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Preparation and characterization of the TiO_2-V_2O_5 photocatalyst with visible-light activity

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Rare Metals 2006年第6期25卷 636-642页

作者： liu jianhua yang rong li songmei School of Materials Science and Engineering Beihang University Beijing 100083 China

Visible-light responsive TiO2-V2O5 catalyst was prepared using a binary sol-gel and in-situ intercalation method. The TiO2 sol and V2O5 sol were mixed to disperse the V2O5 species in the TiO2 phase at molecular level. The binary sol was then intercalated into interspaces of polyaniline （PANI） by means of in-situ polymerization of aniline. Conglomeration of the TiO2-V2O5 dusters during the calcination process was avoided because of the wrap of polyaniline. The surface mor- phology, the crystal phases, the structure, and the absorption spectra of （PANI）,/TiO2-V2O5 and the composite catalyst were studied using SEM, XRD, FT-IR, and UV-Vis. The photoactivity of the prepared catalyst under UV and visible light irradiation were evaluated by decolorization of methylene blue （MB） solution. The results showed that the composite catalyst displayed a homogeneous anatase phase, and the vanadium pentoxide species was highly dispersed in the TiO2 phase. The composite catalyst responded to visible light because of the narrowed band gap. In this study, the catalyst with the sol volume ratio of TiO2： V2O5 = 10：1 presented the best photocatalytic activity.

关键词： inorganic non-metal materials visible-light active photocatalyst binary sol-gel synthesis composite catalyst

7000系高强铝合金微观组织结构对应力腐蚀行为和机制影响的研究进展

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材料保护 2024年第7期57卷 165-180,213页

作者：杨阳李松梅贾雪娇刘建华于美北京航空航天大学材料科学与工程学院北京100191

7000系(Al-Zn-Mg-Cu)高强铝合金是铝合金中强度最高的系列之一,应力腐蚀开裂(SCC)是影响其服役安全稳定性的关键因素。综述了应力腐蚀开裂的阳极溶解机制和氢致开裂(HIC)机制,总结了7000系铝合金中的组织结构对合金SCC行为及机制的影响... 详细信息

7000系(Al-Zn-Mg-Cu)高强铝合金是铝合金中强度最高的系列之一,应力腐蚀开裂(SCC)是影响其服役安全稳定性的关键因素。综述了应力腐蚀开裂的阳极溶解机制和氢致开裂(HIC)机制,总结了7000系铝合金中的组织结构对合金SCC行为及机制的影响;从合金化学成分、热处理、预应变、表面处理等方面对SCC敏感性的影响出发,论述了不同组织结构对SCC行为的影响。提出了降低7000系高强铝合金SCC敏感性的重点研究方向:通过优化合金元素、使用新型的热处理工艺和表面处理技术等方法合理调控合金的微观组织结构,进而延长合金的使用寿命,使材料受到更好地保护。

关键词： 7000系高强铝合金组织结构应力腐蚀开裂阳极溶解氢致开裂研究进展

BMI1/NF-κB轴重塑TAMs表型促进口腔鳞癌恶性生物学行为

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实用口腔医学杂志 2024年第2期40卷 233-240页

作者：李雅慧李欢贺耀东刘荣黄军红胡雅婷李静姚彦冰杨新杰魏建华口颌系统重建与再生全国重点实验室国家口腔疾病临床医学研究中心陕西省口腔疾病临床医学研究中心空军军医大学第三附属医院口腔颌面头颈肿瘤科西安710032

目的:探究口腔鳞癌(OSCC)细胞中BMI1调控肿瘤相关巨噬细胞(TAMs)表型转化的作用及其机制。方法:分析GEPIA 2.0网站中519例头颈鳞癌组织和44例正常组织中BMI1表达。实时荧光定量PCR、蛋白印迹法检测3例OSCC组织和SCC9、SCC15和CAL27细胞... 详细信息

