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Nano-formulated delivery of active ingredients from traditional Chinese herbal medicines for cancer immunotherapy

Acta Pharmaceutica Sinica B 2024年第4期14卷 1525-1541页

作者： Qi Shang wandong liu Faith Leslie Jiapei Yang Mingmei Guo Mingjiao Sun Guangji Zhang Qiang Zhang Feihu Wang School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province Hangzhou 310053China Department of Chemical and Biomolecular Engineering Whiting School of Engineeringthe Johns Hopkins UniversityBaltimoreMD 21218USA Traditional Chinese Medicine“Preventing Disease”Wisdom Health Project Research Center of Zhejiang Hangzhou 310053China Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China

Cancer immunotherapy has garnered promise in tumor progression, invasion, and metastasis through establishing durable and memorable immunological activity. However, low response rates, adverse side effects, and high costs compromise the additional benefits for patients treated with current chemical and biological agents. Chinese herbal medicines (CHMs) are a potential treasure trove of natural medicines and are gaining momentum in cancer immunomodulation with multi-component, multi-target, and multi-pathway characteristics. The active ingredient extracted from CHMs benefit generalized patients through modulating immune response mechanisms. Additionally, the introduction of nanotechnology has greatly improved the pharmacological qualities of active ingredients through increasing the hydrophilicity, stability, permeability, and targeting characteristics, further enhancing anti-cancer immunity. In this review, we summarize the mechanism of active ingredients for cancer immunomodulation, highlight nano-formulated deliveries of active ingredients for cancer immunotherapy, and provide insights into the future applications in the emerging field of nano-formulated active ingredients of CHMs.

关键词： Chinese herbal medicines Nano-formulation Activeingredients Drug delivery Cancer immunotherapy Innate immune system Adaptive immune system

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飞机蒙皮接缝特征的数据融合算法

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传感技术学报 2024年第4期37卷 629-638页

作者：温志辉夏桂锁刘芳刘孙强刘万栋南昌航空大学测试与光电工程学院江西南昌330063 中国航空工业集团公司上海航空测控技术研究所上海201601

利用计算机视觉技术对蒙皮接缝进行测量是该领域的主流发展方向,但单一的视觉测量方法具有自身的局限性。为进一步优化蒙皮接缝特征测量技术,提出了将线结构光视觉测量与面结构光视觉测量相结合的方法检测接缝特征,探索一种基于数据融... 详细信息

利用计算机视觉技术对蒙皮接缝进行测量是该领域的主流发展方向,但单一的视觉测量方法具有自身的局限性。为进一步优化蒙皮接缝特征测量技术,提出了将线结构光视觉测量与面结构光视觉测量相结合的方法检测接缝特征,探索一种基于数据融合的蒙皮接缝特征测量算法,修正接缝的阶差值与间隙值以提高测量精度。依据两种结构光视觉测量技术的特点,利用分布式二级数据融合算法,通过数据对准、剔除异常值以及自适应加权融合相结合的方式,对两种结构光视觉测量数据进行融合处理,并应用于实际蒙皮接缝测量。试验结果表明,经过分布式二级数据融合处理后,阶差测量值最大均值误差为0.0319 mm,间隙测量值最大均值误差为0.0344 mm,阶差和间隙的平均误差分别降低了4%和30%。此融合算法均衡了两种结构光视觉测量技术的优势,降低了系统整体误差,为高效、准确测量蒙皮接缝提供了新思路。

关键词：数据融合自适应加权结构光飞机检查接缝测量

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Polarimeter–interferometer diagnostic using terahertz solid-state sources for fluctuation measurements on Keda Torus e Xperiment(KTX)

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Plasma Science and Technology 2024年第3期26卷 61-65页

作者：汪兴康毛文哲谢锦林兰涛李弘刘阿娣周楚温晓辉卫子安吴捷陈晨刘东宽饶贤昊蔡虎邬佳仁邓鹏刘海庆丁卫星庄革刘万东 School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026People's Republic of China Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People's Republic of China

A multi-channel polarimeter-interferometer has been developed on the Keda Torus eXperiment(KTX)for the study of equilibrium dynamics and internal magnetic fluctuations.A three-wave technique based on terahertz solid-state sources(-650 GHz)is applied for simultaneous measurements of electron density and Faraday rotation *** output power of the microwave source is 2 *** rotation effect using a rotating wave plate is tested with phase noise less than 0.8°,and the density phase noise is less than 0.9°.Measurement of Faraday rotation angle and density for discharges on KTX have demonstrated high sensitivity to internal MHD activities.

