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Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis (BASIS): protocol of a prospective, multicentre, randomised, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 66-74页

作者： Xuan sun Ming Yang Dapeng sun Guangge Peng Yiming Deng Xingquan Zhao Liping liu Ning Ma feng Gao Dapeng Mo Wengui Yu Yongjun Wang Yilong Wang Zhongrong Miao Department of Interventional Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Neurology Comprehensive Stroke&Cerebrovascular CenterUniversity of California IrvineIrvineCaliforniaUSA Chinese institute for Brain Research BeijingChina National Center for Neurological Diseases BeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina china National Clinical Research Center for Neurological Diseases BeijingChina Beijing Laboratory of Oral Health Capital Medical UniversityBeijingChina

Background The superiority of balloon angioplasty plus aggressive medical management(AMM)to AMM alone for symptomatic intracranial artery stenosis(sICAS)on efficacy and safety profiles still lacks evidence from randomised controlled trials(RCTs).Aim To demonstrate the design of an RCT on balloon angioplasty plus AMM for *** Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis(BASIS)trial is a multicentre,prospective,randomised,open-label,blinded end-point trial to investigate whether balloon angioplasty plus AMM could improve clinical outcome compared with AMM alone in patients with *** eligible in BASIS were 35–80 years old,with a recent transient ischaemic attack within the past 90 days or ischaemic stroke between 1. days and 90 days prior to enrolment due to severe atherosclerotic stenosis(70%–99%)of a major intracranial *** eligible patients were randomly assigned to receive balloon angioplasty plus AMM or AMM alone at a 1.1.*** groups will receive identical AMM,including standard dual antiplatelet therapy for 90 days followed by long-term single antiplatelet therapy,intensive risk factor management and life-style *** participants will be followed up for *** outcomes Stroke or death in the next 30 days after enrolment or after balloon angioplasty procedure of the qualifying lesion during follow-up,or any ischaemic stroke or revascularisation from the qualifying artery after 30 days but before 1. months of enrolment,is the primary *** BASIS trail is the first RCT to compare the efficacy and safety of balloon angioplasty plus AMM to AMM alone in sICAS patients,which may provide an alternative perspective for treating *** registration number NCT03703635;https://***.

关键词： balloon prospective centre

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The Spatiotemporal Distribution Characteristics of Cloud Types and Phases in the Arctic Based on CloudSat and CALIPSO Cloud Classification Products

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Advances in Atmospheric Sciences 2024年第2期41卷 310-324页

作者： Yue sun Huiling YANG Hui XIAO Liang {1. Wei CHENG Libo ZHOU Weixi SHU Jingzhe sun Key Laboratory of Cloud-Precipitation physics and Severe Storms(LACS) and Department of Lower Atmospheric Observation Research(LAOR)Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth Sciences University of Chinese Academy of Sciences(UCAS)Beijing 100049China Beijing institute of Applied Meteorology Beijing 100029China

The cloud type product 2B-CLDCLASS-LIDAR based on CloudSat and CALIPSO from June 2006 to May 201. is used to examine the temporal and spatial distribution characteristics and interannual variability of eight cloud types(high cloud, altostratus, altocumulus, stratus, stratocumulus, cumulus, nimbostratus, and deep convection) and three phases(ice,mixed, and water) in the Arctic. Possible reasons for the observed interannual variability are also discussed. The main conclusions are as follows:(1. More water clouds occur on the Atlantic side, and more ice clouds occur over continents.(2)The average spatial and seasonal distributions of cloud types show three patterns: high clouds and most cumuliform clouds are concentrated in low-latitude locations and peak in summer;altostratus and nimbostratus are concentrated over and around continents and are less abundant in summer;stratocumulus and stratus are concentrated near the inner Arctic and peak during spring and autumn.(3) Regional averaged interannual frequencies of ice clouds and altostratus clouds significantly decrease, while those of water clouds, altocumulus, and cumulus clouds increase significantly.(4) Significant features of the linear trends of cloud frequencies are mainly located over ocean areas.(5) The monthly water cloud frequency anomalies are positively correlated with air temperature in most of the troposphere, while those for ice clouds are negatively correlated.(6) The decrease in altostratus clouds is associated with the weakening of the Arctic front due to Arctic warming, while increased water vapor transport into the Arctic and higher atmospheric instability lead to more cumulus and altocumulus clouds.

