检索结果-南通市图书馆

刘晓鹰教授治疗儿童紫癜性肾炎血尿蛋白尿型临床经验

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

世界中医药 2024年第11期19卷 1653-1659页

作者：王天君余亚玲刘晓鹰刘加男湖北中医药大学中医临床学院武汉430065 湖北省中医院儿科武汉430061

目的:探讨刘晓鹰教授治疗儿童紫癜性肾炎(HSPN)血尿蛋白尿型的临床用药经验,为临床诊治HSPN提供思路。方法:对既往接诊的HSPN血尿蛋白尿型,仅用中药治疗且疗效为临床缓解和显效的病例,收集处方建立数据库,运用SPSS 23.0统计软件、R语言... 详细信息

目的:探讨刘晓鹰教授治疗儿童紫癜性肾炎(HSPN)血尿蛋白尿型的临床用药经验,为临床诊治HSPN提供思路。方法:对既往接诊的HSPN血尿蛋白尿型,仅用中药治疗且疗效为临床缓解和显效的病例,收集处方建立数据库,运用SPSS 23.0统计软件、R语言、VOSviewer、Pajek软件分析药物频次、四气五味、归经以及药物规则。结果:纳入病例57例,处方955张,总药物309味,用药总频次15 584次。药物频次最高的前10位药物为甘草、茯苓、连翘、黄芪、赤芍、白术、紫草、漏芦、当归、茜草;药性以寒、凉为主,药味以甘、苦、辛为主,归经以肺、肝、胃、心、脾、肾为主;2味药物组合,提升度最高的为墨旱莲-女贞子;3味药物组合,提升度最高的为牡丹皮-紫草-赤芍;4味药物组合,提升度最高的为牡丹皮-地黄-赤芍-紫草。结论:在治疗HSPN时,抓住其“肺热、血瘀、脾虚”的主要病机特点,选用清肺热、清热凉血止血、活血化瘀、补中益气的中药对疾病进行分期辨证治疗。

关键词：紫癜性肾炎数据挖掘用药规律临床经验中医药儿童 @刘晓鹰

在线全文

学校读者我要写书评

暂无评论

面向地物混杂背景的偏振光谱图像融合方法

中国光学（中英文） 2024年第5期17卷 1098-1111页

作者：李英超赵喆浩王祺刘嘉楠史浩东付强孙洪宇长春理工大学空间光电技术研究所吉林长春130022 长春理工大学光电工程学院吉林长春130022

针对偏振光谱图像融合方法在地物混杂背景遥感探测中多尺度变换融合图像存在边缘轮廓细节模糊、对比度不佳的问题,提出一种基于非下采样轮廓波变换的稀疏表示与引导滤波器相结合的图像融合方法,以改善融合图像的质量和视觉效果。首先,... 详细信息

针对偏振光谱图像融合方法在地物混杂背景遥感探测中多尺度变换融合图像存在边缘轮廓细节模糊、对比度不佳的问题,提出一种基于非下采样轮廓波变换的稀疏表示与引导滤波器相结合的图像融合方法,以改善融合图像的质量和视觉效果。首先,该方法通过非下采样轮廓波变换对光谱图像和偏振图像进行多尺度多方向分解,进而将图像分解成不同子带内的特征信息。其次,低频子带采用稀疏表示融合,从而降低融合图像中物体对比度损失。此外,采用引导滤波器融合高频子带,以增强图像轮廓细节信息。最后,对低频与高频融合系数进行非下采样轮廓波逆变换,最终得出融合图像。分析表明融合图像对比度相对于原始光谱图像与偏振度图像分别提升了54.5%和15.4%,更容易区分混杂背景下阴影中的物体。基于此方法对偏振光谱成像仪所采集的不同波长下的光谱与偏振图像进行融合,并实现真彩还原。真彩还原图像证明此融合方法在保留混杂背景下的环境信息的同时实现了物体和背景的有效区分,有效提高了偏振光谱遥感探测成像的图像质量,有助于提升偏振光谱遥感探测成像中图像信息的完整性和真实性,扩大其在复杂环境遥感探测和图像识别中的应用范围。

关键词：遥感探测成像偏振图像光谱图像图像融合非下采样轮廓波变换

Kinetics of roasting potash feldspar in presence of sodium carbonate

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2017年第7期24卷 1544-1550页

作者： liu jia-nan ZHAI Yu-chun WU Yan ZHANG Jun SHEN Xiao-yi School of Metallurgy Northeastern UniversityShenyang 110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004China

A novel process was proposed for the utilization of potash feldspar by roasting in the presence of sodium carbonate. The effects of roasting temperature, granularity, molar ratio of sodium carbonate to potash feldspar and roasting time on the silica extraction rate were investigated. Under the optimal roasting conditions, the silica extraction rate was 98%. The optimal conditions, determined using an orthogonal experiment, were found to be roasting temperature of 875 A degrees C, potash feldspar granularity of 74-89 mu m, molar ratio of sodium carbonate to potash feldspar of 1.2:1, and roasting time of 80 min. The kinetics of potash feldspar roasting in the presence of sodium carbonate was described by the shrinking core model and the reaction rate was found to be controlled by the chemical reaction at the particle surface. According to the Arrhenius expression, the activation energy was 164.99 kJ/mol, and the process could be expressed as [1-(1-alpha)(1/3)]=2.66x10(5) exp[-164990/(RT)] t.

