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Long-term outcomes of percutaneous coronary intervention for in-stent chronic total occlusion

Chinese Medical Journal 2021年第3期134卷 302-308页

作者： Ming-Lian Gong Yi Mao jing-hua liu Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseasesBeijing 100029China Department of Cardiology Fuwai HospitalChinese Academy of Medical SciencePeking Union Medical CollegeNational Center for Cardiovascular DiseaseBeijing 10037China

Background:The development of the technique has improved the success rate of percutaneous coronary intervention(PCI)for instent chronic total occlusion(IS-CTO).However,long-term outcomes remain *** present study sought to investigate long-term outcomes of PCI for ***:A total of 474 IS-CTO patients were enrolled at two cardiac centers from 2015 to 2018 *** patients were allocated into either successful or failed IS-CTO PCI *** primary endpoint(major adverse cardiac events[MACE])consisted of recurrent angina pectoris(RAP),target-vessel myocardial infarction(MI),heart failure,cardiac death,or ischemia-driven target-vessel revascularization(TVR)at *** Cox regression analysis was used to investigate the association between treatment appropriateness and clinical ***:A total of 367 patients were successfully treated with IS-CTO PCI while 107 patients had failed *** a median follow-up of 30 months(interquartile range:17-42 months),no significant difference was observed between the two groups for the following parameters:cardiac death(successful *** PCI:0.9%vs.2.7%;adjusted hazard ratio[HR]:1.442;95%confidence interval[CI]:0.21-9.887;P=0.709),RAP(successful *** PCI:40.8%vs.40.0%;adjusted HR:1.025;95%CI:0.683-1.538;P=0.905),heart failure(successful *** PCI:6.1%vs.2.7%;adjusted HR:0.281;95%CI:0.065-1.206;P=0.088),target-vessel related MI(successful *** PCI:1.5%vs.2.7%;adjusted HR:1.150;95%CI:0.221-5.995;P=0.868),MACE(successful *** PCI:44.2%vs.45.3%;adjusted HR:1.052;95%CI:0.717-1.543;P=0.797).More patients were free of angina in the successful IS-CTO PCI group compared with failed PCI in the first(80.4%vs.60%,P<0.01)and second years(73.3%vs.60.0%,P=0.02)following *** IS-CTO PCI had a lower incidence of MACE in the first and second years(20.2%vs.40.0%,P<0.01;27.9%vs.41.3%,P=0.023)compared with failed *** a median follow-up o

关键词： In-stent chronic total occlusion Percutaneous coronary intervention Predictive factor Prognosis

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Elastic Modulus of Fe72.5Ga27.5 Magnetostrictive Alloy

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Chinese Physics Letters 2010年第6期27卷 213-216页

作者： ZHU Xiao-Xi liu jing-hua JIANG Cheng-Bao School of Materials Science and Engineering Beihang University Beijing 100083

The elastic modulus of Fe72.5Ga27.5 magnetostrictive alloy is determined by testing ac impedance resonance frequency and first-principle calculations. The observed elastic modulus is 90.2 GPa for a directionally solidified sample and 103.4 GPa for a water-quenched sample tested in a dc magnetic field of 32. 7mT without compressive pre-stress. The bulk modulus by first-principles calculation is 179.3GPa which is basically consistent with the experimental result. The elastic modulus first increases and then decreases with increasing dc magnetic field, attributed to magnetostriction occurrence in the Fe72.5Ga27.5 alloy. The elastic modulus increases with increasing compressive pre-stress, resulting from the initial magnetic states change under the applied compressive pre-stress. The elastic modulus increases match well with the improved magnetostriction after quenching.

