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Immediate implantation of ultrafine fiber slow-release system based on cell electrospinning to induce osteogenesis of mesenchymal stem cells

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Regenerative Biomaterials 2024年第2期3卷 76-87页

作者： Tao Lu long Yang Zhuoyang Li Yin liu Shun'en Xu Chuan Ye Department of Orthopaedics The Affliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Orthopaedics The First People's Hospital of GuiyangGuiyang 550004China Center for Tissue engineering and Stem Cell Research Guizhou Medical UniversityGuiyang 550004China Department of Otolaryngology Head and Neck Surgery Xinqiao HospitalArmy Medical University(Third Military Medical University)Chongqing 400037China Department of Dental implant Stomatological Hospital of GuiyangGuiyang 550000China

This study presents the development and evaluation of a poly(3-hydroxybutyrate-co-4-hydroxybutyrate)(P34HB)ultrafine fiber slow-release system for in vivo osteogenic induction of human umbilical cord mesenchymal stem cells(HUCMSCs).Utilizing dual-nozzle and cell electrospinning techniques,the system encapsulates L-ascorbic acid-2-phosphate magnesium(AsP),βB-glycerophosphate sodium and dexamethasone(DEX)within the'fbers,ensuring sustained osteogenic differentiation.The scaffold's morphology,characterization,hydrophilicity,mechanical properties and cellular behavior were examined.Immediate subcutaneous implantation in rabbits was con-ducted to observe its ectopic osteogenic induction effect.Successfully fabricated P34HB ultrafine fiber slow-release sys-tem.Charact ization med.theuniform distribution of HUCMSCs and inducing components within the scaffold,with no chemical reactions affecting the active components.In vitro tests showcased a prolonged release of DEX and ASP,while biocompatibility assays highlighted the scaffold's suitability for cellular growth.Alizarin Red,type I collagen,and osteopontin(OPN)staining verifed the scaffold's potent osteogenic induction effect on HUCMsCs.Notably,immediate implantation into New Zealand White rabbits led to significant new bone formation within 8 weeks.These findings underscore the system's potential for immediate in vivo implantation without prior in vitro induction,marking a promising advancement in bone tissue engineering.

关键词： bone tissue engineering cell electrospinning in vivo induction immediate implantation biomaterials

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A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis

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Bone Research 2024年第1期12卷 227-239页

作者： Yong Li Zhengwen Cai Wenjuan Ma long Bai en Luo Yunfeng Lin State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengduSichuan 610041PR China Department of Oral and Maxillofacial Surgery Affiliated Stomatological HospitalSouthwest Medical UniversityLuzhouSichuan 646000PR China Sichuan Provincial engineering Research Center of Oral Biomaterials ChengduSichuan 610041China

Diabetic osteoporosis(DOP)is a significant complication that poses continuous threat to the bone health of patients with diabetes;however,currently,there are no effective treatment strategies.In patients with diabetes,the increased levels of ferroptosis affect the osteogenic commitment and differentiation of bone mesenchymal stem cells(BMSCs),leading to significant skeletal changes.To address this issue,we aimed to target ferroptosis and propose a novel therapeutic approach for the treatment of DOP.We synthesized ferroptosis-suppressing nanoparticles,which could deliver curcumin,a natural compound,to the bone marrow using tetrahedral framework nucleic acid(tFNA).This delivery system demonstrated excellent curcumin bioavailability and stability,as well as synergistic properties with tFNA.Both in vitro and in vivo experiments revealed that nanoparticles could enhance mitochondrial function by activating the nuclear factor E2-related factor 2(NRF2)/glutathione peroxidase 4(GPX4)pathway,inhibiting ferroptosis,promoting the osteogenic differentiation of BMSCs in the diabetic microenvironment,reducing trabecular loss,and increasing bone formation.These findings suggest that curcumin-containing DNA tetrahedron-based ferroptosissuppressing nanoparticles have a promising potential for the treatment of DOP and other ferroptosis-related diseases.

关键词： curcumin osteoporosis diabetic

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Design Strategies for Aqueous Zinc Metal Batteries with High Zinc Utilization: From Metal Anodes to Anode-Free Structures

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Nano-Micro Letters 2024年第4期16卷 305-349页

作者： Xianfu Zhang long Zhang Xinyuan Jia Wen Song Yongchang liu School of Materials Science and engineering University of Science and Technology Beijing30 College RoadBeijing 100083People’s Republic of China Beijing Advanced Innovation Center for Materials Genome engineering Institute for Advanced Materials and TechnologyState Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China

