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Jaffe-Campanacci syndrome resulted in amputation: A case report

World Journal of Clinical Cases 2024年第10期12卷 1785-1792页

作者： Jun Jiang min liu Department of Pediatric Surgery West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Jaffe-Campanacci syndrome(JCS)is a very rare *** treatment of JCS is more conservative,and most authors recommend that no surgery should be done in asymptomatic *** conventional concept holds that the natural course of non-ossifying fibromas(NOFs)grows with the development of bones,and the osteolytic region gradually stops expanding and self-healing through bone ossifying around the lesion and ossification within the *** in this case,the bone lesions were potentially biologically aggressive,which led to severe limb deformities and *** SUMMARY We present the case of a 5-year-old girl with JCS presenting with not only NOF sand café-au-lait macules,but also showed features not mentioned before,severe limb pain,and at last resulted in *** was admitted to our hospital after presenting with claudication and mild pain over her right thigh,which worsened when stretching or being *** examination revealed multiple café-au-lait macules on the neck,arm,axilla,and torso,including the nipples and *** revealed multiple lytic lesions in the proximal part of the right humerus,distal part of the right clavicle,proximal and distal parts of the right femur,and proximal parts of the right tibia and *** and biopsy were performed on the distal part of the right *** the age of 7,the girl was re-admitted to our hospital for a pathological fracture in the middle in the right femur and underwent Intralesional excision,internal fixation,bone grafting,and spica *** the age of 10,the girl came to our hospital again for severe pain of the right *** from the middle level of the right femur was *** present the case of a 5-year-old girl with JCS presenting with not only NOFs and café-au-lait macules,but also showed features not mentioned before,severe limb pain,and at last resulted in *** was admitted to our hospital after presenting with claudication and mild pain o

关键词： Jaffe-Campanacci syndrome Multiple non-ossifying fibromas Café-au-lait macule Amputation Case report

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Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling

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Protein & Cell 2024年第6期15卷 441-459页

作者： Feifei liu Yi Lu Xuebao Wang Shuhui Sun huize Pan min Wang Zehua Wang Weiqi Zhang Shuai Ma Guoqiang Sun Qun Chu Si Wang Jing Qu Guang-hui liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Sports Medicine Department Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Division of Life Sciences and Medicine School of Life SciencesUniversity of Science and Technology of ChinaHefei 230001China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China The Fifth People’s Hospital of Chongqing Chongqing 400062China Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China

The synovium,a thin layer of tissue that is adjacent to the joints and secretes synovial fluid,undergoes changes in aging that contribute to intense shoulder pain and other joint ***,the mechanism underlying human synovial aging remains poorly ***,we generated a comprehensive transcriptomic profile of synovial cells present in the subacromial synovium from young and aged *** delineating aging-related transcriptomic changes across different cell types and their associated regulatory networks,we identified two subsets of mesenchymal stromal cells(MSCs)in human synovium,which are lining and sublining MSCs,and found that angiogenesis and fibrosis-associated genes were upregulated whereas genes associated with cell adhesion and cartilage development were downregulated in aged ***,the specific cell-cell communications in aged synovium mirrors that of aging-related inflammation and tissue remodeling,including vascular hyperplasia and tissue *** particular,we identified forkhead box O1(FOXO1)as one of the major regulons for aging differentially expressed genes(DEGs)in synovial MSCs,and validated its downregulation in both lining and sublining MSC populations of the aged *** human FOXO1-depleted MSCs derived from human embryonic stem cells,we recapitulated the senescent phenotype observed in the subacromial synovium of aged *** data indicate an important role of FOXO1 in the regulation of human synovial ***,our study improves our understanding of synovial aging during joint degeneration,thereby informing the development of novel intervention strategies aimed at rejuvenating the aged joint.

