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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第3期11卷 191-201页

作者： li-hua LUO Hong liu Ping li hui WANG State Key Laboratory of Industrial Control Technology Zhejiang UniversityHangzhou 310027China

For automated vehicles,comfortable driving will improve passengers’ *** fuel consumption brings economic profits for car owners,decreases the impact on the environment and increases energy *** addition to comfort and fuel-economy,automated vehicles also have the basic requirements of safety and *** this purpose,an adaptive cruise control (ACC) algorithm with multi-objectives is proposed based on a model predictive control (MPC) *** the proposed ACC algorithm,safety is guaranteed by constraining the inter-distance within a safe range; the requirements of comfort and car-following are considered to be the performance criteria and some optimal reference trajectories are introduced to increase *** performances of the proposed ACC algorithm are simulated and analyzed in five representative traffic scenarios and multiple *** results show that not only are safety and car-following objectives satisfied,but also driving comfort and fuel-economy are improved significantly.

关键词： Adaptive cruise control (ACC) Multi-objectives Comfort Fuel-economy Model predictive control (MPC)

A Possible 456-Day Optical Period of OQ 530

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Chinese Journal of Astronomy and Astrophysics 2007年第3期7卷 380-388页

作者： Yi liu Juan li Jun-hui Fan Center for Astrophysics Guangzhou University Guangzhou 510006

The post-1994 observations of the blazar OQ 530 in optical BVRI bands, and radio observations at 22 GHz and 37 GHz were collected. The date compensated discrete Fourier transform （DCDFr） and CLEANest methods were used to search for possible periodicities. Two possible periods of 456±100 days and 258±29 days were found in the optical bands. The existence of possible correlations between the optical and radio emissions was investigated by means of discrete correlation function （DCF） analysis, and no significant correlation was found. Some possible mechanisms for the periodic variability are discussed.

关键词： galaxies active - BL Lacertae objects general - BL Lacertae objects indi-vidual OQ 530

Effect of herbicide acetochlor on cytochrome P450 monooxygenases and GST of earthworms Eisenia fetida

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Journal of Environmental Sciences 2006年第1期18卷 135-140页

作者： XIAO Neng-wen liu Xiang-hui li Wei GE Feng State Key Lab of Integrated Management of Pest Insects and Rodents Institute of Zoology Chinese Academy of Sciences Beijing 100080 China

To assess the sublethal toxicity of the herbicide acetochlor to earthworms and to find out biomarkers possible inducted under acetochlor exposure, Eiseniafetida was exposed to artificial soils supplemented with different concentrations of acetochlor（5, 10, 20, 40 and 80 mg/kg soil）. Effects of the acetochlor on cytochrome P450 monooxygenases p-nitroanisole O-demethylase（ODM）, aldrin epoxidase（AE） and glutathione-S-transferases （GSTs） activities were determined. The results revealed cytochrome P450 monooxygenases were elevated with increasing concentrations of acetochlor, and the AE activity increased significantly compared with control at the concentration of 80 mg/kg （P〈0.05）. However, ODM activity from E. fetida was not induced significantly by acetochlor at all treatments（P〉0.05）. Sodium dodecyl sulfate-polyacryamide gel electrophoresis（SDS-PAGE） showed that one protein band was visualized and no evident differences were found in protein profiles between treatments and control. The GST activity increased significantly with longer duration（P〈0.05） and increasing concentrations of acetochlor exposure（P〈0.05）. This study showed that the monooxygenases and GSTs activities in E. fetida could be induced by acetochlor, and thus, the AE and GST could be used in sublethal assays for soil contamination surveys and GST could be used as biomarkers of acetochlor exposure in E. fetida.

关键词： acetochlor Eiseniafetida p-nitroanisole O-demethylase aldrin epoxidase GST

FLUID CHARACTERISTICS OF ROTARY WING HEAT METER WITH SINGLE-CHANNEL

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Journal of Hydrodynamics 2008年第1期20卷 101-107页

作者： Du Guang-sheng liu Zheng-gang li li liu Yong-hui MA Yong-kun MENG liang School of Energy and Power Engineering Shandong University Jinan 250061China

Fluid characteristics of a rotary wing heat meter with single-channel were studied through theretical analysis, numerical simulation and experiments. The obtained results show that the number of vanes can obviously influence the heat meter, but the water temperature seldom influence the meter , and the optimal number of vane is 6-8.

