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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin Niu Jiafeng fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

《分析化学仪器设备验证与综合评价指南》解读

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分析仪器 2017年第5期 143-146页

作者：高峰刘萤刘鑫刘来福云环赵靖敏范斐北京出入境检验检疫局检验检疫技术中心北京100026

本文对认证认可标准《分析化学仪器设备验证与综合评价指南》(RB/T160-2017)的目的和内容进行了解读,可帮助使用者更好的理解标准。

关键词：分析化学仪器设备验证综合评价

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“十三五”期间我国科研软件发展现状与对策

今日科苑 2021年第1期 18-26页

作者：刘福来张艾怡盛娟杜瑞燕东北大学秦皇岛分校河北秦皇岛066004 东北大学辽宁沈阳110819

“十三五”国家创新规划发布以来,我国软件行业取得了巨大的进展。科研软件作为软件行业中的一个细分分支,是科学研究中不可或缺的工具,是引领新一轮科技革命和产业变革的关键力量。因此有必要摸清我国科研软件发展现状和突出问题,研究... 详细信息

“十三五”国家创新规划发布以来,我国软件行业取得了巨大的进展。科研软件作为软件行业中的一个细分分支,是科学研究中不可或缺的工具,是引领新一轮科技革命和产业变革的关键力量。因此有必要摸清我国科研软件发展现状和突出问题,研究影响科研软件发展的关键因素。本文通过梳理国家基金委资助项目、国家发布的相关政策、行业现状、人才队伍结构等情况,结合科研软件研发和使用者的特点,分析了科研软件发展中存在的问题,提出了科研软件发展建议等,以期为科研软件的发展及创新提供一定借鉴。

关键词：科研软件发展现状突出问题对应建议

脑脊液系统在颅内高压动力学中作用的数学模型

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中华创伤杂志 2007年第5期23卷 377-380页

作者：焦风李运海曾高王慧敏刘来福梁冶矢栾文忠北京大学人民医院神经外科 100044 北京中医药大学附属东方医院北京师范大学数学科学学院

目的观察兔急性颅内压增高（increased intracranial pressure，iICP）与脑脊液流出阻力（outflow resistance，Ro）和颅内顺应性（intracranial compliance，IC）的关系，建立iICP与Ro和IC之间关系的数学模型。探讨以Ro及IC作为模型参数时模拟颅内压的准确性和临床应用价值。方法兔侧脑室插管，分别向侧脑室内注入0．1，0．2，0，3，0．4，0．5ml的等渗盐水，记录每一次颅内压随注入容积和时间变化的数值。以所得数据建立iICP与IC和Ro关系的数学模型。结果兔急性iICP时Ro模拟方程式为：R=Rot／PVI log[Po）／Pp×（Pp-Ro）／（P（t）-Ro）]，兔急性iICP时IC模拟方程式为：C=I／KP=0．4343（PVI）／P，综合两参数所决定的颅内压的方程为：P（t）=Ro exp（3．2383△V）／｜exp（3．2383△V）＋[（1-exp（3．2383△V）]exp（-3．2383／514．148Ro t）｜。结论数学模型较好地模拟了兔急性iICP时Ro和IC与颅内压的关系，提示Ro和IC可选择作为颅内高压动力学数学模型的重要参数，并有助于探讨急性iICP的病理生理过程及其容积代偿机制。

关键词：颅内高压脑脊髓液非线性动力学顺应性

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雷达/通信信号侦察一体化技术

舰船电子对抗 2008年第2期31卷 5-11页

作者：李朝伟周希元刘福来中国电子科技集团公司第54研究所石家庄050081

为对抗日益复杂的电磁环境,适应一体化综合电子战发展的需要,对单平台雷达/通信侦察一体化技术进行了研究。从电磁频段、功能、功率、信号波形及调制方式等不同角度,详细地分析了雷达与通信信号的特点;对实现雷达/通信侦察一体化的一体... 详细信息

为对抗日益复杂的电磁环境,适应一体化综合电子战发展的需要,对单平台雷达/通信侦察一体化技术进行了研究。从电磁频段、功能、功率、信号波形及调制方式等不同角度,详细地分析了雷达与通信信号的特点;对实现雷达/通信侦察一体化的一体化微波前端技术、一体化数字接收机技术、一体化数字信号处理技术、模块化技术等关键技术进行了研究,尤其是对一体化信号分选、识别技术进行了深入的分析研究。

关键词：雷达信号通信信号一体化技术模块化技术

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便携式可见分光光度计测定桂圆中二氧化硫

分析仪器 2017年第4期 162-165页

作者：窦宏亮刘鑫高峰刘亚芹云环刘萤刘来福北京普析通用仪器有限公司北京101200 北京出入境检验检疫局北京100026

采用便携式可见分光光度计测定桂圆中二氧化硫含量。结果表明,二氧化硫在0~120mg/kg范围内线性关系为y=0.99Abx-0.007,相关系数为0.999;重复性为9.0%。与实验室检测数据相比偏差为2.2%~9.0%。实验证明便携式可见分光光度计测定桂圆中二... 详细信息

采用便携式可见分光光度计测定桂圆中二氧化硫含量。结果表明,二氧化硫在0~120mg/kg范围内线性关系为y=0.99Abx-0.007,相关系数为0.999;重复性为9.0%。与实验室检测数据相比偏差为2.2%~9.0%。实验证明便携式可见分光光度计测定桂圆中二氧化硫的结果与实验室测定结果相当,可以用于桂圆中二氧化硫含量。

关键词：二氧化硫快速检测便携式可见分光光度计

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie liu Changqing Xu Da-Jian Wu Ying Cheng Xiao-Jun liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

基于教学内容特点的混合式教学探索与实践--以非计算机专业的Java程序设计课程为例

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电脑与信息技术 2021年第6期29卷 78-82页

作者：李飞刘福来胡曦孙达明东北大学秦皇岛分校计算中心河北秦皇岛066000 唐山工业职业技术学院河北唐山064000

混合式教学模式是当前疫情趋于常态化背景下的一个研究热点。有效的混合式教学需要根据授课对象、授课目标与授课内容的特性进行合理设计。文章以“非计算机专业的Java程序设计课程”为例,结合非计算机专业学生的学习特点、课程教学目... 详细信息

混合式教学模式是当前疫情趋于常态化背景下的一个研究热点。有效的混合式教学需要根据授课对象、授课目标与授课内容的特性进行合理设计。文章以“非计算机专业的Java程序设计课程”为例,结合非计算机专业学生的学习特点、课程教学目标和知识点的教学特征,提出了线上线下教学内容的划分方法,进而给出一种基于教学内容特点的混合式教学体系。实践表明该体系的实施提高了学生的学习积极性和兴趣,进而提高学生的学习效率。

关键词：非计算机专业混合式教学计算机语言 Java 线上