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Specific CYP450 Genotypes in the Chinese Population Affect Sorafenib Toxicity in HBV/HCV-associated Hepatocellular Carcinoma Patients

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Biomedical and Environmental Sciences 2018年第8期31卷 586-595页

作者： GUO Xing Gang WANG Zhi Heng DONG Wei HE Xu Dong liu fu chen liu Hui The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Respiratory and Endocrine Department The People's Hospital of Wuwei County

Objective The purpose of this study was to screen for frequencies of different CYP450 genotypes in the Chinese population and explore the relationship between sorafenib toxicity and CYP450 polymorphism. Methods A total of 600 peripheral blood samples were obtained from two groups for this study. The first group of 300 samples were from Chinese patients with HBV/HCV-associated HCC, while the remaining 300 samples were from a healthy population of recruited subjects. Allele-specific PCR and long-fragment gene sequencing was used to identify the frequencies of CYP450 polymorphism. Aflatoxin-induced HCC rat models expressing CYP3A4*1, CYP3A5*3, CYP2C19*2, and CYP2D6*10 were established and treated with sorafenib at certain time points. Hepatic and renal function, along with plasma concentration of sorafenib, were monitored regularly. Results The most common forms of CYP mutations in the Chinese population were identified. The levels of sorafenib plasma concentration, as well as damage to hepatic and renal function in aflatoxin-induced HCC rat models varied significantly across the different CYP genotypes. Conclusion The mutational frequencies of CYP3A5, CYP3A4, CYP2C19, and CYP2D6 genotypes varied among different ethnic groups and populations. Individuals with CYP3A5*3 demonstrated minimal sorafenib metabolism, which led to severe hepatic and renal damage. Inter-individual variability in sorafenib-toxicity may be interpreted by CYP450 genetic polymorphisms, suggesting that identification of CYP polymorphism within a certain population should be considered in sorafenib therapy.

关键词： Sorafenib Hepatocellular carcinoma CYP450 polymorphism Inter-individual adverse events

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Synthesis and Crystal Structure of 6-Cyclohexyl-8-methylphenanthridine

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Chinese Journal of Structural Chemistry 2021年第10期40卷 1284-1290页

作者： LUO Zai-Gang WEI Dan-Dan PENG cheng-Tong liu chen-fu chen Qi-Hua ZHANG Rong-Hao XU Xue-Mei State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines College of Chemical EngineeringAnhui University of Science and TechnologyHuainan 232001China School of Pharmaceutical Science Gcwnan Medical UniversityGanzhou 341000China

The target compound Ⅳ (C_(20)H_(21)N) was synthesized through four-step reactions and structurally determined by single-crystal X-ray *** crystal of compound Ⅳ is in the orthorhombic system,space group Fdd2 with a=41.178(19),b=30.389(8),c=4.8182(17)Å,β=90°,C_(20)H_(21)N,M_(r)=275.38,D_(c)=1.213g/cm^(3),V=6029(4)Å^(3),Z=16,F(000)=2368,μ(Mo Ka)=0.527 mm^(-1),T=240(2) K,2200 independent reflections with 1233 observed ones (I>2σ(I)),R=0.1285 and w R=0.2589 with GOF=1.050 (R=0.2058 and w R=0.3055for all data).A one-dimensional interaction model of the title compound was formed by one kind of π-π interactions between the two phenyl rings of the adjacent molecules at upper and lower *** inhibition to the strand transfer process of HIV-1 integrase of the target compound was also evaluated.

