检索结果-南通市图书馆

Non-coding RNAs in acute ischemic stroke:from brain to periphery

Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aligning enhanced feature representation for generalized zero-shot learning

引用

Science China(Information Sciences) 2025年

作者： Zhiyu FANG Xiaobin ZHU Chun YANG Hongyang ZHOU Jingyan qin Xucheng YIN School of Computer&Communication Engineering University of Science and Technology Beijing

Abstract Constructing an effective common latent embedding by aligning the latent spaces of cross-modal variational autoencoders （VAEs） is a popular strategy for generalized zero-shot learning （GZSL）.However,due to the lack of fine-grained instance-wise annotations,existing VAE methods can easily suffer from the posterior collapse *** this paper,we propose an innovative asymmetric VAE network by aligning enhanced feature representation （AEFR） for *** from general VAE structures,we designed two asymmetric encoders for visual and semantic observations and one decoder for visual ***,we propose a simple yet effective gated attention mechanism （GAM） in the visual encoder for enhancing the information interaction between observations and latent variables,alleviating the possible posterior collapse problem *** addition,we propose a novel distributional decoupling-based contrastive learning （D2-CL） to guide learning classification-relevant information while aligning the representations at the taxonomy level in the latent representation *** experiments on publicly available datasets demonstrate the state-of-the-art performance of our *** source code is available at https://***/seeyourmind/AEFR.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Internal Resonances for Heave, Roll and Pitch Modes of A Spar Platform Considering Wave and Vortex-Induced Loads in the Main Roll Resonance

引用

China Ocean Engineering 2017年第4期31卷 408-417页

作者： LI Wei TANG you-gang liu Li-qin LI Yan WANG Bin State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin University Tianjin 300072 China School of Civil Engineering Tianjin University Tianjin 300072 China Coltabomtive Innovation Center for Advanced Ship and Deep-Sea Exploration Shanghai 200240 China

We present a study of the nonlinear coupling internal resonance for the heave roll and pitch performance of a spar platform under the wave and vortex-induced loads when the ratio of the frequencies of heave, roll and pitch are approximately 2：1：1. In consideration of varying wet surface, the three DOFs nonlinear coupled equations are established for the spar platform under the effect of the first-order wave loads in the heave and pitch, and vortex-induced loads in the roll. By utilizing the method of multi-scales when the vortex-induced frequency is close to the natural roll frequency, the first-order perturbation solution is obtained analytically and further validated by the numerical integration. Sensitivity analysis is performed to understand the influence of the damping and the internal detuning parameter. Two cases with internal resonance are shown. The first case is that no saturation phenomenon exists under small vortex-induced loads. The first order perturbation solution illustrates that only the vortex-induced frequency motion in roll and the super-harmonic frequency motion in heave are excited. The second case is that the vortex-induced loads are large enough to excite the pitch and a saturation phenomenon in the heave mode follows. The results show that there is no steady response occurrence for some cases. For these cases chaos occurs and large amplitudes response can be induced by the vortex-induced excitation.

关键词： spar platform three DOFs nonlinear equations multiple scales super-harmonic response energy infiltration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

引用

Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min qin Zhongliang Li Wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

医务人员社会支持与心理健康状况调查

引用

中华医院管理杂志 2010年第6期26卷 449-453页

作者：花蕾王香平白弘冬赵利杰汤哲刘佑琴邢华王卓首都医科大学宣武医院北京100053

目的了解北京市三级综合医院医务人员的社会支持、应对方式及心理健康水平，发现可能存在的心理问题。方法运用社会支持评定量表（SSRS）、简易应对方式问卷（SCSQ）、症状自评量表（SCL-90）及人口学特征问卷，对北京市5所三级综合医院... 详细信息

