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Science China Chemistry 2025年

作者： Shiguo Fu Xiaofeng Zhang Kaixuan Wang Linfeng Chen Fan Xia yong Cui Yan liu School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Faculty of Materials Science and Chemistry China University of Geosciences

Enantioselective separations of racemates using porous materials are highly attractive and significant in both fundamental research and technological applications. However, achieving controlled chiral pore surfaces to create the necessary driving force for enantiomer discrimination poses a fundamental challenge. Herein, we demonstrate that chiral covalent organic frameworks(COFs) possess the essential characteristics for effective enantioseparations through synthetic control over pore surfaces. We synthesized three 3D chiral COFs (CCOFs) featuring abundant chiral recognition sites on the pore walls via the condensation of enantiopure dialdehyde of 2,2′-dihydroxy-1,1′-binaphthyl and tetraamine. All CCOFs with high stability exhibit an 11-fold interpenetrated framework with tubular open channels, decorated with dihydroxyl or diethoxyl groups. The CCOFs with dihydroxyl groups serve as solid adsorbents for the adsorptive separation and solid-phase extraction of various chiral 1-phenylethanol-derived enantiomers, particularly racemic drugs, achieving up to 98%enantiomeric excess. In contrast, the CCOF with diethoxy groups is unable to resolve the racemates. These CCOF materials can be recycled and reused without any apparent loss of performance. Density functional theory (DFT) calculations reveal that the enantiospecific recognition arises from the well-organized chiral inner sphere and multiple chiral host-guest interactions.

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Tunable non-Markovian and quantum coherence in the single-qubit dephasing noise channel

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： Na-Na Zhang Chao-Yi Wu Xu Zhou Qi-Yuan liu Cheng-Ge liu yong-Rui Guo Ren-Pu Li School of Optoelectronic Engineering Chongqing University of Posts and Telecommunications Department of Physics Applied Optics Beijing Area Major Laboratory Beijing Normal University

In this paper, we construct a single-qubit dephasing noise channel based on the nuclear magnetic resonance（NMR） system by employing the bath-engineering technology, and achieve the construction of the tunable non-Markovian environment in the dephasing noise channel. Our findings indicate that for the single-qubit system, the transition of system dynamics from Markovian to non-Markovian can be achieved by adjusting the base frequency of the noise power spectrum. However, the base frequency corresponding to this phase transition point is not fixed, and there is a certain relationship between it and the total evolution time of the single-qubit system. Through our research, we discovered a fundamental relationship: if the single-qubit system dynamics undergoe a transition from Markovian to non-Markovian at ω0within 0-2t ms, shortening the evolution time to 0-t ms results in an increase of the phase transition point to 2ω0. This insight offers crucial guidance for artificially crafting non-Markovian environments across arbitrary time scales in single-qubit systems, and it is not limited by the type of noise. Apart from system dynamics, quantum coherence is also a focal point of our research. We find that when the system dynamics exhibit non-Markovian behavior, the quantum coherence of the single-qubit system experiences revivals. Notably, the timing of these coherence revivals aligns with the instants of the non-Markovianity enhancement. Therefore, our research also serves as a pivotal foundation for the artificial manipulation and realization of quantum coherence revivals within diverse single-qubit systems.

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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不同来源引流熊胆粉的化学成分系统分析

中国中药杂志 2018年第11期43卷 2326-2332页

作者：王杰熊爱珍程绒绒杨莉王峥涛刘绍勇上海中医药大学中药研究所中药标准化教育部重点实验室暨上海市复方中药重点实验室上海201203 上海中药标准化研究中心上海201203 上海凯宝药业股份有限公司上海201401

熊胆粉中含有胆汁酸、胆红素、蛋白质、氨基酸、微量元素等多种成分,其中胆汁酸类是熊胆粉中含量最高且研究最多的活性成分,而非胆汁酸类成分目前却鲜有报道。因此,该研究对来源为四川、黑龙江、云南的熊胆粉中各化学成分进行系统的研... 详细信息