关键词： Elasticity Testing Testes Computers Alloys Magnetic field Sampling Fields District of Columbia Pressing

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Analysis of Renal Artery Stenosis in Patients with Heart Failure： A RASHEF Study

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Chinese Medical Journal 2015年第20期128卷 2777-2782页

作者： Bin Zheng Qin Ma Li-Hong Zheng Qiang Yong Yi-hua He jing-hua liu Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing 100029 China Department of Cardiology Jiaonan Jianyu Hospital Jiaozuo Henan 454000 China Department of Ultrasound Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing 100029 China

Background： Previous data are controversial about the association of renal artery stenosis （RAS） with clinical outcome in patients with heart failure. Definition of RAS in previous studies might not be appropriate. By definition of RAS with renal duplex sonography, we investigated the association of RAS with clinical outcome in patients with heart failure. Methods： In this retrospective study, we identified 164 patients with heart failure （New York Heart Association classification ≥11; left ventricular ejection fraction 〈50%） who had received renal duplex sonography during hospital stay. RAS was defined as renal-aortic ratio 〉3.5 or a peak systolic velocity ≥200 cm/s （or both）, or occlusion of the renal artery. Categorical data of patients were compared using the Chi-square test or Fisher＇s exact test. Cox proportional hazards regression modeling technique was used to investigate the prognostic significance of possible predictors. Results： Finally, 143 patients were enrolled, Median follow-up time was 32 months （1-53 months）. Twenty-two patients were diagnosed as RAS by renal duplex sonography, including 13 unilateral RAS （3 left RAS, l0 right RAS） and 9 bilateral RAS. There were more all-cause mortality and cardiovascular death in patients with RAS than patients without RAS. By multivariate analysis, RAS was a significant predictor for all-cause death and cardiovascular death （hazard ratio [HR] = 4.155, 95% confidence interval [（7/]： 1.546-1 1. 164, P = 0.005; and MR = 3.483, 95% CI： 1.200-10.104, P = 0.022, respectively）. As for composite endpoint events, including death, nonfatal myocardial infarction, ischemic stroke or intracranial hemorrhage, rehospitalization for cardiac failure, and renal replacement therapy, only angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker was significant predictor. RAS was not a significant predictor for composite endpoint events. Conclusions： Our data suggested that RAS is associated with a poorer clinical outc

关键词： Atherosclerosis Cardiac Dysfunction Heart Failure Renal Artery Stenosis

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通过Logstcs回归分析凶险性前置胎盘导致子宫切除的危险因素

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罕少疾病杂志 2024年第8期31卷 93-95页

作者：马琳刘华静刘艳丽徐芝灵商丘市第一人民医院河南商丘476100

目的通过Logistics回归分析凶险性前置胎盘导致子宫切除的危险因素。方法回顾性分析从2019年1月至2022年1月期间在我院就诊的凶险性前置胎盘患者184例根据患者子宫切除情况将患者分为切除组(n=68)与未切除组(n=116)分析切除组与为切除... 详细信息

目的通过Logistics回归分析凶险性前置胎盘导致子宫切除的危险因素。方法回顾性分析从2019年1月至2022年1月期间在我院就诊的凶险性前置胎盘患者184例根据患者子宫切除情况将患者分为切除组(n=68)与未切除组(n=116)分析切除组与为切除组患者临床资料。2.采用Logistics回归分析影响患者子宫切除的危险因素。3.分析危险因素在预测患者子宫切除的能效。结果单因素分析发现,人工流产次数,手术时间,术中出血量,术前预置球囊和胎盘植入程度是影响患者凶险性前置胎盘子宫切除的因素。多因素Logistics回归分析发现,人工流产次数,手术时间,术中出血量和术前预置球囊是影响凶险性前置胎盘患者子宫切除的独立危险因素(P<0.05)。各项指标单独预测的曲线下面积均为超过0.7,但是通过联合预测ROC曲线下面积为0.733。结论人工流产次数、手术时间、术中出血量和术前预置球囊是影响凶险性前置胎盘患者子宫切除的独立危险因素。

关键词： Logistics回归凶险性前置胎盘子宫切除危险因素

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轨道交通TOD导向下传统交通型基建企业参与城市更新模式探讨