目的了解北京市三级综合医院医务人员的社会支持、应对方式及心理健康水平，发现可能存在的心理问题。方法运用社会支持评定量表（SSRS）、简易应对方式问卷（SCSQ）、症状自评量表（SCL-90）及人口学特征问卷，对北京市5所三级综合医院的2460名医务人员进行调查。结果不同人口学特征的医务人员，在积极应对和支持各维度上存在差异。相关分析表明，SCL总分、总症状指数、阳性症状痛苦水平、各因子均分与消极应对方式呈正相关，P〈0．01；与主客观支持、支持利用度、支持总分呈负相关，P〈0．01，结论医疗管理部门应对40岁以下、女性、丧偶或离异、大专及以下学历、初级及以下职称、无职务、急诊和重症监护室人员、医生和护士、经常夜班、自我评价过低、患有慢性病的医务人员进行重点干预，缓解其心理压力。

关键词：医务人员社会支持心理健康人口学特征

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Strong Current-State Opacity Verification of Discrete-Event Systems Modeled With Time Labeled Petri Nets

引用

IEEE/CAA Journal of Automatica Sinica 2025年第1期 54-68页

作者： Tao qin Li Yin Gaiyun liu Naiqi Wu Zhiwu Li the Institute of Systems Engineering Macau University of Science and Technology IEEE the School of Electro-Mechanical Engineering Xidian University

This paper addresses the verification of strong currentstate opacity with respect to real-time observations generated from a discrete-event system that is modeled with time labeled Petri nets. The standard current-state opacity cannot completely characterize higher-level security. To ensure the higher-level security requirements of a time-dependent system, we propose a strong version of opacity known as strong current-state opacity. For any path(state-event sequence with time information)π derived from a real-time observation that ends at a secret state, the strong current-state opacity of the real-time observation signifies that there is a non-secret path with the same real-time observation as π. We propose general and non-secret state class graphs, which characterize the general and non-secret states of time-dependent systems, respectively. To capture the observable behavior of non-secret states, a non-secret observer is ***, we develop a structure called a real-time concurrent verifier to verify the strong current-state opacity of time labeled Petri nets. This approach is efficient since the real-time concurrent verifier can be constructed by solving a certain number of linear programming problems.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The surge-heave-pitch coupling motions of the Φ- type vertical axis wind turbine supported by the truss Spar floating foundation

引用

Journal of Hydrodynamics 2019年第4期31卷 669-681页

作者： Ying Guo Li-qin liu Yan Li Chang-shui Xiao you-gang Tang State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin University Tianjin 300072 China

The motions of the floating vertical axis wind turbine (VAWT) with consideration of the coupling between the aerodynamics and the hydrodynamics are calculated in this paper. The surge-heave-pitch coupling nonlinear equations of the floating VAWT are established. The aerodynamic loads are obtained by applying the double-multiple-stream tube theory with consideration of the dynamic stall and the floating foundation motion. The motion performances of a 5 MW Φ - Darrieus type floating VAWT are studied with its foundation of the Spar type with heave plates. It is shown that the amplitude of the heave motion of the floating VAWT is small when the heave plates are equipped. The effects of the wind and wave loads on the floating VAWT motions are assessed. The results show that the mean values of the surge and the pitch of the floating VAWT are mainly related to the wind loads;the standard deviations of the surge, the heave, and the pitch are mainly related to the wave loads. In the regular wave cases, the frequencies of the surge, the heave and the pitch are dominated by the wave frequencies, and the components of the 2P responses (caused by the aerodynamic loads) of the pitch are small. The 2P responses of the pitch are more significant in the irregular wave cases as compared with those in the regular wave cases.