关键词： phenanthridine synthesis crystal structure HIV-1 integrase

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基于浸入边界-格子波尔兹曼通量求解法的并列双圆柱流动特性数值研究（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第5期19卷 384-398页

作者： Xiao-di WU Hua-ping liu fu chen Department of Energy Science and Engineering Harbin Institute of Technology

目的:本文旨在应用新型数值求解方法,即浸入边界-格子波尔兹曼通量求解法,研究并列双圆柱流动特性,并探索该数值方法在工程应用中的可行性。创新点:1.将浸入边界法与格子波尔兹曼求解法相结合,简单并高效地实现在非均匀直角网格下求解... 详细信息

目的:本文旨在应用新型数值求解方法,即浸入边界-格子波尔兹曼通量求解法,研究并列双圆柱流动特性,并探索该数值方法在工程应用中的可行性。创新点:1.将浸入边界法与格子波尔兹曼求解法相结合,简单并高效地实现在非均匀直角网格下求解不可压流动以及动边界问题;2.应用浸入边界-格子波尔兹曼求解法研究并列双圆柱流场特性。方法:1.通过理论推导,建立状态变量和通量与格子波尔兹曼方程中粒子密度分布函数之间的关系(公式(8)^(10));2.采用强制浸入边界法处理流固界面使固壁表面满足无滑移边界条件,实现在笛卡尔网格下求解运动边界问题;3.通过数值模拟,探讨雷诺数和圆柱间距对静止双圆柱受力及流场尾流特性的影响以及雷诺数、间距和旋转速度对旋转并列双圆柱受力及尾流特性的影响规律。结论:1.浸入边界-格子波尔兹曼求解法可以简单实现采用非贴体网格求解不可压流动及动边界问题。2.对于并列静止双圆柱,随着间距的增加,双圆柱尾流场的相互作用逐渐消失,尾迹由无规则性转变为规则的同相位流动或反向流动;雷诺数影响圆柱受力系数。3.对于并列旋转双圆柱,雷诺数对旋转圆柱受力影响较弱;旋转速度可以抑制单圆柱尾流场的非定常效应;随着圆柱间距的增加,双圆柱后方形成固定的相位关系以及同一频率的脱落涡。

关键词：浸入边界法格子波尔兹曼通量求解法运动边界并列圆柱

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A Unique 2D Layered FeⅢ Coordination Polymer with only Formate Ligand as Bridges: Synthesis, Crystal Structure and Magnetic Properties

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Chinese Journal of Structural Chemistry 2019年第11期38卷 1963-1969页

作者： ZHANG Lin-Lin SHEN Bin ZHAO Jiong-Peng GAO Su-Hua liu fu-chen School of Chemistry and Chemical Engineering Tianjin University of Technology

A novel two-dimensional layered FeⅢ formate, Fe(HCO2)2ClH2O, has been synthesized by solvothermal reaction. The structure of complex is characterized by single-crystal X-ray diffraction. The complex crystallizes in tetragonal space group P4/nmm with a = 5.9588(6), c = 8.3831(17) ?, V = 297.66(7) ?3, Z = 2, F(000) = 198, Dc = 2.224 g/cm3, Mr = 199.35, μ = 2.927 mm-1, the final R = 0.0231 and w R = 0.0585(I > 2σ(I)) for all data. Single-crystal structure analysis indicates that the complex has a 2D metal formate structure with only formate anions as bridges. The anti-anti formats link the FeⅢ ions to form a(4, 4) net, while the chlorine ions and water molecules coordinate to FeⅢ on both sides of the layer. Magnetic study have shown that an antiferromagnetic interactions between the FeⅢ ions in the complex. And a field induced spin-flop was detected at low temperature.

关键词： formate solvothermal reaction low-dimensional materials antiferromagnetism

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Preliminary High Heat Flux Tests of Small-Scale Be/Cu Mock-Ups

Southwestern Institute of Physics Annual Report

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Southwestern Institute of Physics Annual Report 2005年第1期 115-116页

作者： liu Xiang ZHANG fu chen Jiming ZHANG Nianman PAN Chuanhong

China, as one of the members of ITER （international thermonuclear experimental reactor） project, one of the most important construction tasks is the fabrication of the first wall panel and shield blankets, which is the key engineering technology of ITER construction and might be one of the crucial issues of the future reactor too. Since 2004, an associated research team including Southwestern Institute of Physics （ SWIP ）, Ninxia Non-ferrous Metal Co. Itd and Chinese Institute of Engineering Physics, as well as Nuclear Power Institute of China has been established. Up to now, several series of interlayer for hot isostatic press （ HIP ） connection of beryllium and CuCrZr alloy have been tested. They are titanium film or coating, Cu coating and Al or AISiMg alloy etc. The bonding strength （tensile or shear strength ） of HIPed Be/Cu joints is up to 100 MPa.