关键词： FOXO1 degeneration inflammation

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New perspectives in free nitrous acid (FNA) uses for sustainable wastewater management

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 161-168页

作者： Zhiqiang Zuo min Zheng Tao liu Yongzhen Peng Zhiguo Yuan National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology Engineering Research Center of BeijingBeijing University of TechnologyBeijing 100124China Australian Centre for Water and Environmental Biotechnology The University of QueenslandSt.LuciaQLD 4072Australia Water Research Centre School of Civil and Environmental EngineeringUniversity of New South WalesSydneyNew South Wales 2052Australia Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077China School of Energy and Environment City University of Hong KongHong Kong 999077China

The biocidal effects of free nitrous acid (FNA) have found applications in multiple units in an urban wastewater system, including sewer networks, wastewater treatment processes, and sludge treatment processes. However, these applications are associated with chemical costs as both nitrite and acid are needed to produce FNA at the required levels. The recent discovery of novel acid-tolerant ammonia oxidizers offers the possibility to produce FNA from domestic wastewater, enabling the development of next-generation FNA-based technologies capable of achieving self-sustaining FNA production. In this study, we focus on the concept of in situ FNA generation facilitated by acid-tolerant ammonia oxidizers and highlight the multiple benefits it creates, after a brief review of the historical development of FNA-based technologies. We will discuss how wastewater systems can be made more energy-efficient and sustainable by leveraging the potential of acid-tolerant ammonia oxidizers.

关键词： Free nitrous acid Acid-toler antammonia oxidizer In situ generationl Wastewater management

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Jellyfish bio-inspired Fe@CNT@CuNC derived from ZIF-8 for cathodic oxygen reduction

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Nano Research 2024年第4期17卷 2352-2359页

作者： Kai Cheng Zequan liu Demin Jiang min Song Yuqiao Wang Research Center for Nano Photoelectrochemistry and Devices School of Chemistry and Chemical EngineeringSoutheast UniversityNanjing 211189China Yangtze River Delta Carbon Neutrality Strategy Development Institute Southeast UniversityNanjing 210096China School of Energy and Environment Southeast UniversityNanjing 210096China

Biomimetics provides guidance to design and synthesize advanced catalysts for oxygen reduction reaction in microbial fuel cells(MFCs).Herein,jellyfish-inspired Fe clusters on carbon nanotubes connected with CuNC(Fe@CNT@CuNC)were designed and prepared by using zeolitic imidazolate framework(ZIF)-8 precursors to imitate the organic texture and function of *** antibacterial effect of Cu^(+)ions depressed the growth of cathode biofilm to ensure rapid mass *** clusters and CuNC connected by CNTs accelerated the electron transfer from Fe to *** optimization of oxygen adsorption was caused by electron redistribution between sites of Fe and ***-like catalysts achieved a half-wave potential of 0.86 V and onset potential of 0.95 V *** hydrogen electrode(RHE).MFCs gained the maximum power density of 1600 mW·m^(-2) after 500 h *** work provides insights into the special design of advanced catalysts based on bio-inspiration and biomimetics.

关键词： bio-inspiration oxygen reduction reaction antibacterial ability microbial fuel cells density functional theory(DFT)rational design

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Hydrodynamics and OCM reaction performance in a bubbling fluidized bed reactor and a riser reactor

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Particuology 2024年第3期86卷 188-204页

作者： min Cai Shuangzhu Kong Sheng Chen Mengxi liu Chunxi Lu State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China China Special Equipment Inspection and Research Institute Beijing102249China

The reasonable reactor design is of great importance for increasing the C_(2) yield(C2H4 and C2H6)of the oxidative coupling of methane(OCM),and the OCM reactor should remove the heat released in reactions quickly and efficiently and minimize the consecutive reaction of ethylene to carbon *** fluidized bed reactor is characterized by excellent heat transfer,superior mass transport,and large handling capacity,while fewer studies focused on large-scale fluidized bed reactors for the OCM ***,large cold-model experiments and computational fluid dynamics simulations were conducted to investigate hydrodynamics and the OCM reaction performance in a large-scale bubbling fluidized bed(BFB)and a large-scale *** the BFB reactor,consecutive reactions of ethylene are acute because of the strong gas back-mixing,high solids holdup,and non-uniform solids *** the consecutive reactions of ethylene are negligible due to the plug flow structure and low solids holdup in the riser ***,both reactors can achieve isothermal operation for the OCM *** C_(2) selectivity of 45.4% and C_(2) yield of 21.1% are obtained in the riser reactor,increasing by 20.3% and 5.8% individually than that in the BFB *** study provides useful information and reference to the OCM reactor designandcommercialization.

