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Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang rui-rui Fan qiang li Gong li Dong liu zheng-Yao Jin xing-Zhu Cui tian-Xiang Chen Yi-wei yang Rong liu Han Yi yang li zhen yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping Chen zhen Chen Zeng-Qi Cui An-chuan Fan Chang-Qing Feng Fan-zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-cheng He yang Hong Yi-wei Hu Han-Xiong huang wei-Hua Jia Hao-yu Jiang wei Jiang Zhi-jie Jiang ling Kang Bo li Chao li Jia-Wen li Xiao li Jie liu Shu-Bin liu Guang-Yuan Luan Chang-jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao ruan zhao-Hui song Kang Sun Zhi-xin Tan li-Jiao Wang Peng-cheng Wang zhao-Hui Wang Zhong-wei Wen Xiao-Guang Wu Xuan Wu li-Kun Xie Yong-Ji Yu Guo-Hui Zhang lin-Hao Zhang Mo-Han Zhang Qi-wei Zhang Xian-Peng Zhang Yu-liang Zhang Yue Zhang Zhi-Yong Zhang Mao-Yuan zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： qiang li li‑Jiao Wang Jing‑Yu Tang Xiang‑Biao Qiu zhen Chen Mao‑Yuan zhao Chang‑jun Ning Kai Pan wei Xu Tao li Su‑Peng Lu Han Yi rui‑rui Fan Chang‑Qing Feng Rong Zhang Xiao‑yang Sun Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Yong‑Hao Chen Zeng‑Qi Cui An‑chuan Fan Fan‑zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑cheng He yang Hong Yi‑wei Hu Han‑Xiong huang wei Jiang Zhi‑Jie Jiang zheng‑Yao Jin ling Kang Bo li Gong li Xiao li yang li Jie liu Rong liu Shu‑Bin liu Yi‑Na liu Guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao ruan zhao‑Hui song Kang Sun Zhi‑xin Tan Sheng‑Da Tang Jin‑cheng Wang Peng‑cheng Wang zhao‑Hui Wang Zhong‑wei Wen Xiao‑Guang Wu Xuan Wu Cong Xia Yong‑Ji Yu Guo‑Hui Zhang Hang‑Chang Zhang lin‑Hao Zhang Qi‑wei Zhang Xian‑Peng Zhang Yu‑liang Zhang Yue Zhang Zhi‑Yong Zhang Zhi‑Hao Zhou Ke‑jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan songshan Lake future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： qiang li li‑Jiao Wang Xiang‑Biao Qiu Jing‑Wen li wei Xu Tao li Ze‑Bin lin Chang‑jun Ning Yong‑Hao Chen rui‑rui Fan Kang Sun Jing‑Yu Tang Rong Zhang Han‑Tao Jing Bo Mei Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen zhen Chen Zeng‑Qi Cui An‑chuan Fan Chang‑Qing Feng Fan‑zhen Feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑cheng He yang Hong Yi‑wei Hu Han‑Xiong huang wei‑Hua Jia Hao‑Yu Jiang wei Jiang Zhi‑Jie Jiang zheng‑Yao Jin ling Kang Bo li Chao li Gong li Jia‑Wen li Xiao li yang li Jie liu Rong liu Shu‑Bin liu Guang‑Yuan Luan Bin‑Bin Qi Jie Ren Zhi‑Zhou Ren Xi‑Chao ruan zhao‑Hui song Zhi‑xin Tan Sheng‑Da Tang Peng‑cheng Wang zhao‑Hui Wang Zhong‑wei Wen Xiao‑Guang Wu Xuan Wu li‑Kun Xie Yi‑wei yang Han Yi Yong‑Ji Yu Guo‑Hui Zhang lin‑Hao Zhang Mo‑Han Zhang Qi‑wei Zhang Xian‑Peng Zhang Yu‑liang Zhang Yue Zhang Zhi‑Yong Zhang Mao‑Yuan zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan songshan Lake future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

Clinical features and microsurgical reconstruction of congenital unilateral absence of the vas deferens with obstructive azoospermia:a tertiary care center experience

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Asian Journal of Andrology 2023年第1期25卷 73-77页

作者： Yi-Hong Zhou Jian-jun Dong Er-Lei Zhi Chen-cheng Yao Yu-Hua huang ru-Hui tian Hui-xing Chen Ying-Bo Dai Yu-xin Tang Na-chuan liu Hui-Rong Chen fu-jun zhao zheng li Peng li Department of Andrology The Center for Men's HealthUrologic Medical CenterShanghai General HospitalShanghai Jiaotong University School of MedicineShanghai 200080China Department of Urology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China Department of Andrology Jiaozuo Maternity and Infant Health HospitalJiaozuo 454000China

Patients with congenital unilateral absence of the vas deferens(CUAVD)manifest diverse symptoms from normospermia to *** for CUAVD patients with obstructive azoospermia(OA)is complicated,and there is a lack of relevant *** this study,we describe the clinical features and evaluate the treatments and outcomes of CUAVD patients with *** December 2015 to December 2020,33 patients were diagnosed as CUAVD with OA in Shanghai General Hospital(Shanghai,China).Patient information,ultrasound findings,semen analysis,hormone profiles,and treatment information were collected,and the clinical outcomes were *** 33 patients,29 patients were retrospectively ***(VE)or cross VE was performed in 12 patients,the patency rate was 41.7%(5/12),and natural pregnancy was achieved in one of the *** other 17 patients underwent testicular sperm extraction as the distal vas deferens(contralateral side)was *** findings showed that VE or cross VE remains an alternative treatment for CUAVD patients with OA,even with a relatively low rate of patency and natural pregnancy.