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交通企业管理 2024年第5期39卷 92-94页

作者：刘景华向思怡姚苑平中交第四航务工程勘察设计院有限公司

轨道交通作为改善城市客运交通的方式,对优化城市空间格局,倡导紧凑、集约、混合的用地开发模式,提高城市土地开发效益具有重要作用。轨道交通建设与周边区域的融合发展,上海、北京、深圳、武汉、广州等国内一线城市都非常重视。与其他... 详细信息

轨道交通作为改善城市客运交通的方式,对优化城市空间格局,倡导紧凑、集约、混合的用地开发模式,提高城市土地开发效益具有重要作用。轨道交通建设与周边区域的融合发展,上海、北京、深圳、武汉、广州等国内一线城市都非常重视。与其他类型的城市更新相比,依托轨道交通建设的城市更新更多是通过交通设施布局对所在区域进行结构性功能优化,并结合轨道交通建设开发利用区域的地下空间。依托轨道交通建设进行城市更新,使城市片区更新周期明显缩短。

关键词：轨道交通 TOD 城市更新基建企业

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枸杞糖肽对角膜碱烧伤小鼠角膜炎症反应及愈合的作用及其机制研究

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中国现代医学杂志 2024年第11期34卷 34-42页

作者：闫雅蓉刘菁华颜鑫霖井雅朋李轩天津医科大学眼科临床学院天津300070 南开大学医学院天津300071 天津市眼科医院研究所(天津市眼科学与视觉科学重点实验室) 天津300020

目的探讨枸杞糖肽(LbGp)在角膜碱烧伤损伤愈合中的作用及其机制。方法根据治疗方式不同将45只健康、SPF级、6~8周、雄性C57BL/6J小鼠随机分为正常对照组(N组)、损伤对照组(PBS组)、LbGp治疗组(LbGp组),每组15只。PBS组和LbGp组小鼠右眼... 详细信息

目的探讨枸杞糖肽(LbGp)在角膜碱烧伤损伤愈合中的作用及其机制。方法根据治疗方式不同将45只健康、SPF级、6~8周、雄性C57BL/6J小鼠随机分为正常对照组(N组)、损伤对照组(PBS组)、LbGp治疗组(LbGp组),每组15只。PBS组和LbGp组小鼠右眼复制碱烧伤模型,采用点眼联合结膜下注射的方式分别给予PBS溶液或LbGp溶液(10 mg/mL)治疗。治疗后第3天采用裂隙灯显微镜及HE染色观察各组小鼠角膜上皮修复情况和角膜组织结构;实时荧光定量聚合酶链反应、Western blotting及免疫组织化学染色技术检测各组小鼠角膜组织NOD样受体热蛋白结构域相关蛋白3(NLRP3)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、髓过氧化物酶(MPO)的表达及核转录因子κB(NF-κB)的磷酸化水平。治疗后的第14天采用裂隙灯显微镜对角膜混浊程度进行评分,HE染色观察角膜组织结构。结果治疗后第3天LbGp组小鼠角膜上皮愈合速度快于PBS组(P<0.05)。N组、PBS组及LbGp组的NF-κB-p65、NLRP3、IL-1β及IL-6基因和蛋白相对表达量比较,差异均有统计学意义(P<0.05),PBS组均高于N组(P<0.05),LbGp组均低于PBS组(P<0.05)。LbGp组角膜基质中MPO染色阳性的中性粒细胞的浸润较PBS组减轻。治疗后第14天LbGp组小鼠角膜混浊评分低于PBS组(P<0.05)。结论LbGp治疗可以抑制小鼠角膜碱烧伤后NF-κB的激活及NLRP3、IL-1β的表达,从而减轻过度的炎症反应,促进小鼠角膜上皮再生及角膜结构恢复,有助于恢复角膜的透明性和完整性。

关键词：角膜碱烧伤炎症反应枸杞糖肽核转录因子κB NOD样受体热蛋白结构域相关蛋白3 白细胞介素-1β

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优化左心室收缩功能不全合并冠状动脉慢性完全闭塞患者介入治疗结局的研究进展

