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Chinese Chemical Letters 2024年第10期35卷 399-403页

作者： caixia Zhu Qing Hong Kaiyuan Wang Yanfei Shen Songqin liu Yuanjian Zhang Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Devices Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical ResearchSchool of Chemistry and Chemical EngineeringMedical SchoolSoutheast UniversityNanjing 211189China

Reliable and selective sensing of dopamine(DA)is essential for early diagnosis of mental *** the various potential methods,nanozyme-based sensing systems have demonstrated promising sensitivity and ***,owing to the lack of substrate specificity,it is challenging to selectively detect DA using ***,based on the reactivity of the DA oxidation intermediates,we report a cascade colorimetric sensing system for the selective detection of DA using only a single *** was disclosed that the oxidation product of DA catalyzed by Co-N-doped carbon sheets(Co-N-C,a common oxidase-like nanozyme),dopamine quinone(DAQ),showed significant biocatalytic electron-donating activity in the reduction of O_(2)to generate O_(2)·-.Further using O_(2)·-to oxidize3,3,5,5-tetramethylbenzidine(TMB),a colorimetric sensing platform for DA was constructed with a linear detection range of 50 nmol/L to 50μmol/L and a low limit of detection of 4 nmol/*** to the reactivity of the oxidation product,without any biometric units(such as nucleic acids,enzymes,and antibodies/antigens),the reaction selectivity of DA against other interferences(e.g.,ascorbic acid,adrenaline,5-hydroxytryptamine,and glutathione)was enhanced up to *** complicated cascade systems requiring at least two nanozymes,sophisticated artificial recognition via multiple interactions was simplified by exploiting the oxidative properties of product intermediates;thus,only a single common oxidase-like nanozyme was *** work offers a new strategy to enhance the selectivity of nanozymes for bioanalytical applications.

关键词： Nanozyme Colorimetry Selectivity Dopamine Artificial recognition

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认知障碍老年人久坐行为的研究进展

护理管理杂志 2024年第6期24卷 503-507页

作者：李斐斐吴美倩胡镕镕肖进郑瑶刘彩霞浙江中医药大学护理学院杭州市310053 浙江医院干部保健科杭州市310030 浙江医院护理部杭州市310030

认知障碍老年人久坐现象普遍存在,严重影响其生活质量。我国对认知障碍老年人的久坐行为研究尚处于起步阶段。文章综述了久坐行为的概念、评估工具以及认知障碍老年人久坐行为研究现状,从社会人口学、疾病及环境方面分析了影响认知障碍... 详细信息

认知障碍老年人久坐现象普遍存在,严重影响其生活质量。我国对认知障碍老年人的久坐行为研究尚处于起步阶段。文章综述了久坐行为的概念、评估工具以及认知障碍老年人久坐行为研究现状,从社会人口学、疾病及环境方面分析了影响认知障碍老年人久坐行为的相关因素。指出未来需积极研发适合我国认知障碍老年人的久坐行为评估工具、准确评估我国认知障碍老年人久坐行为发生现状、多元化分析认知障碍老年人久坐行为影响因素,为设计有效的干预方案,降低认知障碍老年人久坐行为发生率,促进其健康生活行为方式提供参考。

关键词：老年人认知障碍久坐行为综述

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放射金属组学:以α核素靶向治疗药物为例

中国无机分析化学 2024年第1期14卷 82-92页

作者：刘彩霞李秋硕范玉芹辛岩费钰茜曹浩楠敬罕涛崔丽巍李柏李玉锋吉林大学药学院长春130021 中国科学院高能物理研究所北京100049 山东省妇幼保健院济南250014 河南农业大学国际教育学院郑州450002 济南大学机械工程学院济南250024 中国科学院大学北京100049

金属组学是综合研究生命体内(特别是细胞内)自由或络合的全部金属和类金属的含量、分布、形态、结构及功能的一门学科。作为金属组学的一个分支,放射金属组学重点研究放射性核素的制备和应用,特别是其在环境和生物体内的含量、分布、化... 详细信息

金属组学是综合研究生命体内(特别是细胞内)自由或络合的全部金属和类金属的含量、分布、形态、结构及功能的一门学科。作为金属组学的一个分支,放射金属组学重点研究放射性核素的制备和应用,特别是其在环境和生物体内的含量、分布、化学种态及功能等。靶向α治疗(Targeted alpha therapy,TAT)是一种利用发射α粒子的放射性核素与肿瘤选择性载体分子结合实现靶向癌细胞,进而对肿瘤组织造成杀伤作用的一种医疗方法,是放射金属组学在癌症治疗领域的重要应用方向。α粒子凭借高线性能量传递、短组织射程和较强的相对生物学效应,在放射性免疫和肿瘤治疗方面有着广阔的应用前景。以TAT药物为例,就常用α核素、TAT药物螯合剂及其标记的靶向载体、几种重要α放射性核素靶向治疗进展予以综述,并分析TAT药物研发的挑战和发展前景,从而展示放射金属组学在核医学领域特别是癌症治疗领域的研究进展。随着更多α核素的制备和更多靶向标记方法的建立,TAT药物有望用于多种疾病,这也需要新的放射金属组学方法的建立和应用。因此,放射金属组学在核医学领域具有良好应用前景。