关键词： congenital unilateral absence of the vas deferens natural pregnancy obstructive azoospermia patency vasoepididymostomy

Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China

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Biomedical and Environmental Sciences 2014年第5期27卷 353-359页

作者： HOU xin Guo WANG chuan MA Ze qiang yang wei Fang WANG Ji Xiang li cheng Qiao WANG Yu lian liu Shu Min Hu Xiu Ping ZHANG Xiu Ping JIANG Mei WANG wei Qing NING Guang zhenG Hui zhen MA Ai Xia SUN Yu song jun liN Peng liANG Kai liu fu qiang li Wen Juan XIAO Juan GONG Lei WANG Mei Jian liu Ji Dong YAN Fei yang jun Peng WANG ling Shu tian Meng zhao ru xing JIANG ling CHEN li Department of Endocrinology Qilu Hospital and Institute of Endocrinology and Metabolism Shandong University China National Heavy Duty Truck Group Corporation Hospital Jining Lukang Hospital Department of Endocrinology Jining Second People's Hospital Shantui Community Health Center Department of Endocrine and Metabolic Diseases Ruijin HospitalShanghai Jiaotong University Medical School

Objective To study the optimal waist circumference （WC） cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome （MetS） was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China.

关键词： Waist circumference Metabolic syndrome Central obesity

基于白光中子源的^(197)Au中子辐射俘获截面测量及共振参数分析

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物理学报 2024年第7期73卷 104-113页

作者：罗淏天张奇玮栾广源王晓宇邹翀任杰阮锡超贺国珠鲍杰孙琪黄翰雄王朝辉吴鸿毅顾旻皓余滔解立坤陈永浩安琪白怀勇鲍煜曹平陈昊磊陈琪萍陈裕凯陈朕崔增琪樊瑞睿封常青高可庆韩长材韩子杰何泳成洪杨黄蔚玲黄锡汝季筱璐吉旭阳蒋伟江浩雨姜智杰敬罕涛康玲康明涛李波李超李嘉雯李论李强李晓李样刘荣刘树彬刘星言穆奇丽宁常军齐斌斌任智洲宋英鹏宋朝晖孙虹孙康孙晓阳孙志嘉谭志新唐洪庆唐靖宇唐新懿田斌斌王丽娇王鹏程王琦王涛峰文杰温中伟吴青彪吴晓光吴煊羊奕伟易晗于莉于永积张国辉张林浩张显鹏张玉亮张志永赵豫斌周路平周祖英朱丹阳朱科军朱鹏朱兴华中国原子能科学研究院核数据重点实验室北京102413 中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803 核探测与核电子学国家重点实验室北京100049 中国科学技术大学近代物理系核探测与核电子学国家重点实验室合肥230026 北京大学物理学院核物理与核技术国家重点实验室北京100871 中国工程物理研究院核物理与化学研究所绵阳621900 西北核技术研究院西安710024 中国科学院大学北京100049 中国科学技术大学工程与应用物理系合肥230026 北京航空航天大学物理学院北京100083 华能山东石岛湾核电有限公司荣成264312

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室... 详细信息

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室建立了伽马全吸收装置(Gamma total absorption facility,GTAF),该装置用28块六棱BaF_(2)晶体和12块五棱BaF_(2)晶体构成了外径25 cm,内径10 cm的球壳,覆盖了95.2%的立体角.利用GTAF在中国散裂中子源Back-n束线上,测量了197Au(n,γ)的反应截面数据.测量数据通过能量筛选、PSD方法、晶体多重性筛选进行了初步本底扣除,随后结合对^(nat)C及空样品的测量数据对本底进行了分析及扣除,获得了197Au俘获反应的产额,利用SAMMY程序拟合得到了^(197)Au在1—100 e V的共振能量、中子共振宽度和伽马共振宽度参数.实验测量结果与ENDF/B-VIII.0数据库符合良好,其共振参数存在一定差异,分析原因可能与GTAF能量分辨率、Back-n的中子能谱测量精度、以及实验本底扣除方法相关,这也是下一步工作的重点.

