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Salidroside Ameliorates Lung Injury Induced by PM_(2.5) by Regulating SIRT1-PGC-1αin Mice

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Biomedical and Environmental Sciences 2024年第4期37卷 367-376页

作者： LI Xiao Hong liu Yu Mei SHAN Hui TAN Jin feng zhou jian SONG yuan Jin LI Si Qi liu Chen XU dong Qun YU Li LI Wan wei School of Public Health Shandong Second Medical UniversityWeifang 261053ShandongChina Key Laboratory of Health Inspection and Quarantine Weifang 261053ShandongChina weifang Environmental Monitoring Station Weifang 261042ShandongChina Department of Orthopedics The 80th Army Hospital of PLAWeifang 261000ShandongChina Environment and Health Related Product Safety Institute of Chinese Center for Disease Control and Prevention Beijing 100021China School of Basic Medicine Shandong Second Medical UniversityWeifang 261053ShandongChina

Objective This study aimed to clarify the intervention effect of salidroside(SAL)on lung injury caused by PM_(2.5) in mice and illuminate the function of SIRT1-PGC-1ɑ*** Specific pathogen-free(SPF)grade male C57BL/6 mice were randomly assigned to the following groups:control group,SAL group,PM_(2.5) group,SAL+PM_(2.5) *** the first day,SAL was given by gavage,and on the second day,PM_(2.5) suspension was given by intratracheal *** whole experiment consist of a total of 10 cycles,lasting 20 *** the end of treatment,blood samples and lung tissues were collected and *** of pathological changes in lung tissue using inverted microscopy and transmission electron *** expression of inflammatory,antioxidants,apoptosis,and SIRT1-PGC-1ɑproteins were detected by Western *** Exposure to PM_(2.5) leads to obvious morphological and pathologica changes in the lung of ***_(2.5) caused a decline in levels of antioxidant-related enzymes and protein expressions of HO-1,Nrf2,SOD2,SIRT1 and PGC-1ɑ,and an increase in the protein expressions of IL-6,IL-1β,Bax,caspase-9 and cleaved ***,SAL reversed the aforementioned changes caused by PM_(2.5) by activating the SIRT1-PGC-1α *** SAL can activate SIRT1-PGC-1ɑ to ameliorate PM2.5-induced lung injury.

关键词： PM_(2.5) Salidroside Oxidative stress Inflammation Apoptosis SIRT1-PGC-1α

Design of advanced porous silver powder with high-sintering activity to improve silicon solar cells

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nano Research 2024年第4期17卷 3189-3197页

作者： Yongsheng Li Ziwei Chen Rui zhou Wenguang Zhao Mu Li Jun Chen Zhongyuan Huang jian liu Yuhang Li Maolin Yang Minghan Yu dong zhou yuan Lin feng Pan School of Advanced Materials Peking UniversityShenzhen Graduate SchoolShenzhen 518055China Institute of Advanced Science Facilities Shenzhen 518107China Institute of Zhejiang University-Quzhou Quzhou 324000China Key Laboratory of Photochemistry Institute of ChemistryChinese Academy of SciencesBeijing 100190China Institute of Materials Research(IMR) Tsinghua UniversityTsinghua Shenzhen International Graduate SchoolShenzhen 518055China School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

Silver(Ag)paste is widely used in semiconductor metallization,especially in silicon solar *** powder is the material with the highest proportion in Ag *** morphology and structure of Ag powder are crucial which determine its characteristics,especially for the sintering *** this work,a simple method was developed to synthesize a type of microcrystalline spherical Ag particles(SP-A)with internal pores and the structural changes and sintering behavior were thoroughly studied by combining ultra-small-angle X-ray scattering(USAXS),small-angle X-ray scattering(SAXS),in-situ heating X-ray diffraction(XRD),focused ion beam(FIB),and thermal analysis *** to the unique internal pores,the grain size of SP-A is smaller,and the coefficient of thermal expansion(CTE)is higher than that of traditional solid Ag *** a result,the sintering activity of SP-A is excellent,which can form a denser sintered body and form silver nanoparticles at the Ag–Si interface to improve silver silicon *** silicon solar cell built with SP-A obtained a low series resistance(Rs)and a high photoelectric conversion efficiency(PCE)of 19.26%.These fill a gap in Ag particle structure research,which is significant for the development of high-performance electronic Ag particles and efficient semiconductor devices.