关键词：放射金属组学放射性核素治疗 α核素靶向药物

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方块踏步运动在老年人群中应用的研究进展

护理与康复 2024年第6期23卷 88-92页

作者：李斐斐楼巍敏吴美倩胡镕镕肖进刘彩霞浙江中医药大学护理学院浙江杭州310053 浙江医院浙江杭州310030

对方块踏步运动的起源与发展、步伐模式、训练方法、作用机制以及在老年人群中应用的现状进行综述,为后续方块踏步运动在我国老年人群的相关研究和应用提供参考。

关键词：老年人方块踏步运动运动锻炼综述

矿物掺合料对流态固化土物理力学性能的影响研究

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江西建材 2024年第7期 71-75+82页

作者：余保英刘彩霞王福涛熊明非周晋筑王学朋中建西部建设建材科学研究院有限公司珠海市斗门区建设工程质量监督检测站中建铁路投资建设集团有限公司

文中研究了矿物掺合料对流态固化土物理力学性能的影响。结果表明，随着水泥用量的增加，各龄期强度明显增加。这是由于水泥作为固化剂决定了固化土的水化产物的形成数量和形成速率；适量矿粉掺入使得固化土水化过程生成更多硅铝质胶结... 详细信息

文中研究了矿物掺合料对流态固化土物理力学性能的影响。结果表明，随着水泥用量的增加，各龄期强度明显增加。这是由于水泥作为固化剂决定了固化土的水化产物的形成数量和形成速率；适量矿粉掺入使得固化土水化过程生成更多硅铝质胶结产物，粉煤灰填充土体孔隙，减小孔隙率，颗粒间连接更紧密，固化土整体性更佳。

关键词：流态固化土矿物掺合料力学性能微观形貌

单核细胞增生李斯特菌LIPI-4 Lm4b_02327的基因克隆、生物信息学分析及原核表达

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石河子大学学报（自然科学版） 2024年第3期42卷 313-320页

作者：刘彩霞马勋吕双飞王静寇丽君史唯地孔翠莲钱瑞宣高盛杰任慧杰石河子大学动物科技学院新疆石河子832003

目的试验旨在获得单核细胞增生李斯特菌新疆冷冻鸡肉分离株LM928中LIPI-4 Lm4b_02327基因的重组蛋白。方法根据Gen Bank中LM Clip80459菌株(登录号CAS06084.1)Lm4b_02327序列设计特异性引物,利用PCR对Lm4b_02327基因进行扩增,纯化目... 详细信息

目的试验旨在获得单核细胞增生李斯特菌新疆冷冻鸡肉分离株LM928中LIPI-4 Lm4b_02327基因的重组蛋白。方法根据Gen Bank中LM Clip80459菌株(登录号CAS06084.1)Lm4b_02327序列设计特异性引物,利用PCR对Lm4b_02327基因进行扩增,纯化目的片段后克隆至pMD19-T载体,双酶切筛选阳性克隆进行测序。测序后利用软件预测Lm4b_02327序列编码蛋白质的理化性质、二级结构和三级结构,对该基因片段的核苷酸序列及编码的氨基酸序列进行同源性对比。同时构建pET32a-Lm4b_02327重组质粒,将其转化至大肠杆菌BL21(DE3)感受态细胞中,诱导表达,经SDS-PAGE检测、纯化蛋白后用Western Blot鉴定。结果 LM928菌株的Lm4b_02327基因全长为315 bp,共编码105个氨基酸,该蛋白为偏酸性、无信号肽、亲水性、无跨膜结构、定位于细胞质的不稳定蛋白,该蛋白质预测为PTSLacEⅡA组分。LM928菌株Lm4b_02327基因的核苷酸和氨基酸序列与CFSAN023463、52854、02-6680、02-6679、ICDC-LM188、LM3、N2306、GTA-L356和Clip80459菌株的同源性均为100.0%,与52860、FSL-J1-158和FSL J1-208菌株的核苷酸同源性分别为99.7%、97.8%和97.8%,与52860、FSL-J1-158和FSL J1-208菌株的氨基酸同源性分别为99.0%、94.3%和94.3%。系统进化树显示,LM928菌株的Lm4b_02327基因与4b血清型菌株聚为同一分支。经诱导后,pET32a-Lm4b_02327重组质粒在大肠杆菌BL21中大量表达,经SDS-PAGE和Western Blot鉴定表明该重组蛋白大小约为30 kDa,与预期大小一致。结论本研究成功克隆Lm4b_02327基因,并获得该蛋白的大量表达,为深入研究蛋白功能奠定基础。

关键词：单核细胞增多李斯特菌 Lm4b_02327基因生物信息学分析原核表达

Alloy/layer double hydroxide interphasic synergy via nano-heterointerfacing for highly reversible CO_(2)redox reaction in Li-CO_(2)batteries

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Nano Research 2024年第6期17卷 5206-5215页

