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从“脑气络-病络”理论探析癫痫发作的病机及治疗

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北京中医药大学学报 2024年第8期47卷 1043-1048页

作者：孙田烨王凯悦阎明源黎莉莉刘金民北京中医药大学东方医院北京100078 北京中医药大学东直门医院

癫痫是由脑部神经元过度放电导致的中枢神经系统疾病,具有突然性、反复性及自限性的发作特点。脑气络与脑神经网络在结构及功能方面具有高度相关性和内在一致性,以脑气络结构功能异常导致脑气络不通为核心的“脑气络-病络”病机理论能... 详细信息

癫痫是由脑部神经元过度放电导致的中枢神经系统疾病,具有突然性、反复性及自限性的发作特点。脑气络与脑神经网络在结构及功能方面具有高度相关性和内在一致性,以脑气络结构功能异常导致脑气络不通为核心的“脑气络-病络”病机理论能够较全面地阐释癫痫发作的相关中医病机及疾病演变规律,具有重要的临床价值。本文以癫痫发作特点为切入点,基于“脑气络-病络”理论,认为痰气郁滞、脑气络动风、痰瘀互结滞损脑络,以及脑气络双向流通的结构功能特性是癫痫发作呈现突然性、反复性、自限性的关键因素。根据“络以通为用”理论,提出理气通络法应作为本病的治疗原则贯穿治疗全程,针对不同病理变化辅以化痰、祛瘀之法,同时,结合脏腑辨证,重视癫痫发作的伴随症状,调畅脑气络使风息痫止,以期为癫痫的中医证治提供参考。

关键词：癫痫脑气络病络发作特点病机

从获得性脑淀粉样血管病病机探讨“毒损脑络”的新内涵

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北京中医药大学学报 2024年第5期47卷 598-602页

作者：张帆刘佳霖姜俊辰张元馨陈俊龙刘金民北京中医药大学东方医院北京100078 北京中医药大学研究生院北京中医药大学东直门医院

获得性脑淀粉样血管病作为近年来发现的脑血管疾病,其传播途径与医源性因素相关。本文以获得性脑淀粉样血管病为研究对象,深入探讨王永炎院士提出的“毒损脑络”理论在中风病研究中的新应用及其深层含义。从“毒损脑络”的视角出发,综... 详细信息

获得性脑淀粉样血管病作为近年来发现的脑血管疾病,其传播途径与医源性因素相关。本文以获得性脑淀粉样血管病为研究对象,深入探讨王永炎院士提出的“毒损脑络”理论在中风病研究中的新应用及其深层含义。从“毒损脑络”的视角出发,综合分析获得性脑淀粉样血管病的发病原因及其病理机制,强调了外毒、伏毒和浊毒等在本病发病机制中的重要性,揭示了“毒损脑络”为获得性脑淀粉样血管病的核心病机,在此基础上,提出了“毒损脑络”的新内涵:一为“毒”既包括内毒也包括外毒,二为“毒损脑络”新内涵的具体延伸,指导了中风病理论研究、临床治疗、预防策略的完善,也促进对中风病的深层次理解。从“毒损脑络”认识获得性脑淀粉样血管病的方法不仅展现了中医学理论与现代生物医学的有效融合,也为临床诊治本病提供了思路与参考。

关键词：毒损脑络外毒获得性脑淀粉样血管病医源性脑淀粉样血管病脑淀粉样血管病

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基于病机十九条的癫痫辨治

中华中医药杂志 2024年第4期39卷 1769-1772页

作者：杨松仪王凯悦黎莉莉张宓刘金民北京中医药大学东方医院北京100078

癫痫是一种因神经元同步化异常放电所致的脑功能障碍性疾病,主要临床表现为突发的意识丧失、抽搐、肌强直等。病机十九条是中医病机辨治理论的基础,来源于《黄帝内经》,其内容与癫痫的临床诊疗有较强相关性。根据病机十九条原文,得出以... 详细信息

癫痫是一种因神经元同步化异常放电所致的脑功能障碍性疾病,主要临床表现为突发的意识丧失、抽搐、肌强直等。病机十九条是中医病机辨治理论的基础,来源于《黄帝内经》,其内容与癫痫的临床诊疗有较强相关性。根据病机十九条原文,得出以调节肝、脾、肾三脏为核心,结合风、湿、寒、火热病机,联合下焦共同对癫痫进行辨治的思路。适当应用上述理论有助于提高中医治疗癫痫的临床疗效。

