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Chinese Science Bulletin 2008年第9期53卷 1450-1452页

作者： liu ping jin chunsheng zhang song han jiamao liu tungsheng Institute of Geology and Geophysics Chinese Academy of Science Beijing 100029 China

The anisotropy of magnetic susceptibility (AMS) is a rapid and precise tool for determining paleowind directions. During the past several decades, AMS has been used for determining paleowind directions of Chinese loess. The AMS for a loess-paleosol profile in early Quaternary at Longdan in the Linxia Basin, Gansu Province, northeastern fringe of Qinghai-Xizang (Tibetan) Plateau has been obtained. The primary results show that the AMS of the Longdan profile has its typical normal eolian dust deposit. The AMS is mainly controlled by magnetic foliation (F) and the shape parameter of the AMS ellipsoid is oblate. The declination of maximum susceptibility (K1) was used to determine the paleowind direction of that area in early Quaternary and it was found that the paleowind direction is biased towards NW-SE.

关键词：磁组构青藏高原风向古土壤

Gastrointestinal manifestations of critical ill heatstroke patients and their associations with outcomes:A multicentre,retrospective,observational study

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World Journal of Gastroenterology 2024年第4期30卷 346-366页

作者： Yu-Cong Wang Xin-Yang jin Zheng Lei Xiao-Jiao liu Yu liu Bang-Guo zhang Jian Gong Lie-Tao Wang Lv-Yuan Shi Ding-Yuan Wan Xin Fu Lu-ping Wang Ai-Jia Ma Yi-song Cheng jing Yang Min He Xiao-Dong jin Yan Kang Bo Wang Zhong-Wei zhang Qin Wu Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina School of Pharmacy Macao University of Science and TechnologyMacao 999078China Department of Critical Care Medicine The First People's Hospital of Ziyang CityZiyang 641399Sichuan ProvinceChina Department of Critical Care Medicine The First People's Hospital of Guanghan CityChengdu 618399Sichuan ProvinceChina Department of Critical Care Medicine Lezhi County Traditional Chinese Medicine HospitalChengdu 641599Sichuan ProvinceChina Department of Critical Care Medicine Chengdu Qingbaijiang District People's HospitalChengdu 610399Sichuan ProvinceChina Department of Critical Care Medicine Ziyang People's HospitalChengdu 641399Sichuan ProvinceChina

BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is *** study aimed to assess the incidence of GI symptoms associated with heatstroke and its impact on *** To assess the incidence of GI symptoms associated with heatstroke and its impact on *** Patients admitted to the intensive care unit(ICU)due to heatstroke were included from 83 *** history,laboratory results,and clinically relevant outcomes were recorded at ICU admission and daily until up to day 15,ICU discharge,or *** symptoms,including nausea/vomiting,diarrhoea,flatulence,and bloody stools,were *** characteristics of patients with heatstroke concomitant with GI symptoms were *** regression analyses were performed to determine significant predictors of GI *** A total of 713 patients were included in the final analysis,of whom 132(18.5%)patients had at least one GI symptom during their ICU stay,while 26(3.6%)suffered from more than one *** with GI symptoms had a significantly higher ICU stay compared with those *** mortality of patients who had two or more GI symptoms simultaneously was significantly higher than that in those with one GI *** logistic regression analysis revealed that older patients with a lower GCS score on admission were more likely to experience GI *** The GI manifestations of heatstroke are common and appear to impact clinically relevant hospitalization outcomes.

关键词： Extreme heat Flatulence Sunstroke Intensive care units Diarrhea

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong liu Zheng-Yao jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei Yang Rong liu han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao ping Cao Qi-ping Chen Zhen Chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai han Zi-Jie han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu han-Xiong Huang Wei-Hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie liu Shu-Bin liu Guang-Yuan Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui zhang Lin-Hao zhang Mo-han zhang Qi-Wei zhang Xian-Peng zhang Yu-Liang zhang Yue zhang Zhi-Yong zhang Mao-Yuan Zhao Lu-ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping WEI Hua FU Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei LI Qing-bo LI Shan-shan WANG Shi-dong DAI Fang liu Zhen-jie ZHAO Ling WEN Jian-xuan WU Li-yan ZENG Hui-yan zhang jin-ming LU Qi-yun HE liu song Wei SUN Lu LUO Lu-lu HE Jia-li XIE Wen-wen LIANG Qing-shun HUANG Yuan ZHU Sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai LI Chun-ji OUYANG Wen-wei LI Geng WU Ming-hui LI An-xiang HUANG jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(Phan those in the intervention group(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

青藏高原地区绿色全要素生产率时空分异与驱动机理

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长江流域资源与环境 2024年第6期33卷 1182-1196页

