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Up-conversion fluorescence biosensor for sensitive detection of CA-125 tumor markers

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Journal of Rare Earths 2019年第9期37卷 943-948,I0002页

作者： jingshi liu Sai Xu Liheng Sun Songtao Hu Jiao Sun Min liu Cui Ma Haipeng liu Ziqing Wang Ying Yang Biao Dong Decheng Hong College of Physics Jilin UniversityChangchun 130021China State Key Laboratory on Integrated Optoelectronics College o f Electronic Science and EngineeringJilin UniversityChangchun 130012China Department of Physics Dalian Maritime UniversityDalian 116026China Department of Cell Biology College of Basic Medical SciencesJilin UniversityChangchun 130021China Department of Radiation Oncology. The First Hospital Jilin UniversityChangchun 130021China

Sensitive and specific bioassays of tumor markers are critical for early cancer detection and *** recent years,lanthanide(Ln3+)doped upconversion nanoparticles(UCNPs)have attracted wide attentions in tumor markers detectio ***,we co mbined NaYF4:Yb,Tm and silver nanoparticles,serving as energy donor and receptor,respectively,to form an up-conversion fluorescence based inhibitory tumor marker biosensor *** tumor marker CA-125 molecules are labeled with silver NPs,and the energy transfer fluorescent signal can be detected between the UCNPs and the silver NP *** biosensor shows good stability,high sensitivity and selectivity in the tumor marker concentration range from 5 to 100 ng/mL,as well as a detection limit of 120 pg/*** to the advantage of ease of fabrication and operation,low cost and high information capacity,this technology holds great potential for the clinical applications.

关键词： NaYF4:Yb,Tm CA-125 molecules Silver NPs Energy transfer Good stability High sensitivity and selectivity

Hydrological Characteristics of the Rongbuk Glacier Catchment in *** Region in the Central Himalayas,China

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Journal of Mountain Science 2010年第2期7卷 146-156页

作者： liu Weigang REN Jiawen QIN Xiang liu jingshi liu Qiang CUI Xiaoqing WANG Yetang State Key Laboratory of Cryospheric Sciences Cold andArid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 10085 China

From 8 April to 11 October in 2005, hydrological observation of the Rongbuk Glacier catchment was carried out in the Mr. Qomolangma （Everest） region in the central Himalayas, China. The results demonstrated that due to its large area with glacier lakes at the tongue of the Rongbuk Glacier, a large amount of stream flow was found at night, which indicates the strong storage characteristic of the Rongbuk Glacier catchment. There was a time lag ranging from 8 to 14 hours between daily discharge peaks and maximum melting （maximum temperature）. As melting went on the time lag got shorter. A high correlation was found between the hydrological process and daily temperature during the ablation period. The runoff from April to October was about 80% of the total in the observation period. Compared with the discharge data in 1959, the runoff in 2005 was much more, and the runoff in June, July and August increased by 69%, 35% and 14%, respectively. The rising of temperature is a major factor causing the increase in runoff. The discharges from precipitation and snow and ice melting are separated. The discharge induced by precipitation accounts for about 20% of the total runoff, while snow and ice melting for about 80%.

关键词： Central Himalayas Mt. Qomolangma Rongbuk Glacier Hydrological characteristics

Monitoring Glacier and Supra-glacier Lakes from Space in Mt. Qomolangma Region of the Himalayas on the Tibetan Plateau in China

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Journal of Mountain Science 2009年第3期6卷 211-220页

作者： YE Qinghua ZHONG Zhenwei KANG Shichang Alfred Stein WEI Qiufang liu jingshi Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau Research Chinese Academy of Sciences (CAS) Beijing 100085 China State Key Laboratory of Remote Sensing Science Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University Beijing 100101 China International Institutefor Geo-Information Science and Earth Observation (ITC) PO Box 67500 AA Enschede The Netherlands

Because of the large number and remoteness, satellite data, including microwave data and optical imagery, have commonly been used in alpine glaciers surveys. Using remote sensing and Geographical Information System （GIS） techniques, the paper presents the results of a multitemporal satellite glacier extent mapping and glacier changes by glacier sizes in the Mt. Qomolangma region at the northern slopes of the middle Himalayas over the Tibetan Plateau. Glaciers in this region have both retreated and advanced in the past 35 years, with retreat dominating. The glacier retreat area was 3.23 km2 （or o.75 km^2 yr^-1 during 1974 and 1976, 8.68 km^2 （or 0.36 km^2 yr^-1 during 1976 and 1992, 1.44 km^2 （or 0.12 km^2 yr^-1） during 1992-2ooo. 1.14 km^2 （or 0.22 km^2 yr^-1 during 2000-2003, and 0.52 km^2 （or 0.07 km^2 yr^-1 during 2003-2008, respectively. While supra-glacier lakes on the debris-terminus of the Rongbuk Glacier were enlarged dramatically at the same time, from 0.05 km^2 in 1974 increased to 0.71 km^2 in 2008, which was more than 13 times larger in the last 35 years. In addition, glacier changes also showed spatial differences, for example, glacier retreat rate was the fastest at glacier termini between 5400 and 5700 m a.s.l than at other elevations. The result also shows that glaciers in the middle Himalayas retreat almost at a same pace with those in the western Himalayas.