关键词： silver particles small angle X-ray scattering(SAXS) pore size distribution in-situ heating X-ray diffraction(XRD) sintering silicon solar cells

Effect of heat treatment on microstructural evolution,mechanical properties and tribological properties of H13 steel prepared using selective laser melting

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Journal of Iron and Steel Research International 2024年第5期31卷 1246-1259页

作者： Li-xiong Han Yan Wang Shi-feng liu Zhao-hui Zhang wei liu Xin Yang Dang-shen Ma jian zhou Ying-kang wei College of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina Zhejiang University City College Hangzhou310015ZhejiangChina China Iron and Steel Research Institute Group Co. Ltd.Beijing100081China

H13 tool steel was successfully prepared by selective laser melting(SLM)*** effects of heat treatment on the microstructure,mechanical properties,and tribological properties of SLMed H13 steel were *** heat treatment process involved a solution treatment and a double aging treatment of the deposited H13 tool steel prepared by *** aim is to optimize the microstructure and mechanical properties of SLMed H13 *** to the rapid heating and cooling effects of SLM,carbide precipitation in the deposited H13 steel was not uniform and residual stresses were *** purpose of the solution treatment is to dissolve the solution at a high temperature to eliminate the residual stresses and defects introduced by the SLM-forming *** solution treatment and first aging treatment produced the precipitation of small carbides at the grain boundaries and inside the crystals,which increased the hardness of SLMed H13 *** hardness increased from 538±4.0 HV of the as-deposited sample to 548±5.8 HV of samples after the first aging ***,the ultimate tensile strength and the elongation at break decreased from 1882 MPa and 11.5%in the as-deposited sample to 1697 MPa and 7.9%in those after the first aging treatment,***,the friction coefficient and wear rate in the as-deposited sample decreased from 0.5160 and 2.36×10^(–6)mm^(−3)N^(−1)m^(−1)to 0.4244 and 1.04×10^(–6)mm^(−3)N^(−1)m^(−1),***,the distribution of carbides inside the crystals was not *** second aging treatment adjusted the morphology of carbide precipitation and made it more uniform,but the precipitation of carbides grew and settled at the bottom of the grain *** hardness decreased to 533±6.7 HV compared with that with the first aging treatment,but the ultimate tensile strength and plasticity reached a balance(1807 MPa,14.05%).Accordingly,the friction coefficient and wear rate also showed a stable and decreasin

关键词： Selective laser melting H13 steel Solution aging Double aging Friction and wear Retained austenite

Ciclopirox inhibits SARS-CoV-2 replication by promoting the degradation of the nucleocapsid protein

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2505-2519页

作者： Xiafei wei Yuzheng zhou Xiaotong Shen Lujie Fan donglan liu Xiang Gao jian zhou Yezi Wu Yunfei Li wei feng Zheng Zhang Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalSouthern University of Science and TechnologyShenzhen 518112China Guangzhou Laboratory Guangzhou Medical UniversityGuangzhou 511495China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China

The nucleocapsid protein(NP)plays a crucial role in SARS-CoV-2 replication and is the most abundant structural protein with a long *** its vital role in severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)assembly and host inflammatory response,it remains an unexplored target for drug *** this study,we identified a small-molecule compound(ciclopirox)that promotes NP degradation using an FDA-approved library and a drug-screening cell *** significantly inhibited SARS-CoV-2 replication both in vitro and in vivo by inducing NP *** induced abnormal NP aggregation through indirect interaction,leading to the formation of condensates with higher viscosity and lower *** condensates were subsequently degraded via the autophagy-lysosomal pathway,ultimately resulting in a shortened NP half-life and reduced NP *** results suggest that NP is a potential drug target,and that ciclopirox holds substantial promise for further development to combat SARS-CoV-2 replication.