关键词：中子辐射俘获截面共振参数白光中子源伽马全吸收装置

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The Chinese Hα Solar Explorer(CHASE) mission: An overview

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Science China(Physics,Mechanics & Astronomy) 2022年第8期65卷 2-9页

作者： chuan li cheng Fang zhen li MingDe Ding PengFei Chen Ye Qiu wei You Yuan Yuan MinJie An HongJiang Tao XianSheng li Zhe Chen qiang liu Gui Mei liang yang wei Zhang weiqiang cheng Jianxin Chen ChangYa Chen qiang Gu QingLong huang Mingxing liu chengShan Han Hongwei xin Changzheng Chen Yiwei Ni WenBo Wang shiHao Rao HaiTang li Xi Lu wei Wang jun lin YiXian Jiang lingJie Meng Jian zhao School of Astronomy and Space Science Nanjing University Key Laboratory for Modern Astronomy and Astrophysics (Nanjing University) Ministry of Education Shanghai Institute of Satellite Engineering Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Shanghai Academy of Spaceflight Technology China Center for Resources Satellite Data and Application China Aerospace Science and Technology Corporation Key and Special Project Center of China National Space Administration (CNSA)

The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations.

关键词： space-based telescope solar physics chromosphere photosphere

Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study

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Chinese Medical Journal 2020年第9期133卷 1015-1024页

作者： li-li Ren Ye-Ming Wang Zhi-qiang Wu Zi-Chun Xiang li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-jun li xing-Wang li Hui li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-yang Xu Fan yang xin-Ming Wang Chao Wu Lan Chen Yi-wei liu Bo liu Jian yang Xiao-rui Wang Jie Dong li li Chao-lin huang Jian-Ping zhao Yi Hu zhen-Shun cheng Un-lin liu zhao-Hui qian chuan Qin Qi Jin Bin Cao Jian-wei Wang National Health Commission of the People’s Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineNational Clinical Research Center for Respiratory DiseasesChina-Japan Friendship HospitalBeijing 100029China Institute of Respiratory Medicine Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100029China National Health Commission of the People’s Republic of China Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Vision Medicals Co. LtdGuangzhouGuangdong 510000China Hubei Provincial Center for Disease Control and Prevention WuhanHubei 430079China Wuhan Center for Disease Control and Prevention WuhanHubei 430022China Clinical and Research Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Institute of Clinical Medical Sciences China-Japan Friendship HospitalBeijing 100029China Institute of Laboratory Animal Science Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China Department of Basic Medical Sciences Tsinghua University School of MedicineBeijing 100084China Wuhan Jinyintan Hospital WuhanHubei 430022China Department of Pulmonary and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Sciences and TechnologyWuhanHubei 430030China Department of Pulmonary and Critical Care Medicine The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430014China Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China

Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern ***,we report a novel batorigin CoV causing severe and fatal pneumonia in ***:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,*** acids of the BAL were extracted and subjected to next-generation *** isolation was carried out,and maximum-likelihood phylogenetic trees were ***:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress *** radiography revealed diffuse opacities and *** of these patients *** results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the *** isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate ***,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin ***,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same ***:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans.

关键词： Bat-origin Coronavirus Zoonotic transmission Pneumonia Etiology Next-generation sequencing

Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)

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Military Medical Research 2020年第3期7卷 249-282页

作者： Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng xue-Qun Ren Xun-Tao Yin lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen yang Jianguang Ji Jian Xia Yi-Rong li fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-li Tu li-Ming Tan Min yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu xin-Can liu Jian yang Dong-Chi zhao Yu-Feng Ding Ning Hou fu-Bing Wang Hao Chen Yong-Gang Zhang wei li Wen Chen Yue-Xian shi Xiu-Zhi yang xue-jun Wang Yan-jun Zhong Ming-Juan zhao Bing-Hui li lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-fu Yu Lu-Yao li Qiao huang Hong Weng Xiang-Ying Ren li-Sha Luo Man-ru Fan Di huang Hong-yang xue lin-xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-jun li zhen-Shun cheng Xiao-Mei Yao xing-Huan Wang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical Research Center for Respiratory Diseases China-Japan Friendship HospitalBeijing 100029China Department of Pulmonary and Critical Care Medicine China-Japan Friendship HospitalBeijing 10029China Leishenshan Hospital in Wuhan Wuhan 430200China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institutes of Evidence-based Medicine and Knowledge Translation Henan UniversityKaifeng 475000HenanChina Department of Medical Imaging Guizhou Provincial People’s HospitalGuiyang 550002China Departments of Orthopedics Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical Research Center for Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical Laboratory Peking Union Medical College Hospital(PUMCH)Peking Union Medical CollegeChinese Academy of Medical Sciences(CAMS)Beijing 100730China Center for Primary Health Care Research Lund University and Region Skåne25002 MalmöSweden Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 403371China Department of Allergology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 43071China Department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Emergency Medicine and Chest Pain Center Qilu Hospital of Shandong UniversityJinan 250002China Department of Respiratory and Critical Care Medicine Suizhou Central HospitalHubei University of MedicineSuizhou 441300HubeiChina Department of Clinic Pharmacy Second People’s Hospital of Huaihua Ci

The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the *** and treatment guidelines for clinicians caring for patients are *** the early stage,we have issued"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)";now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based *** formed a working group of clinical experts and *** steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge *** searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)*** were either strong or weak,or in the form of ungraded consensus-based ***,we issued 34 *** them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based *** covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung

关键词： COVID-19 SARS-CoV-2 Recommendation Chemoprophylaxis Diagnosis Treatment Discharge management Traditional Chinese medicine guideline