熊胆粉中含有胆汁酸、胆红素、蛋白质、氨基酸、微量元素等多种成分,其中胆汁酸类是熊胆粉中含量最高且研究最多的活性成分,而非胆汁酸类成分目前却鲜有报道。因此,该研究对来源为四川、黑龙江、云南的熊胆粉中各化学成分进行系统的研究。通过采用微孔板分光光度计法测定胆红素、蛋白质,利用液相色谱质谱联用技术测定胆汁酸和氨基酸,利用电感耦合等离子体质谱仪测定微量元素。并采用相似度评价软件对不同来源的20批熊胆粉进行系统分析,表明不同来源熊胆粉中胆汁酸类成分相似度高（相似度系数为0.922~0.977）,不存在明显差异。所测样本中牛磺熊去氧胆酸与牛磺鹅去氧胆酸是熊胆粉中含量最高的成分,为41%~59%,均符合现行卫生部质量标准。二者总含量在来源为黑龙江的熊胆粉中最高,对不同来源的熊胆粉有分类意义。此外,不同来源熊胆粉中胆红素、蛋白质、氨基酸、微量元素含量也存在着一定的差异。该研究发现不同来源熊胆粉主要化学成分较为相似,但胆汁酸、胆红素、蛋白质、氨基酸、微量元素对不同来源的样本有分类意义,该研究为市售熊胆粉的质量评价和控制提供了更加全面科学的依据。

关键词：熊胆粉胆汁酸氨基酸微量元素胆红素蛋白质

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熊胆粉中熊去氧胆酸结晶条件

中成药 2014年第1期36卷 61-65页

作者：陈正王伯初祝连彩刘绍勇薛东升重庆大学生物工程学院生物流变学与技术教育部重点实验室重庆400030 上海凯宝药业股份有限公司上海201418

目的对熊胆粉中熊去氧胆酸的结晶及重结晶过程加以控制,以提高熊胆粉提取物产率及质量。方法通过溶解度实验确定了结晶及重结晶的最佳起始条件,再采用不同的降温方法对该过程进行梯度控温的优化研究。结果以70℃和30℃做为结晶及重结晶... 详细信息

目的对熊胆粉中熊去氧胆酸的结晶及重结晶过程加以控制,以提高熊胆粉提取物产率及质量。方法通过溶解度实验确定了结晶及重结晶的最佳起始条件,再采用不同的降温方法对该过程进行梯度控温的优化研究。结果以70℃和30℃做为结晶及重结晶的始末温度;筛选出最佳的结晶控温条件为控温8 h,前5 h每1 h降温2℃,后3 h每1 h降温10℃,重结晶工艺控温条件与结晶控温条件一致。应用该结晶工艺,与原工艺相比,熊胆粉提取物产率提高2.38%,转化率提高12.35%,熊去氧胆酸量提高5.83%,鹅去氧胆酸量基本保持不变。结论本研究所建立的结晶工艺,可显著提高熊胆粉中熊去氧胆酸的产率和质量。

关键词：熊去氧胆酸梯度降温结晶过程熊胆粉

DKP-SLAM:A Visual SLAM for Dynamic Indoor Scenes Based on Object Detection and Region Probability

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Computers, Materials & Continua 2025年第1期82卷 1329-1347页

作者： Menglin Yin yong Qin Jiansheng Peng College of Automation Guangxi University of Science and TechnologyLiuzhou545000China Department of Artificial Intelligence and Manufacturing Hechi UniversityHechi546300China Key Laboratory of AI and Information Processing Education Department of Guangxi Zhuang Autonomous RegionHechi546300China Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology School of Chemistry and BioengineeringHechi UniversityHechi546300China

In dynamic scenarios,visual simultaneous localization and mapping(SLAM)algorithms often incorrectly incorporate dynamic points during camera pose computation,leading to reduced accuracy and *** paper presents a dynamic SLAM algorithm that leverages object detection and regional dynamic ***,a parallel thread employs the YOLOX object detectionmodel to gather 2D semantic information and compensate for missed ***,an improved K-means++clustering algorithm clusters bounding box regions,adaptively determining the threshold for extracting dynamic object contours as dynamic points *** process divides the image into low dynamic,suspicious dynamic,and high dynamic *** the tracking thread,the dynamic point removal module assigns dynamic probability weights to the feature points in these *** with geometric methods,it detects and removes the dynamic *** final evaluation on the public TUM RGB-D dataset shows that the proposed dynamic SLAM algorithm surpasses most existing SLAM algorithms,providing better pose estimation accuracy and robustness in dynamic environments.