关键词： Floating VAWT truss Spar floating foundation surge-heave-pitch motions aerodynamics regular waves irregular waves

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A real-time multi-head mixed attention mechanism-based prediction method for tunnel boring machine disc cutter wear

引用

Science China Technological Sciences 2025年第1期 290-311页

作者： Haodi WANG Chengjin qin Honggan YU Zhinan ZHANG Guoqiang HUANG Zhengyang liu Chengliang liu State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong University

In the process of hard rock tunnel excavation, workers often need to enter the tunnel boring machine(TBM)cutterhead at regular intervals to measure cutter wear. However, this method is time-consuming and labor-intensive. Existing cutter prediction models primarily rely on geological parameters to predict overall cutter wear before construction, making it challenging to monitor real-time wear at different locations of the cutter and obtain accurate geological parameters. To address these challenges, this paper proposes a multi-head mixed attention mechanism-based method for real-time wear prediction of TBM disc cutter. First, a method of cutter wear normalization to eliminate measurement noise is explored. Then, considering the complex correlation of TBM operating parameters in feature and time dimensions, a new multi-head mixed attention mechanism model is designed to establish the dependency between different features and different moments, to better establish the mapping model between operating parameters and cutter wear. Finally, the current cutter wear state can be calculated by accumulating the wear amount of all previous small excavation sections. The effectiveness of the method is verified by using field data from the Mumbai tunnel. The results demonstrate that the method is capable of real-time prediction of front cutter and edge cutter wear on the test set, achieving an average accuracy rate of 95.75%. Moreover, the method can update the cutter wear status after every meter of excavation, which has good real-time performance. In addition, the average accuracy of cutter wear prediction of the proposed method is 11.75%, 10.375%, 3.875%, 3.625%, 1.375%, 3.125%, 2.25%, and 0.75%higher than that of LSTM, CNN, LSTM-CNN, CACNN, SACNN, MMADNN, MTACNN, and MFACNN. In summary, this approach offers an accurate prediction of cutter wear state while reducing inspection time and costs and has high application value.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

催经止孕胶囊中挥发油部位的β-环糊精包合工艺研究

引用

时珍国医国药 2003年第11期14卷 652-653页

作者：陈鸿平刘友平秦春梅成都中医药大学四川成都610075

目的 :优选催经止孕胶囊中挥发油部位的 β-环糊精包合工艺。方法 :采用饱和水溶液搅拌法 ,以挥发油与 β-环糊精的比例、包合温度、包合时间、加水量为因素 ,选择不同水平以挥发油利用率、包合物收得率、包合物含油率为指标 ,按正交设... 详细信息

目的 :优选催经止孕胶囊中挥发油部位的 β-环糊精包合工艺。方法 :采用饱和水溶液搅拌法 ,以挥发油与 β-环糊精的比例、包合温度、包合时间、加水量为因素 ,选择不同水平以挥发油利用率、包合物收得率、包合物含油率为指标 ,按正交设计表 L9(3 4)进行试验 ,优选包合条件 ,并用 TL C和光学显微镜对包合物进行了定性验证。结果 :优选出的挥发油部位β-环糊精包合的工艺条件为 :油与β-环糊精的比例为 1∶ 8(ml∶ g) ,包合温度为 40℃ ,包合时间为 2 h,加水量为β-环糊精用量的 10倍。结论 :通过 β-环糊精包合挥发油提高了挥发油部位的稳定性 ,掩盖了其不良气味。

关键词：挥发油 β-环糊精催经止孕胶囊

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Studies on Stochastic Parametric Roll of Ship with Stochastic Averaging Method

引用

China Ocean Engineering 2020年第2期34卷 289-298页

作者： WANG Li-yuan TANG you-gang LI Yan ZHANG Jing-chen liu Li-qin School of Civil Engineering Tianjin UniversityTianjin 300072China State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China

The paper studies the parametric stochastic roll motion in the random *** differential equation of the ship parametric roll under random wave is established with considering the nonlinear damping and ship *** sea surface is treated as a narrow-band stochastic process,and the stochastic parametric excitation is studied based on the effective wave *** nonlinear restored arm function obtained from the numerical simulation is expressed as the approximate analytic *** using the stochastic averaging method,the differential equation of motion is transformed into Ito’s stochastic differential *** steady-state probability density function of roll motion is obtained,and the results are validated with the numerical simulation and model test.

关键词： parametric roll random wave stochastic averaging method probability density function

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：