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中国介入心脏病学杂志 2024年第7期32卷 396-404页

作者：张宇超吴铮王韶屏柳景华首都医科大学附属北京安贞医院冠心病中心北京市心肺血管疾病研究所北京100029

冠状动脉慢性完全闭塞(CTO)病变是经皮冠状动脉介入治疗(PCI)领域极具挑战的病变之一。在接受CTO-PCI的患者中,左心室收缩功能不全(LVSD)较为常见,这类患者通常表现出更为复杂的冠状动脉病变以及较多合并症,面临更高的PCI相关并发症发... 详细信息

冠状动脉慢性完全闭塞(CTO)病变是经皮冠状动脉介入治疗(PCI)领域极具挑战的病变之一。在接受CTO-PCI的患者中,左心室收缩功能不全(LVSD)较为常见,这类患者通常表现出更为复杂的冠状动脉病变以及较多合并症,面临更高的PCI相关并发症发生风险,其血运重建临床获益亦存在争议。如何优化CTO-PCI策略及术后管理并改善患者结局,是当前亟待解决的问题。本文就LVSD合并CTO病变患者的临床特征、介入治疗获益、介入治疗策略、术后管理和近远期预后等方面进行综述,以期为优化LVSD合并CTO病变患者介入治疗的结局提供参考。

关键词：慢性完全闭塞左心室收缩功能不全经皮冠状动脉介入治疗

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Clinical factors associated with the number of gallbladder polyps

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Chinese Medical Journal 2020年第22期133卷 2751-2752页

作者： Wen-Juan Lu Chang-Sheng liu Hong-Yan Li Lan-Lan Zang Fan-Zhi Meng jing-hua liu Department of Laboratory Junan County People's HospitalLinyiShandong 276600China Department of Medical Examination Junan County People's HospitalLinyiShandong 276600China Central Laboratory Linyi People's HospitalLinyiShandong 276000China Department of Hepatobiliary Surgery Linyi People's HospitalLinyiShandong 276000China Prof.Cai's Laboratory Linyi People's HospitalLinyiShandong 276000China

Gallbladder polyps(GBPs),which are defined as a pathological change protruding from the gallbladder mucosa,are one of the main causes of hospital admission for *** incidence of GBPs is 4.2 to 9.5%in *** date,the etiology of GBPs has not yet been clearly *** to previous studies,metabolic status is strongly associated with GBPs.⑵A single polyp is more likely to exhibit a malignant transformation,and large(diameter greater than 10 mm)single polyps should be resected together with the entire ***,multiple polyps seem unlikely to ***,number of GBPs is an important factor that affects the treatment of ***,clinical factors associated w让h the number of GBPs are not completely understood;therefore,the aim of the current study is to investigate these factors.

关键词： gallbladder polyps Clinical

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Impact of primary percutaneous coronary intervention on blood perfusion in nonculprit artery in patients with anterior ST elevation myocardial infarction

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Chinese Medical Journal 2013年第1期126卷 22-26页

作者： WANG Jian liu jing-hua ZHENG Bin ZHANG Ming WANG Shao-ping ZHENG Ze Department of Cardiology Beijing Anzhen Hospital CapitalMedical University Beijing Institute of Heart Lung and VesselDiseases Beijing 100029 China

