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FeCl_3·6H_2O-catalyzed selective reduction of allylic halides to alkenes with concomitant oxidation of benzylic alcohols to aldehydes

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Science China Chemistry 2014年第2期57卷 282-288页

作者： ZHANG HouCai liu ruiting ZHOU XiGeng Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Department of Chemistry Fudan University State Key Laboratory of Organometallic Chemistry

Iron-catalyzed direct reduction of allylic halides with benzylic alcohol was achieved,providing a new,simple,and efficient method for conducting highly regioselective *** method not only features a readily available reductant,an inexpensive catalyst,simple manipulation,and good tolerance of functional groups including nitriles,nitro,esters,and methoxyl groups,it also has mild reaction conditions and shows complete regioselectivity in that only halides sited at the allylic position are ***,this method can be applied in the selective transformation of benzylic alcohols to aromatic aldehydes without overoxidation to carboxylic acids.

关键词： selective reduction allylic halides Fe-based catalysts hydrodehalogenations benzyi alcohols

Lanthanide-catalyzed cyclocarbonylation and cyclothiocarbonylation: a facile synthesis of benzannulated 1,3-diheteroatom five- and six-membered heterocycles

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Science China Chemistry 2014年第8期57卷 1117-1125页

作者： JING YuFeng liu ruiting LIN YangHui ZHOU XiGeng Shanghai Key Laboratory of Molecular Catalysis and Innovative Material Department of Chemistry Fudan University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry

La[N(SiMe3)2]3 proves to be an efficient catalyst system for the cyclocarbonylation of 1,2-disubstituted benzenes with isocyanates. In this approach, aryl/alkyl isocyanates react with o-phenylenediamine, o-aminophenol, o-aminothiophenol, catechols and anilines ortho-substituted by CH2NH2 and CONH2 to form, respectively, the corresponding benzimidazolones, benzoxazolones, benzothiazolones, benzodioxolones, 3,4-dihydroquinazolin-2(1H)-one, and quinazolinediones. These results represent the first example of lanthanide-catalyzed carbonylation. This methodology is also applicable for the preparation of various benzannulated 1,3-diheteroatom cyclic thioketones starting from aryl/alkyl isothiocyanates or CS2 in good to excellent yields. Based on the results of experiments performed using an o-aminobenzamido dianion lanthanide complex, a general mechanism, involving the tandem reaction of two lanthanide-ligand bonds with one heterocumulene molecule, is proposed as well.

关键词： lanthanide catalyst 1 2-disubstituted benzene isocyanate isothiocyanates cyclocarbonylation cyclothiocarbonylation

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Flexible 3D porous metal-organic framework exhibiting selective adsorption for H_2O over organic solvents

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Science China Chemistry 2012年第3期55卷 341-346页

作者： liu Bo REN Chen WANG YaoYu HOU Lei liu ruiting SHI QiZhen Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Shanxi Key Laboratory of Physico-Inorganic ChemistryCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an 710069China

A new flexible 3D porous metal-organic framework （MOF） with 1D open nanotube, [Co2（/zs-CTAl）（dpe）（H20）2]n-6n（H20）（1）（CTA = cyclohexane-1,2,4,5-tetracarboxylic acid, dpe = 1,2-di（4-pyridyl） ethylene） has been prepared and structurally character- ized. Meanwhile, each 1D nanotubes filled with 1D water chain with dimension of 13.711 ~ 12.275/~2. Compound 1 represents a new example that collapse/deform upon dehydration/hydration and shows adsorb 1-120 selectively over organic solvents.

关键词： flexible nanotube water chain adsorb selectively collapse/deform

Three new zinc(Ⅱ) coordination polymers:Modulation of extended structures driven by assistant ligands

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Chinese Science Bulletin 2009年第23期54卷 4285-4290页

作者： DONG Zhe ZHANG WeiHong WANG YaoYu liu ruiting REN Chen SHI QiZhen Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education Shaanxi Key Laboratory ofPhysico-lnorganic Chemistry College of Chemistry & Materials Science Northwest University Xi'an 710069 China

Three new complexes, [Zn(dtb)(4,4'-bipy)]·5H2O (1), [Zn(dtb)(bpp)]·H2O (2) and [Zn(dtb)(phen)2]·CH3CH2OH·H2O (3) (dtb = 5,5'-dithiobis(2-nitrobenzoic acid), 4,4'-bipy = 4,4'-bipyridine, bpp = 1,3-bi(4-pyridyl) propane, phen = 1,10-phenanthroline), have been constructed by dtb ligand and zinc salt in the presence of different assistant N-containing ligands under hydrothermal conditions. The structures of the complexes were established by single-crystal X-ray diffraction analysis. Although compounds 1 and 2 are both 2D networks, the cavities’ forms and pitch of helix are different. The structure of compound 3 shows a 1D helical chain, and is extended by the supermolecule interactions into a 2D framework. These neutral polymeric complexes exhibit structural and dimensional diversity due to the different coordination modes of the flexible dtb ligand and the effect of assistant ligands.