关键词： CloudSat and CALIPSO cloud type cloud phase temporal and spatial distribution interannual variation

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Study of proton resonances in ^(1.)Ne via resonant elastic scattering of ^(1.)F+p and its astrophysical implication

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Science china({1.,Mechanics & Astronomy) 2011年第S1期54卷 32-36页

作者： HE JianJun1. HU Jun1.2, XU ShiWei1. CHEN ZhiQiang1. ZHANG XueYing1. WANG JianSong1. YU XiangQing1. ZHANG LiYong1.2, LI Long1.2, YANG YanYun1.2, MA Peng1.2, ZHANG XueHeng1. HU ZhengGuo1. GUO ZhongYan1. XU Xing1.2, YUAN XiaoHua1. LU Wan1.2, YU YuHong1. ZANG YongDong1.2, TANG ShuWen1.2, YE RuiPing1.2, CHEN JinDa1.2, JIN ShiLun1.2, DU ChengMing1.2, WANG ShiTao1.2, MA JunBing1.2, liu LongXiang1.2, BAI Zhen1.2, LEI XiangGuo1. {1. ZhiYu1. ZHANG YuHu1. ZHOU XiaoHong1. XU HuShan1. SU Jun3, LI ErTao3, WANG HongWei4, TIAN WenDong4 & LI XiangQing5 1.institute of Modern physics (IMP), Chinese Academy of Sciences, Lanzhou 730000, china 2 Graduate university of Chinese Academy of Sciences, Beijing 1.0049, china 3 china institute of Atomic Energy (CIAE), Beijing 1.241., china 4 Shanghai institute of Applied physics (SINAP), Chinese Academy of Sciences, Shanghai 201.00, china 5 School of physics and State Key Laboratory of Nuclear physics and Technology, Peking university, Beijing 1.0871. china institute of Modern {1. (IMP) Chinese Academy of Sciences Lanzhou China Graduate university of Chinese Academy of Sciences Beijing China china {1. of Atomic Energy (CIAE) Beijing China Shanghai institute of Applied {1. (SINAP) Chinese Academy of Sciences Shanghai China School of physics and State Key Laboratory of Nuclear physics and Technology Peking University Beijing China

The proton resonant properties in 1.Ne, which determine the reaction rate of the key stellar 1.O(α,p)1.F reaction, have been studied by using a technique of proton resonant elastic scattering of 1.F+p. A 4.22 MeV/nucleon 1.F radioactive ion (RI) beam was produced via a projectile-fragmentation reaction, and separated by a Radioactive Ion Beam Line in Lanzhou (RIBLL). By bombarding a thick (CH2)n target, the energy spectra of the recoiled protons were measured by two ΔE-E silicon telescopes at the center-of-mass scattering angles of θc.m.≈1.5°±5°, θc.m.≈1.2°±8°, respectively. Several proton resonances in 1.Ne were ob served clearly. A further R-matrix analysis of the experimental data is under way to determine the resonant parameters. The present work reports the preliminary results briefly.

