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Enhancing competency of clinical research nurses:A comprehensive training and evaluation framework

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World Journal of Clinical Cases 2024年第7期12卷 1378-1381页

作者： Yang-xi liu Yi Xu Tumor Interventional Department Taizhou Municipal HospitalTaizhou 318099Zhejiang ProvinceChina

The Sun et al's training program for clinical research nurses(CRNs)in the World Journal of Clinical Cases is a comprehensive and scientific *** includes structured frameworks for CRN training,aiming to improve CRN *** program emphasizes practical abilities,updates training content,and improves evaluation *** cultivation of CRN talents focuses on enhancing the training system,establishing a multifaceted evaluation framework,and continuously refining the training *** feedback and evalua-tion are essential to improve CRNs'competency in practical settings.

关键词： Clinical research nurse Framework Nurse Operations Practice Structure

Flexible and Robust Functionalized Boron Nitride/Poly(p‑Phenylene Benzobisoxazole)Nanocomposite Paper with High Thermal Conductivity and Outstanding Electrical Insulation

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Nano-Micro Letters 2024年第2期16卷 423-437页

作者： Lin Tang Kunpeng Ruan xi liu Yusheng Tang Yali Zhang Junwei Gu Chongqing Key Laboratory of Green Synthesis and Applications College of ChemistryChongqing Normal UniversityChongqing 401331People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China

With the rapid development of 5G information technology,thermal conductivity/dissipation problems of highly integrated electronic devices and electrical equipment are becoming *** this work,“high-temperature solid-phase&diazonium salt decomposition”method is carried out to prepare benzidine-functionalized boron nitride(m-BN).Subsequently,m-BN/poly(pphenylene benzobisoxazole)nanofiber(PNF)nanocomposite paper with nacremimetic layered structures is prepared via sol–gel film transformation *** obtained m-BN/PNF nanocomposite paper with 50 wt%m-BN presents excellent thermal conductivity,incredible electrical insulation,outstanding mechanical properties and thermal stability,due to the construction of extensive hydrogen bonds andπ–πinteractions between m-BN and PNF,and stable nacre-mimetic layered ***λ∥andλ_(⊥)are 9.68 and 0.84 W m^(-1)K^(-1),and the volume resistivity and breakdown strength are as high as 2.3×10^(15)Ωcm and 324.2 kV mm^(-1),***,it also presents extremely high tensile strength of 193.6 MPa and thermal decomposition temperature of 640°C,showing a broad application prospect in high-end thermal management fields such as electronic devices and electrical equipment.

关键词： Poly(p-phenylene-2,6-benzobisoxazole)nanofiber Boron nitride Thermal conductivity Electrical insulation

Bi/Bi_(3)Se_(4) nanoparticles embedded in hollow porous carbon nanorod:High rate capability material for potassium-ion batteries

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Journal of Energy Chemistry 2023年第6期81卷 462-471,I0011页

作者： Zhisong Chen Yuanji Wu xi liu Yiwei Zhang Lichun Yang Hongyan Li Department of Materials Science and Engineering College of Chemistry and Materials ScienceJinan UniversityGuangzhou 510632GuangdongChina School of Materials Science and Engineering and Guangdong Provincial Key Laboratory of Advanced Energy Storage MaterialsSouth China University of TechnologyGuangzhou 510640GuangdongChina

Considering their superior theoretical capacity and low voltage plateau,bismuth(Bi)-based materials are being widely explored for application in potassium-ion batteries(PIBs).Unfortunately,pure Bi and Bibased compounds suffer from severe electrochemical polarization,agglomeration,and dramatic volume *** develop an advanced bismuth-based anode material with high reactivity and durability,in this work,the pyrolysis of Bi-based metal-organic frameworks and in-situ selenization techniques have been successfully used to produce a Bi-based composite with high capacity and unique structure,in which Bi/Bi_(3)Se_(4)nanoparticles are encapsulated in carbon nanorods(Bi/Bi_(3)Se_(4)@CNR).Applied as the anode material of PIBs,the Bi/Bi_(3)Se_(4)@CNR displays fast potassium storage capability with 307.5 m A h g^(-1)at 20 A g^(-1)and durable cycle performance of 2000 cycles at 5 A g^(-1).Notably,the Bi/Bi_(3)Se_(4)@CNR also showed long cycle stability over 1600 cycles when working in a full cell system with potassium vanadate as the cathode material,which further demonstrates its promising potential in the field of ***,the dual potassium storage mechanism of the Bi/Bi_(3)Se_(4)@CNR based on conversion and alloying reaction has also been revealed by in-situ X-ray diffraction.

