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NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli Si Naijia Xue Yi liu Ran Zheng Ying chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

曲美他嗪在缺血性心肌病心力衰竭治疗中临床疗效评估

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系统医学 2017年第2期2卷 49-51页

作者：刘忠诚傅希灵中国重型汽车集团有限公司医院心血管内科山东济南250031 中国重型汽车集团有限公司医院内分泌科山东济南250031

目的评估曲美他嗪在缺血性心肌病心力衰竭治疗中临床疗效。方法选取2015年5月—2016年5月该院收治的114例患者为研究对象,随机划分为两组,各57例,对照组给予常规治疗,研究组给予曲美他嗪治疗,对比两组患者治疗效果。结果研究组的治疗总... 详细信息

目的评估曲美他嗪在缺血性心肌病心力衰竭治疗中临床疗效。方法选取2015年5月—2016年5月该院收治的114例患者为研究对象,随机划分为两组,各57例,对照组给予常规治疗,研究组给予曲美他嗪治疗,对比两组患者治疗效果。结果研究组的治疗总有效率98.2%、治疗满意率96.5%均高于对照组的82.5%、70.2%,差异有统计学意义(P<0.05)。研究组的LVESD、LVEDD、LVEF及6 min步行试验分别为(50.7±2.4)mm、(53.5±1.5)mm、(42.6±1.4)%、(325.8±15.8)m均优于对照组的(55.6±3.4)mm、(59.6±2.1)mm、(36.7±2.1)%、(278.6±23.8)m,差异有统计学意义(P<0.05)。结论在缺血性心肌病心力衰竭治疗中应用曲美他嗪,保证了治疗效果,改善了患者生活质量,满足了其治疗需求,值得推广。

关键词：曲美他嗪缺血性心肌病心力衰竭临床疗效

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电动转向系统助力特性仿真研究

天津工程师范学院学报 2006年第1期16卷 39-41页

作者：温立志魏健刘臣富天津工程师范学院汽车工程系天津300222

以电动转向系统的跟踪性能和稳定性能为控制系统设计目标,将经典PID控制理论应用于控制系统设计。创建了电动助力转向系统机电一体化仿真模型。计算机仿真结果证实,所设计的电动转向系统具有良好的跟踪性和稳定性,为电动转向系统的设计... 详细信息

以电动转向系统的跟踪性能和稳定性能为控制系统设计目标,将经典PID控制理论应用于控制系统设计。创建了电动助力转向系统机电一体化仿真模型。计算机仿真结果证实,所设计的电动转向系统具有良好的跟踪性和稳定性,为电动转向系统的设计提供了依据。

关键词：汽车电动助力转向 PID控制仿真

Einstein Probe discovery of EP240408a: A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 222-240页

作者： Wenda Zhang Weimin Yuan Zhixing Ling Yong chen Nanda Rea Arne Rau Zhiming Cai Huaqing cheng Francesco Coti Zelati Lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue Li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei Yang Bing Zhang chen Zhang Shuang-Nan Zhang Yonghe Zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier Liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong Li Bifang liu Mingjun liu Xing liu Yuan liu Zhu liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria Lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian Zhang Zipei Zhu Hu Zou Congying Bao Fansheng chen Houlei chen Tianxiang chen Wei chen Yehai chen Yifan chen chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin chengkui Li Junfei Li Longhui Li Maoshun Li Wei Li Zhengda Li Tianying Lian Congzhan liu Heyang liu Huaqiu liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan Liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan Zhang Mo Zhang Wenjie Zhang Zhen Zhang Zhen Zhang Ziliang Zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Institute of Space Sciences (ICE) CSIC Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences Department of Physics University of Hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University Department of Physics Anhui Normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas Department of Physics and Astronomy University of Nevada Las Vegas South African Astronomical Observatory Department of Astronomy University of Cape Town Department of Physics University of the Free State Université Paris Cité CNRS Astroparticule et Cosmologie Université Paris Cité CEA Paris-Saclay IRfu/DAp-AIM Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr Institute University of Copenhagen Department of Physics and Astronomy Rutgers the State University of New Jersey Institute for Cosmic Ray Research The University of Tokyo ESA/ESTEC Department of Astronomy School of Physics Huazhong University of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics The University of Sydney Department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Department of Astronomy University of Science and Technology School of Astronomy and Space Sciences University of Science and Technology of China Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical Observatory Chi

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 ke V,～300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 ke V,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for ～4 d,followed by a steep decay till becoming undetectable ～10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of～10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients ${\bm~{Einstein~~Probe}}$

MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self-Powered Motion Sensing

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： Wang, Yu-Ze Wang, Yu-Chang liu, Ting-Ting Zhao, Quan-Liang Li, chen-Sha Cao, Mao-Sheng Beijing Inst Technol Sch Mat Sci & Engn Beijing 100081 Peoples R China Peking Univ Sch Mat Sci & Engn Beijing 100871 Peoples R China North China Univ Technol Sch Mech & Mat Engn Beijing 100144 Peoples R China Heilongjiang Univ Minist Educ Peoples Republ China Key Lab Funct Inorgan Mat Chem Harbin 150080 Peoples R China