关键词： Visual SLAM dynamic scene YOLOX K-means++clustering dynamic probability

Industrial Control Anomaly Detection Based on Distributed Linear Deep Learning

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Computers, Materials & Continua 2025年第1期82卷 1129-1150页

作者： Shijie Tang yong Ding Huiyong Wang School of Computer Science and Information Security Guilin University of Electronic TechnologyGuilin541004China School of Electronic Engineering and Automation Guilin University of Electronic TechnologyGuilin541004China Guangxi Engineering Research Center of Industrial Internet Security and Blockchain Guilin University of Electronic TechnologyGuilin541004China Institute of Cyberspace Technology HKCT Institute for Higher EducationHong Kong999077China School of Mathematics&Computing Science Guilin University of Electronic TechnologyGuilin541004China

As more and more devices in Cyber-Physical Systems(CPS)are connected to the Internet,physical components such as programmable logic controller(PLC),sensors,and actuators are facing greater risks of network attacks,and fast and accurate attack detection techniques are *** key problem in distinguishing between normal and abnormal sequences is to model sequential changes in a large and diverse field of time *** address this issue,we propose an anomaly detection method based on distributed deep *** method uses a bilateral filtering algorithm for sequential sequences to remove noise in the time series,which can maintain the edge of discrete *** use a distributed linear deep learning model to establish a sequential prediction model and adjust the threshold for anomaly detection based on the prediction error of the validation *** method can not only detect abnormal attacks but also locate the sensors that cause *** conducted experiments on the Secure Water Treatment(SWAT)and Water Distribution(WADI)public *** experimental results show that our method is superior to the baseline method in identifying the types of attacks and detecting efficiency.

关键词： Anomaly detection CPS deep learning MLP(multi-layer perceptron)

湛江电厂600MW发电机组定子吊装方案及改进

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机电产品开发与创新 2007年第5期20卷 76-77,83页

作者：刘韶勇夏运阳湖南省火电建设公司湖南株洲412000

介绍了湛江奥里油发电厂利用液压提升装置来吊装600MW发电机组定子的方案,对方案中的施工程序、技术措施、液压提升装置的运用方法、吊装过程的技术关键进行分析总结,为600MW发电机组定子吊装提供经验,同时在原有吊装方案的基础上,对发... 详细信息

介绍了湛江奥里油发电厂利用液压提升装置来吊装600MW发电机组定子的方案,对方案中的施工程序、技术措施、液压提升装置的运用方法、吊装过程的技术关键进行分析总结,为600MW发电机组定子吊装提供经验,同时在原有吊装方案的基础上,对发电机定子拖动的平稳、液压提升装置负荷率的安全性提出改进建议。

关键词： 600MW发电机定子液压提升装置吊装安全

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通用测井仪器维修系统设计

石油仪器 2008年第3期22卷 6-8,11页

作者：刘勇邵高平卢青刘加永信息工程大学信息工程学院

文章设计了一套测井仪器维修系统,能够实现对测井仪器的参数设置、工作控制,以及测井仪器数据的接收、处理和显示,从而给测井仪器的生产测试和维修带来极大便利。系统通过仪器总线直接连接测井仪器,可以支持所有遵循IB总线的测井仪器。... 详细信息

文章设计了一套测井仪器维修系统,能够实现对测井仪器的参数设置、工作控制,以及测井仪器数据的接收、处理和显示,从而给测井仪器的生产测试和维修带来极大便利。系统通过仪器总线直接连接测井仪器,可以支持所有遵循IB总线的测井仪器。通过电脑上进行仪器控制和状态显示,提供了友好的操作界面,软件更新和功能扩展。

关键词：测井仪器维修系统仪器总线

边坡控制在地质灾害危险性评估中的重要性研究

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湖南电力 2009年第6期29卷 46-49页

作者：罗常青刘绍勇湖南省电力勘测设计院湖南长沙410007 长沙科创岩土工程技术开发有限公司湖南长沙410007

地质灾害常造成严重的人身伤亡和巨大的经济损失。在地质灾害中,崩塌、滑坡以及泥石流,都与边坡的稳定直接或间接相关,可见边坡在地质灾害危险性评估中的重要性。阐述了影响边坡稳定性的因素,并结合某特高压变电站现状进行评估。预测评... 详细信息

地质灾害常造成严重的人身伤亡和巨大的经济损失。在地质灾害中,崩塌、滑坡以及泥石流,都与边坡的稳定直接或间接相关,可见边坡在地质灾害危险性评估中的重要性。阐述了影响边坡稳定性的因素,并结合某特高压变电站现状进行评估。预测评估表明,边坡的稳定性状态控制了地质灾害危险性评估结果,不同的边坡坡角决定的边坡稳定性使得工程建设引发和遭受地质灾害的程度不一。

关键词：边坡控制危险性评估地质灾害