关键词： heat meter numerical simulation meter

S100A4 siRNA Inhibits Human Pancreatic Cancer Cell Invasion In Vitro

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Biomedical and Environmental Sciences 2012年第4期25卷 465-470页

作者： li Na SONG Mao Min CHEN Xiao Hua liu li hui li Feng Sheng Department of General Surgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Academy of Military Medical Sciences Beijing 100850 China

Objective Pancreatic cancer is one of the most deadly cancers, which is characterized by its high metastatic potential. S100A4 is a major prometastatic protein involved in tumor invasion and metastasis which precise role in pancreatic cancer has not been fully investigated. We knocked down the S100A4 gene in the Bxpc-3 pancreatic cancer cell line via RNA interference to study the changes in cell behavior. Methods Real-time polymerase chain reaction and western blotting were used to detect mRNA and protein expression levels of S100A4, matrix metalloproteinase （MMP）-2, E-cadherin and thrombospondin （TSP）-I. Transwell chambers were used to detect the migration and invasion abilities; a cell adhesion assay was used to detect adhesion ability; colony forming efficiency was used to detect cell proliferation; flow cytometry was used to detect apoptosis. Results S100A4 mRNA expression was reduced to 17% after transfection with SIOOA4-siRNA, and protein expression had a similar trend, mRNA and protein expression of MMP-2 was reduced and that of E-cadherin and TSP-1 was elevated, indicating that S100A4 affects their expression. S100A4-silenced cells exhibited a marked decrease in migration and invasiveness and increased adhesion, whereas overall proliferation and apoptosis were not overtly altered. Conclusion S100A4 and its downstream factors play important roles in pancreatic cancer invasion, and silencing AIOOA4 can significantly contain the invasiveness of pancreatic cancer.

关键词： Pancreatic cancer S100A4 Matrix metalloproteinase-2 E-cadherin Thrombospondin-1 RNA interference

Resources allocation in an Intserv/Diffserv integrated EPON system

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The Journal of China Universities of Posts and Telecommunications 2009年第3期16卷 108-113,121页

作者： liu Qiong li hui JI Yue-feng QIAO Yao-jun Key Laboratory of Optical Communications and lightwave Technologies Beijing University of Posts and Telecommunications Beijing 100876 China

As one of the most promising next-generation access network （EPON） should pay more attention to its quality of service （QoS）, techniques, the user-oriented Ethernet passive optical network However, now the EPON adopts mostly differentiated services model （Diffserv） that only provides quality control on traffic aggregation, whereas, the quality of user session cannot be guaranteed when the network is overloaded with substantial connections. This article proposes to apply integrated services model （Intserv） in Diffserv-based EPON, which uses per-flow processing to guarantee QoS. In the simulation, a framework of combined Diffserv and Intserv model is employed in an EPON system, with a dynamic bandwidth allocation algorithm that adapts to it. The simulation results demonstrate that the EPON system with the combined models can provide more flexible, various control for user-oriented service quality.

关键词： QoS Intserv Diffserv resource reservation

Silencing of Bcl-2 gene expression by siRNA transfection in- hibits the protective effect of fluvastatin against cell apoptosis in human aortic endothelial cells

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Journal of Geriatric Cardiology 2008年第1期5卷 33-38页

作者： Wenwen Zhong Yang liu Jian li hui Tian Department of Geriatric Endocrinology Chinese PLA General HospitalBeijing 100853China Department of Geriatric EndocrinologyChinese PLA General HospitalBeijing 100853China Department of Geriatric EndocrinologyChinese PLA General HospitalBeijing 100853China Department of Geriatric EndocrinologyChinese PLA General HospitalBeijing 100853China

Objective To study the protective effect of fluvastatin,one of the HMG-CoA reductase inhibitors (statins),against oxygen radical-induced oxidative damages in human aortic endothelial cell,and the role of Bcl-2 in this *** Human aortic endothelial cells with or without Bcl-2 siRNA transfection were subjected to 1-100 nM of fluvastatin and 100 la hydrogen peroxide for 24 ***-2 mRNA and protein expression were measured by Taqman quantitative PCR and Western *** apoptosis was measured by normal and fluorescent microscopy and Cell Death Detection *** In the Bcl-2-expressed cells,fluvastatin significantly reversed hydrogen peroxide-induced microscopic apoptosis and apoptotic DNA fragmentation,which were accompanied by a markedly upregulation of Bcl-2 expression by ***,the endothelial protection by fluvastatin was completely lost in Bcl-2 siRNA transfected *** Fluvastatin protects human endothelial cells against oxygen radical-induced cell apoptosis in vitro,and this protection seemed to be mediated in a Bcl-2 dependent pathway.(J Geriatr Cardil 12008;5:33-38)

关键词： fluvastatin,Bcl-2,gene silencing,apoptosis

Electrostatic Levitation of Plant Seeds and Flower Buds

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Chinese Physics Letters 2012年第6期29卷 125-128页

