检索结果-南通市图书馆

CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway

引用

World Journal of Gastrointestinal Oncology 2024年第3期16卷 1029-1045页

作者： Wen-Qian Ma Ming-Chang Miao Ping-An Ding Bi-bo Tan Wen-bo liu Shuo Guo Li-Mian Er Zhi-Dong Zhang Qun Zhao Department of Endoscopy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer Shijiazhuang 050011Hebei ProvinceChina Department of Radiotherapy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Third Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND CALD1 has been discovered to be abnormally expressed in a variety of malignant tumors,including gastric cancer(GC),and is associated with tumor progression and immune infiltration;however,the roles and mechanisms of CALD1 in epithe-lial-mesenchymal transition(EMT)in GC are unknown.AIM To investigate the role and mechanism of CALD1 in GC progression,invasion,and migration.METHODS In this study,the relationship between CALD1 and GC,as well as the possible network regulatory mechanisms of CALD1,was investigated by bioinformatics and validated by experiments.CALD1-siRNA was synthesized and used to trans-fect GC cells.Cell activity was measured using the CCK-8 method,cell migration and invasive ability were measured using wound healing assay and Transwell assay,and the expression levels of relevant genes and proteins in each group of cells were measured using qRT-PCR and Western blot.A GC cell xenograft model RESULTS Bioinformatics results showed that CALD1 was highly expressed in GC tissues,and CALD1 was significantly higher in EMT-type GC tissues than in tissues of other types of GC.The prognosis of patients with high expression of CALD1 was worse than that of patients with low expression,and a prognostic model was constructed and evaluated.The experimental results were consistent with the results of the bioinformatics analysis.The expression level of CALD1 in GC cell lines was all higher than that in gastric epithelial cell line GES-1,with the strongest expression found in AGS and MKN45 cells.Cell activity was significantly reduced after CALD1-siRNA trans-fection of AGS and MKN45 cells.The ability of AGS and MKN45 cells to migrate and invade was reduced after CALD1-siRNA transfection,and the related mRNA and protein expression was altered.According to bioinfor-matics findings in GC samples,the CALD1 gene was significantly associated with the expression of members of the PI3K-AKT-mTOR signaling pathway as well as the EMT signaling pathway,and was closely related to the PI3K-Akt signaling pathway.Experimen

关键词： Gastric tumor CALD1 Epithelial-mesenchymal transition Gene disruption Invasion Migration Bioinformatics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cobalt phosphide-based composites as anodes for lithium-ion batteries:From mechanism,preparation to performance

引用

Particuology 2024年第5期88卷 11-31页

作者： bo Lan Yishan Wang Jialei Lu Dongdong liu Chuncheng Wei Xueqian Zhang Xiaoxiao Huang Guangwu Wen School of Materials Science and Engineering Shandong University of TechnologyZibo255000China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001China School of Materials Science and Engineering Harbin Institute of TechnologyWeihai264209China

With the further requirements of electronic products and powered vehicles,the development of a new generation with low-voltage and high-capacity anode materials is crucial for lithium-ion batteries(LIBs).Transition metal phosphides,especially cobalt phosphide(CoP)composites,have become a research hotspot for LIBs anode materials in recent years due to their high theoretical specific capacity,low polarization,and suitable voltage plateau.This review first systematically discusses the lithium storage mechanism and preparation methods of CoP in current research.Subsequently,the applications of CoP anode materials in LIBs are categorically reviewed,including the composites of CoP with various types of carbon materials and heterostructures.Finally,the challenges and future development directions of CoP anode materials are summarized to provide guidance for further improving the lithium storage performance of CoP and its practical applications.

