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Journal of Magnesium and Alloys 2024年第8期12卷 3325-3338页

作者： Xinze Lv liming liu Key Laboratory of Liaoning Advanced Welding and Joining Technology School of Materials Science and EngineeringDalian University of TechnologyDalian116024China

A series of Zn-xAl(x=0-35 wt.%)alloy filler metals were designed to join AZ31 Mg alloy to 6061 Al alloy by laser-TIG hybrid *** effect of Al content on the wettability of filler metals,microstructure evolution and strength of joint was *** results indicated that the strength of joints was improved with the increase of Al content in filler *** Zn-15Al filler was used,the ultimate fracture load reached the maximum of 1475.3 N/cm,which was increased by 28%than that with pure Zn *** reason is that the Al element acts as a"reaction depressant"in filler metal,which contributes to inhibiting the dissolution of Mg base metal and the Mg-Zn *** addition of appropriate quantity of Al element promoted the precipitation of Al-rich solid solution instead of Zn solid *** MgZn_(2) IMCs have lower lattice mismatch with Al solid solution than Zn solid solution,thus the strength of joints is ***,the excessive addition of Al caused the formation of brittle Mg32(Al,Zn)49 ternary compounds,leading to the deterioration of joint performance.

关键词： Laser-TIG hybrid welding Mg-Al dissimilar joint Intermetallic compounds Microstructure Fracture

Pharmacokinetics of monoclonal antibodies ]nd Fc-fusion proteins

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Protein & Cell 2018年第1期9卷 15-32页

作者： liming liu Department of Pharmacokinetics Pharrnacodynamics and Drug Metabolism MRL West Point PA 19486 USA

There are many factors that can influence the pharma- cokinetics （PK） of a mAb or Fc-fusion molecule with the primary determinant being FcRn-mediatad recycling. Through Fab or Fc engineering, IgG-FcRn interaction can be used to generate a variety of therapeutic anti. bodies with significantly enhanced half-life or ability to remove unwanted antigen from circulation, Glycosyla- tion of a mAb or *** protein can have a significant impact on the PK of these molecules, mAb charge can be important and variants with pl values of 1-2 unit difference are likely to impact PK with lower pl values being favorable for a longer ***. Most mAbs display target mediated drug disposition （TMOO）, which can have significant consequences on the study designs of preclinical and clinical studies. The PK of mAb can also be influenced by anti-drug antibody （ADA） response and *** binding, which require careful consideration during the discovery stage, mAbs are primarily absor- bed through the lymphatics via convection and can be conveniently administered by the subcutaneous （sc） route in large doses/volumes with co-formulation of hyaluronidase. The human PK of a mAb can be rea- sonably estimated using cynomolgus monkey data and allometric scaling methods.

关键词： monoclonal antibody (mAb) Fc-fusionprotein pharmacokineUcs FcRn target-mediated drugdisposition (TMDD) glycosylation anti-drug antibody (ADA)human PK prediction

Photoacoustic molecular imaging with functional nanoparticles

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Journal of Innovative Optical Health Sciences 2017年第4期10卷 17-28页

作者： liming liu Huan Qin Ministry of Education Key Laboratory of Laser Life Science and Institute of Laser Life Science College of Biophotonics South China Normal UniversityGuangzhou 510631P.R.China

Photoacoustic imaging(PAI)breaks through the optical di®usion limit by making use of the PA e®*** converting incident photons into ultrasonic waves,PAI combines high contrast of optical imaging and high spatial resolution in depth tissue of ultrasound imaging in a single imaging *** imaging modality has now shown potential for molecular imaging,which enables visualization of biological processes with systemically introduced functional *** the current review,the potentials of di®erent optical nanoprobes as PAI contrast agents were elucidated and discussed.

关键词： Photoacoustic imaging optical nanoprobes molecular imaging

Oxidation of Cr(Ⅲ) on birnessite surfaces: The effect of goethite and kaolinite

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Journal of Environmental Sciences 2015年第11期27卷 8-14页

作者： Laiyuan Zhong Jiewen Yang liming liu Baoshan Xing Department of Resources and Environmental Sciences College of Agriculture Guangdong Ocean University Stockbridge School of Agriculture University of Massachusetts Department of Land Resources Management College of Resources and Environmental Sciences China Agricultural University

