia yield rates,which has led to a hindrance in their research of ***,CuMn-PBA-shelled nanoboxes（CuMn-PBA SNBs） synthesized through tannic acid etching and cation exchange approaches are demonstrated for efficient ammonia *** optimal CuMn-PBA SNBs electrode achieves a high nitrate conversion of 91.33% and ammonia selectivity of 98.87% in a 0.2 mol·L-1Na2SO4solution with100×10-6NO3--N at-1.4 V ***,the CuMn-PBA SNB s electrode exhibits exceptional stability throughout a 30 h electrocatalytic *** outstanding electrochemical performance is attributed to the unique hollow nanobox structure with abundant active sites and high-throughput transport pathways for ions' aspects.

关键词： Acid etching Ammonia synthesis Cation exchange Electrocatalytic nitrate reduction Nanobox Prussian blue analogs