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UV-B irradiation enhances the accumulation of beneficial glucosinolates induced by melatonin in Chinese kale sprout

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Horticultural Plant Journal 2024年第4期10卷 995-1006页

作者： Mengyu Wang Jiansheng Wang Yuhe Yang Zhiqing Li Ghazala Mustafa Yubo Li lihong liu Zuofa Zhang Qiaomei Wang Zhejiang Academy of Agricultural Sciences Key Laboratory of Horticultural Plant Growth Development and Quality ImprovementMinistry of AgricultureDepartment of HorticultureZhejiang University Department of Plant Sciences Quaid-i-Azam University

Cruciferous sprout is a new form of vegetable product rich in bioactive compounds, especially glucosinolates. Previous studies have focused on increasing the accumulation of glucosinolates in cruciferous sprouts by applying different chemical regulators, with a particular focus on their contribution to nutritional quality and health benefits. Nevertheless, the effects of melatonin and UV-B irradiation on glucosinolate biosynthesis remain unclear. In this study, it was found that changes in melatonin concentrations significantly affected the contents of individual as well as total aliphatic and indolic glucosinolates. The 5 μmol · L-1melatonin was decided as the optimum concentration that could increase the content of beneficial glucosinolates including glucoraphanin and 4-methoxy glucobrassicin in Chinese kale sprouts. Notably, the enhancement of glucosinolate accumulation by melatonin treatment could be further amplified by UV-B irradiation. Furthermore, our results showed that R2R3-MYB transcription factor BoaMYB28 and BoaMYB51, which are central regulators of aliphatic and indolic glucosinolate biosynthesis respectively, were both involved in the regulation of glucosinolate biosynthesis by melatonin and UV-B irradiation. Additionally,the expression of glucosinolate biosynthetic genes, including BoaCYP79F1, BoaCYP83A1, BoaSUR1, BoaUGT74B1, BoaCYP79B2, BoaCYP79B3, and BoaCYP83B1 participated in the formation of core structures and BoaFMOGS-OX5, BoaAOP2, BoaCYP81F2, and BoaIGMT1 involved in the sidechain modification of aliphatic and indolic glucosinolate, was regulated by melatonin or UV-B irradiation. Taken together, these findings provide a potential strategy for improving the nutritional quality and resistance of Chinese kale sprouts.

关键词： Melatonin Chinese kale sprouts UV-B Glucosinolates Nutritional quality Second metabolism

Phase II study of novel orally PI3Kα/δinhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2193-2201页

作者： Huaqing Wang Jifeng Feng Yanyan liu Zhengzi Qian Da Gao Xuehong Ran Hui Zhou lihong liu Binghua Wang Meiyun Fang Hebing Zhou Zhenqian Huang Shi Tao Zhuowen Chen Liping Su Hang Su Yu Yang Xiaobao Xie Huijing Wu Ping Sun Guoyu Hu Aibin Liang Zhiming Li Department of Oncology Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China The Institute of Translational Medicine Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China Department of Medical Oncology Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009PR China Department of Medical Oncology Henan Cancer HospitalThe Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003PR China Department of Medical Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Hematology The Affiliated Hospital of Inner Mongolia Medical College010050 HohhotPR China Department of Hematology Weifang People’s HospitalThe First Affiliated Hospital of Weifang Medical University261000 WeifangPR China Department of Lymphoma&Hematology Hunan Cancer HospitalThe Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University410013 ChangshaPR China Department of Hematology The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital050011 ShijiazhuangPR China Department of Lymphoma Weihai Central Hospital264400 WeihaiPR China Department of Hematology and Rheumatology The Affiliated Zhongshan Hospital of Dalian University116001 DalianPR China Department of Hematology Beijing Luhe Hospital101199 BeijingPR China Department of Hematology The First Affiliated Hospital of Guangzhou Medical University510120 GuangzhouPR China Department of Hematology The First Affiliated Hospital of Hainan Medical College570102 HaikouPR China Department of Hematology The First People’s Hospital of Foshan528000 FoshanPR China Department of Hematology Shanxi Cancer Hospital030013 TaiyuanPR China Department of Lymphoma Senior Department of HematologyThe Fifth Medical Center of Chinese PLA General Hospital100039 BeijingPR China Department of Lymphoma and Head and Neck Cancer Fujian Cancer Hospital350014 FuzhouPR China Department of Hematology The First People’s Hospit