关键词： potash feldspar sodium carbonate roasting kinetics silica

在线全文

学校读者我要写书评

暂无评论

猪链球菌WapA毒素功能鉴定

畜牧与兽医 2024年第7期56卷 85-94页

作者：范汝慧白乾坤泮欣铭刘嘉楠马家乐于勇姚火春南京农业大学动物医学院/南京农业大学猪链球菌病OIE参考实验室江苏南京210095

胞壁相关蛋白A(WapA)广泛存在于革兰阳性菌中,在细菌致病过程中发挥重要作用。为探究WapA的致病机制和致病作用,本研究对猪链球菌WUSS351株基因组进行分析,发现了2个编码WapA毒素的基因簇,编码的毒素分别命名为WapA1和WapA2,在GenBank... 详细信息

胞壁相关蛋白A(WapA)广泛存在于革兰阳性菌中,在细菌致病过程中发挥重要作用。为探究WapA的致病机制和致病作用,本研究对猪链球菌WUSS351株基因组进行分析,发现了2个编码WapA毒素的基因簇,编码的毒素分别命名为WapA1和WapA2,在GenBank数据库中检索到更多的WapA1和WapA2同源体,通过对它们的C端和N端结构域的系统进化分析,发现猪链球菌中广泛存在编码该毒素的基因簇,提示其可能具有重要的功能。后续通过构建多个WapA毒素的pBAD-His和pBAD-pleB重组质粒在大肠杆菌中表达WapA,结合生长曲线与活菌计数结果发现,WapA1-1对大肠杆菌具有周质毒性,而WapA1-2、WapA1-3、WapA2-1、WapA2-3对大肠杆菌具有胞质毒性,初步确定了WapA的毒性作用。进一步构建wapA1-1、wapA1-2、wapA2-1、wapA2-3基因缺失株(ΔwapA1-1、ΔwapA1-2、ΔwapA2-1、ΔwapA2-3),并通过竞争试验和动物感染试验发现,WapA可介导猪链球菌WUSS351株的竞争生长,并在猪链球菌致病过程中发挥重要作用。本研究结果对于猪链球菌的致病机理研究具有指导意义,为后续疾病治疗和预防提供参考。

关键词：猪链球菌 WapA 毒性致病力

维普期刊数据库博看期刊

Improved Allele-specific Polymerase Chain Reaction for Single Nucleotide Polymorphism Genotyping

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2010年第2期26卷 259-262页

作者： WU Mei DU Zhen-wu liu jia-nan SONG Yang WANG Ya-li ZHANG Gui-zhen Department of Central Research China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China

An improved allele-specific PCR（AS-PCR） approach was applied to investigating -55C/T polymorphism in promoter region of the uncoupling protein 3（UCP3）gene. AS-PCR is a competitive PCR method which is based on positioning the 3＇ base of a PCR primer to match one single nucleotide polymorphism（SNP） allele and accurately extend only the correctly matched primer. But it is limited in use because of its poor specificity. In this study, we improved the specificity of AS-PCR by introducing additional mismatch at the penultimate base of 3＇ end of AS-PCR primer in combination with decreasing the level of dNTP in the reaction mixture. Sensitivity, specificity and reliability of this method were assessed for both simple plasmid model and complex human genomic SNP targets. The -55C/T（rs1800849） polymorphisrn of the UCP3 gene was analyzed via this AS-PCR and restriction fragment length polymorphism（RFLP）, the latter was used as a gold standard. The results suggest that the increase in AS-PCR discrimination with this method should facilitate the use of this simple, rapid, and inexpensive technique for SNP genotyping application.

关键词： AS-PCR Polymorphism UCP3 SNP genotyping

宁波中医药文化药德元素挖掘及其育人路径探究

在线全文

学校读者我要写书评

暂无评论

中国中医药现代远程教育 2024年第1期22卷 194-197页

作者：刘佳楠张云飞汪亚娣陈宏降浙江药科职业大学马克思主义学院浙江宁波315500 浙江药科职业大学中药学院浙江宁波315500

对宁波中医药文化中医药职业道德(以下简称“药德”)元素进行挖掘和梳理,充分发挥其文化育人功能。通过文献研究、实地调研和名人访谈等方式对宁波中医药文化资源进行归纳和整理,挖掘其中的药德元素,并探索其育人途径。宁波中医药发展... 详细信息

对宁波中医药文化中医药职业道德(以下简称“药德”)元素进行挖掘和梳理,充分发挥其文化育人功能。通过文献研究、实地调研和名人访谈等方式对宁波中医药文化资源进行归纳和整理,挖掘其中的药德元素,并探索其育人途径。宁波中医药发展史源远流长,可追溯至河姆渡文化时期,宁波中医药文化中蕴含以“仁、精、诚、正”为核心的药德元素,可通过始业教育启蒙、通识课程渗透、专业课程强化、校园文化熏陶等方式将宁波中医药文化中的药德元素全方位融入人才培养体系。挖掘宁波中医药文化药德元素并全方位融入人才培养体系,以期发挥文化育人功能,培养高素质中医药人才、弘扬优秀中医药文化。