关键词： SARS-CoV-2 Nucleocapsid protein Viral replication Ciclopirox Abnormal aggregation Protein degradation Autophagy-lysosome Drug target

Hydrodynamic characteristics and particle tracking of 90° lateral intakes at an inclined river slope

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Water Science and Engineering 2024年第2期17卷 197-208页

作者： wei He Si-yuan feng jian Zhang Hong-wu Tang Yang Xiao Sheng Chen Chun-sheng liu College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China State Key Laboratory of Hydrology Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China Collaborative Innovation Center on Water Safety and Water Science Hohai UniversityNanjing 210098China

Lateral intakes are common in *** pump effciency and sediment deposition are determined by the local hydrodynamic characteristics and mainstream division *** hydraulic characteristics of lateral withdrawal from inclined river slopes at different intake elevations should be ***,the division width exhibits significant vertical non-uniformity at an inclined river slope,which should be ***,a three-dimensional(3-D)hydrodynamic and particle-tracking model was developed with the Open Source Field Operation and Manipulation(Open FOAM),and the model was validated with physical model tests for 90°lateral withdrawal from an inclined side *** flow fields,withdrawal sources,and division widths were investigated with different intake bottom elevations,withdrawal discharges,and main channel *** study showed that under inclined side bank conditions,water entered the intake at an oblique angle,causing significant 3-D spiral flows in the intake rather than two-dimensional closed recirculation.A lower withdrawal discharge,a lower bottom elevation of the intake,or a higher main channel velocity could further strengthen this *** average division width and turbulent kinetic energy were smaller under inclined side bank conditions than under vertical bank *** a low intake bottom elevation,a low withdrawal discharge,or a high main channel velocity,the sources of lateral withdrawal were in similar ranges near the local inclined bank in the vertical *** inclined slope conditions,sediment deposition near the intake entrance could be reduced,compared to that under vertical slope *** results provide hydrodynamic and sediment references for engineering designs for natural rivers with inclined terrains.

关键词： Lateral withdrawal Hydrodynamic characteristics Particle tracking Inclined river slope Bottom elevation of intake OpenFOAM

Effect of antioxidants on the efficiency of jet milling and the powder characteristics of Sm2Co17 permanent magnets

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Chinese Physics B 2024年第9期33卷 615-620页

作者： Da-Shuai Xu Lei liu jian-Hui yuan Bo zhou Chuang-Hui dong feng-Qing Wang Yong Ding Ying-Li Sun A-Ru Yan School of Materials Science and Engineering Shanghai University of Engineering ScienceShanghai 201620China CISRI&NIMTE Joint Innovation Center for Rare Earth Permanent Magnets CAS Key Laboratory of Magnetic Materials and DevicesZhejiang Province Key Laboratory of Magnetic Materials and Application TechnologyNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China

This study investigated the effect of antioxidants on the grinding efficiency,magnetic powder characteristics,microstructure,and magnetic properties of 2:17 type SmCo permanent magnet *** results show that adding antioxidants helps improve the dispersion among magnetic powders,leading to a 33.3%decrease in jet milling time and a 15.8%increase in magnet powder production ***,adding antioxidants enhances the oxidation resistance of the magnetic *** being stored in a constant temperature air environment at 25C for 48 h,the O content in the powder decreased by 33%compared to samples without *** in the magnet body,the O content decreased from 0.21 wt.%to 0.14 wt.%,which helps increase the effective Sm content and domain wall pinning uniformity in the *** magnetic properties were obtained in the magnet with added antioxidants:B_(r)=11.6 kGs,SF=79.6%,H_(cj)=16.8 kOe,and(BH)_(max)=32.5 MGOe.

关键词： antioxidant SmCo permanent magnet oxidation resistance grinding efficiency

Towards Effective Author Name Disambiguation by Hybrid Attention

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Journal of Computer Science & Technology 2024年第4期39卷 929-950页

作者： Qian zhou wei Chen Peng-Peng Zhao An liu Jia-Jie Xu jian-feng Qu Lei Zhao School of Computer Science and Technology Soochow UniversitySuzhou 215006China

Author name disambiguation(AND)is a central task in academic search,which has received more attention recently accompanied by the increase of authors and academic *** tackle the AND problem,existing studies have proposed various approaches based on different types of information,such as raw document features(e.g.,co-authors,titles,and keywords),the fusion feature(e.g.,a hybrid publication embedding based on multiple raw document features),the local structural information(e.g.,a publication's neighborhood information on a graph),and the global structural information(e.g.,interactive information between a node and others on a graph).However,there has been no work taking all the above-mentioned information into account and taking full advantage of the contributions of each raw document feature for the AND problem so *** fill the gap,we propose a novel framework named EAND(Towards Effective Author Name Disambiguation by Hybrid Attention).Specifically,we design a novel feature extraction model,which consists of three hybrid attention mechanism layers,to extract key information from the global structural information and the local structural information that are generated from six similarity graphs constructed based on different similarity coefficients,raw document features,and the fusion *** hybrid attention mechanism layer contains three key modules:a local structural perception,a global structural perception,and a feature ***,the mean absolute error function in the joint loss function is used to introduce the structural information loss of the vector *** results on two real-world datasets demonstrate that EAND achieves superior performance,outperforming state-of-the-art methods by at least+2.74%in terms of the micro-F1 score and+3.31%in terms of the macro-F1 score.

