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Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3493-3512页

作者： Longhao Cheng Xiaoxue Wang Aijun liu Ying Zhu Hu Cheng Jiangling Yu Lili Gong Honglin liu Guolin Shen lihong liu Institute of Clinical Medical Sciences ChinaeJapan Friendship HospitalCapital Medical UniversityBeijing 100029China Department of Pharmacy ChinaeJapan Friendship HospitalBeijing 100029China Beijing Chao-Yang Hospital Capital Medical UniversityBeijing 100020China Institute of Chemicals Safety Chinese Academy of Inspection and QuarantineBeijing 100020China

Amino acid metabolic remodeling is a hallmark of cancer,driving an increased nutritional demand for amino *** acids are pivotal for energetic regulation,biosynthetic support,and homeostatic maintenance to stimulate cancer ***,the role of phenylalanine in multiple myeloma(MM)remains ***,we demonstrate that phenylalanine levels in MM patients are decreased in plasma but elevated in bone marrow(BM)*** the treatment,phenylalanine levels increase in plasma and decrease in *** suggests that changes in phenylalanine have diagnostic value and that phenylalanine in the BM microenvironment is an essential source of nutrients for MM *** requirement for phenylalanine by MM cells exhibits a similar *** phenylalanine utilization suppresses MM cell growth and provides a synergistic effect with Bortezomib(BTZ)treatment in vitro and murine ***,phenylalanine deprivation induces excessive endoplasmic reticulum stress and leads to MM cell apoptosis through the ATF3eCHOPeDR5 *** with ATF3 significantly affects phenylalanine deprivation *** conclusion,we have identified phenylalanine metabolism as a characteristic feature of MM metabolic *** is necessary for MM proliferation,and its aberrant demand highlights the importance of lowphenylalanine diets as an adjuvant treatment for MM.

关键词： Multiple myeloma Phenylalanine Amino acid metabolism Nutrient deprivation Cancer therapy Endoplasmic reticulum stress ATF3 Apoptosis

UV-B irradiation enhances the accumulation of beneficial glucosinolates induced by melatonin in Chinese kale sprout

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Horticultural Plant Journal 2024年第4期10卷 995-1006页

作者： Mengyu Wang Jiansheng Wang Yuhe Yang Zhiqing Li Ghazala Mustafa Yubo Li lihong liu Zuofa Zhang Qiaomei Wang Zhejiang Academy of Agricultural Sciences HangzhouZhejiang 310021China Key Laboratory of Horticultural Plant Growth Development and Quality ImprovementMinistry of AgricultureDepartment of HorticultureZhejiang UniversityHangzhouZhejiang 310058China Department of Plant Sciences Quaid-i-Azam UniversityIslamabad 45320Pakistan

Cruciferous sprout is a new form of vegetable product rich in bioactive compounds,especially *** studies have focused on increasing the accumulation of glucosinolates in cruciferous sprouts by applying different chemical regulators,with a particular focus on their contribution to nutritional quality and health ***,the effects of melatonin and UV-B irradiation on glucosinolate biosynthesis remain *** this study,it was found that changes in melatonin concentrations significantly affected the contents of individual as well as total aliphatic and indolic *** 5μmol·L^(-1)melatonin was decided as the optimum concentration that could increase the content of beneficial glucosinolates including glucoraphanin and 4-methoxy glucobrassicin in Chinese kale ***,the enhancement of glucosinolate accumulation by melatonin treatment could be further amplified by UV-B ***,our results showed that R2R3-MYB transcription factor BoaMYB28 and BoaMYB51,which are central regulators of aliphatic and indolic glucosinolate biosynthesis respectively,were both involved in the regulation of glucosinolate biosynthesis by melatonin and UV-B ***,the expression of glucosinolate biosynthetic genes,including BoaCYP79F1,BoaCYP83A1,BoaSUR1,BoaUGT74B1,BoaCYP79B2,BoaCYP79B3,and BoaCYP83B1 participated in the formation of core structures and BoaFMOGS-OX5,BoaAOP2,BoaCYP81F2,and BoaIGMT1 involved in the sidechain modification of aliphatic and indolic glucosinolate,was regulated by melatonin or UV-B *** together,these findings provide a potential strategy for improving the nutritional quality and resistance of Chinese kale sprouts.

关键词： Melatonin Chinese kale sprouts UV-B Glucosinolates Nutritional quality Second metabolism

Phase II study of novel orally PI3Kα/δinhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2193-2201页

