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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong qiang liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong ren Yanjuan liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li Xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

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空间太阳电池自动涂胶过程的扩散原理

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上海交通大学学报 2006年第10期40卷 1786-1789页

作者：赵辉付庄吴跃新闫维新刘仁强赵言正上海交通大学机械与动力工程学院上海200030

空间太阳电池封装操作包括:注射器涂胶过程、盖片胶平面扩散以及玻璃盖片封装操作三个阶段.分析了盖片胶从注射器中流出落在电池片上后,逐渐扩散融合的过程.基于非牛顿流体理论,建立了盖片胶的平面扩散模型,使用有限元软件Adina,基于流... 详细信息

空间太阳电池封装操作包括:注射器涂胶过程、盖片胶平面扩散以及玻璃盖片封装操作三个阶段.分析了盖片胶从注射器中流出落在电池片上后,逐渐扩散融合的过程.基于非牛顿流体理论,建立了盖片胶的平面扩散模型,使用有限元软件Adina,基于流体体积法进行运动界面追踪,对模型进行了模拟仿真,并与实验结果进行了对比验证.获得了盖片前胶层的形状,确定了胶层的边缘位置.为封装过程的分析建模提供了胶层厚度和边界等几何参数.对类似的平面扩散问题,也提供了一种新的解决方法.

关键词：空间太阳电池扩散非牛顿流体动边界流体体积法

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实验性神经起步点产生的整数倍簇放电节律

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生物物理学报 2003年第1期19卷 68-72页

作者：古华光李莉杨明浩刘志强任维航天医学工程研究所北京100094

随机Hindmarsh-Rose模型中产生簇(bursting)放电节律是神经放电中存在随机自共振的一个重要理论证据,但是,该簇放电节律在实验中一直没有被发现。在实验性神经起步点细胞外[Ca^(2+)](Ca^(2+)]o)低于周期1节律的[Ca^(2+)]o时,发现了一种... 详细信息

随机Hindmarsh-Rose模型中产生簇(bursting)放电节律是神经放电中存在随机自共振的一个重要理论证据,但是,该簇放电节律在实验中一直没有被发现。在实验性神经起步点细胞外[Ca^(2+)](Ca^(2+)]o)低于周期1节律的[Ca^(2+)]o时,发现了一种簇放电节律。其簇簇间期(inter-burst intervals,IBIs)呈现出与随机自共振引起的整数倍峰放电(integer multiple spiking)节律的峰峰间期类似的整数倍特征。随机Hindmarsh-Rose模型中产生的簇(bursting)放电节律也表现出类似的特征。结果验证了随机自共振簇放电的存在性,揭示该簇放电节律的统计特征。此外,该簇放电节律的参数区间以及其与整数倍峰放电节律的区别被揭示,簇放电节律的[Ca^(2+)]o低于峰放电节律的[Ca^(2+)]o。

关键词：整数倍簇放电随机自共振神经起步点簇簇间期峰峰间期

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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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我国首次牛结节性皮肤病病毒的分离鉴定

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中国预防兽医学报 2020年第10期42卷 1058-1061页

作者：张敏敏孙亚杰刘文兴刘任强王喜军步志高中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室黑龙江哈尔滨150069 内蒙古农业大学兽医学院内蒙古呼和浩特010018

牛结节性皮肤病(LSD)是由羊痘病毒属牛结节性皮肤病病毒(LSDV)引起的牛的烈性传染病。2019年8月,我国首次在新疆伊犁地区发现疑似LSD疫情。本研究采集伊犁疫情临床症状典型病牛病变皮肤组织,接种羊睾丸(LT)细胞,对出现典型细胞病变的培... 详细信息

牛结节性皮肤病(LSD)是由羊痘病毒属牛结节性皮肤病病毒(LSDV)引起的牛的烈性传染病。2019年8月,我国首次在新疆伊犁地区发现疑似LSD疫情。本研究采集伊犁疫情临床症状典型病牛病变皮肤组织,接种羊睾丸(LT)细胞,对出现典型细胞病变的培养物进行了系列鉴定。透射电镜观察到典型痘病毒形态的砖型粒子;山羊痘高免血清间接免疫荧光检测培养病变细胞显示阳性反应;LSDV基因组特异引物PCR检测结果为阳性;二代测序(De novo)全基因组分析显示与LSDV/Russia/Saratov/2017(MH646674.1)同源性最高(99.42%);系统进化分析显示与LSDV/Russia/Saratov/2017株相似,介于疫苗株和野毒株分支之间;病毒生长曲线测定显示感染LT细胞的生长特性与已报道的山羊痘病毒相似。上述结果表明,本实验分离得到引起我国首次LSD疫情的病毒株,命名为LSDV/China/Xinjiang/2019株(Xinjiang/2019),本研究为牛结节性皮肤病的防治奠定了基础。

关键词：牛结节性皮肤病病毒分离鉴定进化分析

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3073例输注血小板细菌培养结果分析

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中国热带医学 2006年第5期6卷 868-868,929页

作者：刘仁强刘赴平叶柱江秦艳兰东莞市中心血站广东东莞523930

目的评估手工混合血小板与单采血小板在血液采集制备过程中细菌污染的危险程度，为防止血小板细菌污染，提高输血安全性并制订预防措施提供参考依据。方法采用生物梅里埃公司生产的BacT／Alert 120全自动细菌培养仪及需氧瓶（BPA Cultur... 详细信息

