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Overexpression of the Suaeda salsa SsNHX1 gene confers enhanced salt and drought tolerance to transgenic Zea mays

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Journal of Integrative Agriculture 2018年第12期17卷 2612-2623页

作者： HUANG Ying ZHANG Xiao-xia li Yi-hong DING Jian-zhou DU Han-mei zhao Zhuo ZHOU li-na liu Chan GAO Shi-bin CAO mo-ju LU Yan-li ZHANG Su-zhi Key Laboratory of Biology and Genetic Improvement of Maize in Southwest Region Ministry of Agriculture/Maize Research Institute Sichuan Agricultural University

Maize is one of the most important crops worldwide, but it suffers from salt stress when grown in saline-alkaline soil. There is therefore an urgent need to improve maize salt tolerance and crop yield. In this study, the SsNHX1 gene of Suaeda salsa, which encodes a vacuolar membrane na~+/H~+ antiporter, was transformed into the maize inbred line 18-599 by Agrobacterium-mediated transformation. Transgenic maize plants overexpressing the SsNHX1 gene showed less growth retardation when treated with an increasing naCl gradient of up to 1%, indicating enhanced salt tolerance. The improved salt tolerance of transgenic plants was also demonstrated by a significantly elevated seed germination rate(79%) and a reduction in seminal root length inhibition. moreover, transgenic plants under salt stress exhibited less physiological damage. SsNHX1-overexpressing transgenic maize accumulated more na~+ and K~+ than wild-type(WT) plants particularly in the leaves, resulting in a higher ratio of K~+/na~+ in the leaves under salt stress. This result revealed that the improved salt tolerance of SsNHX1-overexpressing transgenic maize plants was likely attributed to SsNHX1-mediated localization of na~+ to vacuoles and subsequent maintenance of the cytosolic ionic balance. In addition, SsNHX1 overexpression also improved the drought tolerance of the transgenic maize plants, as rehydrated transgenic plants were restored to normal growth while WT plants did not grow normally after dehydration treatment. Therefore, based on our engineering approach, SsNHX1 represents a promising candidate gene for improving the salt and drought tolerance of maize and other crops.

关键词： na^+/H^+ antiporter salt stress K^+/na^+ drought stress gene transformation

Comparative analysis of the clinical outcomes between wavefront-guided and conventional femtosecond LASIK in myopia and myopia astigmatism

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1581-1588页

作者： Xiao Gui Rui Zhang sha li na zhao Hao-Rui Zhang Yu-Kun Zhou Chen-Yang Huan Chun-Yan zhao Hong-Ying wang Hong-Yuan Song Wei Shen Jian-Hua Zhang Department of Ophthalmology the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

AIM:To compare the clinical outcomes of wavefront guided femtosecond LASIK(WFG LASIK)and conventional femtosecond LASIK(NWFG LASIK)in eyes with myopia and myopia ***:This was a retrospective,nonrandomized,comparative investigation enrolling 236 eyes of 122 patients(18-50 y)with low&moderate and high *** WFG group including 97 eyes(50 patients)undergone WFG LASIK and the NWFG group including 139 eyes(72 patients)undergone conventional *** efficacy index,high order aberrations(HOAs),pupil size and the quality of visual questionnaire were evaluated 6 mo ***:There is no difference between WFG group(-0.054±0.049 in logMAR)and NWFG group(-0.040±0.056)in uncorrected distance visual acuity(UDVA)*** myopia astigmatism is higher in WFG group than that in NWFG group(Pmei)in the WFG group(1.09±0.106)is better than that in the NWFG group(1.036±0.124;Plinical surgery,yet WFG group showed better visual quality using the questionnaire ***,high myopia would result in worse mei,HOAs and visual quality than low&moderate ***:WFG and NWFG FS-LASIK are both effective and safe procedures to correct low&moderate and high myopia,but WFG FS-LASIK gives a better postoperative mei,aberrometric control and predictable ***,WFG FS-LASIK is better than NWFG FS-LASIK in correction of myopia ***&moderate myopia allow better clinical outcomes than high myopia using any surgical method.