Polymeric microwave actuators combining tissue-like softness with programmable microwave-responsive deformation hold great promise for mobile intelligent devices and bionic soft robots. However, their application is challenged by restricted electromagnetic sensitivity and intricate sensing coupling. In this study, a sensitized polymeric microwave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx (MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique space-charge polarization and interfacial polarization, resulting in significant improvements of 230% in the dielectric loss factor and 830% in the apparent efficiency of electromagnetic energy harvest. The sensitized microwave actuation demonstrates as the shortened response time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (up to 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combines driving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of similar to 3 mV) during actuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approach for developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He Jie Peng Qingyun Lin Meng Li Weibin chen Pei liu Tao Huang Zhencheng Huang Yuying liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

占空比对Ni-WC纳米复合镀层耐蚀性及硬度的影响

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电镀与环保 2017年第2期37卷 5-7页

作者：刘元福陈吉袁野陈晓明许志显黄澳宋见辽宁石油化工大学机械工程学院辽宁抚顺113001 大连盐业有限公司辽宁大连116021 赤峰市大井子锡业有限公司内蒙古赤峰025250

采用脉冲电沉积法在304不锈钢基体上制备出Ni-WC纳米复合镀层,并研究了占空比对Ni-WC纳米复合镀层耐蚀性及硬度的影响。结果表明:随着占空比的增大,Ni-WC纳米复合镀层的平均晶粒尺寸先减小后增大,硬度先增大后减小;当占空比为50%时,Ni-W... 详细信息

采用脉冲电沉积法在304不锈钢基体上制备出Ni-WC纳米复合镀层,并研究了占空比对Ni-WC纳米复合镀层耐蚀性及硬度的影响。结果表明:随着占空比的增大,Ni-WC纳米复合镀层的平均晶粒尺寸先减小后增大,硬度先增大后减小;当占空比为50%时,Ni-WC纳米复合镀层的平均晶粒尺寸最小,耐蚀性最好,硬度最大。

关键词：脉冲电沉积 Ni-WC纳米复合镀层占空比耐蚀性硬度

基于Sentinel-2遥感影像的作物信息提取与需水量分析研究

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节水灌溉 2022年第5期 33-38,46页

作者：钱鑫李培显谢宏全郜薇薇王杨刘付程江苏海洋大学海洋技术与测绘学院江苏连云港222005 山东金田测绘地理信息有限公司济南250000

气候变化扰动的水资源稀缺性使得农业可持续水资源利用面临危机,节水农业是现代社会农业转型的主要方式,更是可持续发展的根本出路。黑河流域是我国第二大内陆河,中游绿洲是我国的重要粮食生产基地,了解黑河流域的作物种植信息与作物需... 详细信息

气候变化扰动的水资源稀缺性使得农业可持续水资源利用面临危机,节水农业是现代社会农业转型的主要方式,更是可持续发展的根本出路。黑河流域是我国第二大内陆河,中游绿洲是我国的重要粮食生产基地,了解黑河流域的作物种植信息与作物需水特征,对于指导干旱半干旱区农业高效用水及国家粮食安全具有重要意义。基于Google Earth Engine(GEE)云平台利用Sentinel-2影像,结合黑河流域作物的物候特征选取了6-9月的影像数据,根据作物的物候特征重要性完成了特征优选。研究运用随机森林、支持向量机、决策树及投票法分类器完成了作物的识别分类与结果对比。最后,研究通过CROPWAT模型估算了黑河流域作物的需水量与灌溉用水量。研究结果表明:①GEE能够快速完成影像数据的去云、特征构建等预处理;②基于决策树分类器的土地分类结果精度达到82.5%,平均Kappa系数为0.73;估算了作物各个时期所需水量及灌溉用水量。构建的分类体系及作物的需水量估算为精准化管理、灌溉控制系统提供了一种新思路。

关键词：遥感影像 GEE云平台 Sentinel-2 CROPWAT 作物需水量估算灌溉用水量估算作物识别分类

吉林省伊通县小桥子银多金属矿点矿化地质特征及找矿方向

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吉林地质 2018年第2期37卷 48-51页

作者：金宏波刘芳冰刘福臣吉林省第三地质调查所吉林四平136000

吉林省伊通县小桥子银多金属矿点地处大黑山断隆的中段.即吉黑成矿省,小兴安岭-张广才岭-吉林哈达岭太古宙、晚古生代、中生代铁金铜镍银铅锌成矿带;山门放牛沟银多金属成矿带;放牛沟Pb、Zn成矿远景区。矿体产于华力西早期花岗闪长斑岩... 详细信息

吉林省伊通县小桥子银多金属矿点地处大黑山断隆的中段.即吉黑成矿省,小兴安岭-张广才岭-吉林哈达岭太古宙、晚古生代、中生代铁金铜镍银铅锌成矿带;山门放牛沟银多金属成矿带;放牛沟Pb、Zn成矿远景区。矿体产于华力西早期花岗闪长斑岩与石缝组大理岩接触带中,受东西向层间挤压破碎带控制,含矿围岩为奥陶系石缝组大理岩。矿石矿物有:辉银矿、方铅矿、闪锌矿、孔雀石。围岩蚀变有:硅化、石榴石、黄铁矿化、绿泥石化、透闪石化、绢云母化、方解石等。矿床成因初步认为属热液接触交代--矽卡岩型矿床。所以,区内地层与岩浆岩接触带及构造破碎带是本区的有利找矿部位。

关键词：银多金属矿地质特征找矿方向