目的:探究口腔鳞癌(OSCC)细胞中BMI1调控肿瘤相关巨噬细胞(TAMs)表型转化的作用及其机制。方法:分析GEPIA 2.0网站中519例头颈鳞癌组织和44例正常组织中BMI1表达。实时荧光定量PCR、蛋白印迹法检测3例OSCC组织和SCC9、SCC15和CAL27细胞系中BMI1的表达;siRNA技术建立SCC9细胞的BMI1敲除细胞系,CCK-8、划痕实验、Transwell实验探究BMI1/NF-κB轴介导癌细胞恶性生物学行为;收集各组细胞条件培养基,通过OSCC细胞条件培养基与人单核细胞(THP-1)共培养,检测THP-1的募集和巨噬细胞分型相关标志物的表达情况。裸鼠荷瘤实验进一步体内检测BMI1对移植瘤增生的影响。结果:BMI1在OSCC组织以及细胞系中显著高表达;BMI1/NF-κB轴促进了OSCC细胞增殖、迁移和侵袭能力,也促进了THP-1细胞的募集与M2型极化。体内实验进一步证明了敲低BMI1可以抑制OSCC生长。结论:BMI1/NF-κB轴可通过调控TAMs的M2型转化,促进口腔鳞癌的增殖、迁移和侵袭能力。靶向阻断BMI1/NF-κB轴可能为口腔鳞癌治疗提供新靶点和新策略。

关键词：口腔鳞癌肿瘤微环境肿瘤相关巨噬细胞恶性生物学行为 BMI1

应用于睡眠定时器的纳瓦级功耗超低电压张弛振荡器

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集成电路与嵌入式系统 2024年第7期24卷 65-72页

作者：李振王霖伟杨建行朱建华杨伟涛周荣刘术彬西安电子科技大学微电子学院西安710000

在物联网(IoT)系统中,为了节省功耗引入了电阻电容(RC)张弛振荡器。针对无补偿的传统RC振荡器频率容易受到电源和温度影响的问题,本文所采用的前向体偏置(Forward Body Biasing,FBB)技术降低了低电源电压数字缓冲器的温度漂移,进一步的... 详细信息

在物联网(IoT)系统中,为了节省功耗引入了电阻电容(RC)张弛振荡器。针对无补偿的传统RC振荡器频率容易受到电源和温度影响的问题,本文所采用的前向体偏置(Forward Body Biasing,FBB)技术降低了低电源电压数字缓冲器的温度漂移,进一步的,本文同时利用亚阈区金属-氧化物半导体场效应晶体管(MOSFET,简称MOS)泄漏电流补偿技术(Subthreshold Leakage Current,SLC)和泄漏电流抑制技术(Subthreshold Leakage Suppression,SLS)。相比于传统结构振荡器,温度稳定性提升了约38倍。本文基于65 nm CMOS工艺设计了一款RC张弛振荡器,在室温0.4 V的电源电压下,功耗为8.1 nW,工作频率为4.4 kHz,能量效率为1.84 nW/kHz。在-30~90℃的范围内,振荡器的温度稳定性为75.1 ppm/℃。

关键词：电容电阻张弛振荡器泄露电流补偿前向体偏置物联网

Unconventional Petroleum Sedimentology:A Key to Understanding Unconventional Hydrocarbon Accumulation

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Engineering 2022年第11期18卷 62-78页

作者： Caineng Zou Zhen Qiu Jiaqiang Zhang Zhiyang li Hengye Wei Bei liu jianhua Zhao Tian yang Shifa Zhu Huifei Tao Fengyuan Zhang Yuman Wang Qin Zhang Wen liu Hanlin liu Ziqing Feng Dan liu Jinliang Gao rong liu Yifan li Research Institute of Petroleum Exploration and Development China National Petroleum CorporationBeijing 100083China National Energy Shale Gas Research and Development(Experiment)Center Beijing 100083China State Key Laboratory of lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Department of Geology Colorado College Colorado SpringsColoradoCO 80903USA School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China Key Laboratory of Tectonics and Petroleum Resources of Ministry of Education China University of GeosciencesWuhan 430074China College of Geosciences China University of PetroleumQingdao 266580China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Institute of Sedimentary Geology Chengdu University of TechnologyChengdu 610059China China University of Petroleum Beijing 102249China Oil and Gas Research Center Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Earth Sciences Jilin UniversityChangchun 130061China School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China