关键词： Glacier lake Remote Sensing Mr. Qomolangma region Himalayas Tibetan Plateau

Editorial for the special issue in memoriam to *** Zichu

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Research in Cold and Arid Regions 2020年第6期12卷 I0001-I0004页

作者： ShiYin liu YongJian Ding ZhongQin Li Jiang Tong YinSheng Zhang jingshi liu WanChang Zhang Bo Sun Yu Sheng Li Ma ShiQiao Zhou Xin Wang Institute of International Rivers and Eco-security Yunnan UniversityEast of South Ring RoadChenggong DistrictKunmingYunnan 650500China Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences(CAS)LanzhouGansu 730000China Tianshan Glaciological Station/State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China Institute for Disaster Risk Management/School of Geographical Sciences Nanjing University of Information Science&TechnologyNanjingJiangsu 210044China Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100101China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China Polar Research Institute of China Shanghai 200136China State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China Sichuan Provincial Meteorological Service Chengdu 610072China School of Resource Environment and Safety EngineeringHunan University of Science and TechnologyXiangtanHunan 411201China

*** Zichu passed away on January 25,2020 in Changsha,Hunan Province,China at the age of 83 years *** one of the internationally renowned and highly respected glaciologists of China,this issue is dedicated with all respect in memory of him for his life-long effort and contribution to advance studies on glaciology in *** has undertaken field investigations on glacier mass balance.

关键词： glacier Hunan China.

氯诺昔康超前镇痛对胆道手术病人炎性细胞因子表达的影响

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中国现代医学杂志 2009年第22期19卷 3429-3431页

作者：刘景诗湖南省人民医院麻醉科湖南长沙410005

目的观察氯诺昔康超前镇痛对胆道手术病人炎性细胞因子表达的影响。方法选择择期行开腹胆道手术患者40例,随机分为L、H两组,每组20例。L组患者麻醉诱导前静注氯诺昔康8mg,术后以芬太尼行静脉给药病人自控镇痛(PCIA);H组患者关腹结束时... 详细信息

目的观察氯诺昔康超前镇痛对胆道手术病人炎性细胞因子表达的影响。方法选择择期行开腹胆道手术患者40例,随机分为L、H两组,每组20例。L组患者麻醉诱导前静注氯诺昔康8mg,术后以芬太尼行静脉给药病人自控镇痛(PCIA);H组患者关腹结束时静注氯诺昔康8mg,术后也以芬太尼行PCIA。于麻醉诱导前和关腹结束时(均未给予氯诺昔康前,分别记为术前与术后0h)、术后6h、24h4个时点抽取外周静脉血,测定血清炎性细胞因子包括促炎因子白细胞介素-2(IL-2)和白细胞介素-6(IL-6),抗炎因子白细胞介素-10(IL-10)。结果两组患者术前血清IL-2、IL-6浓度变化无显著差异(P>0.05),术后0、6及24h,H组IL-2、IL-6水平显著高于L组(P0.05),术后0、6及24h,H组IL-10水平明显低于L组(P<0.05)。结论术前使用较术后使用氯诺昔康镇痛能更有效地抑制术后炎性因子的分泌并促进抗炎因子的产生。

关键词：氯诺昔康超前镇痛炎性细胞因子

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拉萨河冬季径流对气候变暖和冻土退化的响应

地理学报 2006年第5期61卷 519-526页

作者：巩同梁刘昌明刘景时北京师范大学水科学研究院中国科学院青藏高原研究所北京100085

20世纪90年代以来,拉萨河流域的气温经历了10年升高0.54oC的气候变暖,这期间以秋冬季升温为主。在近40年(1963￣2004年)气候和28年(1976￣2004年)月径流数据的基础上,研究了具有多年冻土的高海拔拉萨河流域的冻土和水文响应。结果表明,... 详细信息

20世纪90年代以来,拉萨河流域的气温经历了10年升高0.54oC的气候变暖,这期间以秋冬季升温为主。在近40年(1963￣2004年)气候和28年(1976￣2004年)月径流数据的基础上,研究了具有多年冻土的高海拔拉萨河流域的冻土和水文响应。结果表明,冬季径流对11￣2月气温升高具有显著响应,在12￣2月份增加了16%,其中2月份增加22%。水热相关分析表明,10￣11月地表温度升高0.8￣0.9oC导致冬季河流水量增多,介于0.9￣1.5m深度的季节冻土深度和温度变化导致了径流量变化的响应。20世纪90年代的气候变暖使得多年冻土区的季节冻土深度萎缩了大约14cm,冻土区的冬季径流水文响应比气温更快、更显著。但冻土积雪观测的不足使冬季水文变化具有不确定性。