关键词： author name disambiguation multiple-feature information hybrid attention pruning strategy structural information loss of vector space

Neosophoflavonoids A–C, A class of highly oxidized hybrid flavonoids from Sophora flavescens with antidiabetic effects

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Chinese Chemical Letters 2024年第10期35卷 295-298页

作者： Xu Zhang jiang Li Kai-zhou Lu Ya-nan Yang jian-Shuang jiang Xiang yuan Zi-Ming feng Fei Ye Pei-Cheng Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and PekingUnionMedical CollegeBeijing100050China

Three highly oxidized hybrid flavonoids neosophoflavonoids A–C(1,2a,and 2b)were isolated from the roots of Sophora *** A possesses a unique highly oxidized heptacyclic6/6/6/6/6/6/5 *** B and C are isomers and share the same highly oxidized hexacyclic 6/6/6/6/6/6 *** planar structures were elucidated from 1D/2D nuclear magnetic resonance(NMR),ultraviolet spectroscopy(UV),infrared spectroscopy(IR),and high resolution electrospray ionization mass spectroscopy(HRESIMS)*** absolute configurations were determined by thorough GIAO13C NMR(DP4+)calculation protocol and electronic circular dichroism(ECD)calculation *** plausible biosynthetic routes for the compounds were also *** compounds exhibited significant protein tyrosine phosphatase-1B(PTP1B)inhibitory activity with half maximal inhibitory concentration(IC_(5)0)values 3.94±0.01,0.38±0.13,and 0.70±0.01μmol/L,*** addition,compared to a positive control fenofibrate(Feno)at 20μmol/L,compounds 2a and 2b exhibited stronger inhibitory effects on lipid accumulation in the oleic acid(OA)-induced cell model at 5 and 10μmol/L.

关键词： Sophora flavescens Highly oxidized hybrid flavonoids Neosophoflavonoids A-C PTP1B inhibition Lipid accumulation inhibition

Continuous age-and sex-specific reference ranges of liver enzymes in Chinese children and application in pediatric non-alcoholic fatty liver disease

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World Journal of Pediatrics 2024年第9期20卷 949-956页

作者： Zhao-yuan Wu Si-wei Chi liu-jian Ouyang Xiao-Qin Xu Jing-nan Chen Bing-Han Jin Rahim Ullah Xue-Lian zhou Ke Huang Guan-Ping dong Zhe-Ming Li Ying Shen Jie Shao Yan Ni Jun-Fen Fu Qiang Shu wei Wu Department of Endocrinology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child Health3333 Binsheng RoadHangzhou310051China Department of Data and Information Children’s HospitalZhejiang University School of MedicineHangzhouChina Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Thoracic&Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children’s Regional Medical Center3333 Binsheng RoadHangzhou310051China

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(<50 U/L)were developed by laboratories and have not been validated in populations with a large nu... 详细信息

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(weight who underwent evaluation and metabolic tests in the *** receiver operating characteristic curves,we determined age-and sex-specific upper limit percentiles of liver enzymes for fatty liver *** This study revealed a significant correlation between serum transaminase levels and age and sex(P<0.01).These transaminase levels exhibited age-and sex-specific *** individuals in the non-alcoholic fatty liver disease(NAFLD)cohort,elevated ALT levels displayed a positive association with clinical markers of disease severity,including homeostatic model assessment of insulin resistance,waist-hip ratio,and serum uric acid levels(P<0.01).According to the receiver operating characteristic curves,ALT levels at the 92.58th percentile for boys and the 92.07th percentile for girls yielded the highest accuracy and *** This study provides age-and sex-specific reference ranges for ALT,aspartate aminotransferase,andγ-glutamyltransferase in Chinese children and adolescents,making it the largest population study to ***,the study establishes a precise upper limit for ALT levels,facilitating their use in NAFLD screening.

关键词： Alanine aminotransferase Childhood Fatty liver diseases