关键词： Oxidative coupling of methane Bubbling fluidized bed reactor Riser reactor Hydrodynamics Isothermal operation

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Evaluation of COVID-19 outbreak prevention and control in Beijing using the emergency management theory

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Fundamental Research 2024年第3期4卷 671-677页

作者： Yu Wu Jue liu min liu School of Public Health Peking UniversityBeijing 100191China

On April 29,2020,China entered a normalization stage of prevention and *** December 2021,more than 40 outbreaks had occurred in China,which reflected the shortcomings of the pandemic prevention and control measures in China at that *** the capital city of China,Beijing faces more pressure in epidemic prevention and *** used the COVID-19 cluster containment evaluation indicators to determine the effects of prevention and control measures on four COVID-19 outbreaks in *** considering the specificity and operability of evaluation indicators and the availability of evaluation data,the evaluation system in our study consisted of six dimensions:epidemic prevention and control effect,discovery and detection ability,precision prevention and control capability,public protection effect,medical treatment and nosocomial infection prevention and control ability,and information release and public opinion response *** composite scores of the prevention and control effects of the Xinfadi,Shunyi,Daxing,and Ejina Banner–associated COVID-19 outbreaks in Beijing were 62,82,87,and 76,*** the six dimensions,the epidemic prevention and control effect,discovery and detection ability,precision prevention and control capability,and public protection effect scores for the Xinfadi outbreak were lower than those for the Shunyi,Daxing and Ejina Banner–associated *** medical treatment and nosocomial infection prevention and control ability scores for the outbreak associated with Ejina Banner were lower than those for the Xinfadi,Shunyi,and Daxing *** managing cluster outbreaks,Beijing was able to detect index cases early enough to reduce the scale and duration of the outbreak and consistently release official information to reduce public panic,standardize the management of centralized quarantine sites to prevent cross-infection,adhere to the“dynamic COVID‐zero”strategy to accurately prevent and control outbreaks,reduce the societa

关键词： Cluster outbreaks COVID-19 Prevention and control Evaluation Beijing

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Cu,N codoped carbon nanosheets encapsulating ultrasmall Cu nanoparticles for enhancing selective 1,2-propanediol oxidation

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Journal of Energy Chemistry 2024年第4期91卷 27-35页

作者： Yonghai Feng min Yu minjia Meng Lei liu Dewei Rao Institute for Advanced Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang 212013JiangsuChina School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

In the selective oxidation of biomass-based 1,2-propanediol(PDO)with oxygen as the terminal oxidant,it is challenging to improve the lactic acid(LA)selectivity for nonnoble metal nanoparticles(NPs)due to their limited oxygen reduction rate and easy C-C *** the high economic feasibility of nonnoble metals,i.e.,Cu,in this work,copper and nitrogen codoped porous carbon nanosheets encapsulating ultrafine Cu nanoparticles(Cu@Cu-N-C)were developed to realize highly selective of PDO oxidation to *** carbon-encapsulated ultrasmall Cu^(0)NPs in Cu@Cu-N-C have high PDO dehydrogenation activity while N-coordinated Cu(Cu-N)sites are responsible for the high oxygen reduction ***,the performance of catalytic PDO conversion to LA is optimized by a proposed pathway of PDO→hydroxylacetone→lactaldehyde→***,the enhanced LA selectivity is 88.5%,and the PDO conversion is up to 75.1%in an O_(2)-pressurized reaction system(1.0 MPa O_(2)),superior to other Cu-based catalysts,while in a milder nonpressurized system(O_(2)flow rate of 100 mL min-1),a remarkable LA selectivity(94.2%)is obtained with 39.8%PDO conversion,2.2 times higher than that of supported Au nanoparticles(1%Au/C).Moreover,carbon encapsulation offers Cu@Cu-N-C with strong leaching resistance for better recycling.