关键词： resonant reaction reaction rate explosive burning accreting binary systems

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Giant magnetoimpedance effect of multilayered structure(F/SiO_2)_3/Ag/(SiO_2/F)_3 films deposited in a longitudinal magnetic field

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Science china(Technological Sciences) 2010年第3期53卷 287-292页

作者： CHEN WeiPing1.2,Shao XianYi1.2,{1. ShangShen1.2,XIAO ShuQin3 & liu YiHua3 1.School of physics and Electronics Engineering,Zhejiang Taizhou university,Taizhou 31.000,china 2 institute of Function Materials for Electronic Information,Zhejiang Taizhou university,Taizhou 31.000,china 3 School of physics,Shandong university,Jinan 2501.0,china School of physics and Electronics Engineering Zhejiang Taizhou University Taizhou China institute of Function Materials for Electronic Information Zhejiang Taizhou University Taizhou China School of physics Shandong University Jinan China

The soft magnetic properties and giant magnetoimpedance(GMI) effect of the multilayered structure(F/SiO2)3/Ag/(SiO2/F)3(F≡Fe71.5Cu1.r2.5V4Si1.B9) films,which were prepared by radio frequency sputtering without and with a longitudinal magnetic field of about 72 kA/m,are *** results show that the GMI effect almost cannot be detected in the samples deposited without field,whereas,a longitudinal magnetic field applied during deposition process obviously optimizes the soft magnetic properties of the films,and noticeable GMI effect is *** maximum values of the longitudinal and transverse GMI ratios are 45% and 44% at the frequency of 6.81.MHz,*** addition,the dependence of magnetoimpedance ratio,magnetoresistance ratio,magnetoreactance ratio and effective permeability ratio on the frequency has been *** found that the GMI spectrum curves in the longitudinal and transverse cases almost overlap for the field-deposited *** GMI effect is mainly a giant magnetoinductive effect at low *** f >9 MHz,magnetoreactance ratio changes to a negative,i.e.,the property of reactance changes from inductive to capacitive.

关键词： Fe-based soft magnetic alloy as-deposited multilayered films giant magnetoimpedance effect effective permeability magnetic anisotropy

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Progress of Lyman-alpha-based beam emission spectroscopy(Ly BES)diagnostic on the HL-2A tokamak

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Plasma Science and Technology 2024年第3期26卷 118-125页

作者：周艺轩余羿许敏柯锐聂林徐皓赵光义刘灏袁子豪肖晨雨李继全肖池阶 the HL-2A Team Southwestern institute of {1. Chengdu 610041People's Republic of China Sino-French institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082People's Republic of China State Key Laboratory of Nuclear physics and Technology School of PhysicsPeking UniversityBeijing 100871People's Republic of China

An edge Lyman-alpha-based beam emission spectroscopy(LyBES)diagnostic,using a heating NBI(neutral beam injection)system,is currently under development on the HL-2A *** 20-channel edge LyBES,which is intended to measure the density fluctuation in plasma edge(from R=1.60 mm to R=2026 mm)with an improved spatial resolution of 3.3 mm,is a complement to the existing conventional beam emission spectroscopy(BES)*** this article,we introduce the progress of LyBES diagnostic,including the collection optics,the monochromator,and the detector *** reflectance of the collection mirrors is measured to be~82%at 1.2 nm,and the aberration geometrical radius of the collection optics is tested to be~1.0μm in the aimed *** linear dispersion of the LyBES monochromator is designed to be~0.09 nm mm^(-1..The bandwidth of the detector system with the 5×1.^(7)V A^(-1.preamplifier gain is measured to be~280 kHz,and the peak-to-peak noise of the detector system is tested to be~1. *** finalized design,components development and testing of the LyBES diagnostic have been completed at present,and an overall performance of the LyBES diagnostic is to be confirmed in the next HL-2A campaign.

关键词： density fluctuation Ly BES BES vacuum ultraviolet

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Understand the Temperature Sensing Behavior of Solid-state Polymerized PEDOT Hybrid Based on X-ray Scattering Studies

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Chinese Journal of Polymer Science 2024年第1期42卷 105-112,I0010页

作者： Zhen-Hang He Guang-feng {1. Ze-Kun Zhou Zhen {1. Yi-Shu Zeng Peng Zhang School of Materials Science and Engineering Key Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou 510275China Shanghai Advanced Research institute(Zhangjiang Laboratory) Chinese Academy of SciencesShanghai 201204China