关键词：中医药文化医药职业道德育人途径宁波市

Morphology and phylogenetic placement of Mallomonas vietnamica(Synurales,Chrysophyceae)from China

在线全文

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2024年第4期42卷 1325-1335页

作者： Junxue HAO Fangru nan Junping LÜ Qi liu Xudong liu Shulian XIE jia FENG School of Life Science Shanxi UniversityTaiyuan 030006China

The newly described chrysophyte,Mallomonas vietnamica,is reported for the first time in China from specimens collected in Guizhou Province,SW *** morphological characteristics were studied using light and scanning electron *** species was described based on morphological characteristics,including cell size,scale size,dome,V-rib,and ***,molecular sequencing of *** was conducted and a phylogenetic tree was constructed based on concatenated SSU,LSU,and rbc L *** phylogenetic tree led us to suggest raising a new section named Uncatusipedae for this *** study provides new molecular data from the genus Mallomonas and enriches our understanding of the species diversity and geographical distribution of the genus Mallomonas in China.

关键词： Chrysophyta Mallomonas vietnamica phylogenetic study taxonomy

Association of UCP3,APN,and TNF-α Gene Polymorphisms with Type 2 Diabetes in a Population of Northern Chinese Han Patients

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2012年第2期28卷 255-258页

作者： WANG Ling-ling DU Zhen-wu liu jia-nan WU Mei SONG Yang jiaNG Ri-hua ZHANG Gui-zhen Central Research Department China-Japan Union Hospital of Jilin UniversityChangchun 130033P.R.China1 Department of Orthopedics China-Japan Union Hospital of Jilin UniversityChangchun 130033P.R.China1 Department of Neurology the Affiliated Hospital of Beihua UniversityJilin 132000P.R.China

We observed the polymorphism distribution and coaction of uncoupling protein 3（UCP3）-55C/T,adiponectin（APN）＋45T/G and tumor necrosis factor（TNF）-α-308G/A on the onset and development of T2DM in a Northern Chinese Han population of 213[100 type 2 diabete（T2DM） patients and 113 health control subjects] by polymerase chain reaction-restriction fragment length polymorphisum（PCR-RFLP） *** demonstrate the polymorphism of UCP3-55C/T,APN＋45T/G,and TNF-α-308G/A related to T2DM onset and *** the individuals carrying UCP3-55T,APN＋45G and TNF-α-308A allele had higher T2DM *** results are the first report to evaluate the association of the coaction of UCP3,APN,TNF-α genes polymorphism on T2DM risk and the susceptibility of T2DM in the Northern Chinese Han population.

关键词： Uncoupling protein 3(UCP3) Adiponectin(APN) Tumor necrosis factor(TNF)-α Gene polymorphism Type 2 diabete(T2DM) risk

A Dynamic Covalent Bonding-based nanoplatform for Intracellular Co-Delivery of Protein Drugs and Chemotherapeutics with Enhanced Anti-Cancer Effect

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第5期42卷 559-569,I0005页

作者： Sai-nan liu jia-Hui Meng Li-Yun Cui Hua Chen Lin-Qi Shi Ru-jiang Ma Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryTianjin Key Laboratory of Functional Polymer MaterialsState Key Laboratory of Medicinal Chemical BiologyFrontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China

Efficient intracellular delivery of protein drugs is critical for protein *** combination of protein drugs with chemotherapeutics represents a promising strategy in enhancing anti-cancer ***,co-delivery systems for efficient delivery of these two kinds of drugs are still lacking because of their different ***,we show a well-designed delivery system based on dynamic covalent bond for efficient intracellular co-delivery of ribonuclease A(RNase A)and doxorubicin(DOX).Two polymers,PEG-b-P(Asp-co-AspDA)and PAE-b-P(Asp-co-AspPBA),and two 2-acetylphenylboronic acid(2-APBA)-functionalized drugs,2-APBA-RNase A and 2-APBA-DOX,self-assemble into mixed-shell nanoparticles(RNase A/DOX@MNPs)via dynamic phenylboronic acid(PBA)-catechol bond between PBA and dopamine(DA)*** PBA-catechol bond endows the nanoparticles with high stability and excellent stimulus-responsive drug release *** the slight acidic environment at tumor tissue,RNase A/DOX@MNPs are positively charged,promoting their *** cellular uptake into endosome,further protonation of PAE chains leads to the rupture of endosomes because of the proton sponge effect and the cleavage of PBA-catechol bond promotes the release of two *** cytoplasm,the high level of GSH removed the modification of 2-APBA on *** restored RNase A and DOX show a synergistic and enhanced antic-cancer *** system may be a promising platform for intracellular co-delivery of protein drugs and chemotherapeutics.

关键词： Drug co-delivery Combination therapy Dynamic covalent bond