目的评估手工混合血小板与单采血小板在血液采集制备过程中细菌污染的危险程度，为防止血小板细菌污染，提高输血安全性并制订预防措施提供参考依据。方法采用生物梅里埃公司生产的BacT／Alert 120全自动细菌培养仪及需氧瓶（BPA Culture Bottle）、厌氧瓶（BPN Culture Bottle）对3073例血小板进行了细菌培养，细菌培养阳性者转种，转种阳性者进行鉴定。结果在1794例（7—9袋混合，共约14352人份）手工混合血小板中细菌培养阳性13例．假阳性2例，鉴定细菌阳性1例，其余未作鉴定，手工混合血小板细菌培养阳性率为0．72％（单人份为0．09％）；1279例单采血小板细菌培养阳性6例，鉴定假阳性1例，细菌阳性2例，其余未作鉴定，单采血小板细菌培养阳性率为0．47％。结论手工混合血小板细菌培养阳性率高于单采血小板，由于血小板采集后在（22±2）℃振荡保存，有利于细菌生长繁殖，输注血小板存在极高的风险，细菌污染是输注血小板急待解决的问题之一。

关键词：血小板细菌污染细菌培养输血

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Biological Stimuli-responsive Polymer Systems:Design,Construction and Controlled Self-assembly

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Chinese Journal of Polymer Science 2018年第3期36卷 347-365页

作者： Miao-Miao Xu ren-Jie liu qiang Yan Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China

Biological stimuli-responsive polymers have increasingly attracted attention in recent years because it can satisfy many requirements of applications related with human body while traditional systems do not *** to the importance of this burgeoning field,great efforts have been devoted and,up to now,polymer chemists have made a remarkable success in this prospective research *** this review,we systematically generalize the present state of biological stimuli-responsive polymer *** highlight several representative examples to specify the current problems and look ahead a clear sense of direction in this area.

关键词： Biological stimuli Responsive polymer Controlled self-assembly Biomedicine

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血袋保存液细菌内毒素定量检测方法探讨

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中国热带医学 2010年第4期10卷 519-520页

作者：刘仁强钟炽辉秦艳兰东莞市中心血站广东东莞523930

目的探讨定量检测血袋保存液中细菌内毒素(BET)的方法。方法用碱性调节剂来消除血袋保存液中枸椽酸盐类抗凝剂对鲎试剂检查的干扰,建立标准曲线,对处理后的血袋保存液用BET-32M细菌内毒素检测系统进行定量检测,同时用凝胶法作对照。结... 详细信息

目的探讨定量检测血袋保存液中细菌内毒素(BET)的方法。方法用碱性调节剂来消除血袋保存液中枸椽酸盐类抗凝剂对鲎试剂检查的干扰,建立标准曲线,对处理后的血袋保存液用BET-32M细菌内毒素检测系统进行定量检测,同时用凝胶法作对照。结果动态浊度法定量检测细菌内毒素检测数据符合药典规定的限值(5.56EU/mL),并与凝胶法结果一致,检测结果准确、可靠。结论建立的内毒素检测方法可用于血袋保存液的定量检测。

关键词：血袋保存液细菌内毒素 BET-32M检测系统

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Influence of lanthanum on inclusions and as-cast microstructures in a low-alloy high-strength steel

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Journal of Iron and Steel Research International 2023年第12期30卷 2471-2481页

作者： Can liu Ji Zhang qiang ren Li-feng Zhang School of Materials Science and Engineering Yanshan UniversityQinhuangdao066004HebeiChina School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China School of Mechanical Engineering Yanshan UniversityQinhuangdao066004HebeiChina School of Mechanical and Materials Engineering North China University of TechnologyBeijing100144China

Advanced high-strength steel ingots with total lanthanum(TLa)contents of 0,15×10^(–6),86×10^(–6)and 360×10^(–6)were prepared through laboratory *** modification of inclusions and the variation of the as-cast microstructure with the content of lanthanum in the high-strength steel were *** result showed that with the increase in the TLa content in the steel from 0 to 360×10^(–6),the modification path of inclusions in the as-cast steel was Al2O_(3)and calcium aluminate→LaAlO_(3)→La_(2)O_(2)S→La_(2)O_(2)S–La2O_(3).The addition of La in the high-strength steel significantly refined the solidification *** the increase in the TLa content in the steel from 0 to 360×10^(–6),the ratio of the equiaxed crystal region in the macrostructure increased from 30.1%to 50.7%,the proportion of the high-angle grain boundary in the microstructure increased from 36.9%to 69.8%,and the area fraction of the acicular ferrite and the bainite increased from 0 to 93.3%.Inclusions of LaAlO_(3),La_(2)O_(2)S and La2O_(3)in the La-containing steel could act as heterogeneous nucleation cores ofα-Fe during the *** the increase in the TLa content in the steel,the number density of inclusions that could act as effective heterogeneous nucleation cores in the steel gradually increased,which enlarged the ratio of the equiaxed crystal region and the proportion of intragranular acicular ferrite,and refined the as-cast microstructure of the high-strength steel.

关键词： Advanced high-strength steel Lanthanum Inclusion Heterogeneous nucleation As-cast microstructure

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