作者： Tianzhen Jian Wenqing Ma Jiagang Hou Jianping Ma Xianhong Li Haiyang Gao caixia Xu Hong liu Institute for Advanced Interdisciplinary Research(iAIR) Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongSchool of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China Kyiv College at Qilu University of Technology Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China Shandong Sacred Sun Power Sources Co. Ltd.Qufu 273100China

Li-CO_(2)batteries are among the most intriguing techniques for balancing the carbon cycle,but are challenged by the annoyed thermodynamic barrier of the Li_(2)CO_(3)decomposition ***,we demonstrate the electrocatalytic performances of two-dimensional(2D)CoAl-layer double hydroxide(LDH)nanosheets can be significantly improved by trans-dimensional crosslinking with three-dimensional(3D)multilevel nanoporous(MP)-RuCoAl alloy(MP-RuCoAl alloy⊥CoAl-LDH).The MP-RuCoAl alloy⊥CoAl-LDH with multiscale pore channels and abundant nano-heterointerface is directly prepared by controllable etching Al from a Ru-Co-Al master alloy along with simultaneous partial oxidization of Al and Co *** MP-RuCoAl is composed of various intermetallic compounds and Ru with abundant grain boundaries,and forms numerous heterointerface with 2D CoAl-LDH *** multiscale porous metallic network benefits mass and electron transportation as well as discharge product storage and enables a rich multiphase reaction *** situ differential electrochemical mass spectrometry shows that the mass-to-charge ratio in the charging process is~0.733 which is consistent with the theoretical value of 3/4,stating that the reversible co-decomposition of Li_(2)CO_(3)and C can be achieved with the MP-RuCoAl alloy⊥*** Ketjen black(KB)/MP-RuCoAl⊥CoAl-LDH battery demonstrates a high cyclability for over 2270 h(227 cycles)with a lower voltage gap stabilized at~1.3 V at 200 mA·g^(−1).Our findings here provide useful guidelines for developing high efficiency transition metal based electrocatalysts by coupling with conductive porous substrate for impelling the development of practical Li-CO_(2)battery systems.

关键词： heterojunction interface nanoporous Li-CO_(2)battery dealloying

Influence of Tide Models on the Use of Altimetry Data to Research Sea Level Anomaly

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Geo-Spatial Information Science 2007年第2期10卷 100-104页

作者： XU Jun BAO Jingyang liu Yanchun YU caixia Department of Hydrography and Cartography Dalian Naval Academy 667 Jiefang Road Dalian 116018 China

A tide model （named DN1.0）, which contains 12 principal constituents over China seas and the Northwest Pacific is estimated by along-track harmonic analysis with TOPEX/Poseidon altimetry data taken from 1993 to 2002. CSR3.0, FES95.2 and DNI.0 are used respectively to detide the data for the time series of sea level anomaly （SLA） in the Yellow Sea, East China Sea, South China Sea and Northwest Pacific. The SLA curves and the power spectral density show that the major components that exist in SLA in China seas arise from the error of the tide models.

关键词： satellite altimetry sea level anomaly tide model tidal aliasing

Free-Standing Multiscale Porous High Entropy NiFeCoZn Alloy as the Highly Active Bifunctional Electrocatalyst for Alkaline Water Splitting

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Chinese Journal of Chemistry 2024年第13期42卷 1465-1473页

作者： Qiuping Zhang Xu Wang Tianzhen Jian Wenqing Ma caixia Xu Qiuxia Zhou Hong liu Institute for Advanced Interdisciplinary Research(iAIR) Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongSchool of Chemistry and Chemical EngineeringUniversity of JinanJinanShandong 250022China School of Medical Information and Engineering Southwest Medical UniversityLuzhouSichuan 646000China State Key Laboratory of Crystal Materials Shandong UniversityJinanShandong 250100China

In the endeavor of searching for highly active and stable electrocatalysts toward overall water splitting,high-entropy-alloys have been the intense subjects owing to their advanced physicochemical *** non-noble metal free-standing multiscale porous NiFeCoZn high-entropy-alloy is in situ constructed on the surface layer of NiZn intermetallic and Ni heterojunction over nickel foam(NiFeCoZn/NiZn-Ni/NF)by one scalable dealloying protocal to fulfill the outstanding bifunctional electrocatalytic performances toward overall water *** of the high-entropy effects and specific hierarchical porous architecture,the as-made NiFeCoZn/NiZn-Ni/NF displays high intrinsic catalytic activities and durability toward both hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)in alkaline *** particular,the in-situ construction of bimodal porous NiFeCoZn high-entropy-alloy results in the small overpotentials(η1000=254/409 mV for HER and OER),low Tafel slopes,and exceptional long-term catalytic durability for 400 ***,the electrolyzer constructed with NiFeCoZn/NiZn-Ni/NF as both cathode and anode exhibits a low cell voltage of 1.72 V to deliver the current density of 500 mA·cm^(–2) for overall water *** work not only provides a facile and scalable protocol for the preparation of self-supporting high-entropy-alloy nanocatalysts but also enlightens the engineering of high performance bifunctional electrocatalysts toward water splitting.

关键词： High-entropy-alloys Bifunctional electrocatalyst Dealloying/Electrocatalysis Oxygen evolution reaction Hydrogen evolution reaction