关键词： Bi_(3)Se_(4) Potassium ion battery Hollow porous carbon rod Conversion-alloying mechanism Bi MOF

A single-center retrospective study on epidemiological and Traditional Chinese Medicine syndrome characteristics of 21010 patients with reflux/heartburn symptoms

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Journal of Traditional Chinese Medicine 2023年第3期43卷 574-581页

作者： TANG Yanping LI Peicai liu xi liu Lei GONG Yanxia WEI xiaodong liu Lina YANG Li Department of Gastroenterology Tianjin Nankai HospitalTianjin 300100China

OBJECTIVE:To provide a basis for the clinical identification of true and false reflux,integrated traditional Chinese and Western medicine,and psychosomatic treatment,we conducted a retrospective study of the etiology and epidemiological and Traditional Chinese Medicine(TCM) syndrome characteristics of patients with reflux/heartburn ***:The 210 10 patients with reflux/heartburn treated at Tianjin Nankai Hospital from January 1,2016,to December 31,2019,were divided into four groups according to their ***,age,course of disease,incidence rate,gastroscopy,24-h p Himpedance,esophageal manometry,Hamilton Anxiety Scale(HAMA)/Hamilton Depression Scale(HAMD) score,8-week proton pump inhibitor(PPI) treatment effect,and TCM syndrome characteristics were statistically ***:A total of 21010 patients(8864 men and 12146 women),with reflux/heartburn symptoms were screened,including 6284(29.9%) patients with reflux esophagitis(RE),10427(49.6%) patients with nonerosive reflux esophagitis(NERD),2430(11.6%) patients with reflux hypersensitivity(RH),and 1870(8.9%) patients with functional heartburn(FH).The incidence of the disease was higher in women than in men(P xiety and depression in these four groups was FH > RH > NERD > RE(P xiety and more men than women in the groups with depression(P xiety and depression between men and women(P = 0.5689).There were significant differences in TCM syndrome characteristics between NERD,RE,and functional esophageal diseases(P < 0.01).The highest proportion of functional esophageal disease TCM symptoms was Qi stagnation and phlegm obstruction syndrome(36.16%),and there was no significant difference between RH and *** effective rates of PPI treatment at 8 weeks in patients in the RE,NERD,RH,and FH groups were 89%,72%,54%,and 0%,respect

关键词： gastroesophageal reflux esophagitis peptic hypersensitivity heartburn proton pump inhibitors emotional disorders syndrome complex

Novel mutations in LRRC23 cause asthenozoospermia in a nonconsanguineous family

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Asian Journal of Andrology 2024年第5期26卷 484-489页

作者： Song-xi Tang Si-Yu liu Hong xiao xin Zhang Zhuang xiao Shan Zhou Yi-Lang Ding Peng Yang Qiang Chen Hai-Lin Huang xi Chen xi Lin Hui-Liang Zhou Ming-xi liu Department of Andrology and Sexual Medicine First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005China State Key Laboratory of Reproductive Medicine and Offspring Health The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou School of Clinical MedicineNanjing Medical UniversityNanjing 211166China State Key Laboratory of Reproductive Medicine and Offspring Health Department of Histology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 211166China Public Technology Service Center Fujian Medical University Fuzhou 350108China

The cause of asthenozoospermia(AZS)is not well understood because of its complexity and *** some gene mutations have been identified as contributing factors,they are only responsible for a small number of *** spokes(RSs)are critical for adenosine triphosphate-driven flagellar beating and axoneme stability,which is essential for flagellum *** this study,we found novel compound heterozygous mutations in leucine-rich repeat-containing protein 23(LRRC23;c.1018C>T:p.Q340X and c.881_897 Del:p.R295Gfs*32)in a proband from a nonconsanguineous family with AZS and male ***-Quik staining and scanning electron microscopy revealed no abnormal sperm *** blotting and immunofluorescence staining showed that these mutations suppressed LRRC23 expression in sperm ***,transmission electron microscopy showed the absence of RS3 in sperm flagella,which disrupts stability of the radial spoke complex and impairs *** in vitro fertilization and embryo transfer,the proband’s spouse achieved successful pregnancy and delivered a healthy *** conclusion,our study indicates that two novel mutations in LRRC23 are associated with AZS,but successful fertility outcomes can be achieved by in vitro fertilization-embryo transfer techniques.

关键词： asthenozoospermia LRRC23 male infertility whole exome sequencing

Application of modified k-ω model to predicting cavitating flow in centrifugal pump

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Water Science and Engineering 2013年第3期6卷 331-339页

作者： Hou-lin liu Dong-xi liu Yong WANG xian-fang WU Jian WANG Research Center of Fluid Machinery Engineering and Technology Jiangsu University

Considering the compressibility of the cavity in the cavitating flow, this paper presents a modified k-ω model for predicting the cavitating flow in a centrifugal pump, in which the modified k-ω model and Schnerr-Sauer cavitation model were combined with ANSYS CFX. To evaluate the modified and standard k-co models, numerical simulations were performed with these two models, respectively, and the calculation results were compared with the experimental data. Numerical simulations were executed with three different values of the flow coefficient, and the simulation results of the modified k-ω model showed agreement with most of the experimental data. The cavitating flow in the centrifugal pump obtained by the modified k-ω model at the design flow coefficient of 0.102, was analyzed. When the cavitation number decreases, the cavity initially generates on the suction side of the blade near the leading edge and then expands to the outlet of the impeller, and the decrease of the total pressure coefficient mainly occurs upstream of the impeller passage, while the downstream remains almost unaffected by the development of cavitation.

