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Recent advances in chemical protein synthesis:method developments and biological applications

Science china Chemistry 2024年第4期67卷 1060-1096页

作者： Suwei Dong Ji-Shen Zheng Yiming Li Huan Wang Gong Chen Yongxiang Chen Gemin Fang Jun guo Chunmao He Honggang Hu Xuechen Li Yanmei Li Zigang Li Man Pan Shan Tang changlin Tian Ping Wang Bian Wu Chuanliu Wu Junfeng Zhao Lei liu State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Division of Life sciences and Medicine University of Science and Technology of ChinaHefei 230027China School of Food and Biological Engineering Engineering Research Center of Bio-processMinistry of EducationHefei University of TechnologyHefei 230009China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China Department of Chemistry Tsinghua UniversityBeijing 100084China institute of Health sciences Anhui UniversityHefei 230601China College of Chemistry Central China Normal UniversityWuhan 430079China School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510640China School of Medicine or institute of Translational Medicine Shanghai UniversityShanghai 200444China Department of Chemistry The University of Hong KongHong Kong 999077China Shenzhen Graduate School Peking UniversityShenzhen 518055China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Life sciences University of Science and Technology of ChinaHefei 230026China Department of Chemical Biology Shanghai Jiao Tong UniversityShanghai 200240China institute of Microbiology Chinese Academy of SciencesBeijing 100101China Department of Chemistry Xiamen UniversityXiamen 361005China School of Pharmaceutical Science Guangzhou Medical UniversityGuangzhou 511436China

The central dogma of modern biology underscores the pivotal roles proteins play in diverse biological processes,the study of which necessitates advanced methods to produce proteins with precision and *** protein synthesis,a powerful approach utilizing chemical reactions for the de novo construction of structurally accurate proteins,has emerged as a transformative tool for studying proteins and generating protein derivatives/mimics inaccessible by natural biological machinery,including post-translationally modified proteins,proteins comprised of unnatural amino acids,as well as mirror-image *** review summarizes recent strides in synthetic method developments for chemical protein synthesis,including innovative techniques in solid-phase peptide synthesis,the challenges presented by difficult sequences in either synthesis or folding and the exploration of novel ligation reactions using both chemical and enzymatic ***,the review also delves into newly developed protocols for site-selective protein modifications and the generation of stapled or macrocyclized peptides/miniproteins,highlighting the power of chemical methods to make structurally diverse *** applications of synthetic proteins in investigating post-translational modifications(phosphorylation,lipidation,glycosylation,ubiquitination,etc.),mirror-image biological processes and drug development are further ***,these topics provide a comprehensive overview of the current landscape of chemical protein synthesis.

关键词： chemical protein synthesis solid-phase peptide synthesis ligation reactions post-translational modifications mirror-image proteins peptide drugs

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Comparative analysis of temperature and CO2 fluxes for winter wheat in Tibetan Plain and North china Plain using the EMD method

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Progress in Natural Science:Materials International 2006年第10期16卷 1066-1071页

作者： JIANG Zhaoyang, YU Qiang, LEI Shuhe, WANG Tianduo, SUN Xiaomin and ZHANG Renhua ( chinese academy of Meteorological Science, Beijing 100081, china institute of Geographic sciences and Natural Resources Research, chinese academy of sciences, Beijing 100101, china Mathematics Department, Ocean University of china, Qingdao 266071, china shanghai institute of Plant Physiology and Ecology, chinese academy of sciences, shanghai 200032, china) [a]chinese academy of Meteorological Science Beijing China [b]chinese academy of sciences Institute of Geographic sciences and Natural Resources Research Beijing China [c]Mathematics Department Ocean University of China Qingdao China [d]chinese academy of sciences Shanghai Institute of Plant Physiology and Ecology Shanghai China

Comparative study of spectral properties of temperature and CO2 fluxes measured by eddy covariance method at Yucheng (36°57'N, 116°36'E, 28 m a.s.l., in the North china Plain) and at Lhasa (29°41'N, 91°20'E, 3688 m a.s. 1., on the Tibetan Plateau) is described using the empirical mode decomposition (EMD) method. The main results are: (1) The intrinsic oscillation modes or intrinsic mode functions (IMFs) were extracted from data of temperature ( T) and CO2 fluxes (F) measured at Yucheng ( T1 and F1) and Lhasa ( T2 and F2) . (2) Hilbert transform was applied to these IMF components, then the Hubert-Huang spectra and the marginal spectra of these data were obtained. (3) Comparison of temperature and CO2 fluxes in North china Plain and on Tibetan Plain illustrated that the characteristic frequencies corresponding to T1, F1, T2 and F2 are 0.05 Hz, 0.03 Hz, 0.014 Hz and 0.005 Hz, respectively.

