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基于网络药理学和大鼠体内验证的藏药红景天改善脑微循环障碍作用机制研究

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中国药理学通报 2024年第9期40卷 1781-1791页

作者：马四清时宇静李园白杨阳李萌杜昱李逸豪刘方舟青海省人民医院青海西宁810007 中国中医科学院中药研究所北京100700 中国中医科学院中医药信息研究所北京100700

目的基于文献研究、网络药理学、分子对接与实验验证的方法,探究藏药红景天改善脑微循环障碍的核心靶点、关键成分和作用机制。方法通过文献和数据库收集红景天化学成分,利用反向药效团匹配预测红景天的潜在靶点;获取脑微循环障碍靶点,... 详细信息

目的基于文献研究、网络药理学、分子对接与实验验证的方法,探究藏药红景天改善脑微循环障碍的核心靶点、关键成分和作用机制。方法通过文献和数据库收集红景天化学成分,利用反向药效团匹配预测红景天的潜在靶点;获取脑微循环障碍靶点,并与红景天靶点映射,构建交集靶点蛋白互作网络,获取核心靶点;构建“中药-成分-核心靶点-疾病”调控网络并获取关键成分;进行GO和KEGG富集分析,构建“核心靶点-信号通路-生物过程”网络;进行分子对接验证;采用RT-qPCR和Western blot进行动物实验验证,进一步证实网络药理学分析结果。结果从红景天中筛选出76个活性成分和285个靶点,获取脑微循环障碍靶点1074个,交集靶点97个,核心靶点6个,关键成分6个。分子对接结果表明,有3个关键成分与核心靶点的结合性大于核心靶点蛋白与其原始配体结合性。RT-qPCR结果显示红景天能下调核心靶点CASP3、AKT1 mRNA水平,Western blot检测结果显示藏药红景天能降低CASP3、AKT1蛋白表达(P<0.05)。结论藏药红景天可通过多成分、多靶点、多通路协同改善脑微循环障碍,该研究为临床应用藏药红景天治疗脑微循环障碍提供实验依据。

关键词：脑微循环障碍藏药红景天网络药理学反向药效团匹配分子对接 RT-qPCR Western blot 作用机制

TWO-SCALE FINITE ELEMENT DISCRETIZATIONS FOR PARTIAL DIFFERENTIAL EQUATIONS

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Journal of Computational Mathematics 2006年第3期24卷 373-392页

作者： fang liu Aihui zhou LSEC ICMSEC Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China

Some two-scale finite element discretizations are introduced for a class of linear partial differential equations. Both boundary value and eigenvalue problems are studied. Based on the two-scale error resolution techniques, several two-scale finite element algorithms are proposed and analyzed. It is shown that this type of two-scale algorithms not only significantly reduces the number of degrees of freedom but also produces very accurate approximations.

关键词： Finite element Two-scale discretization Parallel computation Sparse grids.

Experimental Investigation and X-Ray Computed Microtomography Simulation on Thermal Physical Properties of Foundation Materials after Molten Salt Leakage in the Storage Tank

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Journal of Thermal Science 2024年第2期33卷 591-601页

作者： WANG Zhaowen zhou Hao LUO Jiawei LI Yawei fang Hao liu Tianxiao State Key Laboratory of Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou310027China

This paper studied the thermal physical properties of foundation materials in the molten salt tank of thermal energy storage system after molten salt leakage by Transient plane source experiment and X-ray computed microtomography simulation *** microstructure,thermal properties and pressure resistance with different particle diameters were *** measured heat conductivities from Transient plane source experiment for three cases are 0.49 W/(m·K),0.48 W/(m·K),and 0.51 W/(m·K),and the porosity is 30.1%,30.7%,and 31.2% *** heat conductivity simulating results of three cases are 0.471 W/(m·K),0.482W/(m·K),and 0.513 W/(m·K).The ratio of difference between the results of simulation and Transient plane source measurement is as low as 1.2%,verifying the reliability of experimental and simulation results to a certain *** with the heat conductivity of 0.097-0.129 W/(m·K) and porosity of 71.6%-78.9% without leaking salt,the porosity is reduced by more than 50% while the heat conductivity increased by 4 to 5 times after molten salt *** significant increase in heat conductivity has a great impact on security operation,structure design,and modeling of the tank foundation for solar power plants.