This registration study assessed clinical outcomes of TQ-B3525,the dual phosphatidylinositol-3-kinase(PI3K)α/δinhibitor,in relapsed and/or refractory follicular lymphoma(R/R FL).This phase II study(ClinicalTrials.gov NCT04324879.Registered March 27,2020)comprised run-in stage and stage 2.R/R FL patients after≥2 lines therapies received oral 20 mg TQ-B3525 once daily in a 28-day cycle until intolerable toxicity or disease progression.Primary endpoint was independent review committee(IRC)-assessed objective response rate(ORR).Based on results(ORR,88.0%;duration of response[DOR],11.8 months;progression-free survival[PFS],12.0 months)in 25 patients at run-in stage,second stage study was initiated and included 82 patients for efficacy/safety analysis.Patients received prior-line(median,3)therapies,with 56.1%refractory to previous last therapies;73.2%experienced POD24 at baseline.At stage 2,ORR was 86.6%(71/82;95%CI,77.3-93.1%),with 28(34.2%)complete responses.Disease control rate was 95.1%due to 7(8.5%)stable diseases.Median time to response was 1.8 months.Among 71 responders,median DOR was not reached;18-month DOR rate was 51.6%.with median follow-up of 13.3 months,median PFS was 18.5(95%CI,10.2-not estimable)months.Median overall survival(OS)was not reached by cutoff date;24-month OS rate was estimated as 86.1%.Response rates and survival data were consistent across all subgroups.Grade 3 or higher treatment-related adverse events were observed in 63(76.8%)cases,with neutropenia(22.0%),hyperglycemia(19.5%),and diarrhea(13.4%)being common.TQ-B3525 showed favorable efficacy and safety for R/R FL patients after≥2 lines prior therapies.

关键词： lymphoma assessed initiated

Separation of small molecular peptides with the same amino acid composition but different sequences by high performance liquid chromatography-electrospray ionization-mass spectrometry

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Science China Chemistry 2009年第12期52卷 2264-2268页

作者： liu lihong CHEN ZiLin Department of Pharmaceutical Analysis College of PharmacyWuhan UniversityWuhan 430072China

Peptidomics has emerged as a new discipline in recent years. Mass spectrometry (MS) is the most universal and efficient tool for structure identification of proteins and peptides. However,there is a limitation for the identification of peptides with the same amino acid composition but different se-quences because these peptides have identical mass spectra of molecular ions. This paper presents a high performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS) method for the separation of small molecular peptides with the same amino acid composition but dif-ferent sequences. Two tripeptides of Gly-Ser-Phe and Gly-Phe-Ser were used as a model sample. The separation behavior has been investigated and the separation conditions have been optimized. Under the optimum conditions,good repeatability was achieved. The developed method could provide a helpful reference for the separation of other peptides with the same amino acid composition but different sequences in the study of proteomics and peptidomics.

关键词： reversed-phase chromatography mass spectrometry peptides amino acid

Effects of Health Education with Problem-Based Learning Approaches on the Knowledge, Attitude, Practice and Coping Skills of Women with High-Risk Pregnancies in Plateau Areas

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Open Journal of Nursing 2024年第5期14卷 192-199页

作者： Ying Wu Suolang Sezhen Renqing Yuzhen Hong Wei Zhijuan Zhan Baima Hongying Yuhong Zhang lihong liu Department of Nursing Linzhi People&#8217s Hospital Linzhi China Department of Obstetrics and Gynecology Linzhi People&#8217s Hospital Linzhi China