关键词：扩展结构锌(Ⅱ) 配位聚合物配体单晶X射线衍射分析超分子相互作用驱动调制

Advanced polymer-based electrolytes in zinc-air batteries

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eScience 2022年第5期2卷 453-466页

作者： Qingqing liu ruiting liu Chaohui He Chenfeng Xia Wei Guo Zheng-Long Xu Bao Yu Xia Key Laboratory of Material Chemistry for Energy Conversion and Storage(Ministry of Education) Hubei Key Laboratory of Material Chemistry and Service FailureSchool of Chemistry and Chemical EngineeringHuazhong University of Science and Technology(HUST)1037 Luoyu RdWuhan430074PR China State Key Laboratory of Ultraprecision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHong Kong SARPR China

Zinc–air batteries(ZABs)are expected to be some of the most promising power sources for wearable and portable electronic devices and have received widespread research *** an ion conductor connecting anodes and cathodes,the electrolyte is critical for the overall performance of ZABs(e.g.,energy density,rechargeability,and operating voltage).Compared with liquid electrolytes,polymer-based electrolytes have superior characteristics for ZABs,such as negligible electrolyte leakage,three-phase interface stabilization,and dendrite *** this perspective,we focus on recent progress in polymer-based electrolytes for *** a brief introduction to ZABs and electrolytes,we emphasize the development of polymer-based electrolytes in terms of their intrinsic properties and interfacial ***,challenges and viable strategies are proposed for polymer-based electrolytes in *** hope that this work will provide useful guidance to spur the development of high-performance ZABs based on advanced polymer-based electrolytes.

关键词： Zinc–air batteries Electrolytes Interface Polymers Gels

Engineering self-catabolic DNAzyme nanospheres for synergistic anticancer therapy

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Science China Chemistry 2024年第7期67卷 2412-2422页

作者： Yu Chen Yu Guo Jiaoli Wang ruiting liu Xiaohai Yang Kemin Wang Ying Pu Hui Shi Jin Huang Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringKey Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan ProvinceHunan UniversityChangsha 410082China National Clinical Research Center for Geriatric Disorders Department of GeriatricsXiangya HospitalCentral South UniversityChangsha 410008China

DNAzyme-based gene therapy faces some challenges including cell penetration,activity limitation,and co-delivery ***-assembled DNA nanomedicine has attracted widespread attention due to its many *** is urgent to develop a universal DNA degradation strategy for precise programmable drug ***,we reported a self-catabolic DNAzyme nanospheres(SCNS),which could simultaneously achieve cell penetration,activity enhancement,and co-delivery *** SCNS were assembled through Y-DNA stepwise hybridization with each other,which were then loaded with aptamer(Apt),doxorubicin(Dox),and zinc oxide nanoparticles(ZnO NPs).The acid-triggered dissociation of ZnO NPs leads to the generation of Zn^(2+)ions cofactors for immediately self-catabolic DNAzyme *** the disassembly of the SCNS,three types of anticancer treatments would be activated,which include Zn^(2+)involved reactive oxygen species(ROS),Dox-induced chemotherapy,and DNAzyme-based gene *** experimental results show that the nanoplatform(Apt-SCNS-Dox-ZnO)has a good tumor-killing effect and minimal side *** a smart self-driven drug delivery nanoplatform,it is anticipated to displace extraordinary potential in biomedicine and bioengineering.

关键词： DNAzyme nanosphere ZnO NPs ROS Dox anticancer therapy

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4-巯基吡啶法测定葱属植物制品总硫代亚磺酸酯含量

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中国食品添加剂 2025年第2期36卷 134-142页

作者：李世颖刘睿婷李兰兰杜娟李新霞新疆医科大学药学院乌鲁木齐830011 新疆大蒜药用研究重点实验室乌鲁木齐830013 新疆胡蒜研究院(有限公司) 乌鲁木齐830011

该研究以大蒜中典型酶促反应产物大蒜辣素优化4-巯基吡啶与硫代亚磺酸酯的反应条件,并测定大蒜粉、洋葱粉中总硫代亚磺酸酯。结果表明:优化的反应溶剂体系为50%甲醇、反应温度为37℃、反应时间为60分钟,反应率达90%以上,并测定了该条件... 详细信息