关键词： heat conductivity X-ray computed microtomography foundation materials three-phase threshold algorithm molten salt leakage

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写字楼智慧能耗平台研究与节能应用

智能建筑与智慧城市 2024年第7期 158-161页

作者：蒲靖祁熙鹏党涛刘方舟王欢陕西建工集团股份有限公司陕西华山路桥集团有限公司陕西正诚路桥工程研究院有限公司

文章针对综合写字楼能耗大的问题,对各类能耗进行专业集成,构建综合能耗管控平台,建立了写字楼的能源精细化、智慧化管理系统,同时介绍了该管控平台的架构、数据采集、数据分析、能耗管理等多方面功能。该管控系统的运用,实现了写字楼... 详细信息

文章针对综合写字楼能耗大的问题,对各类能耗进行专业集成,构建综合能耗管控平台,建立了写字楼的能源精细化、智慧化管理系统,同时介绍了该管控平台的架构、数据采集、数据分析、能耗管理等多方面功能。该管控系统的运用,实现了写字楼能源的高效利用、响应了国家节能减排方针政策,进一步朝着“双碳”目标前行。

关键词： BIM 建筑物可视化平台监控运维

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Penetrating canaloplasty in corticosteroid-induced glaucoma:a report of two cases

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 770-772页

作者： fang liu liu-Shan zhou Wei-Wei Zhang Department of Ophthalmology Daqing Longnan Hospitalthe Fifth Affiliated Hospital of Qiqihar Medical CollegeDaqing 163453Heilongjiang ProvinceChina

Dear Editor,We have treated two patients of glucocorticoid-induced glaucoma with penetrating canaloplasty(PCP)since *** is a new type internal drainage surgery for glaucoma,which is a bleb-independent filtering surgery combined canaloplasty with trabeculectomy,and the surgery shows a great efficacy of intraocular pressure(IOP)reduction with no surgical *** surgery started with a fornix-based conjunctival flap and double scleral flap,and Schlemm’s canal was opened,a 10-0 prolene suture was positioned and tensioned within Schlemm’s canal,trabucular meshwork segment was excised and peripheral iridectomy was performed,the scleral flap and the conjunctival flap were closed watertight with 10-0 prolene sutures.

关键词： glaucoma surgery glucocorticoid

Dynamic Effect of Landslides Triggered by Earthquake:A Case Study in Moxi Town of Luding County,China

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Journal of Earth Science 2024年第1期35卷 221-234页

作者： Hongfu zhou Fei Ye Wenxi Fu Bin liu Tian fang Rui Li Chengdu Center China Geological SurveyChengdu 610081China State Key Laboratory of Hydraulics and Mountain Rivers Protection Sichuan UniversityChengdu 610065China Sichuan Geological Survey Chengdu610081China Shandong University of Science and Technology Qingdao 266590China

The dynamic effect is a very important issue widely debated by scholars when studying the genetic and disaster-causing mechanisms of earthquake-triggered ***,the dynamic effect mechanism and phenomena of earthquake-triggered landslides were summarized in this ***,the primary types of dynamic effects were further used to interpret the Mogangling landslide in Moxi Town of Luding County,China.A field investigation,remote sensing,numerical calculation and theoretical analysis were carried out to illustrate the failure mechanism of slope rock masses affected by *** interaction between seismic waves and slope rock masses and the induced dynamic effect of slope rock masses were primarily accounted for in the *** slope topography,rock mass weathering and unloading characteristics,river erosion,regional seismogenic structure,and rock mass structure characteristics were also *** results showed that the formation of the Mogangling landslide was mainly related to the high amplification effect of seismic acceleration and back slope effects,interface dynamic stress effects,and double-sided slope effects of seismic waves caused by the catastrophic Ms 7.75 Moxi Earthquake in *** principles for the site and route selection of large-scale infrastructure in the planning stage and the scientific prevention of seismic geological disasters were proposed on the basis of the dynamic effect of earthquake-induced landslides.

关键词： dynamic effect coupling of endogenic and exogenic processes landslides earthquakes disaster prevention

Junshanyinzhen tea extract prevents obesity by regulating gut microbiota and metabolic endotoxemia in high-fat diet fed rats

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Food Science and Human Wellness 2024年第4期13卷 2036-2047页

作者： Jian Ouyang Xiuping Li Changwei liu Danmin Lu Jie Ouyang fang zhou Qi liu Jianan Huang Zhonghua liu Key Laboratory of Tea Science of Ministry of Education Hunan Agricultural UniversityChangsha 410128China National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals Hunan Agricultural UniversityChangsha 410128China Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients Hunan Agricultural UniversityChangsha 410128China Key Laboratory for Evaluation and Utilization of Gene Resources of Horticultural Crops Ministry of Agriculture and Rural AffairsHunan Agricultural UniversityChangsha 410128China

Obesity is associated with gut dysbiosis and metabolic *** tea extract(JSTE)reduced fat accumulation and body weight in obese ***,the effects and mechanism of JSTE in preventing obesity were ***,we used different doses of JSTE(75,150 and 300 mg/(kg·day))to evaluate the effect on high-fat diet(HFD)-induced rats under 8 weeks of ***,our results showed that JSTE could significantly reduce body weight gain,blood lipid levels and fat accumulation,improve fatty damage in liver tissue(P<0.05).In addition,JSTE increased the expression of intestinal tight junction proteins(P<0.05),relieved metabolic endotoxemia(P<0.05)and chronic low-grade inflammation in HFD *** of fecal samples showed that JSTE could effectively reverse the microbial diversity and the ratio of Firmicutes to Bacteroidetes to normal levels in HFD-fed *** and Erysipelotrichaceae,which are positively related to obesity,were decreased by JSTE intervention(P<0.05).while Bifidobacteriaceae,Bacteroidaceae,Akkermansia,and Clostridium,which are negatively related to obesity,were ***,these results suggested that JSTE might effectively prevent obesity by modulating gut microbiota dysbiosis,intestinal barrier dysfunction,metabolic endotoxemia and chronic low-grade infl ammation in HFD-induced rats.