关键词： empirical mode decomposition (EMD) intrinsic mode function (IMF) flux Hilbert transform wheat Tibet.

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Some considerations of organic materials for high density optical disk data storage

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chinese Science Bulletin 2000年第6期45卷 572-576页

作者： GAN Fuxishanghai institute of Optics and Fine Mechanics, chinese academy of sciences, shanghai 201800, china shanghai institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai China

The application possibilities of organic materials for high density optical disk data storage are discussed. Several points, such as physical and chemical stabilities, wavelength match and reversible property changes,... 详细信息

关键词： organic materials high density optical disk.

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Hydrothermal route to Eu doped LuO(OH) and Lu_2O_3 nanorods

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Science china(Technological sciences) 2010年第6期53卷 1576-1582页

作者： QIU HuaJun1,SHI Ying1,XIE JianJun1,XIE Jie1,ZHANG LinLin2 & XU FangFang2 1 School of Materials Science and Engineering,shanghai University,shanghai 200072,china 2 shanghai institute of ceramics,chinese academy of sciences,shanghai 200050,china 1. School of Materials Science and Engineering Shanghai University Shanghai 200072 China2. Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

A facile method was developed to synthesize Eu doped LuO(OH) nanorods through hydrothermal processing and Lu2O3 nanorods by subsequent *** microstructural morphologies of the Lu-based nanostructures could be controlled by simply varying the concentration of NaOH in hydrothermal processing as *** observation revealed that the obtained LuO(OH) nanorods after hydrothermal processing had a uniform diameter of 10-25 nm and a length around 100 *** heat treatment at 600-700°C for 2 h,the high length/diameter ratio was sustained in the obtained Lu2O3 nanorods with different sizes depending on the calcining temperatures.

关键词： nanorods hydrothermal processing LuO(OH) Lu2O3

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The first protein ever synthesized in vitro—a personal reminiscence of the total synthesis of crystalline insulin

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Science china(Life sciences) 2010年第1期53卷 16-18页

作者： ZHANG YouShang institute of Biochemistry and Cell Biology,shanghai institutes for Biological sciences,chinese academy of sciences shanghai 200031,china 1. institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

The total synthesis of crystalline bovine insulin started in 1958 was fully accomplished in 1965. This formidable task was a collaboration of the institute of Biochemistry in shanghai,

关键词： The first protein ever synthesized in vitro a personal reminiscence of the total synthesis of crystalline insulin

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GmSTF accumulation mediated by DELLA protein GmRGAs contributes to coordinating light and gibberellin signaling to reduce plant height in soybean

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The Crop Journal 2024年第2期12卷 432-442页

作者： Zhuang Li Qichao tu Xiangguang Lyu Qican Cheng Ronghuan Ji Chao Qin Jun liu Bin liu Hongyu Li Tao Zhao State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Plant height influences plant architecture,lodging resistance,and yield *** is modulated by gibberellic acid(GA)metabolism and *** proteins,acting as central repressors of GA signaling,integrate various environmental and hormonal signals to regulate plant growth and development in *** examined the role of two DELLA proteins,GmRGAa and GmRGAb,in soybean plant height *** of these proteins led to longer internodes and increased plant height,primarily by increasing cell *** functioned under different light conditions,including red,blue,and far-red light,to repress plant *** studies revealed that GmRGAs interacted with the blue light receptor *** with this,GmCRY1b partially regulated plant height via ***,DELLA proteins were found to stabilize the protein GmSTF1/2,a key positive regulator of *** stabilization led to increased transcription of GmGA2ox-7b and subsequent reduction in plant *** study enhances our understanding of DELLA-mediated plant height control,offering Gmrgaab mutants for soybean structure and yield optimization.