关键词： ITER High heat flux tests Be/Cu mock-ups

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劈裂灌浆对土石坝应力应变和稳定的影响

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岩土力学 2009年第8期30卷 2452-2456页

作者：刘福臣程兴奇山东水利职业学院教务与科研处山东日照276826

土坝劈裂灌浆对坝体的应力、应变、稳定的影响很大。采用Duncan-Chang非线性模型,模拟了某土石坝劈裂灌浆的灌浆-停灌施工过程,进行了应力、应变、稳定有限元分析。劈裂灌浆可以同时增大大小主应力,在灌浆轴线附近区域,小主应力增加幅... 详细信息

土坝劈裂灌浆对坝体的应力、应变、稳定的影响很大。采用Duncan-Chang非线性模型,模拟了某土石坝劈裂灌浆的灌浆-停灌施工过程,进行了应力、应变、稳定有限元分析。劈裂灌浆可以同时增大大小主应力,在灌浆轴线附近区域,小主应力增加幅度大于大主应力增加幅度,应力水平较灌浆前降低,土坝稳定性增加。与原型观测资料进行对比分析,表明计算结果与实测资料基本吻合。

关键词：劈裂灌浆 Duncan—Chang模型应力水平稳定分析

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Role of the Greenland Sea ice anomaly in the late-spring drought over Northwest China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 1-5页

作者： Yang liu Huopo chen Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and TechnologyNanjingChina

Drought across Northwest China in late spring has exerted a vital effect on the local climate and agricultural production,and has been alleviated during the past *** study explored the influence of the preceding Arctic sea ice on the May drought in Northwest China caused by the precipitation *** analysis indicated that when the Greenland Sea ice concentration is abnormally high during February to April,the dry conditions in Northwest China tend to be *** increase of sea ice in the Greenland Sea can excite a meridional circulation,which causes sea surface temperature(SST)anomalies in the North Atlantic via the sea-air interaction,manifested as significant warm SST anomalies over the south of Greenland and the subtropical North Atlantic,but negative SST anomalies over the west of the *** abnormal SST pattern maintains to May and triggers a zonal wave train from the North Atlantic through Scandinavia and Central Asia to Northwest China,leading to abnormal cyclones in Northwest ***,Northwest China experiences a more humid climate than usual.

关键词： Arctic sea ice Greenland Sea North Atlantic SST Drought Northwest China

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基于浸入边界-格子Boltzmann通量求解法的椭圆柱流动特性分析

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计算力学学报 2018年第3期35卷 283-290页

作者：吴晓笛刘华坪陈浮哈尔滨工业大学能源科学与工程学院哈尔滨150001

基于浸入边界-格子Boltzmann通量求解法,开展了雷诺数Re=100不同几何参数下单椭圆柱及串列双椭圆柱绕流流场与受力特性对比研究。结果表明,随长短轴比值的增加,单椭圆柱绕流阻力系数先减小后缓慢上升,最大升力系数则随长短轴比值的增大... 详细信息

基于浸入边界-格子Boltzmann通量求解法,开展了雷诺数Re=100不同几何参数下单椭圆柱及串列双椭圆柱绕流流场与受力特性对比研究。结果表明,随长短轴比值的增加,单椭圆柱绕流阻力系数先减小后缓慢上升,最大升力系数则随长短轴比值的增大而减小;尾迹流动状态从周期性脱落涡到稳定对称涡。间距是影响串列圆柱及椭圆柱流场流动状态的主要因素,间距较小时,串列圆柱绕流呈周期性脱落涡状态,而椭圆柱则为稳定流动;随着间距增加,上下游圆柱及椭圆柱尾迹均出现卡门涡街现象,且串列椭圆柱临界间距大于串列圆柱。串列椭圆柱阻力的变化规律与圆柱的基本相同,上游平均阻力大于下游阻力;上游椭圆柱阻力随着间距的变大先减小,下游随间距的变大而增加,当间距达到临界间距时上下游阻力跃升,随后出现小幅度波动再逐渐增加,并趋近于相同长短轴比值下单柱体绕流的阻力。