Objective: Given the unique cultural background, way of life, and physical environment of the Tibetan Plateau, this study aims to investigate the effects of health education using problem-based learning (PBL) approaches on the knowledge, attitude, practice, and coping skills of women with high-risk pregnancies in this region. Methods: 76 high-risk pregnancy cases were enrolled at Tibet’s Linzhi People’s Hospital between September 2023 and April 2024. 30 patients admitted between September 2023 and December 2023 were selected as the control group and were performed with regular patient education. 46 patients admitted between January 2024 and April 2024 were selected as the observation group and were performed regular patient education with problem-based learning approaches. Two groups’ performance on their health knowledge, attitude, practice and coping skills before and after interventions were evaluated, and patient satisfaction were measured at the end of the study. Results: There was no statistical significance (P P P Conclusions: Health education with problem-based learning approaches is worth promoting as it can help high-risk pregnant women in plateau areas develop better health knowledge, attitude and practice and healthier coping skills. Also, it can improve patient sanctification.

关键词： Plateau Areas Patients with High-Risk Pregnancies Problem-Based Learning Health Education Health Knowledge Attitude and Practice Coping Skills

Cetyltrimethylammonium Bromide（CTAB）-Ionic Liquid Composite Modified Electrode for Sensitive Cyclic Voltammetric Determination of Bisphenol A

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Chemical Research in Chinese Universities 2016年第6期32卷 992-995页

作者： liu lihong WANG Chunfeng ZHUO Kelei Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals Key Laboratory of Green Chemical Media and Reactions Ministry of EducationSchool of Chemistry and Chemical Engineering Henan Normal University Xinxiang 453007 P. R. China

A sensitive electrochemical sensor for determining bisphenol A（BPA） was designed. The sensor was aglassy carbon electrode modified with the surfactant cetyltrimethylammonium bromide and the ionic liquid1-decyl-3-methylimidazolium tetrafluoroborate. The ability of the new sensor to measure BPA was investigated incyclic voltanmletry experiments. Under optimized conditions, the sensor gave a linear response range for BPA of2.19×10^-7 -3.28× 10^-5 mol/L and a detection limit of 7.31×10^8 mol/L（S/N=3） BPA could be determined with a lowerdetection limit, a wider linear range, and more sensitivity using the sensor than using other electrochemical sensors orhigh performance liquid chromatography with UV detection. The new sensor was used to determine BPA in tap waterwith recoveries of 97.5%--98.7% and a relative standard deviation 〈2.9%. The results show that the sensor can beused to determine trace BPA concentrations in tap water.

关键词： Bisphenol A Ionic liquid Surfactant Electrochemical sensor

Efficacy of an Yinyanghuo(Herba Epimedii Brevicornus)-Xianmao(Rhizoma Curculiginis)drug pair in a rat model of polycystic ovary syndrome

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Journal of Traditional Chinese Medicine 2021年第4期41卷 588-599页

作者： liu Chang liu lihong LI Nan XIU Aihui ZHANG Zhixing AI Hao Department of Gynecological Ward The Third Affiliated HospitalJinzhou Medical UniversityJinzhou 121000China Liaoning Provincial Key Laboratory of Follicle Development and Reproductive Health(Office of Science and Technology) Jinzhou 121000China Department of Gynecological Ward The First Affiliated HospitalJinzhou Medical UniversityJinzhou 121000China Department of Pathology College of Basic Medical ScienceJinzhou Medical UniversityJinzhou 121000China

OBJECTIVE:To identify active compounds in an Yinyanghuo(Herba Epimedii Brevicornus)-Xianmao(Rhizoma Curculiginis)drug pair(ECD)and investigate its efficacy on polycystic ovary syndrome(PCOS),and its possible mechanism in a rat model of PCOS.METHODS:A network pharmacology approach involving a characteristic drug assessment,active compound and target prediction,PCOS gene collection as well as network analysis was employed.The ovary morphology after treatment was observed using an animal model and western blotting and real-time PCR were used to verify AKT1 as the molecular target.RESULTS:Six networks were constructed,an active compound-target network for the ECD(C-T network),a drug-target network(D-T network),a related genes network,a targets interaction network,a key genes interaction network,and a gene-pathway network.A total of 41 compounds and 261 targets were identified for the ECD,232 PCOS-related genes,31 cogenes,and 14 pathways.These pathways may be involved in the efficacy of ECD on PCOS.The proteins most involved in the signal pathways for all targets were AKT1,IL6,INSR,ESR,and GSK3B.The AKT1 target was selected for experimental verification.Based on the Western blot and real-time PCR results,the expression of AKT1 in the PCOS model varied after treatment with ECD.CONCLUSIONS:Our findings suggest that the ECD can reverse the negative morphological changes in ovarian tissue that occur in model rats of PCOS.AKT1 may be a key mediator of the observed ability of the ECD to protect against PCOS in the model rats.