关键词： modified k-co model cavitation model centrifugal pump experimental investigation

NUMERICAL SIMULATIONS OF SEA ICE WITH DIFFERENT ADVECTION SCHEMES

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Journal of Hydrodynamics 2011年第3期23卷 372-378页

作者： liu xi-ying State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Institute of Meteorology PLA University of Science and Technology Nanjing 211101 China

Numerical simulations are carried out for sea ice with four different advection schemes to study their effects on the simulation results. The sea ice model employed here is the Sea Ice Simulator （SIS） of the Geophysical Fluid Dynamics Laboratory （GFDL） Modular Ocean Model version 4b （MOM4b） and the four advection schemes are, the upwind scheme originally used in the SIS, the Multi-Dimensional Positive Advection （MDPA） scheme, the Incremental Remapping Scheme （IRS） and the Two Step Shape Preserving （TSSP） scheme. The latter three schemes are newly introduced. To consider the interactions between sea ice and ocean, a mixed layer ocean model is introduced and coupled to the SIS. The coupled model uses a tri-polar coordinate with 120x65 grids, covering the whole earth globe, in the horizontal plane. Simulation results in the northern high latitudes are analyzed. In all simulations, the model reproduces the seasonal variation of sea ice in the northern high latitudes well. Compared with the results from the observation, the sea ice model produces some extra sea ice coverage in the Greenland Sea and Barents Sea in winter due to the exclusion of ocean current effects and the smaller simulated sea ice thickness in the Arctic basin. There are similar features among the results obtained with the introduced three advection schemes. The simulated sea ice thickness with the three newly introduced schemes are all smaller than that of the upwind scheme and the simulated sea ice velocities of movement are all smaller than that of the upwind scheme. There are more similarities shared in the results obtained with the MPDA and TSSP schemes.

关键词： advection scheme sea ice simulation

EXPERIMENTS OF SEA ICE SIMULATION

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Journal of Hydrodynamics 2005年第6期17卷 686-692页

作者： liu xi-ying State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics （LASG） Institute of Atmospheric Physics （IAP） Chinese Academy of Sciences Beijing 100029 China

As a substitute for the original displaced pole grids, a simple rotated spherical coordinate system was intro duced into the Community Sea Ice Model version 4（CSIM4）, which is a component of the Community Climate System Model（CCSM） of the American National Center of Atmospheric Researeh（NCAR）, to deal with the ＂pole problems＂. In the new coordinates, both the geographical North Pole and South Pole lie in the model equator and grid sizes near the polar region are more uniform. With reanalysis dataset of American National Centers for Environment Prediction （NCEP） and Levitus dataset without considering sub-mixed layer heat flux, the model was integrated for 100 years with thermodynamics *** involved only in the former 49 years and both dynamic and thermodynamic processes involved in the left time. Inner consistency of model results was checked with no contradiction found. The results of last 10 years＇ model output were analyzed and it is shown that the simulated sea ice seasonal variation is rational whereas sea ice extent in the Barcnts Sea in winter is larger than that of observation, Numerical experiment on influence of sub-mixed layer heat flux was also carried out and it is shown that the sub-mixed layer heat flux can modulate seasonal variation of sea ice greatly. As a model component, the sea ice model with rotated spherical coordinates was coupled with other models （the oceanic general cir culation model is the LASG/IAP Climate System Ocean Model （LICOM） with reduced grid, other models are components of NCAR CCSM2） forming a climate system model and its preliminary results were also given briefly.

关键词： sea ice numerical simulation climate system model

Analysis of cracks origin behaviors during sulfide stress corrosion (SSC) in HSLA steel at different temperatures by electrochemical noise

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Journal of Iron and Steel Research International 2022年第11期29卷 1836-1845页

作者： xiao-hua Li Chen-xi liu Biao He Chuan-tao Lv Zhi-ming Gao Yong-chang liu School of Mechanical Engineering Tianjin University of Technology and EducationTianjin 300222China State Key Lab of Hydraulic Engineering Simulation and Safety School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Tianjin Pipe Corporation Tianjin 300301China

The sulfide stress corrosion(SSC)behaviors of the high strength low alloy steel at the different temperatures were investigated by the microstructural observation and electrochemical noise(EN)*** the corrosion temperature increasing from 20 to 40℃,SSC ruptured time is *** increase in corrosion temperature results in the decrease of the saturation solubility of H_(2)S in the solution and thus increases pH value of *** increase in corrosion temperature decreases the size of the holes and cracks in the corrosion product film on the surface of the sample,which is due to the formation of the dense FeS corrosion product *** current kurtosis results indicate that the time for the first occurrence of crack initiation is postponed by the increase in the corrosion *** standard deviation of current noise signals,current kurtosis,power spectral density and energy distribution plot results shows a great consistency,which suggests that EN analysis method can reflect SSC behaviors in real time.

关键词： Sulfide stress cracking High strength low alloy(HSLA)steel Electrochemical noise Corrosion temperature Hydrogen sulfide corrosion products