关键词：浸入边界法格子Boltzmann通量求解串列椭圆柱层流尾迹

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Engineering atomic Rb-N configurations to tune radical pathways for highly selective photocatalytic H2O2 synthesis coupled with biomass valorization

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Journal of Energy Chemistry 2025年第1期100卷 215-225页

作者： Jiaye Li Shuang Pan Yihuang chen Qiong liu College of Chemistry and Materials Engineering Wenzhou University Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology (China) Institute of Analysis Guangdong Academy of Sciences (China National Analytical CenterGuangzhou)

Photocatalytic oxygen reduction for hydrogen peroxide （H2O2） synthesis presents a green and costeffective production ***,achieving highly selective H2O2synthesis remains challenging,necessitating precise control over free radical reaction pathways and minimizing undesirable oxidative ***,we report for the visible light-driven simultaneous co-photocatalytic reduction of O2to H2O2and oxidation of biomass using the atomic rubidium-nitride modified carbon nitride（CNRb）.The optimized CNRb catalyst demonstrates a record photoreduction rate of 8.01 mM h-1for H2O2generation and photooxidation rate of 3.75 mM h-1for furfuryl alcohol to furoic acid,achieving a remarkable solar-to-chemical conversion （SCC） efficiency of up to 2.27%.Experimental characterizations and DFT calculation disclosed that the introducing atomic Rb–N configurations allows for the high-selective generation of superoxide radicals while suppressing hydroxyl free radical *** is because the Rb–N serves as the new alternative site to perceive a stronger connection position for O2adsorption and reinforce the capability to extract protons,thereby triggering a high selective redox product *** study holds great potential in precisely regulating reactive radical processes at the atomic level,thereby paving the way for efficient synthesis of H2O2coupled with biomass valorization.

关键词： Atomic economy Radical pathway regulation Rubidium atom coordination Biomass valorization

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Multi-layer multi-pass friction rolling additive manufacturing of Al alloy:Toward complex large-scale high-performance components

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 425-438页

作者： Haibin liu Run Hou chenghao Wu Ruishan Xie Shujun chen College of Mechanical&Energy Engineering Beijing University of TechnologyBeijing 100124China Chongqing Research Institute of Beijing University of Technology Chongqing 401121China

At present,the emerging solid-phase friction-based additive manufacturing technology,including friction rolling additive man-ufacturing(FRAM),can only manufacture simple single-pass *** this study,multi-layer multi-pass FRAM-deposited alumin-um alloy samples were successfully prepared using a non-shoulder tool *** material flow behavior and microstructure of the over-lapped zone between adjacent layers and passes during multi-layer multi-pass FRAM deposition were studied using the hybrid 6061 and 5052 aluminum *** results showed that a mechanical interlocking structure was formed between the adjacent layers and the adja-cent passes in the overlapped center *** friction and rolling of the tool head led to different degrees of lateral flow and plastic deformation of the materials in the overlapped zone,which made the recrystallization degree in the left and right edge zones of the over-lapped zone the highest,followed by the overlapped center zone and the non-overlapped *** tensile strength of the overlapped zone exceeded 90%of that of the single-pass deposition *** is proved that although there are uneven grooves on the surface of the over-lapping area during multi-layer and multi-pass deposition,they can be filled by the flow of materials during the deposition of the next lay-er,thus ensuring the dense microstructure and excellent mechanical properties of the overlapping *** multi-layer multi-pass FRAM deposition overcomes the limitation of deposition width and lays the foundation for the future deposition of large-scale high-performance components.

关键词： aluminum alloy additive manufacturing solid-state friction stir welding multi-layer multi-pass

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