关键词：病机十九条癫痫中医药《黄帝内经》病机辨证

Characterization of the prior particle boundaries in a powder metallurgy Ti2AlNb alloy

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Journal of Materials Science & Technology 2019年第11期35卷 2513-2525页

作者： Jinhu Zhang jinmin liu Dongsheng Xu Jie Wu Lei Xu Rui Yang Institute of Metal Research Chinese Academy of Sciences

Ti2 AlNb-based alloy powder metallurgy(PM)compacts were prepared via hot isostatic pressing(HIP)under relatively low temperature(920 and 980℃)and at certain pressure(130 MPa).The microstructure,composition and orientation of B2,α2 and O phases in the compacts were characterized and analyzed with an aim to investigate the effect of unsuitable HIPping parameters on the appearance of prior particle boundary(PPB),which seriously affects the mechanical properties of the *** results show that moreα2 phase is the characteristics of the PPB in Ti2AlNb-based alloy when HIPped at relatively low *** HIPping temperature to the upper part of the two-phase region can effectively inhibit the formation of *** backscatter diffraction measurements show the specific orientation relationship between phases,which helps us understand the origin of a2 and O phase and the corresponding transformation *** HIPping at a higher temperature can weaken the micro-texture intensity of theα2 and O phase due to the increase of misorientation in B2 ***α2 phase at cell wall keeps the Burgers orientation relationship(BOR)with the grain on one side,and does not satisfy the BOR with the *** is found that some O phase variants inside the cell HIPped at 980℃can only maintainα2-O OR withα2 owing to theα2→O phase transformation forming the O phase,while these O variants deviate from B2-O OR with B2 phase.

关键词： Powder metallurgy Titanium alloys Hot isostatic pressing Prior particle boundary(PPB) Microtexture Ti-22Al-24Nb-0.5Mo alloy

基于ThingsCloud平台的冷链监控系统设计与实现

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无线互联科技 2024年第15期21卷 93-96页

作者：刘金敏丁星晨郑书芳南京邮电大学通达学院江苏扬州225127

在冷链市场需求不断扩大的情况下,针对现阶段我国冷链物流管理技术面临着无统一数据系统支持、实时性差、监管脱节、无法进行预警、损失率大等问题,文章设计开发了一套冷链监控系统。该系统借助传感技术采集GPS、温湿度信息,采用MQTT通... 详细信息

在冷链市场需求不断扩大的情况下,针对现阶段我国冷链物流管理技术面临着无统一数据系统支持、实时性差、监管脱节、无法进行预警、损失率大等问题,文章设计开发了一套冷链监控系统。该系统借助传感技术采集GPS、温湿度信息,采用MQTT通信协议将采集数据上传至ThingsCloud云平台,通过云平台实现多个车载网关与中心监控端的数据交互,对冷藏车资源进行有效的跟踪定位和监测,为冷链物流创造了一种崭新的智慧管理和控制冷藏车辆资源的科学模式。

关键词：智慧冷链 ThingsCloud云平台 MQTT 实时监控

Petrogenesis of Shangyu gabbro-diorites in western Shandong:Geochronological and geochemical evidence

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Science China Earth Sciences 2008年第4期51卷 481-492页

作者： YANG ChengHai XU WenLiang YANG DeBin WANG Wei WANG WeiDe liu jinmin College of Earth Sciences Jilin UniversityChangchun 130061China Shandong Bureau of Geology and Mineral Resources Jinan 250013China

Chronology and geochemistry of the Shangyu gabbro-diorite in western Shandong were studied to understand their petrogenesis and the nature of the Mesozoic lithospheric mantle. The Shangyu intru-sion is mainly composed of a suite of gabbro-diorite. Zircons from the intrusion display eu-hedral-subhedral in shape and have high Th/U ratios (1.23―2.87), implying their magmatic origin. LA-ICP-MS zircon U-Pb dating results for two samples indicate that they were formed in the Early Cre-taceous, yielding weighted mean 206Pb/238U ages of 129±1Ma and 134±2Ma, respectively. Except for early cumulate such as sample QT-19, their SiO2 and MgO contents range from 50.12% to 56.37% and from 3.52% to 6.37%, respectively. Moreover, the gabbro-diorites are characterized by high Mg# (0.54―0.63), enrichment in Na (Na2O/K2O ratios more than 1), Cr (73×10-6―217×10-6) and Ni (34×10-6―241×10-6), and intensive enrichments in light rare earth elements (LREEs) and large ion lithophile elements (LILEs) and depletion in high field strength elements (HFSEs). Their initial 87Sr/86Sr ratios and ε Nd(t) values range from 0.70962 to 0.71081 and from-16.60 to-13.04, respectively. Taken together with the Early Creta-ceous high-Mg diorites and the mantle xenoliths from the Tietonggou and Jinling as well as basalts from the Fangcheng and Feixian, it is suggested that the primary magma for the Shangyu gab-bro-diorites should be derived from the enriched lithospheric mantle intensively modified by conti-nental crust. The Sr-Nd-Pb isotopic compositions for the Early Cretaceous high-Mg diorites in western Shandong display a trend of spatial variations, i.e., initial 87Sr/86Sr, 207Pb/204Pb and 208Pb/204Pb ratios de-creasing and ε Nd(t) values increasing from southeast to northwest in western Shandong, which is con-sistent with the tectonic model that the Yangtze Craton subducted beneath the North China Craton oriented in north-west direction in the Early Mesozoic.