作者： HU liang WANG Hai-Peng li liu-hui WEI Bing-Bo Department of Applied Physics Northwestern Polytechnical UniversityXi’an 710072

We report the electrostatic levitation of various kinds of seeds and flower *** berry and pepper near a spherical shape show a stable levitation *** prolate ellipsoid soybeau and flower buds are always “standing” in the free space with satisfactory levitation *** the irregular mushroom and wheat grain,the levitation state is characterized as a “top-heavy” *** special stable equilibrium states are proved by the analysis of surface charge *** obtained saturation polarization charge of samples presents a good accordance with experimental *** levitation ability is weighed by thefactor m(ε_(r) + 2) / (εrD^(2)).

关键词： grain charge electrostatic

Determination of risperidone in human plasma by HPLC-MS/MS and its application to a pharmacokinetic study in Chinese volunteers

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第2期9卷 114-120页

作者： Ming-zhu HUANG Jian-zhong SHENTU Jun-chun CHEN Jian liu hui-li ZHOU Research Center of Clinical Pharmaceutical Science the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

This study presents a rapid, specific and sensitive liquid chromatography/tandem mass spectrometry (LC-MS/MS) assay for determination of risperidone (RIS) in human serum using paroxetine as an internal standard (IS). An Alltima-C18 column (2.1 mm×100 mm, 3 μm) and a mobile phase consisting of 0.1% formic acid-acetonitrile (40:60, v/v) were used for separation. The analysis was performed by selected reaction monitoring (SRM) method, and the peak area of the m/z 411.3→191.1 transition for RIS was measured versus that of the m/z 330.1→192.1 transition for IS to generate the standard curves. The assay linearity of RIS was confirmed over the range 0.25～50.00 ng/ml and the limit of quantitation was 0.05 ng/ml. The linear range corresponds well with the serum concentrations of the analytes obtained in clinical pharmacokinetic studies. Intraday and interday relative standard deviations were 1.85%～9.09% and 1.56%～4.38%, respectively. The recovery of RIS from serum was in the range of 70.20%～84.50%. The method was successfully applied to investigate the bioequivalence between two kinds of tablets (test versus reference products) in 18 healthy male Chinese volunteers. The result suggests that two formulations are bioequivalent.

关键词： Risperidone High performance liquid chromatography-mass spectrometry (HPLC-MS) Pharmacokinetics

Gamma-aminobutyric acid promotes human hepatocellular carcinoma growth through overexpressed gamma-aminobutyric acid A receptor α3 subunit

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World Journal of Gastroenterology 2008年第47期14卷 7175-7182页

作者： Yan liu Yue-hui li Feng-Jie Guo Jia-Jia Wang Rui-li Sun Jin-Yue Hu Guan-Cheng li Tumor ImmunobiologyLaboratory of Cancer Research Institute Central SouthUniversity Chan~sha 410078 Hunan Province. China

AIM:To investigate the expression pattern of gamma-aminobutyric acid A(GABAA) receptors in hepatocellular carcinoma(HCC) and indicate the relationship among gamma-aminobutyric acid(GABA),gamma-aminobutyric acid A receptor α3 subunit(GABRA3) and ***:HCC cell line Chang,HepG2,normal liver cell line L-02 and 8 samples of HCC tissues and paired non-cancerous tissues were analyzed with semiquantitative polymerase chain reaction(PCR) for the expression of GABAA ***2 cells were treated with gamma-aminobutyric acid(GABA) at serial concentrations(0,1,10,20,40 and 60 μmol/L),and their proliferating abilities were analyzed with the 3-(4,5-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay,cell doubling time test,colon formation assay,cell cycle analysis and tumor planted in nude *** interfering RNA was used for knocking down the endogenous GABRA3 in *** abilities of these cells treated with or without GABA were ***:We identified the overexpression of GABRA3 in HCC *** of endogenous GABRA3 expression in HepG2 attenuated HCC cell growth,suggesting its role in HCC cell *** determined the in vitro and in vivo effect of GABA in the proliferation of GABRA3-positive cell lines,and found that GABA increased HCC growth in a dose-dependent ***,the addition of GABA into the cell culture medium promoted the proliferation of GABRA3-expressing HepG2 cells,but not GABRA3-knockdown HepG2 *** means that GABA stimulates HepG2 cell growth through ***:GABA and GABRA3 play important roles in HCC development and progression and can be a promising molecular target for the development of new diagnostic and therapeutic strategies for HCC.

关键词： Hepatocellular carcinoma Proliferation Gamma-aminobutyric acid Gamma-aminobutyric acid A receptor a3 subunit RNAi