关键词： CoP Composites Preparation Anodes Lithium-ion batteries

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The role of intraoperative neurophysiological monitoring in intramedullary spinal cord tumor surgery

引用

Chinese Neurosurgical Journal 2024年第1期10卷 57-66页

作者： Kai liu Chengyuan Ma Dapeng Li Haisong Li Xuechao Dong bo liu Ying Yu Yuxiang Fan Hongmei Song Department of Neurosurgery Bethune First Hospital of Jilin UniversityChangchunJilinChina

Intramedullary tumors are a class of central nervous system tumors with an incidence of 2 to 4%.As they are located very deep and frequently cause postoperative neurological complications,surgical resection is difficult.In recent years,many surgeons have performed electrophysiological monitoring to effectively reduce the occurrence of post-operative neurological complications.Modern electrophysiological monitoring technology has advanced considerably,leading to the development of many monitoring methods,such as SSEPs,MEPs,DCM,and EMG,to monitor intramedullary tumors.However,electrophysiological monitoring in tumor resection is still being studied.In this article,we discussed the different monitoring methods and their role in monitoring intramedullary tumors by reviewing previous studies.Intratumorally tumors need to be monitored for a summary of the condition of the patient.Only by using various monitoring methods flexibly and through clear communication between surgeons and neurophysiological experts can good decisions be made during surgery and positive surgical results be achieved.

关键词： Intramedullary spinal cord tumor Intraoperative neurophysiological monitoring D-wave

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Near-zero-adhesion-enabled intact wafer-scale resist-transfer printing for high-fidelity nanofabrication on arbitrary substrates

引用

International Journal of Extreme Manufacturing 2024年第1期6卷 313-326页

作者： Zhiwen Shu bo Feng Peng liu Lei Chen Huikang Liang Yiqin Chen Jianwu Yu Huigao Duan College of Mechanical and Vehicle Engineering National Engineering Research Centre for High Efficiency GrindingHunan UniversityChangsha 410082People’s Republic of China Greater Bay Area Institute for Innovation Hunan UniversityGuangzhou 511300People’s Republic of China School of Mechanical Engineering Hunan University of Science and TechnologyXiangtan 411201People’s Republic of China Shenzhen Research Institute Hunan UniversityShenzhen 518000People’s Republic of China

There is an urgent need for novel processes that can integrate different functional nanostructures onto specific substrates,so as to meet the fast-growing need for broad applications in nanoelectronics,nanophotonics,and fexible optoelectronics.Existing direct-lithography methods are difficult to use on fexible,nonplanar,and biocompatible surfaces.Therefore,this fabrication is usually accomplished by nanotransfer printing.However,large-scale integration of multiscale nanostructures with unconventional substrates remains challenging because fabrication yields and quality are often limited by the resolution,uniformity,adhesivity,and integrity of the nanostructures formed by direct transfer.Here,we proposed a resist-based transfer strategy enabled by near-zero adhesion,which was achieved by molecular modification to attain a critical surface energy interval.This approach enabled the intact transfer of wafer-scale,ultrathin-resist nanofilms onto arbitrary substrates with mitigated cracking and wrinkling,thereby facilitating the in situ fabrication of nanostructures for functional devices.Applying this approach,fabrication of three-dimensional-stacked multilayer structures with enhanced functionalities,nanoplasmonic structures with~10 nm resolution,and MoS2-based devices with excellent performance was demonstrated on specific substrates.These results collectively demonstrated the high stability,reliability,and throughput of our strategy for optical and electronic device applications.

关键词： resist-based transfer printing near-zero adhesion critical surface energy wafer-scale nanofabrication in situ fabrication optoelectronic devices

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Highly selective photocatalytic oxidation of methane to methyl hydroperoxide

引用

Nano Research 2024年第4期17卷 2473-2480页

作者： Chunling bo Li Zhang Xiaolong liu Huaiqiu Chang Yingxue Sun Xinyi Zhang Ting Tan Lingyu Piao National Center for Nanoscience and Technology Beijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China

Partial oxidation of methane into primary oxidation products with high value remains a challenge.In this work,photocatalytic oxidation of methane(CH_(4))with high methyl hydroperoxide(CH_(3)OOH)selectivity is achieved using pure titanium oxide(TiO_(2))without any cocatalyst at room temperature and atmospheric pressure.The CH_(3)OOH production rate can reach up to 2050±88μmol·g^(-1)·h^(-1) at pH≈7.0 with 100%selectivity in the liquid product.The stable reaction cycle can reach more than 30 times.This low-cost system achieves superior CH_(4) conversion activity and selectivity compared with similar work.The energy of hydrogen peroxide(H_(2)O_(2))to adsorbed hydroperoxyl radical(^(*)OOH)has a significantly lower reaction energy than conversion to adsorbed hydroxyl radical(*OH)on the(210)surface of the TiO_(2).The^(*)OOH preferentially combines with methyl radical(·CH_(3))to form the most energetically favorable CH_(3)OOH.The mild oxidative environment of this system prevents the reduction of CH_(3)OOH to CH_(3)OH or over-oxidation of CH_(4),which ensures the final CH_(3)OOH with high selectivity and stability.This work provided a low-cost but highly efficient method to achieve partial oxidation with superior selectivity,i.e.,to convert CH_(4) into high-value chemicals.