关键词： polycystic ovary syndrome Pharmacology Yinyanghuo(Herba Epimedii Brevicornus)Xianmao(Rhizoma Curculiginis)drug pair

基于数字技术的自然资源“一张蓝图”建设实践——以福建省南平市为例

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产业科技创新 2024年第2期6卷 39-43页

作者：刘利泓福建省地质测绘院福建福州350011

为了响应工程建设项目审批制度改革工作,为“多规合一”业务协同平台应用提供数据支撑,建设一个“发展目标、用地指标、空间坐标”相协调一致的“一张蓝图”是十分必要的。本文以南平市“一张蓝图”建设方式为研究对象,结合数据现状及... 详细信息

为了响应工程建设项目审批制度改革工作,为“多规合一”业务协同平台应用提供数据支撑,建设一个“发展目标、用地指标、空间坐标”相协调一致的“一张蓝图”是十分必要的。本文以南平市“一张蓝图”建设方式为研究对象,结合数据现状及数据特点,从数据库的标准规范建设、库体设计、数据整合、显示方案配置和服务发布等方面提出了具体建设措施。实践的结果表明,采用该方案建设的南平市“一张蓝图”基本满足建设项目空间落位审批的需求。

关键词：多规合一一张蓝图数据库资源目录数据整合

A New Example of Retrograde Solubility Model for Carbonate Rocks

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Acta Geologica Sinica(English Edition) 2017年第3期91卷 1145-1146页

作者： liu lihong WANG Chunlian WANG Daming WANG Haida Oil & Gas Survey China Geological Survey Oil and Gas Research Center School of Earth and Space SciencesPeking University MLR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological Sciences China Geological Survey

Objective The dissolution and precipitation of carbonate during burial diagenetic process controls the reservoir property in deep buried strata. The geological process related with it has become a research focus during recent years. The most important dissolution fluids to carbonates are probably H2S and CO2 as byproducts of sulfate reduction in deep-buried setting with sulfate minerals, but carbonates are more soluble in relatively low temperature, which is the so-called retrograde solubility. Several geological processes can result in the decrease of temperature, including the upward migration of thermal fluids and tectonic uplift.

关键词： of on with well A New Example of Retrograde Solubility Model for Carbonate Rocks for

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水平泥砂互层围岩隧道受力特性及稳定性分析

粉煤灰综合利用 2024年第2期38卷 58-63,102页

作者：刘立宏中铁第一勘察设计院集团有限公司陕西西安710043

水平层岩结构特殊,分布广泛,施工中极易发生离层、掉块等工程事故,分析互层状水平层岩隧道的受力特性和稳定性对于隧道设计和施工意义重大。从水平层岩的结构特点出发,对拱顶的离层及塌落拱的形成进行理论分析,建立简化的梁模型和薄板模... 详细信息

水平层岩结构特殊,分布广泛,施工中极易发生离层、掉块等工程事故,分析互层状水平层岩隧道的受力特性和稳定性对于隧道设计和施工意义重大。从水平层岩的结构特点出发,对拱顶的离层及塌落拱的形成进行理论分析,建立简化的梁模型和薄板模型,对水平互层围岩隧道受力特性和稳定性进行系统性对比分析,推导出了水平层岩可承受的最大正应力、最大剪应力和最大变形值表达式,较好的解释了拱顶水平层岩受力后的变形以及破坏过程。模型计算与现场实测、数值模拟结果,在量级与趋势上基本一致,显示出及时支护、控制拱部变形的重要性。

关键词：公路隧道水平层状围岩受力特性稳定性分析