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Microstructure and properties of aging Cu–Cr–Zr alloy

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Rare Metals 2014年第2期33卷 134-138页

作者： Kun wang Ke-fu liu jing-bo Zhang Institute of Electric Lighting Source Fudan University No.23 Research Institute China Electronics Technology Group Corporation No. 23 Research Institute China Electronics Technology Group Corporation

The crystallography and morphology of precipitate particles in a Cu matrix were studied using an aged Cu–Cr–Zr alloy by transmission electron microscopy（TEM） and high-resolution transmission electron microscopy（HRTEM）. The tensile strength and electrical conductivity of this alloy after various aging processes were tested. The results show that two kinds of crystallographic structure associated with chromium-rich phases, fcc and bcc structure, exist in the peak-aging of the alloy. The orientation relationship between bcc Cr precipitate and the matrix exhibits Nishiyama–Wasserman orientation relationship. Two kinds of Zr-rich phases（Cu4Zr and Cu5Zr）can be identified and the habit plane is parallel to {111}Cu plane during the aging. The increase in strength is ascribed to the precipitation of Cr- and Zr-rich phase.

关键词： Cu–Cr–Zr alloy Aging process Crystallography Morphology Strengthening mechanism

Feasibility of emergent transcatheter aortic valve replacement sequentially followed by cardiac computed tomography angiography:experience from the procedure

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Journal of Geriatric Cardiology 2023年第8期20卷 602-607页

作者： Dong-Kai SHAN bo JIANG Ze-Yu SUN jing wang Yun-Dai CHen Chang-fu liu Senior Department of Cardiology the Sixth Medical CentreChinese PLA General HospitalBeijingChina

Transcatheter aortic valve replacement(TAVR)has emerged as an effective alternative to surgical aortic valve replacement in symptomatic aortic stenosis(AS).^([1,2])Approximately one in five cases of AS are emergent with acute decompensation of cardiac function;^([3])therefore,emergent TAVR is an essential approach for severe AS patients with acute condition.

关键词： aortic acute stenosis

Effect of low intensity pulsed ultrasound on expression of TIMP-2 in serum and expression of mmp-13 in articular cartilage of rabbits with knee osteoarthritis

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Asian Pacific Journal of Tropical Medicine 2015年第12期8卷 1014-1019页

作者： jing-bo Ji Xue-fu Li Lei liu Guang-Zhong wang Xin-Feng Yan Department of bone and Joint Affiliated Qianfoshan Hospital of Shandong University Department of Orthopedics.Liaocheng No.3 Hospital

Objective:To study the effect of low intensity pulsed ultrasound(LIPUS) on the expression of tissue inhibitor of metalloproteinase-2(TIMP-2) in the serum and expression of matrix metallopeptidase 13(MMP-13) in the articular cartilage cells of rabbits with knee osteoarthritis(OA).Methods:Inner patellar ligament defect method was used to establish the model of knee *** weeks after the modeling,the arterial blood was drawn from the ear of each rabbit,while ELISA was employed to detect the expression of TIMP-2 in the *** chondrocytes were separated from animals in each group and then cultured in *** rabbits were divided into control group,OA model group and OA + LIPUS *** in the control and OA groups were not treated,while cells in the OA+ LIPUS group were treated with LIPUS(40 mW/cnr.1 time/day).Cells were collected 7 d later and the RNA and total protein were extracted ***-time PCR and Western blotting were employed to analyze the expression of MMP-13 in chondrocytes at the mRNA and protein level,***:The success rate of establishment of OA model was 83%.The results of ELISA showed that the content of TIMP-2 in the serum of animals with OA was 22.3%,lower than the one in the control group(Pent defect method is a mature method to establish the rabbit OA model,with high success *** expression of serum TIMP-2 in the OA model group is significantly *** can up-regulate TIMP-2 and down-regulate MMP-13.

关键词： Low intensity pulsed ultrasound Osteoarthritis TIM

Constitutive model for Ya'an mudstone based on mesoscopic breakage mechanism

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Journal of Mountain Science 2023年第4期20卷 1159-1169页

作者： HE Yun-yong CHen Cong wang fu-ming GUO Cheng-chao XIANG bo YU Di liu en-long DING Chun School of Civil engineering Southwest Jiaotong UniversityChengdu610031China Sichuan Highway Planning SurveyDesign and Research Institute LtdChengdu610041China State Key Laboratory of Hydraulics and Mountain River engineering College of Water Resources and HydropowerSichuan UniversityChengdu610065China School of Civil engineering Sun Yat-sen UniversityGuangzhou510275China Ya’an Transportation Construction Group Co. Ltd.Ya’an625000China