作者： Huaqing Wang Jifeng Feng Yanyan liu Zhengzi Qian Da Gao Xuehong Ran Hui Zhou lihong liu Binghua Wang Meiyun Fang Hebing Zhou Zhenqian Huang Shi Tao Zhuowen Chen Liping Su Hang Su Yu Yang Xiaobao Xie Huijing Wu Ping Sun Guoyu Hu Aibin Liang Zhiming Li Department of Oncology Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China The Institute of Translational Medicine Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China Department of Medical Oncology Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009PR China Department of Medical Oncology Henan Cancer HospitalThe Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003PR China Department of Medical Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Hematology The Affiliated Hospital of Inner Mongolia Medical College010050 HohhotPR China Department of Hematology Weifang People’s HospitalThe First Affiliated Hospital of Weifang Medical University261000 WeifangPR China Department of Lymphoma&Hematology Hunan Cancer HospitalThe Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University410013 ChangshaPR China Department of Hematology The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital050011 ShijiazhuangPR China Department of Lymphoma Weihai Central Hospital264400 WeihaiPR China Department of Hematology and Rheumatology The Affiliated Zhongshan Hospital of Dalian University116001 DalianPR China Department of Hematology Beijing Luhe Hospital101199 BeijingPR China Department of Hematology The First Affiliated Hospital of Guangzhou Medical University510120 GuangzhouPR China Department of Hematology The First Affiliated Hospital of Hainan Medical College570102 HaikouPR China Department of Hematology The First People’s Hospital of Foshan528000 FoshanPR China Department of Hematology Shanxi Cancer Hospital030013 TaiyuanPR China Department of Lymphoma Senior Department of HematologyThe Fifth Medical Center of Chinese PLA General Hospital100039 BeijingPR China Department of Lymphoma and Head and Neck Cancer Fujian Cancer Hospital350014 FuzhouPR China Department of Hematology The First People’s Hospit

This registration study assessed clinical outcomes of TQ-B3525,the dual phosphatidylinositol-3-kinase(PI3K)α/δinhibitor,in relapsed and/or refractory follicular lymphoma(R/R FL).This phase II study(*** *** March 27,2020)comprised run-in stage and stage 2.R/R FL patients after≥2 lines therapies received oral 20 mg TQ-B3525 once daily in a 28-day cycle until intolerable toxicity or disease *** endpoint was independent review committee(IRC)-assessed objective response rate(ORR).Based on results(ORR,88.0%;duration of response[DOR],11.8 months;progression-free survival[PFS],12.0 months)in 25 patients at run-in stage,second stage study was initiated and included 82 patients for efficacy/safety *** received prior-line(median,3)therapies,with 56.1%refractory to previous last therapies;73.2%experienced POD24 at *** stage 2,ORR was 86.6%(71/82;95%CI,77.3-93.1%),with 28(34.2%)complete *** control rate was 95.1%due to 7(8.5%)stable *** time to response was 1.8 *** 71 responders,median DOR was not reached;18-month DOR rate was 51.6%.with median follow-up of 13.3 months,median PFS was 18.5(95%CI,10.2-not estimable)*** overall survival(OS)was not reached by cutoff date;24-month OS rate was estimated as 86.1%.Response rates and survival data were consistent across all *** 3 or higher treatment-related adverse events were observed in 63(76.8%)cases,with neutropenia(22.0%),hyperglycemia(19.5%),and diarrhea(13.4%)being ***-B3525 showed favorable efficacy and safety for R/R FL patients after≥2 lines prior therapies.

关键词： lymphoma assessed initiated

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老年人体育融入数字化社会的问题与对策研究

体育与科学 2024年第03期45卷 103-109页

作者：刘利鸿刘晓侠湖南师范大学体育学院湖南软件职业技术大学人文素质教学部

近年来，我国大力推进体育的数字化建设。然而由于我国人口老龄化进程加快，老年人体育的数字化跟不上时代的快速发展，从而产生“数字鸿沟”,因此，找到帮助老年人体育更好地融入数字化社会的对策具有重要意义。文章运用德尔菲法、问... 详细信息

近年来，我国大力推进体育的数字化建设。然而由于我国人口老龄化进程加快，老年人体育的数字化跟不上时代的快速发展，从而产生“数字鸿沟”,因此，找到帮助老年人体育更好地融入数字化社会的对策具有重要意义。文章运用德尔菲法、问卷调查法等研究方法得出：相关的政策制度不够完善，需要进一步健全及完善；社会体育组织和社会体育指导员的作用发挥不够充分，急需发挥其带动作用；公共智能体育设施的供给是短板，急需加大对社区智能体育环境建设的投入，完善智能体育设施；相关智能产品的适老化设计质量不高，应在设计时充分考虑老年人群体的适用性及安全性；社会帮扶和数字化监控缺乏，亟待建立社会帮扶机构，健全老年人体育志愿者服务体系，搭建老年人体育数字平台。

关键词：老年人体育融入影响因素体系数字化智能化

Effects of Health Education with Problem-Based Learning Approaches on the Knowledge, Attitude, Practice and Coping Skills of Women with High-Risk Pregnancies in Plateau Areas

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Open Journal of Nursing 2024年第5期14卷 192-199页

作者： Ying Wu Suolang Sezhen Renqing Yuzhen Hong Wei Zhijuan Zhan Baima Hongying Yuhong Zhang lihong liu Department of Nursing Linzhi People&#8217s Hospital Linzhi China Department of Obstetrics and Gynecology Linzhi People&#8217s Hospital Linzhi China