关键词： photocatalytic methane oxidation methyl hydroperoxide titanium oxide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Revealing the role of pyramidal slip in the high ductility of Mg-Li alloy

引用

Journal of Magnesium and Alloys 2024年第3期12卷 1021-1025页

作者： Jing Xu bo Guan Yunchang Xin Guangjie Huang Peidong Wu Qing liu International Joint Laboratory for Light Alloys College of Materials Science and EngineeringChongqing UniversityChongqing 400030China Key Laboratory for Light-weight Materials Nanjing Tech UniversityNanjing 210009China Department of Mechanical Engineering McMaster UniversityHamiltonON L8S 4L7Canada

The high ductility of Mg-Li alloy has been mainly ascribed to a high activity of pyramidalslip to accommodate plastic strain.In the present study,however,a quantitative analysis reveals that Li-addition can only slightly stimulate the activation of pyramidalslip under compression along the normal direction of a hot-rolled Mg-4.5 wt.%Li plate,with a relative activity of approximately 18%.Although the limited activity of pyramidalslip alone cannot accommodate a large plastic strain,it effectively reduces the number of{10.11}−{10.12}double twins,which are believed to be favorable sites for crack initiation.The evidently reduced activity of double twins leads to a lower cracking tendency,and therefore improves ductility.

关键词： Mg alloy Plasticity Plastic deformation Slip Twinning.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modeling Near-Field Impulsive Waves Generated by Deformable Landslide Using the HBP Model Based on the SPH Method

引用

Journal of Ocean University of China 2024年第2期23卷 328-344页

作者： WANG Wei WEI Weicheng CHAI bo XIA Hao WANG Yang DU Juan liu Jizhixian School of Environmental Studies China University of GeosciencesWuhan 430078China Hubei Key Laboratory of Yangtze Catchment Environmental Aquatic Science Wuhan 430078China Faculty of Engineering China University of GeosciencesWuhan 430074China Research Center for Geohazards Monitoring and Warning in Three Gorges Reservoir Wanzhou 404000China

Landslide-generated impulsive waves(LGWs)in reservoir areas can seriously threaten waterway safety as well as hu-man life and properties around the two side slopes.The risk reduction and mitigation of such a hazard require the accurate prediction of near-field wave characteristics,such as wave amplitude and run-up.However,near-field LGW involves complicated fluid-solid interactions.Furthermore,the wave characteristics are closely related to various aspects,including the geometry and physical features of the slide,river,and body of water.However,the empirical or analytical methods used for rough estimation cannot derive accurate results,especially for deformable landslides,due to their significant geometry changes during the sliding process.In this study,the near-field waves generated by deformable landslides were simulated by smoothed particle hydrodynamics(SPH)based on multi-phase flow.The deformable landslides were generalized as a kind of viscous flow by adopting the Herschel-Bulkley-Papanastasiou(HBP)-based nonNewtonian rheology model.The HBP model is capable of producing deformable landslide dynamics even though the high-speed sliding process is involved.In this study,an idealized experiment case originating from Lituya LGW and a practical case of Gongjiafang LGW were reproduced for verification and demonstration.The simulation results of both cases show satisfactory consistency with the experiment/investigation data in terms of landslide movement and near-field impulsive wave characteristics,thus indicating the applicability and accuracy of the proposed method.Finally,the effects of the HBP model’s rheological parameters on the landslide dynamics and near-field wave characteristics are discussed,providing a parameter calibration method along with sug-gestions for further applications.