Poly(3,4-ethylenedioxythiophene)(PEDOT) is one of the most successful conductive polymers that recently has been used in wearable sensors for human health monitoring. In this work, we prepared a series of PEDOT hybrids consisting of PEDOT, sodium poly(styrene sulfonate)(PSSNa) and polyethylene oxide(PEO), and their preparation could be scaled-up via an adapted solid-state polymerization process. The resistance of the as-prepared PEDOT:PSS/PEO hybrid shows clear temperature response, i.e., it decreases almost linearly with the temperature increase. To understand this phenomenon, the in situ synchrotron radiation wide-and small-angle X-ray scattering(WAXS/SAXS) characterizations were undertaken to study the temperature-dependent microstructure change of the PEDOT:PSS/PEO hybrid. It demonstrated that PEDOT formed conductive paths in the hybrids, which were not destroyed by the PEO crystallization. As temperature increased, the PEO crystals' melting and the accompanying reorganization of PEDOT chains endowed the hybrid sample temperature responsiveness. Based on these fundamental knowledges, the hybrid materials were used to fabricate flexible wearable sensor that showing temperature sensing performance with an accuracy of 1.℃. These findings shed lights on the scalable manufacturing of wearable sensors for body temperature monitoring.

关键词： Solid-state polymerization PEDOT hybrid Structure-property correlation X-ray scattering

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MicroRNA-451. is a candidate biomarker and therapeutic target for major depressive disorder

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General Psychiatry 2024年第1期37卷 151-162页

作者： Panpan Hu Qiuchen Cao Hu feng Yun {1. Yan Chen Jingfan Xu Weixi feng Huaiqing sun Huachen Ding Chun Wang Junying Gao Ming Xiao Jiangsu Key Laboratory of Neurodegeneration Nanjing Medical UniversityNanjingJiangsuChina Department of Neurology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Nanjing Brain Hospital Affliated to Nanjing Medical university NanjingJiangsuChina Functional Brain Imaging institute of Nanjing Medical {1. NanjingJiangsuChina

Background Increasing evidence supports the role of microRNAs(miRNAs)in major depressive disorder(MDD),but the pathophysiological mechanism remains *** To explore the mechanism of microRNA-451.(miR-451.)in the pathology and behaviours of *** Abnormal miRNAs such as miR-451. reported previously in the serum of patients with MDD were screened and then confirmed in a mouse model of depression induced by chronic restraint stress(CRS).Eight-week-old male C57BL/6 mice had miR-451. overexpression in the medial prefrontal cortex(mPFC)via adeno-associated virus serotype 9 vectors encoding a pri-mmu-miR-451.-GFP fusion protein followed by behavioural and pathological ***,molecular biological experiments were conducted to investigate the potential mechanism of miR-451. against *** The serum levels of miRNA-451.were significantly lower in patients with MDD,with a negative correlation with the Hamilton Depression Scale ***,a negative association between serum miR-451. and behavioural despair or anhedonia was observed in CRS ***,miR-451. expression was significantly downregulated in the mPFC of CRS-susceptible *** miR-451. in the mPFC reversed the loss of dendritic spines and the depression-like phenotype of CRS ***,miR-451. could inhibit CRS-induced corticotropin-releasing factor receptor 1.expression via targeting transcription factor 2,subsequently protecting dendritic spine *** Together,these results highlighted miR-451. as a candidate biomarker and therapeutic target for MDD.

关键词： therapeutic medial behaviour

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Potential for soil carbon sequestration under conservation agriculture in a warming climate

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Science Bulletin 2024年第13期69卷 2030-2033页

作者： Lijun Yu Wen Zhang Jingjing liu Wenjuan {1. Qing Zhang State Key Laboratory of Atmospheric Boundary Layer physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China university of Chinese Academy of Sciences Beijing 100049China Anyang Meteorological Service Anyang 455000China State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China

Agricultural soil has numerous links with climate *** comprises a substantial part of farming systems that are affected by climate change and can significantly impact food security[1..An increase in the soil carbon(C)stock is associated with an increase in the crop ***,agricultural soil remains a source for all three major greenhouse gases(GHGs),i.e.,carbon dioxide(CO_(2)),methane and nitrous oxide,which contributes directly to climate *** addition,enhancing soil C sequestration in agricultural land could offset GHG emissions,promote more sustainable and climate-resilient agricultural systems.