关键词： refractive surgery high order aberration visual quality wavefront-guided femtosecond LASIK

Estimated prevalence and sociodemographic correlates of mental disorders in medical students of Hebei Province,China:A crosssectional study

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World Journal of Psychiatry 2023年第5期13卷 215-225页

作者： Wen-Ting Lu Pei-Hua Hu na li Lan wang Ran wang Zeng wang mei Song Tian-Yu zhao Shi-Jie Guo Fan-Fan Huang Bu-Fan liu Ruo-Jia Ren li Yang Quan lin Yue-Hang Xu na Jin Huan Chen Yuan-Yuan Gao Zhi-feng Wu Guang-Yu Shi Da-Peng liu Zhong-Qi Pan Chun-Chao Du Cui-Xia An Xue-Yi wang Mental Health Center Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina Hebei Technical Innovation Center Mental Health Assessment and InterventionShijiazhuang 050031Hebei ProvinceChina Hebei Clinical Research Center of Mental Disorders Institute of Mental HealthShijiazhuang 050031Hebei ProvinceChina Counseling and Mental Health Research Center Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina Hebei Saitron Information Technology Co. LtdCangzhou 060000Hebei ProvinceChina

BACKGROUND In China,the identification rate and treatment rate of mental disorders are low,and there are few surveys on the prevalence of mental disorders among college students using diagnostic tools such as Mini-International Neuropsychiatric Interview(MINI),so the prevalence and treatment of mental disorders among college students are *** To estimate prevalence of mental disorders among medical students in Hebei Province,and provide guidance for improving their mental *** This was a cross-sectional study based on an Internet-based *** levels of medical students in Hebei Province were randomly selected(by cluster sampling)for *** the information network assessment system,the subjects scanned the 2D code with their mobile phones,clicked to sign the informed consent,and answered a scale.A self-designed general status questionnaire was used to collect information about age,gender,ethnicity,grade,and origin of *** MINI *** used to investigate mental *** analysis was performed with SPSS *** significant findings were determined using a two-tailed P value of *** A total of 7117 subjects completed the survey between October 11 and November 7,*** estimated prevalence of any mental disorders within 12 mo was 7.4%.mood disorders were the most common category(4.3%),followed by anxiety disorders(3.9%);15.0%had been to psychological counseling,while only 5.7%had been to a psychiatric consultation,and only 10%had received drug therapy in the past 12 *** Although the estimated prevalence of mental disorders in medical students is lower than in the general population,the rate of adequate treatment is *** determined that improving the mental health of medical students is an urgent matter.

关键词： Hebei sectional college

Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)

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Military Medical Research 2020年第3期7卷 249-282页

作者： Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin lin Cai Yu-feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu feng Xu Ming-li Tu li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang mei Zeng Yu Zhu Xin-Can liu Jian Yang Dong-Chi zhao Yu-feng Ding Ning Hou Fu-Bing wang Hao Chen Yong-Gang Zhang Wei li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun wang Yan-Jun Zhong Ming-Juan zhao Bing-Hui li lin-Lu Ma Hao Zi na wang yun-yun wang shao-Fu Yu Lu-Yao li Qiao Huang Hong Weng Xiang-Ying Ren li-sha Luo Man-Ru Fan Di Huang Hong-Yang Xue lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun li Zhen-Shun Cheng Xiao-mei Yao Xing-Huan wang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China national Clinical Research Center for Respiratory Diseases China-Japan Friendship HospitalBeijing 100029China Department of Pulmonary and Critical Care Medicine China-Japan Friendship HospitalBeijing 10029China Leishenshan Hospital in Wuhan Wuhan 430200China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institutes of Evidence-based Medicine and Knowledge Translation Henan UniversityKaifeng 475000HenanChina Department of Medical Imaging Guizhou Provincial People’s HospitalGuiyang 550002China Departments of Orthopedics Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China national Clinical Research Center for Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical Laboratory Peking Union Medical College Hospital(PUMCH)Peking Union Medical CollegeChinese Academy of Medical Sciences(CAMS)Beijing 100730China Center for Primary Health Care Research Lund University and Region Skåne25002 MalmöSweden Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 403371China Department of Allergology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 43071China Department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Emergency Medicine and Chest Pain Center Qilu Hospital of Shandong UniversityJinan 250002China Department of Respiratory and Critical Care Medicine Suizhou Central HospitalHubei University of MedicineSuizhou 441300HubeiChina Department of Clinic Pharmacy Second People’s Hospital of Huaihua Ci

