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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui liu Chao Fang Qiuxia Peng Wen qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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生态足迹分析方法研究回顾和展望

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南京晓庄学院学报 2007年第6期23卷 75-81页

作者：刘钦普曹建军南京晓庄学院地理科学学院江苏南京210017

文章介绍了生态足迹分析方法产生的历史背景和计算方法,回顾了国内外研究的进展,并对生态足迹研究方法的优缺点进行了评述,并且对今后生态足迹的研究重点提出了展望.

关键词：生态足迹分析方法回顾展望

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河南省地市经济发展水平和区域划分研究

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许昌师专学报 2001年第5期20卷 94-98页

作者：刘钦普袁胜元许昌师专地理系河南许昌461000

对河南省地市经济发展水平进行评价和区域划分研究首先建立评价指标体系 ,然后用主成分分析法对原始数据进行数学处理 ,得出表示经济水平的综合指标 ,再用聚类分析方法进行经济发展水平层次和区域的划分最后分析了河南省经济发展水... 详细信息

对河南省地市经济发展水平进行评价和区域划分研究首先建立评价指标体系 ,然后用主成分分析法对原始数据进行数学处理 ,得出表示经济水平的综合指标 ,再用聚类分析方法进行经济发展水平层次和区域的划分最后分析了河南省经济发展水平地域差异的原因 ,并提出了河南省发展区域经济、平衡区域差异的基本策略 .

关键词：河南经济发展水平区域划分主成分分析聚类分析研究方法评价指标

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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying liu Bei Peng Xiaoyan Zhou Lixia qin Lingyan Liang Yichen Wei qingping Zhang Xiaocheng Li Haixia qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang Jian-qin liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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三元复合驱油井中硅垢的形成机理及预测模型

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石油学报 2003年第5期24卷 63-66页

作者：李萍程祖锋王贤君刘钦甫丁述理河北建筑科技学院河北邯郸056038 中国矿业大学地质系北京100083

油层内及油井底结垢是大庆油田三元复合驱现场试验过程中须解决的一个重大问题。基于试验区地层岩石及流体特点 ,对碱、表面活性剂、聚合物及三元复合体系在相关条件下的动态、静态水岩反应进行了模拟试验 ,以确定这些因素对成垢作用... 详细信息

油层内及油井底结垢是大庆油田三元复合驱现场试验过程中须解决的一个重大问题。基于试验区地层岩石及流体特点 ,对碱、表面活性剂、聚合物及三元复合体系在相关条件下的动态、静态水岩反应进行了模拟试验 ,以确定这些因素对成垢作用的影响。在此基础上 ,根据溶度积理论建立了结垢预测模型 ,运用该模型对大庆杏北油田三元复合驱试验区进行了结垢定量预测。研究表明 ,三元复合体系中的碱对储层岩石产生了明显的溶蚀作用 ,使Si4+ 、Al3 + 、Ca2 + 、Mg2 + 等成垢离子进入溶液 ,在特定条件下形成了非晶质SiO2 垢等。对现场采集垢样的检测分析表明 ,预测结果与实际情况基本吻合。该预测模型可用于选择油田注水水质。

关键词：三元复合驱硅垢形成机理预测模型大庆油田

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City-Bus-Route Demand-based Efficient Coupling Driving Control for Parallel Plug-in Hybrid Electric Bus

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Chinese Journal of Mechanical Engineering 2018年第3期31卷 168-178页

作者： qin-pu Wang Chao Yang Ya-Hui liu Yuan-Bo Zhang Zhongtong Bus Hold Co. Ltd. State Key Laboratory of Automotive Safety and Energy Tsinghua University

Recently,plug?in hybrid electric bus has been one of the energy?e cient solutions for urban transportation. However,the current vehicle e ciency is far from optimum,because the unpredicted external driving conditions are di cult to be obtained in advance. How to further explore its fuel?saving potential under the complicated city bus driving cycles through an e cient control strategy is still a hot research issue in both academic and engineering area. To realize an e cient coupling driving operation of the hybrid powertrain,a novel coupling driving control strategy for plug?in hybrid electric bus is presented. Combined with the typical feature of a city?bus?route,the fuzzy logic inference is employed to quantify the driving intention,and then to determine the coupling driving mode and the gear?shifting strategy. Considering the response deviation problem in the execution layer,an adaptive robust controller for electric machine is designed to respond to the transient torque demand,and instantaneously compensate the response delay and the engine torque fluctuation. The simulations and hard?in?loop tests with the actual data of two typical driving conditions from the real?world city?bus?route are carried out,and the results demonstrate that the pro?posed method could guarantee the hybrid powertrain to track the actual torque demand with 10.4% fuel economy improvement. The optimal fuel economy can be obtained through the optimal combination of working modes. The fuel economy of plug?in hybrid electric bus can be significantly improved by the proposed control scheme without loss of drivability.