关键词： Junshanyinzhen tea Obesity Gut microbiota Gut barrier function Metabolic endotoxemia

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Developing a fluorescence substrate for HRP-based diagnostic assays with superiorities over the commercial ADHP

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Chinese Chemical Letters 2024年第6期35卷 439-444页

作者： Zhichao zhou Fuqian Chen Xiaotong Xia Dong Ye Rong zhou Lei Li Tao Deng Zhenhua Ding fang liu Department of Radiation Medicine Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhou 510515China School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China Artemisinin Research Center Guangzhou University of Chinese MedicineGuangzhou 510006China State Key Laboratory of Respiratory Disease the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510120China Guangzhou Laboratory Bio-IslandGuangzhou 510030China Nanshan Pharmaceutical Innovation Research Institute of Guangdong Province Foshan 528225China

The combination of horseradish peroxidase(HRP)and a fluorescence substrate has been attracting great interests in developing sensitive biochemical analysis and immunoassays.10-Acetyl-3,7-dihydroxyphenoxazine(ADHP or Amplex red)is the most sensitive fluorogenic substrate known for HRP in current market,however,it suffers from some drawbacks,such as non-specific reactivity to carboxylesterase and limited fluorescence *** the present study,a novel HRP substrate10-cyclopropylcarbonyl-dichloro-dihydroxyphenoxazine(AR-2),has been prepared,which exhibited improved sensitivity than ADHP in sensing ***,the fluorescence of AR-2/HRP demonstrated improved tolerance to physiological relevant p H fluctuation as compared to ADHP/*** detection of uric acid/urate oxidase reaction indicated excellent application prospect of AR-2/HRP for monitoring H_(2)O_(2)-generating biochemical *** interestingly,an enzyme-linked immunosorbent assay(ELISA)using AR-2 as the fluorescence reporter has been successfully used in detecting IgG against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)from human serum ***,AR-2 exhibits improved performances over the commercial ADHP,which will be an ideal alternative to ADHP in HRP-based fluorescence biochemical analysis and immunoassays.

关键词： Fluorescence immunoassay HRP fluorescence substrate Hydroresorufin Amplex red/ADHP SARS-CoV-2

Experimental study on wax deposition of highly paraffinic oil in intermittent gas-oil flow in pipelines

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Petroleum Science 2024年第3期21卷 2080-2088页

作者： Chuan-Shuo Wang Qian-Li Ma Xiao-fang Lv Jie Zhang Yang liu Shi-Dong zhou Jiangsu Key Laboratory of Oil and Gas Storage and Transportation Technology Changzhou UniversityChangzhou213164JiangsuPR China Hade Oil and Gas Development Department Tarim Oilfield BranchKorla841000XinjiangPR China

Oil-gas two phase wax deposition is a fairly common and open-ended question in flow assurance of multiphase transportation *** paper investigated the two main aspects of oil-gas two phase wax deposition layer:apparent thickness and crystal structure characteristics.A typical highly paraffinic oil in Bohai Sea,China,was used as the experimental material to investigate the wax deposition thickness in oil-gas two phase under the influence of different oil temperatures,superficial gas/liquid phase velocities and gas-oil ratios by using multiphase flow loop experimental *** as in the classical theory of wax molecular diffusion,it showed that wax deposition thickness of oil-gas two phase increased with increasing oil *** of the impact of different superficial phase velocities found that the actual liquid flow heat transfer and shear stripping was the gas phase dominant mechanisms determining wax deposit *** addition,the crystal structure of the wax deposition layer was characterized with the help of small-angle X-ray scattering(SAXS)for different circumferential positions,flow rates and gas-oil *** bottom deposition layer had a complex crystal structure and high hardness,which were subject to change over flow rate ***,the SAXS results provided evidence that the indirect effect of the actual liquid velocity modified by the gas phase was the main *** study of the effect of gas phase on the wax deposition of oil-gas two phase will help shed light onto the mechanism by which this important process *** findings address a very urgent need in the field of wax deposition of highly paraffinic oil to understand the flow security of oilgas two phase that occurs easily in multiphase field pipelines.

关键词： Oil-gas two phase Highly paraffinic oil Wax deposition SAXS