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Assimilating temperature and salinity profiles using Ensemble Kalman Filter with an adaptive observation error and T-S constraint

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Acta Oceanologica Sinica 2016年第1期35卷 30-37页

作者： LIU Danian SHI Ping SHU Yeqiang YAO Jinglong WANG Dongxiao SUN Lu State Key Laboratory of Tropical Oceanography South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China South China Sea Monitoring Center South China Sea Branch State Oceanic Administration Guangzhou 510301 China

Temperature （T） and salinity （S） profiles from conductivity-temperature-depth data collected during the Northern South China Sea Open Cruise from August 16 to September 13, 2008 are assimilated using Ensemble Kalman Filter （EnKF）. An adaptive observational error strategy is used to prevent filter from diverging. In the meantime, aiming at the limited improvement in some sites caused by the T and S biases in the model, a T-S constraint scheme is adopted to improve the assimilation performance, where T and S are separately updated at these locations. Validation is performed by comparing assimilated outputs with independent in situ data （satellite remote sensing sea level anomaly （SLA）, the OSCAR velocity product and shipboard ADCP）. The results show that the new EnKF assimilation scheme can significantly reduce the root mean square error （RMSE） of oceanic T and S compared with the control run and traditional EnKF. The system can also improve the simulation of circulations and SLA.

关键词： Ensemble Kalman Filter adaptive observation error T-S constraint

A Gravity Forward Modeling Method based on Multiquadric Radial Basis Function

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Acta Geologica Sinica(English Edition) 2021年第S01期95卷 62-64页

作者： liu Yan LV Qingtian HUANG Yao SHI danian MENG Guixiang YAN Jiayong ZHANG Yongqian China Deep Exploration Center-SinoProbe Center Chinese Academy of Geological SciencesBeijing 100037China China University of Geosciences Wuhan 430074China

It is one of the most important part to build an accurate gravity model in geophysical exploration.Traditional gravity modelling is usually based on grid method,such as difference method and finite element method wide... 详细信息

关键词： geophysical exploration gravity forward modeling mesh-free method radial basis function

Edge detection of gravity anomaly with an improved 3D structure tensor

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Global Geology 2018年第2期21卷 108-113页

作者： DAI Weiming LI Tonglin HUANG danian YUAN Yuan liu Kai QIAO Zhongkun College of Geo-Exploration Science and Technology Jilin University Second Institute of Oceanography State Oceanic Administration China Water Northeastern Investigation Design&Research Co.Ltd

Edge detection plays an important role in geological interpretation of potential field data,which can indicate the subsurface faults,contact,and other tectonic features.A variety of methods have been proposed to detect and enhance the edges.3 D structure tensor can well delineate the edges of geological bodies,however,it is sensitive to noise and additional false edges need to be removed artificially.In order to overcome these disadvantages,this paper redefines the 3 D structure tensor with a Gaussian envelop and proposes a new normalized edge detector,which can remove the additional false edges and reduce the influence of noise effectively,and balance the edges of different amplitude anomalies completely.This method has been tested on the synthetic and measured gravity data,showing that the new improved method achievesbetter results and reveals more details.

关键词： edge detection improved 3D structure tensor gravity anomaly

Observation system simulation experiments using an ensemble-based method in the northeastern South China Sea

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Journal of Oceanology and Limnology 2020年第6期38卷 1729-1745页

作者： GENG Wu CHENG Feng XIE Qiang ZOU Xiaoli HE Weihong WANG Zhaozheng SHU Yeqiang CHEN Gengxin LIU Danian YE Dong WANG Ruiwen liu Chuanyu State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of Sciences(SCSIO)Guangzhou 510301China China General Nuclear Power Yangjiang Nuclear Power Co.Ltd.Yangjiang 529941China Laboratory for Regional Oceanography and Numerical Modeling Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China Institute of Deep-sea Science and Engineering Chinese Academy of SciencesSanya 572000China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Public Weather Service Center of China Meteorological Administration Beijing 100081China National Meteorological Center of China Meteorological Administration Beijing 100081China Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences(IOCAS)Qingdao 266071China Marine Dynamic Process and Climate Function Laboratory Pilot National Laboratory for Marine Science and Technology(Qingdao)(QNLM)Qingdao 266237China

An ensemble-based method for the observation system simulation experiment(OSSE)is employed to design optimal observation stations and assess the present observation stations in the northeastern South China Sea(SCS).We employed the 20-year(1992-2012)sea surface height(SSH)data to design an array to monitor the intraseasonal to interannual variability.The results show that the most key region was found located at the northwest of Luzon Island(LI)where the energetic Luzon cyclonic gyre(LCG)occurs;other key regions include the edge of the LCG,the northwest of the Luzon Strait(LS),and the southwest of Taiwan,China.By contrast,we found that the present observation stations might oversample at the northwest of the LS and undersample at the northwest of LI.In addition,the optimal stations perform better in a larger area than the present stations.In vertical direction,the key layer is located within the upper 200-m depth,of which the surface and subsurface layers are most valuable to the observing system.