Oxidation of Cr（Ⅲ） by manganese oxides may pose a potential threat to environments due to the formation of toxic Cr（Ⅵ） species. At present, it was still unclear whether the extent of Cr（Ⅲ） oxidation and fate of Cr（Ⅵ） would be changed when manganese oxides co-exist with other minerals, the case commonly occurring in soils. This study investigated the influence of goethite and kaolinite on Cr（Ⅲ） oxidation by birnessite under acidic p H condition（p H 3.5）and background electrolyte of 0.01 mol/L Na Cl. Goethite was found not to affect Cr（Ⅲ）oxidation, which was interpreted as the result of overwhelming adsorption of cationic Cr（Ⅲ） onto the negatively-charged birnessite（point of zero charge（PZC）〈 3.0） rather than the positively-charged goethite（PZC = 8.8）. However, more Cr（Ⅵ） would be retained by the surface with the increase in addition of goethite because of its strong ability on adsorption of Cr（Ⅵ） at low p H. Moreover, either Cr（Ⅲ） oxidation or distribution of the generated Cr（Ⅵ）between the solid and solution phases was not affected by kaolinite（PZC 〈 3.0）, indicating its low affinity for Cr species. Reactions occurring in the present mixed systems were suggested, which could be partly representative of those in the soils and further indicates that the mobility and risk of Cr（Ⅵ） would be decreased if goethite was present.

关键词： Cr(Ⅲ) oxidation Birnessite Goethite Kaolinite

Guaranteed cost control for saturated uncertain linear systems

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控制理论与应用（英文版） 2009年第4期7卷 400-404页

作者： Sheng liu liming ZHOU College of Automation Harbin Engineering University Harbin Heilongjiang 150001 China

In this paper, we discuss the problem of guaranteed cost control for uncertain linear systems subject to actuator saturation. Based on the quadratic and non-quadratic Lyapunov functions, sufficient conditions for the robust stability and performance are derived. Moreover, all the conditions can be expressed as linear matrix inequalities （LMIs） or bilinear matrix inequalities （BMIs） in terms of the feedback gain. Thus, the static controller can be effectively synthesized via convex optimization. A numerical example illustrates the effectiveness of the method.

关键词： Guaranteed cost control Uncertain linear systems Actuator saturation Quadratic Lyapunov function

Concentration-Dependent Effect of Nickel Ions on Amyloid Fibril Formation Kinetics of Hen Egg White Lysozyme:a Raman Spectroscopy Study

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Chinese Journal of Chemical Physics 2023年第5期36卷 517-525,I0001页

作者： Xinfei Li Xiaodong Chen Ning Chen liming liu Xiaoguo Zhou Shilin liu Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China

Nickel,an important transi-tion metal element,is one of the trace elements for hu-man body and has a crucial impact on life and *** evidences show the excess exposure to metal ions might be associated with neurological ***,we applied Raman spectroscopy to study the Ni(II)ion effect on kinetics of amyloid fibrillation of hen egg white lysozyme(HEWL)in thermal and acidic *** the well-known Raman indicators for protein tertiary and secondary structures,we monitored and analyzed the concentration effect of Ni(II)ions on the unfolding of tertiary structures and the transformation of sec-ondary *** experimental evidence validates the accelerator role of the metal ion in the ***,the additional analysis of the amide I band profile,combined with thioflavin-T fluorescence assays,clearly indicates the inhibitory effect of Ni(II)ions on the formation of amyloid fibrils with organizedβ-sheets ***,a more significant promotion influence is affirmed on the assembly into other aggregates with disordered *** present results provide rich information about the specific metal-mediated protein fibrillation.

关键词： Amyloid fibrillation Protein denaturation Kinetics Nickel ion Lysozyme

Distributed Virtual Inertia Based Control of Multiple Photovoltaic Systems in Autonomous Microgrid

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IEEE/CAA Journal of Automatica Sinica 2017年第3期4卷 512-519页

作者： Won-Sang Im Cheng Wang Wenxin liu liming liu Jang-Mok Kim Lehigh University IEEE ABB Inc. Pusan National University

The large inertia of a traditional power system slows down system's frequency response but also allows decent time for controlling the *** an autonomous renewable microgrid usually has much smaller inertia,the control system must be very fast and accurate to fight against the small inertia and *** reduce the demanding requirements on control,this paper proposes to increase the inertia of photovoltaic(PV) system through inertia *** inertia emulation is realized by controlling the charging/discharging of the direct current(DC)-link capacitor over a certain range and adjusting the PV generation when it is feasible and/or *** well designing the inertia,the DC-link capacitor parameters and the control range,the negative impact of inertia emulation on energy efficiency can be *** proposed algorithm can be integrated with distributed generation setting algorithms to improve dynamic performance and lower implementation *** studies demonstrate the effectiveness of the proposed solution.