关键词： Selective oxidation Copper and nitrogen doped carbon 1,2-Propanediol Ultrasmall Cu nanoparticles Lactic acid

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FMSA:a meta-learning framework-based fast model stealing attack technique against intelligent network intrusion detection systems

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Cybersecurity 2024年第1期7卷 110-121页

作者： Kaisheng Fan Weizhe Zhang Guangrui liu hui He School of Cyberspace Science Harbin Institute of TechnologyHarbin 150001China Department of New Networks Peng Cheng LaboratoryShenzhen 518055GuangdongChina

Intrusion detection systems are increasingly using machine *** machine learning has shown excellent performance in identifying malicious traffic,it may increase the risk of privacy *** paper focuses on imple-menting a model stealing attack on intrusion detection *** model stealing attacks are hard to imple-ment in practical network environments,as they either need private data of the victim dataset or frequent access to the victim *** this paper,we propose a novel solution called Fast Model Stealing Attack(FMSA)to address the problem in the field of model stealing *** also highlight the risks of using ML-NIDS in network ***,meta-learning frameworks are introduced into the model stealing algorithm to clone the victim model in a black-box ***,the number of accesses to the target model is used as an optimization term,resulting in minimal queries to achieve model ***,adversarial training is used to simulate the data distribution of the target model and achieve the recovery of privacy *** experiments on multiple public datasets,compared to existing state-of-the-art algorithms,FMSA reduces the number of accesses to the target model and improves the accuracy of the clone model on the test dataset to 88.9%and the similarity with the target model to 90.1%.We can demonstrate the successful execution of model stealing attacks on the ML-NIDS system even with protective measures in place to limit the number of anomalous queries.

关键词： AI security Model stealing attack Network intrusion detection Meta learning

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Density Clustering Algorithm Based on KD-Tree and Voting Rules

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Computers, Materials & Continua 2024年第5期79卷 3239-3259页

作者： hui Du Zhiyuan Hu Depeng Lu Jingrui liu The College of Computer Science and Engineering Northwest Normal UniversityLanzhou730070China

Traditional clustering algorithms often struggle to produce satisfactory results when dealing with datasets withuneven density. Additionally, they incur substantial computational costs when applied to high-dimensional datadue to calculating similarity matrices. To alleviate these issues, we employ the KD-Tree to partition the dataset andcompute the K-nearest neighbors (KNN) density for each point, thereby avoiding the computation of similaritymatrices. Moreover, we apply the rules of voting elections, treating each data point as a voter and casting a votefor the point with the highest density among its KNN. By utilizing the vote counts of each point, we develop thestrategy for classifying noise points and potential cluster centers, allowing the algorithm to identify clusters withuneven density and complex shapes. Additionally, we define the concept of “adhesive points” between two clustersto merge adjacent clusters that have similar densities. This process helps us identify the optimal number of clustersautomatically. Experimental results indicate that our algorithm not only improves the efficiency of clustering butalso increases its accuracy.

关键词： Density peaks clustering KD-Tree K-nearest neighbors voting rules

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高迁移率组蛋白1在狼疮性肾炎患者肾组织中的表达和临床意义

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临床皮肤科杂志 2014年第4期43卷 224-227页

作者：刘慧敏河北工程大学附属医院皮肤性病科河北邯郸056002

目的:探讨高迁移率组蛋白1(high mobility group box1,HMGB1)在狼疮性肾炎(lupus nephritis,LN)患者肾组织中的表达及其临床意义。方法:LN患者63例,B超引导下行肾穿刺活检术获得肾脏组织标本,外伤性肾粉碎性破裂患者切除的正常肾组织15... 详细信息

目的:探讨高迁移率组蛋白1(high mobility group box1,HMGB1)在狼疮性肾炎(lupus nephritis,LN)患者肾组织中的表达及其临床意义。方法:LN患者63例,B超引导下行肾穿刺活检术获得肾脏组织标本,外伤性肾粉碎性破裂患者切除的正常肾组织15例,用免疫组织化学SP法检测HMGB1蛋白在肾脏组织中的表达,并分析其与肾脏活动指数(AI)、慢性指数(CI)和LN病理分型之间的关系。结果:LN组的HMGB1蛋白表达显著高于对照组(t=9.263,P<0.05);其表达水平与系统性红斑狼疮活动性指数(SLEDAI)评分(r=0.579,P<0.05)、AI(r=0.708,P<0.05)和肾小管间质病变(TIL)评分(r=0.815,P<0.05)呈正相关,与CI评分呈负相关(r=0.582,P<0.05)。结论:HMGB1可能参与了LN发病过程,促进了LN的病情进展。

关键词：肾炎,狼疮性红斑狼疮,系统性高迁移率组蛋白

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