The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the *** and treatment guidelines for clinicians caring for patients are *** the early stage,we have issued"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)";now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based *** formed a working group of clinical experts and *** steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge *** searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)*** were either strong or weak,or in the form of ungraded consensus-based ***,we issued 34 *** them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based *** covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung

关键词： COVID-19 SARS-CoV-2 Recommendation Chemoprophylaxis Diagnosis Treatment Discharge management Traditional Chinese medicine guideline

Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China

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Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： MA Yan ZHU Dong shan CHEN Ren Bo SHI nan nan liu Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang feng CHEN Hong CHEN li Ying feng Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao mei HU yun Hong HUANG Jin HUANG Qiu Hua HUANG shao Zhen JI liang JIN Hai Hao LEI Xiao li Chun Yan li Min Qing li Qun Tang li Xian Yong liu Hong De liu Jin Ping liu Zhang MA Yu Ting MAO Ya mo liu Fen na Hui wang Jing Wei SONG Fang li SUN Sheng wang Dong Ting wang Ming Xuan wang Xiao Yan wang Yin Zhen wang Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng li ZHANG Gong Qi ZHANG Jin Bo ZHANG lin Song zhao Shu Sen zhao Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min wang Yan Ping wang Yong Yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina Department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina Department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina Department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina Department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina Department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina Department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina Department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina Department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina Department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina Department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina Department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina Department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

Recognition for avian influenza virus proteins based on support vector machine and linear discriminant analysis

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Science China Chemistry 2008年第2期51卷 166-170页

作者： liANG Guizhao CHEN ZeCong YANG shanBin mei Hu ZHOU Yuan YANG li ZHOU Peng YANG ShengXi SHU Mao liAO ChunYang WU ShiRong li GenRong HE liu GAO JianKun Gan MengYu li DeJing CHEN GuoPing wang GuiXue LONG sha JING JuHua ZHENG Xiaolin ZENG Hui ZHANG QiaoXia ZHANG MengJun YANG Qi TIAN FeiFei TONG JianBo wang Jiaona liu YongHong li Bo QIU liangJia CAI shaoXi zhao na YANG Yan SU Xiali SONG Jian CHEN meiXia ZHANG XueJiao SUN JiaYing li JingWei CHEN GuoHua CHEN Gang DENG Jie PENG ChuanYou ZHU WanPing XU Luonan WU YuQuan liAO liMin li Zhi li Jun LU DaJun SU Qinliang HUANG ZhengHu ZHOU Ping li Zhiliang College of Chemistry and Chemical Engineering Chongqing UniversityChongqing 400044China Key Laboratory for Biomechanics and Tissue Engineering under Ministry of Education at Chongqing University Chongqing 400044China College of Bioengineering Chongqing UniversityChongqing 400044China Technology Centre for life Sciences and Biotechnology Singapore PolytechnicSingapore 139651Singapore

Total 200 properties related to structural characteristics were employed to represent structures of 400 HA coded proteins of influenza virus as training samples. Some recognition models for HA proteins of avian influenza virus (AIV) were developed using support vector machine (SVM) and linear discriminant analysis (LDA). The results obtained from LDA are as follows: the identification accuracy (Ria) for training samples is 99.8% and Ria by leave one out cross validation is 99.5%. Both Ria of 99.8% for training samples and Ria of 99.3% by leave one out cross validation are obtained using SVM model, respectively. External 200 HA proteins of influenza virus were used to validate the external predictive power of the resulting model. The external Ria for them is 95.5% by LDA and 96.5% by SVM, respectively, which shows that HA proteins of AIVs are preferably recognized by SVM and LDA, and the performances by SVM are superior to those by LDA.