关键词： DELLA protein GmRGAs GmSTFs Plant height Soybean

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SYNTHESIS AND CHARACTERIZATION OF A NOVEL FLUORINE-CONTAINING HYDROPHOBICALLY ASSOCIATING POLYMER

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chinese Journal of Polymer Science 1999年第3期17卷 281-288页

作者： Jin Yang Wei-yuan Huang Laboratory of Organofluorine Chemistry, shanghai institute of Organic Chemistry, chinese academy of sciences, shanghai 200032, china chinese Acad Sci Shanghai Inst Organ Chem Lab Organofluorine Chem Shanghai 200032 Peoples R China

In this article, the synthesis and characterization of a novel fluoromonomer and its copolymer with acrylamide is reported. 2-perfluoroamyl-4-hydroxylquinoline 2 was synthesized from ethyl 2, 2-dihydroperfluoroheptanoate in high yields. The monomer 4 was then synthesized from 2 in two steps readily in high yields. Synthesis and characterization of copolymers of acrylamide (AM) and the fluoromonomer were investigated. The composition and intrinsic viscosity of these copolymers were studied. It was found that the rheological properties of aqueous solutions of polyacrylamide were modified significantly when a small proportion of the fluoromonomer 4 was incorporated on investigating the viscosity-concentration profiles, pseudoplasticity of these solutions and the effect of the presence of surfactant. These results could be explained by the hydrophobic association of the fluorocarbon segments in the aqueous solutions of these copolymers.

关键词： hydrophobically associating polymer fluorine-containing acrylate perfluoroalkylation with RFI/Na2S2O4

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Progress in glial cell studies in some laboratories in china

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Science china(Life sciences) 2010年第3期53卷 330-337页

作者： DUAN ShuMin institute of Neuroscience,State Key Laboratory of Neuroscience,shanghai institutes for Biological sciences,chinese academy of sciences,shanghai china,200031 1. institute of Neuroscience State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China 200031

Glial cells in the central nervous system(CNS) consist of a heterogeneous population of cell types,each characterized by distinct morphological features,physiological properties,and specific *** contrast to the previous view that glial cells were passive elements in the brain,accumulating evidence suggests that glial cells are active participants in various brain functions and brain *** review summarizes recent progress of glial cell studies from several groups in china,ranging from studies about the mechanisms of neuron-glia crosstalking to investigations on the roles of glial cells in various CNS disorders.

关键词： neuron-glia interaction ATP plasticity pain ischemia neural injury and repair

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Detection of tumor Marker CA125 in Ovarian Carcinoma Using Quantum Dots

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Acta Biochimica et Biophysica Sinica 2004年第10期36卷 681-686页

作者： Hui-Zhi WANG, Hai-Yan WANG, Ru-Qiang LIANG, and Kang-Cheng RUAN* Key Laboratory of Proteomics, institute of Biochemistry and Cell Biology, shanghai institutes for Biological sciences,chinese academy of sciences, Graduate School of the chinese academy of sciences, shanghai 200031, china Key Laboratory of Proteomics Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesGraduate School of the Chinese Academy of SciencesShanghai 200031China

Semiconductor quantum dots (QDs) offer several advantages over organic dyes in fluores- cence-imaging applications, such as higher quantum yield, exceptional photostability, and a narrow, tunable, and symmetric emission spectrum. To explore whether QDs could specifically and effectively label tumor markers and be used in immunohistochemistry as a novel type of fluorescent probe, we used quantum dots with maximum emission wavelength 605 nm (QD605) to detect the ovarian carcinoma marker CA125 in specimens of different types (fixed cells, tissue sections, and xenograft piece). Additionally, we compared the photostability of QD signals with that of a conventional organic dye, FITC. All labeling signals of QDs were found to be more specific and brighter than those of FITC. Moreover, the QDs exhibited exceptional photostability during continuous illumination for 1 h by a high-intensity laser (Ar laser power 100 mW) at 488 nm, while the FITC signals faded very quickly and became undetectable after 24 min of illumination. These results indicate that QD-based probes can offer substantial advantages over existing fluorophores in many applications, and can be used effectively in immunohistochemistry as a novel class of fluorescent probes.

关键词： quantum dots detection of tumor marker CA125 ovarian carcinoma

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Productions of kaon and lambda by 50 GeV protons incident on nuclear targets

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Nuclear Science and Techniques 1998年第2期9卷 74-77页

作者： Xu Xiao-Ming (shanghai institute of Nuclear Research, the chinese academy of sciences, shanghai 201800) shanghai institute of Nuclear Research Chinese Academy of Sciences Shanghai 201800 China

A Glauber multiple scattering theory in terms of pations and nucleons is applied to study productions of kaon, lambda and antilambda ill 50 GeV proton-nucleus scatterings at JHF (the Japan Hadron Facility). Tile ratios of tile differential cross sections of nucleontungsten to nucleon-beryllium are calclutated versus the transverse momentum at central rapidity. The cancellation between the single and double scattering amplitudes leads to nuclear enhancement of strangeness production at central rapidity.

关键词：质子核子靶 K介子 Α粒子

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