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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen hua-Xing Chen huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing beijing Computational Science Research Center Beijing beijing Conveyi LTD Beijing beijing Glass Research Institute Co. LtdBeijing beijing Institute of Technology Beijing beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhu&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.15)and the Conceptual Design Report(CDR,2.18),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

The Chinese Society of Clinical Oncology(CSCO)clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma

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Cancer Communications 2021年第11期41卷 1195-1227页

作者： Ling-Long Tang Yu-Pei Chen Chuan-Ben Chen Ming-Yuan Chen Nian-Yong Chen Xiao-Zhong Chen Xiao-Jing Du Wen-feng Fang Mei feng Jin Gao {2. Han Xia He Chao-Su hu De-sheng hu Guang-Yuan hu Hao jiang Wei jiang feng Jin Jin-Yi Lang Jin-Gao Li Shao-Jun Lin Xu liu Qiu-Fang liu Lin Ma Hai-Qiang Mai Ji-Yong Qin Liang-Fang Shen Ying Sun Pei-Guo Wang Ren-Sheng Wang Ruo-Zheng Wang Xiao-Shen Wang Ying Wang hui Wu Yun-{2. Xia Shao-Wen Xiao Kun-Yu Yang Jun-Lin Yi Xiao-Dong zhu Jun Ma Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Fujian Provincial Cancer HospitalFujian Medical University Department of Radiation OncologyTeaching Hospital of Fujian Medical University Provincial Clinical CollegeCancer Hospital of Fujian Medical UniversityFuzhouFujian 350014P.R.China Department of Nasopharyngeal Carcinoma State Key Laboratory of Oncology in South ChinaCollaborative Innovation Centre for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041P.R.China Cancer Hospital of the university of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Cancer and Basic Medicine(IBMC)Chinese Academy of Sciences HangzhouZhejiang 310000P.R.China State Key Laboratory of Oncology in South china Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610041P.R.China Department of Radiation Oncology Anhui Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui 230001P.R.China Department of Clinical Laboratory Affiliated Cancer Hospital of Nanjing Medical UniversityJiangsu Cancer HospitalJiangsu Institute of Cancer ResearchNanjingJiangsu 210000P.R.China Department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghai 200032P.R.China Department of Radiotherapy Hubei Cancer HospitalTong

Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North *** develop these comprehensive guidelines for the diagnosis and management of NPC,the Chinese Society of Clinical Oncology(CSCO)arranged a multi-disciplinary team comprising of experts from all sub-specialties of NPC to write,discuss,and revise the *** on the findings of evidencebased medicine in china and abroad,domestic experts have iteratively developed these guidelines to provide proper management of ***,the guidelines describe the screening,clinical and pathological diagnosis,staging and risk assessment,therapies,and follow-up of NPC,which aim to improve the management of NPC.

关键词： Chinese Society of Clinical Oncology CSCO Nasopharyngeal carcinoma Diagnosis Staging Risk Radiotherapy Chemotherapy Surgery Immunotherapy

2.2. Roadmap on two-dimensional nanomaterials for environmental catalysis

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Chinese Chemical Letters 2019年第12期30卷 2065-2088页

作者： Yulu Yang Mingguang Wu Xingwang zhu hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming {2. Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli {2. Jianzhong Ma Ze-Lin Wang Ling Tan Yu-fei Zhao Yu-fei Song Pardeep Singh Pankaj Raizada Deli jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang Song hu Rongjuan feng Gang {2. Minghua {2. Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun Ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma School of Physics and Electronics Hunan UniversityChangsha 410082China School of the Environment and Safety Engineering Institute for Energy ResearchJiangsu UniversityZhenjiang 212013China college of Chemistry Jilin UniversityChangchun 130012China State Key Laboratory on Integrated Optoelectronics College of Electronic Science and TechnologyJilin UniversityChangchun 130012China Key Laboratory for Powder Metallurgy Central South UniversityChangsha 410083China Multidisciplinary Platform of Advanced Engineering Chemical Engineering DisciplineSchool of EngineeringMonash UniversityJalan Lagoon SelatanBandar SunwaySelangor 47500Malaysia university of Palermo Department of EngineeringPalermo 90128Italy university of Trento Department of Industrial EngineeringTrento 38123Italy School of Materials Science and Engineering Shaanxi University of Science&TechnologyXi'an 710021China college of Bioresources Chemistry and Materials Engineering Shaanxi University of Science&TechnologyXi'an 710021China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China School of Chemistry Faculty of Basic SciencesShoolini UniversitySolanHP 173229India Himalayan Centre for Excellence in Nanotechnology Shoolini UniversitySolanmHP 173229India School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013China Institute for Energy Research Jiangsu UniversityZhenjiang 212013China Nanomaterials and Nanotechnology Department Advanced Materials DivisionCentral Metallurgical R&D Institute(CMRDI)Cairo 11421Egypt Key Laboratory for Colloid and Interface Chemistry Ministry of EducationSchool of Chemistry and Chemical Engineering Shandong UniversityJi'nan 250100China National Laboratory for Molecular Science(BNLMS) CAS Laboratory of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence i

environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical *** and electrocatalysis play important roles in these *** can decompose and remove organic pollutants from the aqueous environment,and prepare some fine ***,they also can carry out some important reactions,such as 02.reduction reaction(ORR),O2.evolution reaction(OER),H2.evolution reaction(HER),CO2.reduction reaction(C02.RR),and N2.fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted *** recentyears,two-dimensional(2.D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural *** progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and *** content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental *** hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions.

关键词： Two-dimensional materials Graphene Black phosphorus C3N4 Metal organic frameworks MXenes

Nucleic acids analysis

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Science china Chemistry 2021年第2期64卷 171-203页

作者： Yongxi Zhao Xiaolei Zuo Qian Li feng Chen Yan-Ru Chen Jinqi Deng Da Han Changlong Hao Fujian huang Yanyi huang Guoliang Ke hua Kuang Fan Li jiang Li Min Li Na Li Zhenyu Lin Dingbin {2. Juewen {2. Libing {2. Xiaoguo {2. Chunhua Lu Fang Luo Xiuhai Mao Jiashu Sun Bo Tang fei Wang Jianbin Wang Lihua Wang Shu Wang Lingling Wu Zai-Sheng Wu Fan Xia Chuanlai Xu Yang Yang Bi-feng Yuan Quan Yuan Chao Zhang Zhi zhu Chaoyong Yang Xiao-Bing Zhang huanghao Yang Weihong Tan Chunhai Fan Institute of Analytical Chemistry and Instrument for Life Science The Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and NanomedicineRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesInstitute of Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China Cancer Metastasis Alert and Prevention Center Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and ChemotherapyState Key Laboratory of Photocatalysis on Energy and EnvironmentCollege of ChemistryFuzhou UniversityFuzhou 350108China CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China State Key Lab of Food Science and Technology International Joint Research Laboratory for Biointerface and BiodetectionSchool of Food Science and TechnologyJiangnan UniversityWuxi 214122China Faculty of Materials Science and Chemistry Engineering Research Center of Nano-Geomaterials of Ministry of EducationChina University of GeosciencesWuhan 430074China college of Chemistry and Molecular Engineering Biomedical Pioneering Innovation Center(BIOPIC)Beijing Advanced Innovation Center for Genomics(ICG)Peking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Division of Physical Biology CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China Bioimaging Center Shanghai Synchrotron Radiation FacilityZhangjiang LaboratoryShanghai Advanced

Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis, food safety and forensic *** the past decades, the field of nucleic acids analysis has been rapidly advancing with many technological *** this review, we focus on the methods developed for analyzing nucleic acids, nucleic acids-based analysis, device for nucleic acids analysis, and applications of nucleic acids analysis. The representative strategies for the development of new nucleic acids analysis in this field are summarized, and key advantages and possible limitations are discussed. Finally, a brief perspective on existing challenges and further research development is provided.

关键词： nucleic acids analysis signal amplification DNA nanotechnology aptamer biosensing

A chromosome-level genome assembly of rugged rose (Rosa rugosa) provides insights into its evolution, ecology, and floral characteristics

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Horticulture Research 2021年第1期8卷 1939-1951页

作者： fei Chen Liyao Su Shuaiya hu Jia-Yu Xue hui liu Guanhua liu Yifan jiang Jianke Du Yushan Qiao Yannan Fan huan liu Qi Yang Wenjie Lu zhu-Qing Shao Jian Zhang Liangsheng Zhang feng Chen Zong-Ming(Max)Cheng college of Horticulture Nanjing Agricultural UniversityNanjing 210095China Academy for Advanced Interdisciplinary Studies Nanjing Agricultural UniversityNanjing 210095China BGI-Shenzhen Beishan Industrial ZoneYantian DistrictShenzhen 518083China Department of Biology University of CopenhagenCopenhagenDenmark Grandomics Biosciences Co. LtdWuhanChina School of Life Sciences Nanjing UniversityNanjingChina college of life science Nantong UniversityNantongChina Genomics and Genetic Engineering Laboratory of Ornamental Plants College of Agriculture and BiotechnologyZhejiang UniversityHangzhouChina Department of plant sciences University of TennesseeKnoxvilleTNUSA