The commercial exploitation of unconventional petroleum resources(e.g.,shale oil/gas and tight oil/gas)has drastically changed the global energy structure within the past two ***-spot intervals(areas),the most prolific unconventional hydrocarbon resources,generally consist of extraordinarily high organic matter(EHOM)deposits or closely associated sandstones/carbonate *** formation of sweet-spot intervals(areas)is fundamentally controlled by their depositional and subsequent diagenetic settings,which result from the coupled sedimentation of global or regional geological events,such as tectonic activity,sea level(lake level)fluctuations,climate change,bottom water anoxia,volcanic activity,biotic mass extinction or radiation,and gravity flows during a certain geological *** shales with EHOM content and their associated high-quality reservoir rocks deposited by the coupling of major geological events provide not only a prerequisite for massive hydrocarbon generation but also abundant hydrocarbon storage *** Ordovician-Silurian Wufeng-Longmaxi shale of the Sichuan Basin,Devonian Marcellus shale of the Appalachian Basin,Devonian-Carboniferous Bakken Formation of the Williston Basin,and Triassic Yanchang Formation of the Ordos Basin are four typical unconventional hydrocarbon systems selected as case studies *** each case,the formation of sweet-spot intervals for unconventional hydrocarbon resources was controlled by the coupled sedimentation of different global or regional geological events,collectively resulting in a favorable environment for the production,preservation,and accumulation of organic matter,as well as for the generation,migration,accumulation,and exploitation of *** petroleum sedimentology,which focuses on coupled sedimentation during dramatic environmental changes driven by major geological events,is key to improve the understanding of the formation and distribution of sweet-spot intervals(areas)

关键词： Sedimentology Black shales Fine-grained sediments Organic matter accumulation Extraordinarily high organic matter Unconventional petroleum

Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19

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National Science Review 2020年第9期7卷 1428-1436页

作者： Mingxing Huang Man li Fei Xiao Pengfei Pang Jiabi liang Tiantian Tang Shaoxuan liu Binghui Chen Jingxian Shu Yingying You yang li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong songmei He Zhaoqin Wang jianhua Feng Changqing lin Yinong Ye Zhilong Wu Yaocai li Bei Zhong Ruilin Sun Zhongsi Hong Jing liu Huili Chen Xiaohua Wang Zhonghe li Duanqing Pei lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan Department of Infectious Diseases The Fifth Affiliated HospitalSun Yat-sen University Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging The Fifth Affiliated HospitalSun Yat-sen University Center for Interventional Medicine The Fifth Affiliated HospitalSun Yat-sen University Department of Pharmacy The Fifth Affiliated HospitalSun Yat-sen University Department of Respiratory and Critical Care Medicine Sun Yat-sen Memorial HospitalSun Yat-sen University Clinical Research Center Office The Fifth Affiliated HospitalSun Yat-sen University Department of Radiology The Fifth Affiliated HospitalSun Yat-sen University Department of Stomatology The Fifth Affiliated HospitalSun Yat-sen University Department of Hematology The Fifth Affiliated HospitalSun Yat-sen University Department of Clinical Laboratory The Fifth Affiliated HospitalSun Yat-sen University