关键词： assimilation observation system simulation experiment(OSSE) ensemble South China Sea(SCS) Kalman filter

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中国现代物理学研究的兴起——燕京大学物理系与洛克菲勒基金会

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Chinese Annals of History of Science and Technology 2019年第2期3卷 4-61页

作者：胡大年 Department of History The City College of The City University of New YorkNew YorkNY 10031US

根据在美、英、中三国发现的原始档案材料,本文仔细考察了此前完全被忽视的协和医学院预科学校物理系的短暂历史,并揭示了该系与燕京大学(简称燕大)物理系之间的密切联系。本研究还深入调查了创立于1927年的燕大物理系硕士研究生项目,... 详细信息

根据在美、英、中三国发现的原始档案材料,本文仔细考察了此前完全被忽视的协和医学院预科学校物理系的短暂历史,并揭示了该系与燕京大学(简称燕大)物理系之间的密切联系。本研究还深入调查了创立于1927年的燕大物理系硕士研究生项目,这是中国第一个物理学研究生项目。正是这一研究生项目,将燕大物理系由一个主要帮助协和医学院准备合格医科学生的培训中心,转变成为中国物理学研究工作的一处重要发源地。燕大物理系的教授很少而且历史短暂,然而从那里却走出了许多杰出的中国物理学家,如孟昭英、张文裕、王明贞、袁家骝、王承书、卢鹤绂、葛庭燧、黄昆和谢家麟。这些突出成就的取得与该系头四位系主任郭查理、安德森、谢玉铭和班威廉的富有成效的领导和开拓性工作密不可分,同时也得益于相对充裕的、主要来自美国的私募经费以及与西方教育机构的深厚联系。本文不仅详细介绍了这四位物理系的领军人物及其贡献,而且展示了洛克菲勒基金会通过中华医学基金会与协和医学院在燕大物理系发展过程中所发挥的独特作用。

关键词：协和医学院预科学校燕京大学物理系中华医学基金会洛克菲勒基金会 W.W.Stifler(1883—1954) 郭查理(C.H.Corbett,1881—1963) 安德森(P.A.Anderson,1898—1990) 谢玉铭(1895—1986) 班威廉(William Band,1906—1993)

长链非编码RNA HOTAIR在胶质瘤中的研究进展

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中国现代应用药学 2021年第1期38卷 115-121页

作者：刘光东王闯刘大年龚海东牡丹江医学院黑龙江牡丹江157000 牡丹江医学院附属红旗医院黑龙江牡丹江157000

胶质瘤是严重威胁人类健康的神经系统疾病之一,在中国,其发病率约占所有颅内肿瘤的60%。探索胶质瘤发病的分子机制已成为诊断和治疗这种疾病的热门话题。长链非编码RNA(long non-coding RNA,lncRNA)长度>200个核苷酸且不具有蛋白编码功... 详细信息

胶质瘤是严重威胁人类健康的神经系统疾病之一,在中国,其发病率约占所有颅内肿瘤的60%。探索胶质瘤发病的分子机制已成为诊断和治疗这种疾病的热门话题。长链非编码RNA(long non-coding RNA,lncRNA)长度>200个核苷酸且不具有蛋白编码功能。针对lncRNA的研究表明,其在基因的遗传、转录和翻译等方面均有重要调控作用。在多种lncRNA中,HOX转录反义RNA(HOX transcript antisense intergenic RNA,HOTAIR)是一种典型的反义lncRNA,同时也是第一种被发现的具有反式转录作用且远距离调控2号染色体上的HOXD基因簇的lncRNA,在多种肿瘤组织和细胞中高表达,具有肿瘤基因作用。HOTAIR可通过多种分子机制参与胶质瘤细胞的增殖、凋亡、侵袭和自噬等过程,本文就HOTAIR在胶质瘤的作用机制方面进行综述。

关键词：长链非编码RNA HOX转录反义RNA 胶质瘤

Haploidentical transplantation has a superior graft-versus-leukemia effect than HLA-matched sibling transplantation for Ph- high-risk B-cell acute lymphoblastic leukemia