Background Recent studies have demonstrated that epicardial flow in nonculprit arteries, which has been assumed to be normal, was slowed in the setting of ST-elevation myocardial infarction （STEMI）. However, the impact of primary percutaneous coronary intervention （PCI） on blood perfusion in nonculprit arteries in patients with STEMI has not been clarified. The purpose of this study was to investigate the impact of primary PCI on blood perfusion in nonculprit arteries in patients with STEMI and correlated clinical factors. Methods A total of 117 patients with anterior wall STEMI, the culprit artery being the left anterior descending artery （LAD）, undergoing primary PCI （the study group） and 100 patients with normal coronary angiography （the control group） were enrolled. To observe the differences of corrected TIMI frame count （cTFC） and myocardial blush grade （MBG） before and after primary PCI in both culprit and nonculprit arteries, the left circumflex coronary artery （LCX）, cTFC and MBG in the LAD and LCX were measured in the study group and control group. The study group was divided into three groups; refiow in the culprit artery group （the R group）, no reflow in culprit artery group （the NR group）, and no reflow in both the culprit artery and nonculprit artery group （the NRB group） according to MBG grade. The level of serum C-reactive protein （CRP）, catecholamine, and fibroblast growth factor-21 （FGF21）were assayed. The clinical and angiographic characteristics were also analyzed. Results cTFC （28.1±24.3 vs. 20.3±19.3, P 〈0.05） and MBG in the LCX were different in the study group compared to the control group before primary PCI. cTFC （25.2±22.3 vs. 28.1±24.3, P 〈0.05） and the MBG level in the LCX were improved after successful primary PCI, but were not recovered to the normal level. Patients with no reflow in the culprit artery had a higher incidence of no-reflow in the nonculprit artery （78% vs. 19%, P 〈0.0001）, and the levels of CRP （（3.29±1.31） mg/dl vs. （2.5

关键词： ST elevation myocardial infarction nonculprit artery blood flow perfusion primary percutaneous coronary intervention

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Change of Inflammatory Factors in Patients with Acute Coronary Syndrome

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Chinese Medical Journal 2018年第12期131卷 1444-1449页

作者： Cai-Yun Ma Zhen-Ye Xu Shao-Ping Wang Hong-Yu Peng Fang liu jing-hua liu Feng-Xue Ren Department of Cardiology Aviation General Hospital Beijing 100016 China Department of Cardiology Beijing Daxing Hospital Capital Medical University Beijing 102600 China Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and-Blood Vessel Diseases Beijing 100029 China

Background： Acute coronary syndrome （ACS） is closely related to unstable plaques and secondary thrombosis. The inflammatory cells in plaques and their inflammatory products may be the cause for plaque instability and ruptures. The study aimed to disclose the changes of inflammatory factors including serum intracellular adhesion molecule-1（ICAM-1 ）, chitinase-3-like protein I （YKL-40）, and lipoprotein-associated phospholipase A2 （Lp-PLA2） in patients with ACS and its clinical significance. Methods： A total of 120 patients with coronary heart disease （CHD） were categorized into 2 groups： 69 with ACS and 51 with stable angina pectoris （SAP）： 20 patients with chest pain and normal angiography served as a control group. The 120 patients with CHD were categorized into single-vessel disease group, double-vessel disease group, and three-vessel disease group based on the number of coronary artery stenosis. The severity of coronary artery stenosis was quantified based on coronary angiography using Gensini score. They were further divided into mild CHD group with its Gensini score 〈26 （n = 36）, moderate CHD group with its Gensini score being 26-54 （n = 48） and severe CHD group with its Gensini score 〉54 （n = 36）. Serum levels of ICAM-1, YKL-40, and Lp-PLA2 of different groups were determined by enzyme-linked immunosorbent assay. Correlation between ICAM-1, YKL-40, Lp-PLA2, and Gensini score was analyzed. Results： The levels of serum inflammatory factors ICAM-1, YKL-40, and Lp-PLA2 were significantly higher in the ACS group than those in control group and SAP group （all P 〈 0.05）： and compared with control group, no significant difference was observed in terms of the serum ICAM-1, YKL-40, and Lp-PLA2 levels in the SAP group （P 〉 0.05）.The levels of serum ICAM-1, YKL-40, and Lp-PLA2 were not significantly different among control group, single-vessel disease group, double-vessel disease group, and three-vessel disease group （all P 〉 0.05）. The levels of serum ICAM-1, YKL-40, and

关键词： Acute Coronary Syndrome Chitinase-3-Like Protein 1 Coronary Heart Disease Intracellular Adhesion Molecule-1:Lipoprotein-Associated Phospholipase A2

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