该研究以大蒜中典型酶促反应产物大蒜辣素优化4-巯基吡啶与硫代亚磺酸酯的反应条件,并测定大蒜粉、洋葱粉中总硫代亚磺酸酯。结果表明:优化的反应溶剂体系为50%甲醇、反应温度为37℃、反应时间为60分钟,反应率达90%以上,并测定了该条件下4-巯基吡啶的ε值为21521 M-1·cm-1。样品测定结果显示本实验室冻干的大蒜粉、洋葱粉均可产生硫代亚磺酸酯,网购大蒜粉、洋葱粉样品除江苏大蒜(G9)含少量硫代亚磺酸酯,其他均测不到硫代亚磺酸酯。大蒜、洋葱经冻干工艺加工能最大限度保留相关酶的活性。在测定的大蒜冻干粉中,大蒜辣素占总硫代亚磺酸酯60%以上。本法可用于大蒜等葱属植物及加工制品中总硫代亚磺酸酯的含量测定,评价大蒜等相关制品的加工工艺与质量,并在加工过程通过硫代亚磺酸酯的测定进行过程质量控制。

关键词： 4-巯基吡啶硫代亚磺酸酯葱属植物大蒜粉洋葱粉

A novel and effective hyperthermia method for Schistosomiasis japonica prevention and treatment

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Science Bulletin 2015年第16期60卷 1461-1464页

作者： Huixia Yang Tao Tang Pei He Youren Zhang Le Xie Guangqi liu Li Li Weichao Kong Jingdingsha Li ruiting liu Yukun Li Junjian Hu Xiaowen Wang Liya Li Guanghong Xiang Geoffrey Gobert Yuesheng Li Jintian Tang The Yuquan Hospital Tsinghua University Laboratory of Innovative Medical Technology Department of Engineering Physics Tsinghua University The WHO Collaborating Centre for Research and Control of Schistosomiasis on Lake Region Hunan Institute of Parasitic Diseases Department of Pharmaceutics Beijing University of Chinese Medicine Graduate School Hunan University of Chinese Medicine School of Measuring and Optical Engineering Nanchang Hangkong University Department of Oncology Xiangya Hospital Central South University Department of Medical Oncology China-Japan Friendship Hospital Queensland Institute of Medical Research Clinic for Vascular and Endovascular Surgery University Clinic of Muenster

The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was investigated by the skin hyperthermia device. The survival rate of cercariae decreased from 68.15 % （37 ℃, 5 min） to 0 （49℃, 10 min） with the thermal dosages increased, which proved the preventing effect of hyperthermia therapy （P 〈 0.05）. Therapeutic effects were assessed in Schistosoma japonicum-infected BALB/c mice. When the cercarial contact region of the skin was treated at 45-49℃ for 5 min within 8 h of infection, worm reduction rate （WRR） reached 74 %-83 % （P 〈 0.01）. The sensitivity of adult schistosoma to heat was also investigated using microwave intraperitoneal hyperthermia （thermal dosages 42-43℃, 20 min）. The WRR, hepatic shift rates and egg reduction rates were 23.7 %, 40 % and 30 %, respectively, comparing with 80.2 %, 59.6 % and 53.9 % of praziquantel （PZQ）-treated group. Encouraging results have been obtained that hyperthermia can effectively kill schistosomula, especially with the appearance of cercarial dermatitis, while PZQ lacks efficacy against the cercariae. Thus, hyperthermia therapy would show significant benefit in preventing and treatment of schistosoma, especially in the early stage.

关键词： Hyperthermia Schistosomiasis japonica Praziquantel (PZQ) Cercariae

Pd（OAc）2/CuI分步催化合成多取代3-烃硫（硒）基吲哚化合物（英文）

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有机化学 2019年第11期39卷 3215-3222页

作者：刘瑞婷李振王圣克周锡庚复旦大学化学系上海200438 中国科学院上海有机化学研究所金属有机化学国家重点实验室上海20032

发展了一种Pd(OAc)2/CuI分步催化2-(2,2-二溴乙烯基)胺、苯硼酸和联硫(硒)化合物发生偶联/环化/硫烷基化反应合成3-烃硫(硒)基吲哚化合物的新方法.底物中不同的官能团,如甲氧基、氯、三氟甲基在反应中都能很好地兼容.

关键词：吲哚 Pd(OAc)2/CuI 催化合成