The slope stability of Ya’an expressway in Sichuan dominated by mudstone strata,is influenced greatly by both the mechanical properties and stressstrain relationship of *** this paper,the mechanical properties of the Ya’an mudstone samples under triaxial compression conditions were studied,based on an established constitutive model under the framework of breakage mechanics to simulate the mechanical properties of ***,triaxial compression tests and SEM tests at the confining pressures of 0.5 MPa,1.0 MPa,and 2.0 MPa were carried out on the mudstone samples,and it was found that the mudstone sample undergoes strain softening and dilatancy followed by the volumetric ***,based on analysis on the breakage mechanism of the above test results,we idealized the mudstone sample as a binary medium material consisting of the bonded elements and frictional elements,of which the bonded elements are composed of solid matrix and pores,and the frictional elements are composed of broken *** the loading process,the cementation between clay minerals and non-clay minerals in the mudstone sample is first destroyed,leading to the formation of micro-cracks within the particle aggregate,that is,the bonded elements are gradually damaged during the loading process and gradually turned into the frictional elements,and the two jointly bear the external *** bonded elements are composed of mudstone matrix and pores,which have the cementitious characteristics of mudstone,and the frictional elements are composed of the broken aggregate with the frictional characteristics of the broken *** on the homogenization theory,the constitutive model for the mudstone is established,and the determining method for model parameters is also ***,the results of the triaxial compression tests of the mudstone samples are predicted by the constitutive model proposed here,which can reflect the main mechanical properties of the mudstone samples.

关键词： Mudstone Breakage mechanism Constitutive model Strain softening Binary medium model

Syntheses and Liquid Crystal Properties of New Rare Earth Sandwich Type Heteropoly Compounds

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Chemical Research in Chinese Universities 1999年第4期15卷 364-366页

作者： BI Li-hua liu jing-hua wang en-bo HUANG Ru-dan YU Yong-zhang WU Ping-song Department of Chemistry Northeast Normal UniversityChangchun 130024P.R.China

Zinc oxide nanoparticles inhibit osteosarcoma metastasis by downregulatingβ-catenin via HIF-1α/BNIP3/LC3B-mediated mitophagy pathway

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Bioactive Materials 2023年第1期19卷 690-702页

作者： Guanping He jing-Jun Nie Xiao liu Zihao Ding Peng Luo Yu liu bo-Wen Zhang Renxian wang Xiaoguang liu Yong Hai Da-fu Chen Department of Orthopedics Beijing Chao-Yang HospitalCapital Medical UniversityBeijing100020China Laboratory of bone Tissue engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan HospitalBeijing100035China Department of Orthopedics Peking University Third HospitalBeijing100191China

Osteosarcoma(OS)therapy faces many challenges,especially the poor survival rate once metastasis ***,it is crucial to explore new OS treatment strategies that can efficiently inhibit OS *** nanoparticles such as zinc oxide nanoparticles(ZnO NPs)can efficiently inhibit OS growth,however,the effect and mechanisms of them on tumor metastasis are still not *** this study,we firstly prepared well-dispersed ZnO NPs and proved that ZnO NPs can inhibit OS metastasis-related malignant behaviors including migration,invasion,and epithelial-mesenchymal transition(EMT).RNA-Seqs found that differentially expressed genes(DEGs)in ZnO NP-treated OS cells were enriched in wingless/integrated(Wnt)and hypoxia-inducible factor-1(HIF-1)signaling *** further proved that Zn^(2+)released from ZnO NPs induced downregulation ofβ-catenin expression via HIF-1α/BNIP3/LC3B-mediated mitophagy *** NPs combined with ICG-001,aβ-catenin inhibitor,showed a synergistic inhibitory effect on OS lung metastasis and a longer survival *** addition,tissue microarray(TMA)of OS patients also detected much higherβ-catenin expression which indicated the role ofβ-catenin in OS *** summary,our current study not only proved that ZnO NPs can inhibit OS metastasis by degradingβ-catenin in HIF-1α/BNIP3/LC3B-mediated mitophagy pathway,but also provided a far-reaching potential of ZnO NPs in clinical OS treatment with metastasis.

关键词： Zinc oxide nanoparticle HIF-1α/BNIP3/LC3B-mediated mitophagy pathway Metastasis Osteosarcoma

Fabrication and Evaluation of Porous Keratin/chitosan(KCS) Scaffolds for Effectively Accelerating Wound Healing

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Biomedical and environmental Sciences 2015年第3期28卷 178-189页

作者： TAN Hong bo wang fu You DING Wei ZHANG Ying DING jing CAI Di Xin YU Kai fu YANG Jun YANG liu XU Yong Qing Department of Orthopedics Kunming General Hospital of Chinese People's Liberation Army Center for Joint Surgery Southwest HospitalThe Third Military Medical University Department of Clinical Laboratory Kunming General HospitalChinese People's Liberation Army