作者：刘庆芳谢佳亮张先甜吴卫宋金平杨显明北京师范大学地理科学学部北京100875 华南理工大学旅游管理系广东广州510006 湖南师范大学旅游学院湖南长沙410081 湖南财政经济学院湖南省经济地理研究所湖南长沙410205 青海师范大学地理科学学院青海西宁810016

提高绿色全要素生产率是促进青藏高原地区经济社会高质量发展的重要举措。基于2000~2019年青藏高原地市州面板数据,综合运用全域Malmquist-Luenberger指数、非参数Kernel核密度估计、空间马尔科夫链和面板分位数回归等方法,分析青藏高... 详细信息

提高绿色全要素生产率是促进青藏高原地区经济社会高质量发展的重要举措。基于2000~2019年青藏高原地市州面板数据,综合运用全域Malmquist-Luenberger指数、非参数Kernel核密度估计、空间马尔科夫链和面板分位数回归等方法,分析青藏高原地区绿色全要素生产率的时空演化特征及其驱动机理。结果表明:(1)研究期内,青藏高原地区绿色全要素生产率的演化趋势相对稳定,在省区和地市州层面上均波动起伏,上下徘徊,呈现“多峰”波浪型集聚形态;(2)青藏高原地区地市州绿色全要素生产率空间分异的连续性和稳定性良好,在空间上存在跨越式转移的可能,并在连续转移过程中存在“马太效应”;(3)经济发展水平、产业结构和人口规模均能在不同水平上促进青藏高原地区绿色全要素生产率的提升,而城镇化进程的加速不利于绿色全要素生产率的增长。

关键词：高质量发展绿色全要素生产率全域Malmquist-Luenberger指数空间马尔科夫链青藏高原地区

超临界流体抗溶剂技术制备丹参酮ⅡA超细微粒

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中成药 2024年第7期46卷 2173-2177页

作者：雷华平彭超刘金花姚飞虹宋松泉唐翠芳费思恬张辉湘南学院药学院湖南郴州423000 湘南学院南岭现代种业研究院湖南郴州423000 湘南学院化学与环境科学学院湖南郴州423000

目的采用超临界流体抗溶剂技术制备丹参酮ⅡA超细微粒。方法以超临界CO_(2)为抗溶剂,采用扫描电镜、红外光谱、X射线衍射、热重、差示扫描量热分析对超细微粒进行表征,测定其溶解度和体外溶出度。结果超临界CO_(2)流体制备后,超细微粒... 详细信息

目的采用超临界流体抗溶剂技术制备丹参酮ⅡA超细微粒。方法以超临界CO_(2)为抗溶剂,采用扫描电镜、红外光谱、X射线衍射、热重、差示扫描量热分析对超细微粒进行表征,测定其溶解度和体外溶出度。结果超临界CO_(2)流体制备后,超细微粒粒度更集中,结晶度更高,化学结构和晶型未发生改变,溶出率增加至2.40倍。结论本实验为增加丹参酮ⅡA溶出、促进其吸收提供了一种新方法,具有良好的应用前景。

关键词：丹参酮ⅡA 超细微粒超临界流体抗溶剂技术 CO_(2)

Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke

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Frontiers of Medicine 2022年第3期16卷 429-441页

作者： Yao Chen Fahuan song Mengjiao Tu Shuang Wu Xiao He Hao liu Caiyun Xu Kai zhang Yuankai Zhu Rui Zhou Chentao jin ping Wang Hong zhang Mei Tian Department of Nuclear Medicine and Medical PET Center The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Institute of Nuclear Medicine and Molecular Imaging Zhejiang UniversityHangzhou 310009China Key Laboratory of Medical Molecular Imaging of Zhejiang Province Hangzhou 310009China Shanxi Medical University Taiyuan 030001China Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou 310027China College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhou 310027China Department of Radiology Zhejiang HospitalHangzhou 310030China Department of PET Center The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310006China

The local microenvironment is essential to stem cell-based therapy for ischemic stroke,and spatiotemporal changes of the microenvironment in the pathological process provide vital clues for understanding the therapeutic ***,relevant studies on microenvironmental changes were mainly confined in the acute phase of stroke,and long-term changes remain *** study aimed to investigate the microenvironmental changes in the subacute and chronic phases of ischemic stroke after stem cell ***,induced pluripotent stem cells(iPSCs)and neural stem cells(NSCs)were transplanted into the ischemic brain established by middle cerebral artery occlusion *** emission tomography imaging and neurological tests were applied to evaluate the metabolic and neurofunctional alterations of rats transplanted with stem *** proteomics was employed to investigate the protein expression profiles in iPSCs-transplanted brain in the subacute and chronic phases of *** with NSCs-transplanted rats,significantly increased glucose metabolism and neurofunctional scores were observed in iPSCs-transplanted *** proteomic data of iPSCs-transplanted rats identified a total of 39 differentially expressed proteins in the subacute and chronic phases,which are involved in various ischemic stroke-related biological processes,including neuronal survival,axonal remodeling,antioxidative stress,and mitochondrial function *** together,our study indicated that iPSCs have a positive therapeutic effect in ischemic stroke and emphasized the wide-ranging microenvironmental changes in the subacute and chronic phases.