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Chinese Medical Journal 2022年第8期135卷 930-939页

作者： Fan Menglin Wang Yu Lin Ren Lin Tong Huang Fen Fan Zhiping Xu Yajing Yang Ting Xu Na Shi Pengcheng Nie danian Lin Dongjun Jiang Zujun Wang Shunqing Sun Jing Huang Xiaojun liu Qifa Xuan Li Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Hematology Peking University People’s HospitalPeking University Institute of HematologyBeijing 100044China Department of Hematology Xiangya HospitalCentral South UniversityChangshaHunan 110051China Department of Hematology Fujian Institute of HematologyFujian Medical University Union HospitalFuzhouFujian 350001China Department of Hematology Sun Yat-Sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510130China Department of Hematology The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Hematology Guangzhou General Hospital of Guangzhou Military CommandGuangzhouGuangdong 510010China Department of Hematology Guangzhou First People’s HospitalGuangzhouGuangdong 510080China

Background: Compared with human leukocyte antigen (HLA)-matched sibling donor (MSD) transplantation, it remains unclear whether haploidentical donor (HID) transplantation has a superior graft-versus-leukemia (GVL) effect for Philadelphia-negative (Ph-) high-risk B-cell acute lymphoblastic leukemia (B-ALL). This study aimed to compare the GVL effect between HID and MSD transplantation for Ph- high-risk B-ALL.Methods: This study population came from two prospective multicenter trials (NCT01883180, NCT02673008). Immunosuppressant withdrawal and prophylactic or pre-emptive donor lymphocyte infusion (DLI) were administered in patients without active graft-versus-host disease (GVHD) to prevent relapse. All patients with measurable residual disease (MRD) positivity posttransplantation (post-MRD+) or non-remission (NR) pre-transplantation received prophylactic/pre-emptive interventions. The primary endpoint was the incidence of post-MRD+.Results: A total of 335 patients with Ph- high-risk B-ALL were enrolled, including 145 and 190, respectively, in the HID and MSD groups. The 3-year cumulative incidence of post-MRD+ was 27.2% (95% confidence interval [CI]: 20.2%-34.7%) and 42.6% (35.5%-49.6%) in the HID and MSD groups(P = 0.003), respectively. A total of 156 patients received DLI, including 60 (41.4%) and 96 (50.5%), respectively, in the HID and MSD groups (P= 0.096). The 3-year cumulative incidence of relapse was 18.6% (95% CI: 12.7%-25.4%) and 25.9% (19.9%-32.3%;P = 0.116) in the two groups, respectively. The 3-year overall survival (OS) was 67.4% (95% CI: 59.1%-74.4%) and 61.6% (54.2%-68.1%;P = 0.382), leukemia-free survival (LFS) was 63.4% (95% CI: 55.0%-70.7%) and 58.2% (50.8%-64.9%;P= 0.429), and GVHD-free/relapse-free survival (GRFS) was 51.7% (95% CI: 43.3%-59.5%) and 37.8% (30.9%-44.6%;P= 0.041), respectively, in the HID and MSD groups.Conclusion: HID transplantation has a lower incidence of post-MRD+ than MSD transplantation, suggesting that HID transplantation might have a superior GVL effect than MSD transpla

关键词： Haploidentical HLA-matched sibling Philadelphia-negative high-risk B-cell acute lymphoblastic leukemia Graft-versus-leukemia Transplantation

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我国海外版权保护：问题及路径选择

现代出版 2010年第6期 73-77页

作者：刘大年中国传媒大学出版社语言艺术编辑室中国传媒大学出版社编辑出版研究中心

我国版权输出的数量近年大幅度攀升,海外版权受到侵害所造成的损失也不断增加,必须从完善版权法律体系、构建各方共同参与的版权保护体系,加强企业版权保护战略建设等方面促进我国海外版权的保护。

关键词：海外版权保护法律体系路径

Theoretical calculation of the coefficients of thermal expansion for various AB type halides

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Chinese Science Bulletin 1998年第4期43卷 339-340页

作者： Zhang Zhenyu Ye danian liu Weiling Chinese Acad Sci Inst Geol Beijing 100029 Peoples R China

By analyzing the relationship between thermal expansion coefficients of AB type halides and their crystal chemistry properties, an empirical formula for theoretical calculation of their thermal expansion coefficients ... 详细信息

关键词： halide thermal expansion coefficient theoretical calculation.