Objective To develop a dressing with desired antibacterial activity, good water maintaining ability and mechanical properties for wound healing and skin regeneration. Methods The chitosan with different concentrations were added in keratin solution to form porous keratin/chitosan（KCS） scaffolds. The morphological characteristics, chemical composition, wettability, porosity, swelling ratio and degradation of the scaffolds were evaluated. The antibacterial activity was tested by using S. aureus and E. coli suspension for 2 h. And L929 fibroblast cells culture was used to evaluate the cytotoxicity of the KCS scaffolds. Results The adding of chitosan could increase the hydrophobicity, decrease porosity, swelling ratio and degradation rate of the KCS porous scaffolds. Mechanical properties of KCS scaffolds could be enhanced and well adjusted by chitosan. KCS scaffolds could obviously decrease bacteria number. The proliferation of fibroblast cells in porous KCS patch increased firstly and then decreased with the increase of chitosan concentration. It was appropriate to add 400 μg/m L chitosan to form porous KCS scaffold for achieving best cell attachment and proliferation compared with other samples. Conclusion The porous KCS scaffold may be used as implanted scaffold materials for promoting wound healing and skin regeneration.

关键词： Keratin Chitosan Porous scaffold Wound healing Skin regeneration

PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4

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Journal of Molecular Cell Biology 2018年第2期10卷 147-160页

作者： Wenyong Long Wei Zhao bo Ning jing Huang Junjun Chu Linfeng Li Qianquan Ma Changsheng Xing Helen Y. wang Qing liu Rong-fu wang Department of Neurosurgery in Xiangya Hospital Central South University Changsha 410008 China Center for inflammation and Epigenetics Houston Methodist Research Institute Houston TX 77030 USA Key Laboratory of Stem Cells and Tissue engineering Ministry of Education Zhongshan School of Medicine Sun Yat-sen University Guangzhou 510080 China Institute Center for Molecular Design and Biomimetics The Biodesign Institute Arizona State University Tempe AZ 85287 USA Department of Microbiology and Immunology WeiU Cornell Medicine Cornell University New York NY 10065 USA Institute of Biosciences and Technology Texas A&M University Health Science Center Houston TX 77030 USA

The differentiation status of neuroblastoma （NB） strongly correlates with its clinical outcomes; however, the molecular mechanisms driving maintenance of sternness and differentiation remain poorly understood. Here, we show that plant homeodomain finger-containing protein 20 （PHF20） functions as a critical epigenetic regulator in sustaining stem cell-like phenotype of NB by using CRISPR/Casg-based targeted knockout （KO） for high-throughput screening of gene function in NB cell differentiation. The expression of PHF20 in NB was significantly associated with high aggressiveness of the tumor and poor outcomes for NB patients. Deletion of PHF20 inhibited NB cell proliferation, invasive migration, and stem ceU-Uke traits. Mechanistically, PHF20 interacts with poly（ADP-ribose） polymerase 1 （PARP1） and directly binds to promoter regions of octamer-binding transcription factor 4 （OCT4） and sex determining region Y-box 2 （SOX2） to modulate a histone mark associated with active transcription, trimethylation of lysine 4 on histone H3 protein subunit （H3K4me3）. Overexpression of OCT4 and SOX2 restored growth and progression of PHF20 KO tumor cells. Consistently, OCT4 and SOX2 protein levels in clinical NB specimens were positively correlated with PHF20 expression. Our results establish PHF20 as a key driver of NB stem cell-like properties and aggressive behaviors, with implications for prognosis and therapy.

关键词： PHF20 neuroblastoma PARP1 cancer stem cell-like traits epigenetic regulation

A high-throughput screening method for breeding Aspergillus niger with 12C6+ ion beam-improved cellulase

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Nuclear Science and Techniques 2017年第1期28卷 1-7页

作者： bo-Ling Jiang Shu-Yang wang Yu-Chen wang Ji-Hong Chen Wen-Jian Li jing liu Wei Hu Guo-Qing Xiao Miao-Ying Dong fu-Qiang Xu Institute of Modern Physics Chinese Academy of Sciences509 Nanchang Rd Lanzhou 730000 China University of Chinese Academy of Sciences No. 19A Yuquan Road Beijing 100049 China Lanzhou University 222 South Tianshui RoadLanzhou 730000 Gansu Province China Gansu Agricultural University Lanzhou 730000 Gansu Province China

In this study,a high-throughput screening method was established through the 24-square deep-well microliter plate(MTP) fermentation and micro-plate detection for large-scale screening of the *** was suitable for screening a large number of mutants and improving the breeding efficiency after heavy-ion beam *** strains showed higher cellulase activity compared with the initial strain after the screening of plate and MTP *** filter paper activity and β-glucosidase activity of Aspergillus niger H11201 had increased 38.74 and 63.23%separately compared with *** H11 by shaking flask fermentation,and it was genetically stable after being passaged to nine *** results indicate that the high-throughput screening method can be used for the quick breeding of *** with high cellulase activity.

关键词： High-throughput screening method Aspergillus niger H11 Cellulase 12C6+ ion beam