关键词： ischemic stroke microenvironment induced pluripotent stem cells(iPSCs) positron emission tomography(PET) quantitative proteomics

Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3940-3954页

作者： Ting Gao Lin Zhu Hainan liu Xiaopeng zhang Tingting Wang Yangbo Fu Hongzhen Li Qincai Dong Yong Hu zhang zhang jing jin Zijing liu Weihong Yang Yaoning liu Yanwen jin Kaitong Li Yongjiu Xiao Junli liu Huailong Zhao Yue liu ping Li Jibo song Lu zhang Yuwei Gao Sisi Kang Shoudeng Chen Qingjun Ma Xiuwu Bian Wei Chen Xuan liu Qing Mao Cheng Cao Institute of Biotechnology Academy of Military Medical SciencesBeijing 100850China Institute of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230601China Beijing Key Laboratory of Bio-products Safety Assessment Joinn Laboratories(China)Co.LtdBeijing 100176China The 940th Hospital of the People’s Liberation Army LanzhouGansu 730050China Department of Gastroenterology the 960th Hospital of the People’s Liberation ArmyZiboShandong 255300China Academy of Military Medical Science of PLA 666 Liuyingxi StChangchun 130122China Molecular Imaging Center Guangdong Provincial Key Laboratory of Biomedical ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China First Affiliated Hospital Army Medical UniversityChongqing 400038China

Excessive inflammatory responses contribute to the pathogenesis and lethality of highly pathogenic human coronaviruses,but the underlying mechanism remains *** this study,the N proteins of highly pathogenic human coronaviruses,including severe acute respiratory syndrome coronavirus(SARS-CoV),middle east respiratory syndrome coronavirus(MERS-CoV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),were found to bind MASP-2,a key serine protease in the lectin pathway of complement activation,resulting in excessive complement activation by potentiating MBL-dependent MASP-2 activation,and the deposition of MASP-2,C4b,activated C3 and *** inflammatory lung injury was observed in mice infected with adenovirus expressing the N *** hyperactivation was also observed in SARS-CoV-2-infected *** blocking the N protein:MASP-2 interaction,MASP-2 depletion or suppressing complement activation can significantly alleviate N protein-induced complement hyperactivation and lung injury in vitro and in ***,these data suggested that complement suppression may represent a novel therapeutic approach for pneumonia induced by these highly pathogenic coronaviruses.

关键词： lung inflammation activation

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深圳市新生儿脑卒中多中心现况调查

中国当代儿科杂志 2024年第5期26卷 450-455页

作者：时莉秀冯晋兴韦艳芳路欣茹张雨茜杨林颖何胜男陈佩娟韩静陈诚涂惠英余章斌黄进洁曾淑娟陈晚铃刘颖郭燕平毛姣玉李晓东张谦慎谢治利黄梅英晏昆山应尔雅陈俊王艳荣刘亚萍宋波刘华艳肖晓冬唐红王宇娜蔡茵莎龙琦许汉强王会战孙倩韩芳张瑞彪杨传忠窦蕾时会菊王瑞蒋萍无深圳市儿童医院新生儿科广东深圳518034 深圳市宝安区妇幼保健院新生儿科广东深圳518101 深圳市龙岗区妇幼保健院/汕头大学医学院龙岗妇幼临床学院新生儿科广东深圳518172 深圳市人民医院/暨南大学第二临床医学院/南方科技大学第一附属医院新生儿科广东深圳518020 深圳市龙岗中心医院/广州中医药大学深圳临床医学院新生儿科广东深圳518116 北京大学深圳医院新生儿科广东深圳518036 华中科技大学协和深圳医院新生儿科广东深圳518052 香港大学深圳医院新生儿科广东深圳518053 深圳市龙岗区人民医院新生儿科广东深圳518172 深圳市南山区妇幼保健院新生儿科广东深圳518067 深圳市第三人民医院新生儿科广东深圳518112 深圳市龙华区中心医院新生儿科广东深圳518110 深圳市盐田区人民医院新生儿科广东深圳518081 深圳远东妇产医院新生儿科广东深圳518002 深圳市第二人民医院新生儿科广东深圳518025 陆丰市人民医院新生儿科广东陆丰516500 惠阳三和医院新生儿科广东惠州518200 惠州市第三人民医院新生儿科广东惠州516100 深圳市妇幼保健院新生儿科广东深圳518028 南方科技大学医院新生儿科广东深圳518055 深圳市罗湖区人民医院新生儿科广东深圳518005 深圳新生儿数据协作网