关键词： soil warming agricultural

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Exploring hidden-charm and hidden-strange hexaquark states from lattice QCD

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Science china({1.,Mechanics & Astronomy) 2024年第1期67卷 30-37页

作者： Hang liu Jinchen He liuming liu Peng sun Wei Wang Yi-Bo Yang Qi-An Zhang INPAC Key Laboratory for Particle Astrophysics and Cosmology(MOE)Shanghai Key Laboratory for Particle Physics and CosmologySchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Maryland Center for Fundamental physics Department of PhysicsUniversity of MarylandCollege ParkMaryland 20742USA institute of Modern {1. Chinese Academy of SciencesLanzhou 730000China university of Chinese Academy of Sciences Beijing 100049China Department of physics and {1. of Theoretical physics Nanjing Normal UniversityNanjing 210023China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China CAS Key Laboratory of Theoretical physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Fundamental physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China International Centre for Theoretical physics Asia-Pacific Beijing 100049/Hangzhou 310024China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of physics Beihang UniversityBeijing 102206China

Based on five different ensembles of newly generated(2+1.-flavor configurations with pion mass of approximately mπ■(1.0-31.)MeV,we present a lattice analysis of hidden-charm and hidden-strange hexaquarks with the quark content■.The correlation matrices of two types of operators with JPC=0++,0-+,1.+and 1.-are simulated to extract the masses of the hexaquark candidates,which are subsequently extrapolated to the physical pion mass and continuum *** results indicate that ground state masses are below the■threshold and provide a characteristic signal for the experimental discovery of hexaquark candidates,which may enrich the versatile structure of multiquarks;moreover,it is an indispensable step to decipher the nonperturbative nature of the fundamental interactions of quarks and gluons.

关键词： quantum chromodynamics lattice QCD multiquark states

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Cluster-based composition rule for Laves phase-related BCC solid solution hydrogen storage alloys

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Rare Metals 2006年第Z1期25卷 252-255页

作者： WANG Qing CHEN feng WU Jiang QIANG Jianbing DONG Chuang ZHANG Yao XU Fen {1. Lixian State Key Laboratory of Materials Modification Dalian University of Technology Dalian 116024 China State Key Laboratory of Materials Modification Dalian University of Technology Dalian 116024 China State Key Laboratory of Materials Modification Dalian University of Technology Dalian 116024 China State Key Laboratory of Materials Modification Dalian University of Technology Dalian 116024 China State Key Laboratory of Materials Modification Dalian University of Technology Dalian 116024 China International Center of Materials physics Metals Research Institute Chinese Academy of Sciences Shenyang 110015 China Materials & Thermochemistry Laboratory Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China Materials & Thermochemistry Laboratory Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China Materials & Thermochemistry Laboratory Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China

A new cluster line approach for the composition rule of Laves phase-related BCC solid solution hydrogen-storage alloys was presented. The cluster line in a ternary phase diagram refers to a straight composition line linking a specific binary cluster to the third element. In the Laves phase-related BCC solid solution alloy system such as Ti-Cr-V, Ti-Cr tends to form binary Cr2Ti Laves phase while Ti-V and Cr-V to form solid solutions. This Laves phase is characterized by a close-packing icosahedral cluster Cr7Ti6. A cluster line Cr7Ti6-V is then constructed in this system. Alloy rods with a diameter of 3 mm of compositions along this line were prepared by copper-mould suction method. The alloy structure is found to vary with the V contents. Furthermore, the P-C-T measurements indicate that the cluster-line (Cr7Ti6)1.xVx alloys have large hydrogen storage capacities.

关键词： Ti-Cr-V alloys composition rule cluster hydrogen storage

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