关键词： avian influenza virus (AIV) HA protein support vector machine (SVM) linear discriminant analysis (LDA)

A comprehensive analysis of the Bencao(herbal)small Rna Atlas reveals novel Rna therapeutics for treating human diseases

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Science China(life Sciences) 2023年第10期66卷 2380-2398页

作者： Yinghao Cao Yexuan lin na Sun Xinyi Du Yixin Dong Song mei Xingyu Deng Xiaobei li shaoting Guo Kegong Tang Jiaqi liu Xiangyu Qiao Dandan zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song fengming Huang Xiaoyue wang Chengyu Jiang State Key Laboratory of Common Mechanism Research for Major Diseases Department of BiochemistryInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Key Laboratory of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of ChinaEngineering Research Center of Chinese Medicine Resource of Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Department of Traditional Chinese Medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100005China Hefei national Laboratory for Physical Sciences at the Microscale and School of life Sciences University of Science and Technology of ChinaHefei 230027China MRC Human Immunology Unit MRC Weatherall Institute of Molecular MedicineRadcliffe Department of MedicineUniversity of OxfordOxford OX37FZUK Chinese Academy of Medical Sciences(CAMS) CAMS Oxford Institute(COI)Nuffield Department of MedicineUniversity of OxfordOxfordOX37FZUK shanghai Research Center for modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Target Discovery Institute Centre for Medicines DiscoveryNuffield Department of MedicineUniversity of OxfordOxfordOX37FZUK Department of Electrical Engineering and Computer Science and Christopher S.Bond Life Sciences CenterUniversity of MissouriColumbia MO 65211USA

Cross-kingdom herbal mi Rna was first reported in *** a modified herbal extraction protocol,we obtained 73,677,287sequences by Rna-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique *** constructed a Bencao(herbal)small Rna(s Rna)Atlas(http://***),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s *** profiles of 21,757 mi Rnas in the Atlas were highly consistent with those of plant mi Rnas in mi *** software tools,our results demonstrated that all human genes might be regulated by s Rnas from the Bencao s Rna Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s Rnas might be one of the main bioactive components of herbal *** established roadmaps for oligonucleotide drugs development and optimization of TCM ***,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical *** propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic *** Bencao s Rna Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine.

关键词： small Rna herbal decoction cross-kingdom regulation traditional Chinese medicine Rna oligonucleotide drug Rna therapeutics Bencao small Rna Atlas