关键词： Inertia emulation microgrid photovoltaic system renewable energy voltage source converter

Efficient synthesis of tyrosol from L-tyrosine via heterologous Ehrlich pathway in Escherichia coli

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Chinese Journal of Chemical Engineering 2022年第7期35卷 18-30页

作者： Xiaobo Ruan Sheng Zhang Wei Song Jia liu Xiulai Chen liming liu Jing Wu School of Pharmaceutical Science Jiangnan UniversityWuxi 214122China State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China Tianrui Chemical Co. LtdDepartment of ChemistryQuzhou 324400China

For the efficient conversion of L-tyrosine(L-Tyr)to tyrosol,which is an aromatic compound widely used in the pharmaceutical and chemical industries,a novel four-enzyme cascade pathway based on the Ehrlich pathway of Saccharomyces cerevisiae was designed and reconstructed in Escherichia ***,the expression levels of the relevant enzymes were coordinated using a modular approach and gene duplication after the identification of the pyruvate decarboxylase from Candida tropicalis(CtPDC)as the rate-limiting enzymatic *** situ product removal(ISPR)strategy with XAD4 resins was explored to avoid product inhibition and further improve tyrosol *** a result,the titer and conversion rate of tyrosol obtained were 35.7 g·L^(-1) and 93.6%,respectively,in a 3-L *** presented here provide a potential enzymatic process for industrial production of tyrosol from cheap amino acids.

关键词： Tyrosol L-tyrosine Ehrlich pathway Enzyme cascade In situ product removal

Preparation and performance analysis of a coking coal dust suppressant spray

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International Journal of Coal Science & Technology 2021年第5期8卷 1003-1014页

作者： Jiuhong Jiang Pengfei Wang Ye Pei Ronghua liu liming liu Yunchu He School of Resource Environment and Safety EngineeringHunan University of Science and TechnologyXiangtan 411201China Work Safety Key Lab On Prevention and Control of Gas and Roof Disasters for Southern Coal Mines Hunan University of Science and TechnologyXiangtan 411201China Hunan Jiujiu Environmental Protection Intelligent Co.Ltd Changsha 410000China

Coking coal dust is extremely hydrophobic;therefore,combination with droplets in the air is difficult and dust suppression is ***,a dust suppressant spray for coking coal dust was studied in order to improve of the combination of droplets and coking coal *** on monomer optimization and compounding analysis,two surfactant monomers,fatty alcohol ether sodium sulfate(AES)and sodium dodecyl benzene sulfonate(SDBS)were selected as the surfactant components of the dust *** surfactant monomers were combined with four inorganic salts and the reverse osmosis moisture absorption of each solution was *** combining the reverse osmosis moisture absorption values with the water retention experimental results,CaCl_(2)was identified as the optimal inorganic salt additive for the dust ***,the optimal concentration of each component was obtained using orthogonal experimental design i.e.,AES(0.03%),SDBS(0.05%),and CaCl_(2)(0.4%).The dust suppressant solution formulated using this method had a high moisture absorption capacity and excellent performance.

关键词： Coking coal Dust Spray Dust suppressant Surfactant Inorganic salt additive

Weighted Linear Loss Large Margin Distribution Machine for Pattern Classification

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Chinese Journal of Electronics 2024年第3期33卷 753-765页

作者： Ling liu Maoxiang CHU Rongfen GONG liming liu Yonghui YANG School of Electronic and Information Engineering University of Science and Technology Liaoning

Compared with support vector machine,large margin distribution machine(LDM) has better generalization *** central idea of LDM is to maximize the margin mean and minimize the margin variance *** the computational complexity of LDM is *** order to reduce the computational complexity of LDM,a weighted linear loss LDM(WLLDM) is *** framework of WLLDM is built based on LDM and the weighted linear *** weighted linear loss is adopted instead of the hinge loss in *** modification can transform the quadratic programming problem into a simple linear equation,resulting in lower computational ***,WLLDM has the potential to deal with large-scale *** WLLDM is similar in principle to the LDM algorithm,which can optimize the margin distribution and achieve better generalization *** WLLDM algorithm is compared with other models by conducting experiments on different *** results show that the proposed WLLDM has better generalization performance and faster training speed.

关键词： Training Support vector machines Pattern classification Transforms Fasteners Mathematical models Vectors