关键词： deformable landslide impulsive waves near-field SPH nonNewtonian fluids

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pyramid-resolution person restoration for cross-resolution person re-identification

引用

Science China(Information Sciences) 2024年第6期67卷 451-452页

作者： Chunlei PENG bo WANG Decheng liu Nannan WANG Xinbo GAO State Key Laboratory of Integrated Services Networks Xidian University School of Cyber Engineering Xidian University School of Telecommunications Engineering Xidian University Chongqing Key Laboratory of Image Cognition Chongqing University of Posts and Telecommunications

Person images captured by surveillance cameras are typically with various resolutions and are susceptible to pose changes,occlusion and background variations,thus affecting the performance of person Re ID.Existing approaches[1,2]either use an image restoration model to restore the lowresolution images to obtain a corresponding high-resolution image,

关键词： Restoration

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Giant panda(Ailuropoda melanoleuca)neonates use broadband calls to communicate with their mothers

引用

Integrative Zoology 2024年第2期19卷 277-287页

作者： Lin ZHAO Jianbin CHENG Wen ZENG bo YANG Guiquan ZHANG Desheng LI Hemin ZHANG Christina DBUESCHING Dingzhen liu Ministry of Education Key Laboratory of Biodiversity Science and Ecological EngineeringCollege of Life SciencesBeijing Normal UniversityBeijingChina Key Laboratory of State Forestry and Grassland Administration on Conservation Biology of Rare Animals in The Giant Panda National Park China Conservation and Research Center for the Giant PandaDujiangyanSichuan611830China Department of Biology Irving K.Barber Faculty of ScienceUniversity of British ColumbiaOkanaganKelownaBritish ColumbiaCanada

Infant call structure should have evolved to elicit maximum maternal attention and investment.Neonates of giant pandas produce three types of vocalizations reported to be vitally important in the context of mother–infant communications.However,how cubs,0–15 days old,communicate with their mothers to elicit maternal care remains unknown.We analyzed 12 different call parameters of 3475 squawks,1355 squalls,and 491 croaks from 11 captive giant panda(Ailuropoda melanoleuca)neonates from age 0 to 15 days.In playback experiments,we also tested whether mothers could detect ultrasound.Our results show that neonates use broadband calls with ultrasonic frequencies up to 65 kHz to convey information about their physiological needs and to attract maternal care.In playback experiments,we tested if mothers reacted differently to broadband calls(BBC)than to artificially altered calls that included only frequencies20 kHz(USC).Playback confirmed that,although adult females responded significantly less often to USC,BBC than to or AUDC,they could detect USC,BBC and generally made appropriate behavioral responses,indicating a potential benefit for neonates to utilize ultrasonic and broadband frequencies.Our findings provide a new insight into mother–infant communication in giant pandas and will be helpful for reducing the mortality of cubs,younger than 1 month old,in captivity.

关键词： acoustic communication broadband calls maternal care neonates ultrasonic frequencies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Endogenous retrovirus activation: potential for immunology and clinical applications

引用

National Science Review 2024年第4期11卷 21-23页

作者： Jundan Yu Peishan Qiu Jingwen Ai bo liu Guan-Zhu Han Fan Zhu Wenhong Zhang Jie Cui Department of Infectious Diseases Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response National Medical Center for Infectious Diseases Huashan Hospital Shanghai Medical College Fudan University CAS Key Laboratory of Molecular Virology &Immunology Shanghai Institute of Immunity and Infection Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai Huashen Institute of Microbes and Infections College of Life Sciences Nanjing Normal University State Key Laboratory of Virology and Department of Medical Microbiology School of Basic Medical SciencesWuhan University The Institute of Infection and Health Research Fudan University Key Laboratory of Medical Molecular Virology(MOE/MOH) Shanghai Medical CollegeFudan University Laboratory for Marine Biology and Biotechnology Qingdao Marine Science and Technology Center

Endogenous retroviruses (ERVs), the remnants of ancient retrovirus infections, constitute approximately 8% of the human genome and play important roles in human evolution, development,and diseases. Multiple drugs, such as DNA methyltransferase inhibitors and lysine-specific histone demethylase 1inhibitors, reactivate ERVs, induce viral mimicry and trigger innate immune responses to enhance tumor immunogenicity.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：