关键词：拉萨河冻土 Mann-Kendall检验气温冬季径流

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喜马拉雅山北坡卡鲁雄曲径流与气候变化

地理学报 2006年第11期61卷 1141-1148页

作者：张菲刘景时巩同梁王宏中国科学院青藏高原研究所北京100085 西藏自治区水文水资源局拉萨850000

以冰川融水补给为主的喜马拉雅山北坡的卡鲁雄曲流域,近20年平均气温以0.34oC/10a的趋势上升,高于西藏年均温0.26oC/10a的增长率,更是明显高于全国和全球气温的增长率,且极端最高温都出现在20世纪90年代。后10年气温(1994￣2003年)比前... 详细信息

以冰川融水补给为主的喜马拉雅山北坡的卡鲁雄曲流域,近20年平均气温以0.34oC/10a的趋势上升,高于西藏年均温0.26oC/10a的增长率,更是明显高于全国和全球气温的增长率,且极端最高温都出现在20世纪90年代。后10年气温(1994￣2003年)比前十年(1983￣1993年)升高0.5oC,径流量增加了26%;不同月份径流增加强度不同,10￣2月增加了44%,7￣9月增加了27%,3￣6月增加了24%。径流对气候变化的响应最灵敏(一年中有8个月的增加趋势通过了!=0.05的显著性检验),尤其是秋冬季的径流(增加趋势超过"=0.01的显著性检验)。受冰川消融和季风影响,不同时期的径流有不同的影响因素,但存在共性,即气温对径流起着积极主导作用,而降水对径流的影响具有不确定性,即正负双面效应。

关键词：水情气候变化 Mann-Kendall检验卡鲁雄曲西藏

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高水头水泵水轮机转轮的抗振防裂纹设计

机械工程学报 2013年第4期49卷 140-147页

作者：庞立军吕桂萍刘晶石贾伟哈尔滨大电机研究所水力发电设备国家重点实验室哈尔滨150040 哈动国家水力发电设备工程技术研究中心有限公司哈尔滨150040

流体激发转轮振动是目前高水头水泵水轮机稳定运行的关键问题之一。转轮的振动问题主要是由于活动导叶和转轮叶片之间形成的无叶区内不稳定流体相互作用所引发的水力激振在转轮上的力学响应。通过对叶栅干扰的产生机理分析,揭示了这种... 详细信息

流体激发转轮振动是目前高水头水泵水轮机稳定运行的关键问题之一。转轮的振动问题主要是由于活动导叶和转轮叶片之间形成的无叶区内不稳定流体相互作用所引发的水力激振在转轮上的力学响应。通过对叶栅干扰的产生机理分析,揭示了这种水力激振力的频率和振型决定于不同活动导叶数和转轮叶片数形成的叶栅组合方式,当转轮在水下的固有频率以及与之相对应的同相振型或反相振型同水力激振力发生耦合时,将会诱发转轮共振,并造成疲劳破坏。结果表明,选择最佳的叶栅组合可以最大限度地降低转轮发生共振的可能性,采用有限元法开展转轮结构的水下振动特性分析和控制局部高应力水平,以及保证良好的制造质量,可以有效提高转轮的抗振防裂纹能力。

关键词：水泵水轮机转轮水力激振叶栅干扰共振

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冲击式水轮机水斗高应力区结构优化及加工

机械工程学报 2015年第21期51卷 148-155页

作者：王波刘献礼刘晶石计伟翟元盛梁维燕哈尔滨理工大学机械动力工程学院哈尔滨150080 哈动国家水力发电设备工程技术研究中心有限公司哈尔滨150040 哈尔滨电气集团公司哈尔滨150040

水斗高应力区的结构优化和高品质加工是保证冲击式水轮机水力性能的关键。建立了水斗有限元模型,并确定合理的边界条件;根据机组运行特点,确定水斗计算载荷工况,以及应力考核标准。同时在满足水力性能及强度要求的前提下,充分考虑水斗... 详细信息

水斗高应力区的结构优化和高品质加工是保证冲击式水轮机水力性能的关键。建立了水斗有限元模型,并确定合理的边界条件;根据机组运行特点,确定水斗计算载荷工况,以及应力考核标准。同时在满足水力性能及强度要求的前提下,充分考虑水斗根部的可加工性。研究表明:斗根曲率均匀度、斗根深度和厚度是水斗应力水平的主要影响因素;通过水斗根部结构优化,水斗综合应力降低16%,交变应力幅值降低13.3%,交变应力平均值降低15.5%;通过强度计算验证了根部结构优化的水斗满足应力和疲劳设计要求。通过有限元和试验优化大长径比(20:1)减振刀柄中心孔尺寸,结果表明:当内孔直径为8 mm,振幅最小,通过试验验证和加工产品的实际应用,表明优化后的方案可满足设计结构水力性能及制造精度要求。

关键词：冲击式水轮机水斗有限元结构优化切削振动减振刀柄