Rosa rugosa,commonly known as rugged rose,is a perennial ornamental *** produces beautiful flowers with a mild fragrance and colorful seed *** many other cultivated roses,*** adapts to a wide range of habitat types and harsh environmental conditions such as salinity,alkaline,shade,drought,high humidity,and frigid ***,we produced and analyzed a high-quality genome sequence for *** to understand its ecology,floral characteristics and *** HiFi reads were initially used to construct the draft genome of ***,and then Hi-C sequencing was applied to assemble the contigs into 7 *** obtained a 382.6Mb genome encoding 39,704 protein-coding *** genome of *** appears to be conserved with no additional whole-genome duplication after the gamma whole-genome triplication(WGT),which occurred~100 million years ago in the ancestor of core *** on a comparative analysis of the high-quality genome assembly of *** and other high-quality Rosaceae genomes,we found a unique large inverted segment in the Chinese rose *** and a retroposition in strawberry caused by post-WGT *** also found that floral development-and stress response signaling-related gene modules were retained after the *** MADS-box genes involved in floral development and the stress-related transcription factors DREB2.-INTERACTING PROTEIN 2.DRIP2.and PEPTIDE TRANSPORTER 3(PTR3)were found to be positively selected in evolution,which may have contributed to the unique ability of this plant to adapt to harsh *** summary,the high-quality genome sequence of *** provides a map for genetic studies and molecular breeding of this plant and enables comparative genomic studies of Rosa in the near future.

关键词： breeding characteristics evolution

基于个体化机器学习的原发性免疫性血小板减少症危重出血预测模型:一项全国前瞻性队列研究

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科学通报:英文版 2023年第18期68卷 2106-2114,M0004页

作者： zhuo-Yu An Ye-Jun Wu Yu Hou Heng Mei Wei-Xia Nong Wen-Qian Li hu Zhou Ru feng Jian-Ping Shen Jun Peng Hai Zhou Yi {2. Yong-Ping Song Lin-hua Yang Mei-Yun Fang Jian-Yong Li Yun-feng Cheng Peng {2. Ya-Jing Xu Zhao Wang Yi Luo Zhen Cai hui {2. Jing-Wen Wang Juan Li Xi Zhang Zi-Min Sun Xiao-Yu zhu Xin Wang Rong Fu Liang huang Shao-Yuan Wang Tong-hua Yang Li-Ping Su Liang-Ming Ma Xie-Qun Chen Dai-Hong {2. Hong-Xia Yao Jia feng Hong-Yu Zhang Ming jiang Ze-Ping Zhou Wen-Sheng Wang Xu-Liang Shen Yangjin Baima Yue-Ying Li Qian-fei Wang Qiu-Sha huang Hai-Xia Fu Xiao-Lu zhu Yun He Qian jiang Hao jiang Jin Lu Xiang-Yu Zhao Ying-Jun Chang Tao Wu Yao-zhu Pan Lin Qiu Da Gao A-Rong Jin Wei Li Su-Jun Gao Lei Zhang Ming Hou Xiao-Jun huang Xiao-hui Zhang on behalf of the National Cooperative ITP Working Group peking university People’s Hospital Peking University Institute of HematologyBeijing 100044China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100044China beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Department of Hematology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250014China Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Department of Hematology First Affiliated HospitalSchool of MedicineShihezi UniversityShihezi 832002China Department of Hematology Qinghai Provincial People’s HospitalXining 810007China Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou UniversityHenan Institute of HematologyZhengzhou 450008China Department of Hematology Beijing HospitalBeijing 100044China Department of Hematology Zhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310006China Department of Hematology Senior Department of Hematologythe Fifth Medical Center of PLA General HospitalBeijing 100044China Department of Hematology the Second Hospital of Shanxi Medical UniversityTaiyuan 030001China Department of Hematology Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001China Department of Hematology The First Affiliated Hospital with Nanjing Medical University(Jiangsu Province Hospital)Nanjing 210029China Department of Hematology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Hematology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Hematology Beijing Friendship HospitalCapital Medical UniversityBeijing 100044China Institute of Hematology the First Affiliated HospitalZhejiang UniversityHangzhou 310058China Department of Hematology Beijing Tongren HospitalBeijing 100005China Department of Hematology The First Affiliated HospitalSun Yat-sen UniversityGuang