关键词： High-Mg diorite geochemistry zircon U-Pb dating petrogenesis Mesozoic western Shandong

Using ultrasound to improve the sequential post-synthesis modification method for making mesoporous Y zeolites

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Frontiers of Chemical Science and Engineering 2020年第2期14卷 275-287页

作者： Rongxin Zhang Peinan Zhong Hamidreza Arandivan Yanan Guan jinmin liu Na Wang Yilai Jiao Xiaolei Fan Department of Chemical Engineering and Analytical Science School of EngineeringThe University of ManchesterManchesterM139PLUK Laboratory of Advanced Catalysis for Sustainability School of ChemistryThe University of SydneySydney 2006Australia Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Sino-Spanish Advanced Materials Institute Shenyang University of Chemical TechnologyShenyang 110142China Advanced Manufacturing Institute of Polymer Industry(AMIPI) Shenyang University of Chemical TechnologyShenyang 110142China Key Laboratory of Materials and Advanced Equipment for Resource Chemical Technology(Ministry of Education) Shenyang University of Chemical TechnologyShenyang 110142China

Mesoporous Y zeolites were prepared by the sequential chemical dealumination(using chelating agents such as ethylenediaminetetraacetic acid,H EDTA,and citric acid aqueous solutions)and alkaline desilication(using sodium hydroxide,NaOH,aqueous solutions)***,the ultrasound-assisted alkaline treatment(i.e.,ultrasonic treatment)was proposed as the alternative to conventional alkaline treatments which are performed under hydrothermal *** comparison with the hydrothermal alkaline treatment,the ultrasonic treatment showed the comparatively enhanced efficiency(with the reduced treatment time,i.e.,5 min vs.30 min,all with 0.2 mol·L NaOH at 65°C)in treating the dealuminated Y zeolites for creating *** example,after the treatment of a dealuminated zeolite Y(using 0.1 mol·L H EDTA at 100°C for 6 h),the ultrasonic treatment produced the mesoporous zeolite Y with the specific external surface area()of 160 m·g and mesopore volume()of 0.22 cm·g,being slightly higher than that by the conventional method(i.e.,=128 m·g and=0.19 cm·g).The acidic property and catalytic activity(in catalytic cracking of-octane)of mesoporous Y zeolites obtained by the two methods were *** ultrasonic desilication treatment was found to be generic,also being effective to treat the dealuminated Y zeolites by citric ***,the first step of chemical dealumination treatment was crucial to enable the effective creation of mesopores in the parent Y zeolite(with a silicon-to-aluminium ratio,Si/Al=2.6)regardless of the subsequent alkaline desilication treatment(i.e.,ultrasonic or hydrothermal).Therefore,appropriate selection of the condition of the chemical dealumination treatment based on the property of parent zeolites,such as Si/Al ratio and crystallinity,is important for making mesoporous zeolites effectively.