关键词： Hybrid electric vehicle Single?shaft parallel electromechanical powertrain Coupling driving mode Adaptive robust control

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Harmonic Amplification Analysis of Cable Lines with Distributed Parameters Based on Kalman Filter and Convolution Inversion

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Journal of Modern Power Systems and Clean Energy 2023年第6期11卷 1804-1813页

作者： Yang pu qin Shu Fangwei Xu College of Electrical Engineering Sichuan UniversityChengdu 610065China IEEE

Harmonic amplification phenomena could appear at the point of common connection(PCC) of the cable line terminal. However, the distributed parameter model of the cable line contains hyperbolic functions with plural variables, which makes it challenging to obtain the harmonic amplification factor(HAF). Hence, a time-domain method combining the Kalman filter and convolution inversion(KFCI) methods is proposed to address this problem. First, the Kalman filter method optimizes the square wave pulse response(SWPR) with measurement error. Then, the optimized SWPR data are used to get the HAF by the convolution inversion method. Next, the harmonic amplification characteristics of cable lines are explored. Finally, an experimental simulation model is built on the PSCAD software, verifying the optimization effectiveness of Kalman filter for the SWPR with error and the accuracy of the HAF calculated by the proposed method. The analysis rationality of harmonic amplification properties is also demonstrated.

关键词： Cable line distributed parameter Kalman filter convolution inversion harmonic amplification

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Preparation of fine copper powders and their application in BME-MLCC

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Journal of University of Science and Technology Beijing 2006年第3期13卷 250-255页

作者： Songping Wu Haoli qin pu Li College of Chemistry South China University of Technology Guangzhou 510641 China

The preparation of fine copper powders by chemical reduction method was investigated. The reaction of [Cu（NH3）4]2^＋ complex with hydrazine hydrate gives spherical monodispersed fine copper powders. The spherical copper powder with a uniform size of 3.5 ± 0.5 μtm was processed to obtain flake copper powder having a uniform size of 8-10 μm, excellent dispersibility and uniform shape. The spherical copper powder of 2.5 ±0.3 μm in size, flake copper, glass frit and vehicle were mixed to prepare copper paste, which was fired in 910-920℃ to obtain BME-MLCC （base metal multilayer ceramic capacitor） with a dense surface of end termination, high adhesion and qualified electrical behavior. Polarized light photo and SEM were employed to observe the copper end termination of BME-MLCC. The rough interface from the interracial reaction between glass and chip gives high adhesion.

关键词： spherical copper powder flake copper powder chemical reduction BME-MLCC

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长链非编码RNA通过p38MAPK信号通路直接或间接影响骨质疏松症

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中国组织工程研究 2025年第1期29卷 175-184页

作者：覃浩亢腾刘钢贵州医科大学附属医院临床学院贵州省贵阳市550004 贵州医科大学附属医院骨科贵州省贵阳市550004

背景:近年来大量的研究发现长链非编码RNA参与骨质疏松症的发生和发展。p38MAPK信号通路参与骨髓间充质干细胞、成骨细胞以及破骨细胞的分化等过程而参与骨质疏松症的发展,而长链非编码RNA可通过影响p38MAPK信号通路,直接或间接参与骨... 详细信息

背景:近年来大量的研究发现长链非编码RNA参与骨质疏松症的发生和发展。p38MAPK信号通路参与骨髓间充质干细胞、成骨细胞以及破骨细胞的分化等过程而参与骨质疏松症的发展,而长链非编码RNA可通过影响p38MAPK信号通路,直接或间接参与骨质疏松症的发生及发展过程。目的:综述长链非编码RNA通过p38MAPK信号通路,直接或间接影响骨质疏松症的进展,为长链非编码RNA在骨质疏松症中预防和治疗提供一个新思路。方法:检索pubMed、中国知网和万方数据库的相关文献,以“长链非编码RNA,骨质疏松,间充质干细胞,成骨细胞,破骨细胞,p38信号通路”为中文检索词,以“long non-coding RNA,osteoporosis,mesenchymal stem cells,osteoblasts,osteoclast,p38 signaling pathway”为英文检索词,排除陈旧、重复以及可信度低的观点,将检索到的文献进行归纳、总结和分析,选取76篇具有代表性的文章。结果与结论:(1)长链非编码RNA通过多种途径参与骨质疏松症的防治,包括促进骨髓间充质干细胞的成骨分化、促进成骨细胞分化和成骨细胞分泌活性、抑制破骨细胞增殖和对骨的吸收作用,以及调节成骨相关细胞通路的激活或抑制,激活p38MAPK信号通路延缓骨质疏松症进展,抑制该信号通路抑制破骨细胞的吸收作用,从而影响骨质疏松的发生和发展。(2)相应长链非编码RNA的过表达或低表达会通过p38MAPK信号通路来影响成骨细胞和破骨细胞的增殖或分化,调节骨重塑过程,进而影响骨质疏松症的发生和发展。大量的基础研究结果显示,长链非编码RNA和p38MAPK信号通路或许可以成为骨质疏松症治疗中的潜在应用和临床转化价值;且相应的长链非编码RNA过表达或低表达慢病毒、转染质粒,相应的p38MAPK信号通路抑制剂等在体外细胞实验及动物模型中都被证实有靶向调控作用。(3)因此,通过靶向调控长链非编码RNA和p38MAPK信号通路来调节骨髓间充质干细胞的分化和功能,或通过长链非编码RNA和p38MAPK信号通路来抑制破骨细胞的增殖分化,或许能提供一种创新的治疗策略,可以延缓骨质疏松症的进展。

关键词：骨质疏松长链非编码RNA p38MAPK 间充质干细胞成骨细胞破骨细胞信号通路骨重塑雌激素双膦酸盐

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