原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者... 详细信息

原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者致命出血事件的预测模型。本研究首次采用国际血栓与止血学会新提出的ITP致命出血标准,利用大样本数据开发了首个基于机器学习的在线应用,用于预测ITP患者的致命出血.研究中,我们使用中国各地大型多中心数据进行开发,并对全国39家医疗中心进行为期一年的外部测试,得到了较好的训练、验证和测试数据集预测能力该基于新算法的便捷网络工具能够快速识别ITP患者的出血风险,辅助临床决策,有望未来降低不良事件的发生。

关键词： Critical bleeding Severe bleeding Immune thrombocytopenia Machine learning Prediction model

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei liu Yi-Peng Jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei feng Jian-Ning Fu Peng Gao Xue-{2. Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-hui Hou Wen Hou Hong-zhuan hu Ning-Sheng hu Zhong-Wen hu Zhi-Ying huo Lei Jia Fang-hua jiang Xiang jiang Zhi-Bo jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-hua Li Chang-hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang feng-{2. Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang Yue-{2. Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-{2. Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-hua Yang Hai-feng Yang hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie zhu Yong-Tian zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences university of Science and Technology of china Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2.11 and ended in June 2.12. and the data have been released to the public as the LAMOST Pilot Data Release in August 2.12. The regular survey started in September 2.12. and completed its first year of operation in June 2.13. The LAMOST DR1 includes a total of 12.2.plates containing 2.955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2.are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2.2.4 696 spectra, of which 1 944 32. are stellar spectra, 12.082.are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（12. 52. entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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肺癌适应性治疗中国专家共识

循证医学 2024年第4期24卷 193-200页

作者：吴一龙陆舜程颖周清张嘉涛潘燚汪斌超韩宝惠陈海泉周清华王绿化陈明王洁周彩存刘晓晴马智勇黄诚宋启斌莫树锦钟文昭朱正飞宋勇陈蓉蓉陈克终刘基巍杨帆胡晓桦胡毅杨懿岳东升王群赵军范江陈椿孟庆威闫小龙董晓荣朱波邢力刚李兆澄李子明褚倩陈元林根段建春田攀文范云刘安文刘慧刘哲峰杨农汪步海张同梅信涛刘思阳王志杰马锐于起涛林劼涂海燕姚煜赵明芳王慧娟张海波蔡尚立张绪超李慧杜瀛瀛吴芳严令华崔久嵬王燕邬麟周建娅汪笑男黄媚娟冯卫能周进李力中国抗癌协会肺癌专业委员会广东省临床试验协会/中国胸部肿瘤研究协作组广东省肺癌研究所南方医科大学附属广东省人民医院(广东省医学科学院)广州510080 上海交通大学医学院附属胸科医院上海200030 吉林省肿瘤医院长春130021 复旦大学附属肿瘤医院上海200032 四川大学华西医院成都610041 中国医学科学院肿瘤医院深圳医院广东深圳518116 中山大学肿瘤防治中心广州510060 中国医学科学院肿瘤医院北京100021 同济大学附属上海市肺科医院上海200433 解放军总医院第五医学中心北京100039 郑州大学附属肿瘤医院/河南省肿瘤医院郑州450003 福建省肿瘤医院福州350011 武汉大学人民医院肿瘤中心武汉430060 香港中文大学医学院中国香港东部战区总医院南京210002 北京吉因加科技有限公司北京102206 北京大学人民医院北京100044 大连医科大学附属第一医院辽宁大连116011 广西医科大学第一附属医院南宁530020 解放军总医院北京100071 成都市第三人民医院/西南交通大学医学院成都610031 天津医科大学肿瘤医院天津300060 复旦大学附属中山医院上海200032 北京大学肿瘤医院北京100142 上海交通大学附属上海市第一人民医院上海200025 福建医科大学附属协和医院福州350001 哈尔滨医科大学附属肿瘤医院哈尔滨150081 空军军医大学唐都医院西安710038 华中科技大学同济医学院附属协和医院武汉430022 陆军军医大学第二附属医院-新桥医院重庆400037 山东省肿瘤医院济南250117 华中科技大学同济医学院附属同济医院武汉430030 中国医学科学院肿瘤医院山西医院太原030013 中国科学院大学附属肿瘤医院/浙江省肿瘤医院杭州310022 南昌大学附属第二医院南昌330006 湖南省第二人民医院长沙410035 南京大学医学院附属苏北人民医院江苏扬州225001 首都医科大学附属北京胸科医院北京101149 哈尔滨医科大学附属第二医院哈尔滨150001 暨南大学附属第一医院广州510630 辽宁省肿瘤医院沈阳110042 广西医科大学附属肿瘤医院南宁530012 昆明医科大学第二附属医院昆明650101 西安交通大学第一附属医院西安710061 中国医科大学附属第一医院沈阳110001 广东省中医院广州510120 广州燃石医学检验所有限公司广州510300 安徽医科大学第一附属医院合肥230022 中南大学湘雅二医院长沙410011 上海桐树生物科技有限公司上海200444 吉林大学白求恩第一医院长春130021 湖南省肿瘤医院长沙410013 浙江大学医学院附属第一医院杭州310031 南京世和基因生物技术股份有限公司南京210032 佛山市第一人民医院广东佛山528000 四川省肿瘤医院成都610042 陆军军医大学大坪医院重庆400042 不详