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin liu Yue Huang Guang-Cheng Xiao Qing-Cui Bu Jin-Lu Qu Shu Zhang Shuang-nan Zhang Shu-mei Jia Fang-Jun Lu Xiang Ma lian Tao Wei Zhang li Chen li-Ming Song Ti-Pei li Yu-Peng Xu Xue-Lei Cao Yong Chen Cong-Zhan liu Ce Cai Zhi Chang Gang Chen Tian-Xiang Chen Yi-Bao Chen Yu-Peng Chen Wei Cui Wei-Wei Cui Jing-Kang Deng Yong-Wei Dong Yuan-Yuan Du Min-Xue Fu Guan-Hua Gao He Gao Min Gao Ming-Yu Ge Yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-Wei Han Jia Huo Lu-Hua Jiang Wei-Chun Jiang Jing Jin Yong-Jie Jin ling-Da Kong Bing li Cheng-Kui li Gang li Mao-Shun li Wei li Xian li Xiao-Bo li Xu-Fang li Yang-Guo li Zheng-Wei li Xiao-Hua liang Jing-Yuan liao Bai-Sheng liu Guo-Qing liu Hong-Wei liu Xiao-Jing liu Yi-Nong liu Bo Lu Xue-feng Lu Qi Luo Tao Luo Bin Meng Yi nang Jian-Yin Nie Ge Ou na Sai Ren-Cheng shang Xin-Ying Song liang Sun Ying Tan You-li Tuo Chen wang Guo-feng wang Juan wang ling-Jun wang Weng-Shuai wang Yu-Sa wang Xiang-Yang Wen Bai-Yang Wu Bo-Bing Wu mei Wu Shuo Xiao shao-lin Xiong He Xu Jia-Wei Yang Sheng Yang Yan-Ji Yang Yi-Jung Yang Qi-Bin Yi Qian-Qing Yin Yuan You Ai-mei Zhang Cheng-mo Zhang Fan Zhang Hong-mei Zhang Juan Zhang Tong Zhang Wan-Chang Zhang Wen-zhao Zhang Yi Zhang Yi-Fei Zhang Yong-Jie Zhang Yuan-Hang Zhang Yue Zhang zhao Zhang Zhi Zhang Zi-liang Zhang Hai-Sheng zhao Xiao-Fan zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou Jian-feng Zhou Yu-Xuan Zhu Ren-lin Zhuang Yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

Prediction of recurrence risk in early breast cancer using human epidermal growth factor 2 and cyclin A2

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Chinese Medical Journal 2010年第4期123卷 431-437页

作者： li Hui-ping JI Jia-fu HOU Kuan-yong LEI Yu-tao zhao Hong-mei wang Jing ZHENG Jie liu Jian-ying wang mo-pei XIAO Yu wang You-fan LU You-yong SUN Yan Department of Medical Oncology Peking University Third Hospital Beijing 100191 China Department of Surgery Peking University Third Hospital Beijing 100191 China Department of Pathology Department of SurgeryPeking University Third Hospital Beijing 100191 China Department of Surgery Peking University School of Oncology Beijing Cancer Hospital Beijing 100036 China Department of Medical Oncology Cancer Institute & Hospital Chinese Academy of Medical Sciences Beijing 100021 China

Background Human epidermal growth factor 2 （HER2） is one of the most important prediction factors, but only 25%-30% of breast cancer patients HER2 are positive. It is unknown whether there are other molecular markers that could be used to predict prognosis and recurrence in HER2 negative *** study investigated correlations of cyclin A2 and HER2 levels with clinical outcomes in 281 patients with invasive breast cancer in order to identify whether cyclin A2 can serve as a prognostic factor in HER2 negative patients. Methods Immunohistochemical staining was used to detect cyclin A2 and HER2 expression in 281 patients. Cyclin A2 and HER2 gene amplifications were analyzed using gene analysis and RT-PCR in 12 patients. Risk and survival estimates were analyzed using Log-rank, Kaplan-meier, and Cox regression analysis; cyclin A2 and HER2 consistency with survival were analyzed using Kappa analysis. Results Patients with higher cyclin A2 and HER2 expressions had significantly shorter disease-free survival periods （P=0.047 and P=-0.05, respectively）. Kappa analysis performed that cyclin A2 and HER2 showed a low Kappa index （kappa=0.37）, allowing us to conclude that cyclin A2 and HER2 detect different pathologies. Gene analysis and RT-PCR showed that cyclin A2 was upregulated in patients with early relapse; the average increase was 3.69-2.74 fold. Conclusions Cyclin A2 and HER2 are associated with proliferation and high recurrence, particularly when combined. Cyclin A2 is easily detected by nuclear staining and might be a useful biomarker for recurrence risk in HER2 negative patients.

关键词： breast neoplasms cyclin A2 human epidermal growth factor 2 prognosis