Effective therapies are urgently needed for the SARS-CoV-2 pandemic. Chloroquine has been proved to have antiviral effect against coronavirus in vitro. In this study, we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19. In this multicenter prospective observational study, we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces. Eligible patients received chloroquine phosphate500 mg, orally, once(half dose) or twice(full dose) daily. Patients treated with non-chloroquine therapy were included as historical controls. The primary endpoint is the time to undetectable viral RNA. Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14, hospitalization time, duration of fever, and adverse events. A total of 197 patients completed chloroquine treatment, and 176 patients were included as historical controls. The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days; 95% CI-6.0 to-4.0). The duration of fever is shorter in chloroquine(geometric mean ratio 0.6; 95% CI 0.5 to 0.8). No serious adverse events were observed in the chloroquine group. Patients treated with half dose experienced lower rate of adverse events than with full dose. Although randomized trials are needed for further evaluation, this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic.

关键词： COVID-19 SARS-CoV-2 treatment chloroquine

酒石酸钠体系中TC18钛合金阳极氧化膜的制备、表征与疲劳性能

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航空学报 2014年第3期35卷 902-910页

作者：刘建华杨康于美李松梅吴量郁秀梅北京航空航天大学材料科学与工程学院北京100191

在以酒石酸钠为成膜剂的新型无氟环保电解液体系中对TC18钛合金进行阳极氧化,制备出一种钛合金阳极氧化膜。通过扫描电子显微镜和拉曼光谱仪分析了阳极氧化膜的形貌和相结构。采用电化学方法研究了阳极氧化后TC18钛合金的耐腐蚀性能。... 详细信息

在以酒石酸钠为成膜剂的新型无氟环保电解液体系中对TC18钛合金进行阳极氧化,制备出一种钛合金阳极氧化膜。通过扫描电子显微镜和拉曼光谱仪分析了阳极氧化膜的形貌和相结构。采用电化学方法研究了阳极氧化后TC18钛合金的耐腐蚀性能。采用万能高频疲劳试验机进行高频疲劳试验。结果表明:膜层具有沟壑与鼓包的表面形貌。膜层具有非晶态、锐钛矿型及金红石型TiO2结构,可能有板钛矿TiO2结构。阳极氧化后TC18钛合金的耐蚀性有显著的提高。阳极氧化后TC18钛合金的拉伸性能与疲劳性能基本不降低,相比于传统硫酸-磷酸型阳极氧化,拉伸性能和疲劳性能得到了一定的改善。

关键词：酒石酸钠钛合金阳极氧化膜二氧化钛疲劳

Recommendations for the diagnosis and treatment of paroxysmal kinesigemc dyskinesia: an expert consensus in China

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Translational Neurodegeneration 2021年第1期10卷 67-76页

作者： li Cao Xiaojun Huang Ning Wang Zhiying Wu Cheng Zhang Weihong Gu Shuyan Cong jianhua Ma ling Wei Yanchun Deng Qi Fang Qi Niu Jin Wang Zhaoxia Wang You Yin Jinyong Tian Shufen Tian Hongyan Bi Hong Jiang Xiaorong liu yang Lu Meizhen Sun Jianjun Wu Erhe Xu Tao Chen Tao Chen Xu Chen Wei li Shujian li Qinghua li Xiaonan Song Ying Tang Ping yang Yun yang Min Zhang Xiong Zhang Yuhu Zhang Ruxu Zhang Yi Ouyang Jintai Yu Quanzhong Hu Qing Ke Yuanrong Yao Zhe Zhao Xiuhe Zhao Guohua Zhao Furu liang Nan Cheng Jianhong Han rong Peng Shengdi Chen Beisha Tang Department of Neurology Ruijin Hospital Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology The Sixth People's Hospital Shanghai Jiaotong UniversityShanghaiChina Department of Neurology and Institute of Neurology The First Affiliated HospitalFujian Medical University/Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouChina Department of Neurology and Research Center of Neurology The Second Affiliated Hospital/Key Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of MedicineHangzhouChina Department of Neurology The First Affiliated HospitalSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases/National Key Clinical Department and Key Discipline of NeurologyGuangzhouChina Department of Neurology China-Japan Friendship HospitalMovement Disorder and Neurogenetics Research CenterBeijingChina Department of Neurology Shengjing Hospital of China Medical UniversityShenyangChina Department of Neurology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityCollaborative Innovation Center for Neuropsychiatric Disorders and Mental HealthAnhui Medical University/Anhui Province Key Laboratory of Cognition and Neuropsychiatry DisordersHefeiChina Department of Neurology Xijing HospitalFourth Military Medical UniversityXi'anChina Department of Neurology The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Neurology The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina Department of Neurology The First Affiliated Hospital of Guangxi Medical UniversityNanningChina Department of Neurology Peking University First HospitalBeijingChina Department of Neurology Changzheng Hospitalthe PLA Naval Medical UniversityShanghaiChina Department of Neurology and Department of Emergency Guizhou Provincial People's Hospital

Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different *** kinesigenic dyskinesia(PKD)is the most common type of paroxysmal dyskinesia and can be divided into primary and secondary types based on the ***,PKD is characterized by recurrent and transient attacks of involuntary movements precipitated by a sudden voluntary *** major cause of primary PKD is genetic abnormalities,and the inheritance pattern of PKD is mainly autosomal-dominant with incomplete *** proline-rich transmembrane protein 2(PRRT2)was the first identified causative gene of PKD,accounting for the majority of PKD cases *** increasing number of studies has revealed the clinical and genetic characteristics,as well as the underlying mechanisms of *** seeking the views of domestic experts,we propose an expert consensus regarding the diagnosis and treatment of PKD to help establish standardized clinical evaluation and therapies for *** this consensus,we review the clinical manifestations,etiology,clinical diagnostic criteria and therapeutic recommendations for PKD,and results of genetic analyses in PKD patients performed in domestic hospitals.

关键词： Paroxysmal kinesigenic dyskinesia Diagnosis and treatment Expert consensus China

温度冲击对不同阳极氧化温度SiC_P/2A12复合材料阳极氧化膜开裂行为的影响

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复合材料学报 2016年第8期33卷 1733-1741页

作者：王一博于美刘建华李松梅杨茗佳王永平王蕾北京航空航天大学材料科学与工程学院空天先进材料与服役教育部重点实验室北京100083 北京星航机电装备有限公司北京100074

通过己二酸-硫酸工艺制备了SiCP/A1合金（2A12）复合材料阳极氧化膜,研究了不同阳极氧化温度下（15~35℃）制备的SiCP/2A12复合材料阳极氧化膜温度冲击后的开裂行为及耐蚀性能。采用FE-SEM对温度冲击前后SiCP/2A12复合材料阳极氧化膜的... 详细信息

通过己二酸-硫酸工艺制备了SiCP/A1合金（2A12）复合材料阳极氧化膜,研究了不同阳极氧化温度下（15~35℃）制备的SiCP/2A12复合材料阳极氧化膜温度冲击后的开裂行为及耐蚀性能。采用FE-SEM对温度冲击前后SiCP/2A12复合材料阳极氧化膜的微观形貌进行了分析,采用电化学阻抗谱（EIS）研究了冲击前后SiCP/2A12复合材料阳极氧化膜的耐腐蚀性能。结果表明：温度冲击对不同阳极氧化温度制备的SiCP/2A12复合材料阳极氧化膜影响程度不同,随着阳极氧化温度的升高,温度冲击后SiCP/2A12复合材料阳极氧化膜的裂纹密度逐渐增加。阳极氧化温度为25℃时,温度冲击后SiCP/2A12复合材料阳极氧化膜耐蚀性最好。SiCP/2A12复合材料阳极氧化膜的耐温度冲击性能优于2A12铝合金氧化膜。

关键词：铝基复合材料 SiC 阳极氧化温度冲击耐蚀性