由中国抗癌协会肺癌专业委员会和广东省临床试验协会/中国胸部肿瘤研究协作组主办的“第2.届中国肺癌高峰论坛”于2.2.年3月2.在广州顺利召开。此次论坛以肺癌适应性治疗为主题,从肺癌适应性治疗定义、早中晚期临床应用以及生物标志物... 详细信息

由中国抗癌协会肺癌专业委员会和广东省临床试验协会/中国胸部肿瘤研究协作组主办的“第2.届中国肺癌高峰论坛”于2.2.年3月2.在广州顺利召开。此次论坛以肺癌适应性治疗为主题,从肺癌适应性治疗定义、早中晚期临床应用以及生物标志物对适应性治疗的指导价值等角度展开探讨并达成了专家共识。

关键词：肺癌适应性治疗共识

The DIRECT consortium and the REST-meta-MDD project:towards neuroimaging biomarkers of major depressive disorder

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Psychoradiology 2022年第1期2卷 32-42页

作者： Xiao Chen Bin Lu hui-Xian Li Xue-Ying Li Yu-Wei Wang Francisco Xavier Castellanos Li-Ping Cao Ning-Xuan Chen Wei Chen Yu-Qi Cheng Shi-Xian Cui Zhao-Yu Deng Yi-Ru Fang Qi-Yong Gong Wen-Bin Guo Zheng-Jia-Yi hu Li Kuang Bao-Juan Li Le Li Tao Li Tao Lian Yi-Fan Liao Yan-Song liu Zhe-Ning liu Jian-Ping Lu Qing-hua Luo hua-Qing Meng Dai-hui Peng {2. Qiu Yue-Di Shen Tian-Mei Si Yan-Qing Tang Chuan-Yue Wang fei Wang hua-Ning Wang Kai Wang Xiang Wang Ying Wang Zi-Han Wang Xiao-Ping Wu Chun-Ming Xie Guang-Rong Xie Peng Xie Xiu-feng Xu Hong Yang Jian Yang Shu-Qiao Yao Yong-Qiang Yu Yong-Gui Yuan Ke-Rang Zhang Wei Zhang Zhi-Jun Zhang Jun-Juan zhu Xi-Nian Zuo Jing-Ping Zhao Yu-feng Zang the DIRECT consortium Chao-Gan Yan CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China International Big-Data Center for Depression Research Chinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Sino-Danish college University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Graduate University of Chinese Academy of SciencesBeijing 101408China Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNY 10016USA Nathan Kline Institute for Psychiatric Research OrangeburgNew YorkNY 10962USA 9Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Capital Normal university Beijing 100089China Department of Psychiatry Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020ZhejiangChina Department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengduSichuan 610044China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610052China Department of Psychiatry and National Clinical Research Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011HunanChina Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Xijing Hospital of Air Force Military Medical university Xi’anShaanxi 710032China Center for Cognitive Science of Language Beijing Language and Culture UniversityBeijing 100083China Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital Zhejiang University School of

Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder(MDD),repro-ducible findings are lacking,probably reflecting mostly small sample sizes and heterogeneity in analytic *** address these issues,the Depression Imaging REsearch ConsorTium(DIRECT)was *** REST-meta-MDD project,pooling 2.2. functional brain images processed with a standardized pipeline across all participating sites,has been the first effort from *** this review,we present an overview of the moti-vations,rationale,and principal findings of the studies so far from the REST-meta-MDD *** from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network,in whole-brain topological properties,in dynamic features,and in functional *** well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven *** these fruitful explorations,DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations.A state-of-the-art,surface-based preprocessing pipeline has also been introduced to improve *** images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diag-nosis *** addition,large-scale longitudinal studies targeting brain network alterations following antidepressant treatment,aggregation of diffusion tensor images,and the development of functional magnetic resonance imaging-guided neuromodulation approaches are *** these endeavours,we hope to accelerate the translation of functional neuroimaging findings to clinical use,such as evaluating longitudinal effects of antidepressant medications and developing individualized

关键词： major depressive disorder DIRECT R-fMRI database neuroimaging