目的总结深圳市新生儿脑卒中发病率、临床特征及预后等情况,提高脑卒中新生儿的早期诊治能力。方法由深圳市儿童医院牵头,收集2020年1月—2022年12月深圳新生儿数据协作网组织21家单位收治的新生儿脑卒中36例,分析深圳市新生儿脑卒中发... 详细信息

目的总结深圳市新生儿脑卒中发病率、临床特征及预后等情况,提高脑卒中新生儿的早期诊治能力。方法由深圳市儿童医院牵头,收集2020年1月—2022年12月深圳新生儿数据协作网组织21家单位收治的新生儿脑卒中36例,分析深圳市新生儿脑卒中发病率、临床特征、治疗、预后等情况。结果深圳市21家医院2020、2021、2022年新生儿脑卒中的发病率分别为1/15137、1/6060、1/7704。缺血性脑卒中占75%(27/36),男性患儿占64%(23/36)。86%(31/36)的患儿在生后3d内起病,53%(19/36)以惊厥起病。颅脑影像学结果显示,22例(61%)大脑左侧发生梗死,13例(36%)基底节梗死;12例完成磁共振血管成像检查,9例(75%)累及大脑中动脉。29例患儿完成脑电图检查,21例(72%)出现尖波,10例(34%)出现电发作。不同医院对症支持治疗不同。12例(33%)完善新生儿行为神经测定评分,平均得分(32±4)分。共随访27例患儿12月龄左右的预后情况,44%(12/27)的患儿预后良好。结论新生儿脑卒中主要为缺血性脑卒中,多以惊厥为首发症状,多累及大脑中动脉,脑电图多出现尖波,神经发育评分较低,以对症支持治疗为主,部分患儿预后不良。

关键词：脑卒中多中心研究新生儿

Scedosporium apiospermum infection of the lumbar vertebrae:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3251-3260页

作者： Xue-Wen Shi Sheng-Tang Li jin-Peng Lou Bo Xu Jian Wang Xin Wang Hua liu song-Kai Li ping Zhen Tao zhang Orthopaedic Centers The 940^(th) Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Orthopaedic Centers The Clinical Medical College of Ningxia Medical UniversityYinchuan 750000Ningxia Hui Autonomous RegionChina Orthopaedic Centers The Second Clinical Medical College of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Orthopaedic Centers The Clinical Medical College of Gansu University of Traditional Chinese MedicineLanzhou 730000Gansu ProvinceChina

BACKGROUND Scedosporium apiospermum(***)is a clinically rare and aggressive fungus mainly found in contaminated water,wetlands,decaying plants,stagnant water,and potted plants in *** lung,bone,joint,eye,brain,skin,and other sites are easily infected,and there is a marked risk of *** have been few case reports of infection by *** of the lumbar vertebrae;most reports have focused on infection of the *** SUMMARY An otherwise healthy 60-year-old man presented with a 4-mo history of lumbosacral pain,stooping,and limited *** symptoms were significantly aggravated 10 d prior to hospitalization,and radiating pain in the back of his left lower leg developed,which was so severe that he could not *** of the lumbar spine was significantly limited,anterior flexion was about 30°;backward extension,right and left lateral curvature,and rotational mobility were about 10°;tenderness of the spinous processes of the lumbar 3-5 vertebrae was evident,and the muscle strength of both lower limbs was gradeⅣ.Imaging suggested bony destruction of the lumbar 3,4,and 5 vertebrae and sacral 1 vertebra;in addition,the corresponding intervertebral spaces were narrowed and the lumbar 5 vertebra was posteriorly displaced and *** vertebral infection was also noted,and the possibility of lumbar tuberculosis was *** first performed surgical intervention on the lesioned lumbar vertebrae,cleared the infected lesion,and performed stable fixation of the lesioned vertebral body using a lumbar internal fixation device,which restored the stability of the lumbar *** and pathological examination of the lesioned tissue removed during surgery confirmed *** infection of the lumbar vertebrae;on this basis,the patient was administered *** the 6-mo followup,efficacy was significant,no drug-related side effects were observed,and imaging examination showed no evidence of ***

关键词： Scedosporium apiospermum Lumbar vertebrae Fungal infection Treatment Voriconazole Case report