Objective: Given the unique cultural background, way of life, and physical environment of the Tibetan Plateau, this study aims to investigate the effects of health education using problem-based learning (PBL) approaches on the knowledge, attitude, practice, and coping skills of women with high-risk pregnancies in this region. Methods: 76 high-risk pregnancy cases were enrolled at Tibet’s Linzhi People’s Hospital between September 2023 and April 2024. 30 patients admitted between September 2023 and December 2023 were selected as the control group and were performed with regular patient education. 46 patients admitted between January 2024 and April 2024 were selected as the observation group and were performed regular patient education with problem-based learning approaches. Two groups’ performance on their health knowledge, attitude, practice and coping skills before and after interventions were evaluated, and patient satisfaction were measured at the end of the study. Results: There was no statistical significance (P P P Conclusions: Health education with problem-based learning approaches is worth promoting as it can help high-risk pregnant women in plateau areas develop better health knowledge, attitude and practice and healthier coping skills. Also, it can improve patient sanctification.

关键词： Plateau Areas Patients with High-Risk Pregnancies Problem-Based Learning Health Education Health Knowledge Attitude and Practice Coping Skills

基于数字技术的自然资源“一张蓝图”建设实践——以福建省南平市为例

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产业科技创新 2024年第2期6卷 39-43页

作者：刘利泓福建省地质测绘院福建福州350011

为了响应工程建设项目审批制度改革工作,为“多规合一”业务协同平台应用提供数据支撑,建设一个“发展目标、用地指标、空间坐标”相协调一致的“一张蓝图”是十分必要的。本文以南平市“一张蓝图”建设方式为研究对象,结合数据现状及... 详细信息

为了响应工程建设项目审批制度改革工作,为“多规合一”业务协同平台应用提供数据支撑,建设一个“发展目标、用地指标、空间坐标”相协调一致的“一张蓝图”是十分必要的。本文以南平市“一张蓝图”建设方式为研究对象,结合数据现状及数据特点,从数据库的标准规范建设、库体设计、数据整合、显示方案配置和服务发布等方面提出了具体建设措施。实践的结果表明,采用该方案建设的南平市“一张蓝图”基本满足建设项目空间落位审批的需求。

关键词：多规合一一张蓝图数据库资源目录数据整合

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水平泥砂互层围岩隧道受力特性及稳定性分析

粉煤灰综合利用 2024年第2期38卷 58-63,102页

作者：刘立宏中铁第一勘察设计院集团有限公司陕西西安710043

水平层岩结构特殊,分布广泛,施工中极易发生离层、掉块等工程事故,分析互层状水平层岩隧道的受力特性和稳定性对于隧道设计和施工意义重大。从水平层岩的结构特点出发,对拱顶的离层及塌落拱的形成进行理论分析,建立简化的梁模型和薄板模... 详细信息

水平层岩结构特殊,分布广泛,施工中极易发生离层、掉块等工程事故,分析互层状水平层岩隧道的受力特性和稳定性对于隧道设计和施工意义重大。从水平层岩的结构特点出发,对拱顶的离层及塌落拱的形成进行理论分析,建立简化的梁模型和薄板模型,对水平互层围岩隧道受力特性和稳定性进行系统性对比分析,推导出了水平层岩可承受的最大正应力、最大剪应力和最大变形值表达式,较好的解释了拱顶水平层岩受力后的变形以及破坏过程。模型计算与现场实测、数值模拟结果,在量级与趋势上基本一致,显示出及时支护、控制拱部变形的重要性。

关键词：公路隧道水平层状围岩受力特性稳定性分析

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原料药生产车间防爆区净化系统施工关键技术

模具制造 2024年第7期24卷 255-257页

作者：刘丽红上海苏臻洁净科技有限公司上海200000

以江苏吉贝尔药业股份有限公司综合制剂车间一、二层净化及装饰装修和机电安装项目为例,阐述了无菌粉针剂原料药生产车间在空调系统安装和结构装修方面如何解决防爆区相对负压和生物安全问题。一方面对结构装修彩钢板安装的密闭性有更... 详细信息

以江苏吉贝尔药业股份有限公司综合制剂车间一、二层净化及装饰装修和机电安装项目为例,阐述了无菌粉针剂原料药生产车间在空调系统安装和结构装修方面如何解决防爆区相对负压和生物安全问题。一方面对结构装修彩钢板安装的密闭性有更高的要求,另一方面对净化空调系统的排风做了更高的过滤和防泄漏等保护措施。采用袋进袋出新型技术在末端,高效过滤器的更换过程中有效地避免了操作人员对过滤器的直接接触,从而降低了人员被感染的风险。

关键词：防爆无菌粉针剂袋进袋出过滤器安装

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电气火灾监控系统在地铁中的应用

电子技术（上海） 2024年第5期53卷 122-123页

作者：刘立鸿北京市轨道交通建设管理有限公司北京100086

阐述地铁电气火灾监控系统的设计,包括监控系统配置、剩余电流式和测温式电气火灾监控探测器的设计。从集中控制数据、电气线路实时监控方面,探讨电气火灾监控系统在地铁中的应用。

关键词：监控系统地铁工程探测器