关键词： zeolite Y mesoporous zeolite post-synthesis treatment ultrasound chemical dealumination treatment alkaline desilication treatment

柴贝止痫汤对癫痫—抑郁共病模型大鼠大脑皮层及海马中5-HTT、5-HT_(1A)R、5-HT_(2A)R和DA_(2)R表达的影响

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环球中医药 2024年第2期17卷 196-202页

作者：王越刘金民王凯悦徐薇薇天津中医药大学第二附属医院急诊科 300150 北京中医药大学东方医院脑病一科

目的观察柴贝止痫汤对氯化锂—匹罗卡品慢性颞叶癫痫—抑郁共病模型大鼠大脑皮层及海马中5-羟色胺转运体(5-hydroxytryptamine transporter, 5-HTT)、5-羟色胺受体(5-hydroxytryptamine repreceptor, 5-HTR)(5-HT_(1A)R、5-HT_(2A)R)和多巴胺(dopamine, DA)受体(DA_(2)R)表达的影响,探讨柴贝止痫汤对癫痫—抑郁共病的干预机制。方法建立氯化锂—匹罗卡品慢性颞叶癫痫—抑郁共病大鼠模型。造模成功后,将大鼠随机分为6组:正常组、模型组、西药组(西酞普兰给药)和柴贝止痫汤低、中、高剂量组,连续灌胃给药14天,每天2次。干预后,通过糖水偏好及强迫游泳实验进行抑郁行为学监测;酶联免疫吸附法检测大鼠大脑皮层及海马中5-HT、DA含量;实时定量PCR法检测大鼠大脑皮层及海马中5-HTT、5-HT_(1A)R、5-HT_(2A)R和DA_(2)R基因的mRNA表达水平;蛋白免疫印迹法检测大鼠大脑皮层及海马中5-HTT、5-HT_(1A)R、5-HT_(2A)R和DA_(2)R的蛋白表达水平。结果药物干预后,与模型组相比,柴贝止痫汤中、高剂量组大鼠糖水消耗量显著增加(P<0.01),不动时间显著减少(P<0.01);与模型组比较,柴贝止痫汤中(P<0.05)、高剂量组(P<0.01)大鼠大脑皮层及海马中5-HT含量、皮层中DA含量升高,高剂量组(P<0.05)大鼠大脑海马中DA含量升高;与模型组相比,柴贝止痫汤高剂量组大鼠大脑皮层5-HTT mRNA表达降低(P<0.01),而海马中5-HTT mRNA表达升高(P<0.05);同时,柴贝止痫汤高剂量组大鼠大脑皮层和海马中5-HT_(1A)R mRNA表达明显升高(P<0.05),蛋白表达水平与mRNA水平表达一致。5-HT_(2A)R和DA_(2)R的mRNA和蛋白表达水平在处理前后均无变化。结论柴贝止痫汤能够通过下调慢性颞叶癫痫—抑郁共病模型大鼠大脑皮层5-HTT,上调海马5-HTT,以及上调大脑皮层和海马中5-HT_(1A)R的表达水平,改善抑郁行为。

关键词：柴贝止痫汤癫痫—抑郁共病 5-羟色胺转运体 5-羟色胺受体多巴胺受体

Reevaluation of the effect of Dianxianning on seizure rate of refractory epilepsy as additive treatment in clinical practice

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Frontiers of Medicine 2011年第2期5卷 229-234页

作者： Liyun He Tiancai Wen Shiyan Yan Runjin Li Zufa liu Hui Ren jinmin liu Fengshan Zhang Jianzhong Wu Jian liu Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Inner Mongolia People’s Hospital Hohhot 010017China Wangjing Hospital of China Academy of Chinese Medical Sciences Beijing 100102China The First Affiliated Hospital of Kunming Medical College Kunming 650032China Beijing University of Traditional Chinese Medicine Oriental Hospital Beijing 100078China Tongliao Hospital Tongliao 026000China China Association Against Epilepsy Beijing 100044China Kunming Chinese Medicine Factory Co. Ltd.Kunming 650228China

We observed the effect of Dianxianning,which was used as additive treatment to treat 206 epilepsy patients,on the epilepsy seizure *** on a multicenter,prospective,randomized,and controlled clinical trial design,we used the seizure rate of epilepsy as the main *** the treatment group comprising 137 patients,we combined Dianxianning with chemical medicine,which is the basic *** the control group with 69 patients,we added *** results showed that 1)Effect on seizure rate:After a three-month treatment,the seizure rate of the treatment group decreased by 37.84%on average,whereas that of the control group decreased by 13.18%on *** comparing the two groups,there was a significant difference between these groups(P<0.05).2)Effect on seizure frequency:As time passed,the frequency in each group gradually *** a three-month treatment,there was a significant difference between the two groups(P<0.05).3)Comparison between the before and after treatment of each group:There was a very significant difference between the two groups(P<0.0001).The results indicated that,as an additive treatment,Dianxianning has a good effect on controlling the epilepsy seizure rate and frequency *** is more effective than using chemical medicine alone.

关键词： Dianxianning epilepsy seizure evaluation