Aqueous zinc metal batteries(AZMBs)are promising candidates for next-generation energy storage due to the excellent safety, environmental friendliness, natural abundance, high theoretical specific capacity, and low redox potential of zinc(Zn) metal. However,several issues such as dendrite formation, hydrogen evolution, corrosion, and passivation of Zn metal anodes cause irreversible loss of the active materials. To solve these issues, researchers often use large amounts of excess Zn to ensure a continuous supply of active materials for Zn anodes. This leads to the ultralow utilization of Zn anodes and squanders the high energy density of AZMBs. Herein, the design strategies for AZMBs with high Zn utilization are discussed in depth, from utilizing thinner Zn foils to constructing anode-free structures with theoretical Zn utilization of 100%, which provides comprehensive guidelines for further research. Representative methods for calculating the depth of discharge of Zn anodes with different structures are first summarized. The reasonable modification strategies of Zn foil anodes, current collectors with pre-deposited Zn, and anode-free aqueous Zn metal batteries(AF-AZMBs) to improve Zn utilization are then detailed. In particular, the working mechanism of AF-AZMBs is systematically introduced. Finally, the challenges and perspectives for constructing high-utilization Zn anodes are presented.

关键词： Aqueous zinc metal batteries Zinc anodes High zinc utilization Depth of discharge Anode-free structures

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Improved Segmented Belief Propagation List Decoding for Polar Codes with Bit-Flipping

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China Communications 2024年第3期21卷 19-36页

作者： Mao Yinyou Yang Dong liu Xingcheng Zou en School of Electronics and Information Technology(SEIT) Sun Yat-sen University(SYSU)Guangzhou 510006China School of Information Science Guangzhou Xinhua UniversityGuangzhou 510520China Southern Marine Science and engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China

Belief propagation list(BPL) decoding for polar codes has attracted more attention due to its inherent parallel nature. However, a large gap still exists with CRC-aided SCL(CA-SCL) decoding.In this work, an improved segmented belief propagation list decoding based on bit flipping(SBPL-BF) is proposed. On the one hand, the proposed algorithm makes use of the cooperative characteristic in BPL decoding such that the codeword is decoded in different BP decoders. Based on this characteristic, the unreliable bits for flipping could be split into multiple subblocks and could be flipped in different decoders simultaneously. On the other hand, a more flexible and effective processing strategy for the priori information of the unfrozen bits that do not need to be flipped is designed to improve the decoding convergence. In addition, this is the first proposal in BPL decoding which jointly optimizes the bit flipping of the information bits and the code bits. In particular, for bit flipping of the code bits, a H-matrix aided bit-flipping algorithm is designed to enhance the accuracy in identifying erroneous code bits. The simulation results show that the proposed algorithm significantly improves the errorcorrection performance of BPL decoding for medium and long codes. It is more than 0.25 d B better than the state-of-the-art BPL decoding at a block error rate(BLER) of 10^(-5), and outperforms CA-SCL decoding in the low signal-to-noise(SNR) region for(1024, 0.5)polar codes.

关键词： belief propagation list(BPL)decoding bit-flipping polar codes segmented CRC

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A robust tensor watermarking algorithm for diffusion-tensor images

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Frontiers of Information Technology & Electronic engineering 2024年第3期25卷 384-397页

作者： Chengmeng liu Zhi LI Guomei WANG long ZHenG State Key Laboratory of Public Big Data College of Computer Science and TechnologyGuizhou UniversityGuiyang 550025China

Watermarking algorithms that use convolution neural networks have exhibited good robustness in studies of deep learning networks.However,after embedding watermark signals by convolution,the feature fusion eficiency of convolution is relatively low;this can easily lead to distortion in the embedded image.When distortion occurs in medical images,especially in diffusion tensor images(DTIs),the clinical value of the DTI is lost.To address this issue,a robust watermarking algorithm for DTIs implemented by fusing convolution with a Transformer is proposed to ensure the robustness of the watermark and the consistency of sampling distance,which enhances the quality of the reconstructed image of the watermarked DTIs after embedding the watermark signals.In the watermark-embedding network,Ti-weighted(Tlw)images are used as prior knowledge.The correlation between T1w images and the original DTI is proposed to calculate the most significant features from the T1w images by using the Transformer mechanism.The maximum of the correlation is used as the most significant feature weight to improve the quality of the reconstructed DTI.In the watermark extraction network,the most significant watermark features from the watermarked DTI are adequately learned by the Transformer to robustly extract the watermark signals from the watermark features.Experimental results show that the average peak signal-to-noise ratio of the watermarked DTI reaches 50.47 dB,the diffusion characteristics such as mean diffusivity and fractional anisotropy remain unchanged,and the main axis deflection angleαAc is close to 1.Our proposed algorithm can effectively protect the copyright of the DTI and barely affects the clinical diagnosis.

关键词： Robust watermarking algorithm Transformer Image reconstruction Diffusion tensor images Soft attention Hard attention Tl-weighted images

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