关键词： plasma diagnostics interferometry terahertz polarimeter

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对某中型水库清淤工程建设方案的研究

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云南水力发电 2024年第8期40卷 185-187页

作者：刘万东大禹节水集团股份有限公司甘肃兰州730000

甘肃省某中型水库在多年的运行过程中,至2021年水库已经淤积了985.9×104m3,库容损失了32%左右,入库沙量近50×104t,严重的制约了该水库工程经济效益的发挥。文章在分析清淤工程建设必要性基础上,从工程选址、淤积处理方式、工程总布置... 详细信息

甘肃省某中型水库在多年的运行过程中,至2021年水库已经淤积了985.9×104m3,库容损失了32%左右,入库沙量近50×104t,严重的制约了该水库工程经济效益的发挥。文章在分析清淤工程建设必要性基础上,从工程选址、淤积处理方式、工程总布置、总体施工方案等方面进行研究,提出了水库清淤的工程方案,为水库清淤工程设计施工提供技术参考和实践经验。

关键词：中型水库必要性清淤范围清淤方式总体方案

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Comparison of transport coefficients before and after density pump-out induced by resonant magnetic perturbation using a BOUT++ six-field model on the EAST tokamak

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Plasma Science and Technology 2024年第6期26卷 111-119页

作者：邓成成刘子奚夏天阳刘彦君厉鹏程龙飞飞高翔王守信李国强刘海庆臧庆李玖瑛杨康宁吴茗甫尹晓宇李弘谢锦林兰涛毛文哲刘阿娣周楚丁卫星庄革刘万东 the EAST Team Department of Plasma Physics and Fusion Engineering University of Science and Technology of ChinaHefei 230026People’s Republic of China Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China

Many experiments have demonstrated that resonant magnetic perturbation(RMP) can affect the turbulent transport at the edge of the tokamak. Through the Experimental Advanced Superconducting Tokamak(EAST) density modulation experiment, the particle transport coefficients were calculated using the experimental data, and the result shows that the particle transport coefficients increase with RMP. In this study, the six-field two-fluid model in BOUT++ is used to simulate the transport before and after density pump-out induced by RMP,respectively referred as the case without RMP and the case with RMP. In the linear simulations,the instabilities generally decreases for cases with RMP. In the nonlinear simulation, ELM only appears in the case without RMP. Additionally, the particle transport coefficient was analyzed,and the result shows that the particle transport coefficient becomes larger for the case with RMP,which is consistent with the experimental conclusion. Moreover, its magnitude is comparable to the results calculated from experimental data.

关键词： BOUT++ resonant magnetic perturbation(RMP) transport coefficients

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Investigations on the time evolution of the plasma density in argon electron-beam plasma at intermediate pressure

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Plasma Science and Technology 2017年第3期19卷 47-53页

作者： Xiaoyan BAI Chen CHEN Hong LI wandong liu KTX Laboratory and Department of Modem Physics University of Science and Technology of China Hefei 230026 People＇s Republic of China State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear Technology Xi＇an 710024 People＇s Republic of China

The time evolution of the argon electron-beam plasma at intermediate pressure and low electron beam intensily was *** applying the amplitude modulation with the frequency of 20 Hz on the stable beam current,the plasma evolution was studied.A Faraday cup was used for the measurement of the electron beam current and a single electrostatic probe was used for the measurement of the ion *** results indicated that the ion current was in phase with the electron beam current in the pressure range from 200 Pa to 3000 Pa and in the beam current range lower than 20 mA,the residual density increased approximately linearly with the maximum density in the log-log plot and the fitting coefficient was irrelative to the *** then three kinds of kinetic models were developed and the simulated results given by the kinetic model,without the consideration of the excited atoms,mostly approached to the experimental *** indicated that the effect of the excited atoms on the plasma density can be ignored at intermediate pressure and low electron beam current intensity,which can greatly simplify the kinetic *** the *** decrease of the plasma density when the beam current was suddenly off was studied based on the simplified model and it was found that the decease characteristic at intermediate pressure was approximate to the one at high pressure at low electron beam intensity,which was in good accordance with the experimental results.

关键词： electron-beam plasma kinetic model time evolution residual density phase lag

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基于PP料的安全仓储与双层物流网络模型优化设计研究

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粘接 2024年第1期51卷 153-156页

作者：吴璇马俊明刘万东国网甘肃省电力公司甘肃兰州730087

随着我国仓储物流的需求量不断增大,需进一步提高仓储物流的配送效率,提升物流服务水平。为优化仓储物流网络的规划,使用协同物流网络资源配置对仓储物流网络进行优化调整,以供应商、中转仓库以及卖方为研究对象,建立了双层动态优化模... 详细信息

随着我国仓储物流的需求量不断增大,需进一步提高仓储物流的配送效率,提升物流服务水平。为优化仓储物流网络的规划,使用协同物流网络资源配置对仓储物流网络进行优化调整,以供应商、中转仓库以及卖方为研究对象,建立了双层动态优化模型。研究结果表明,优化后的双层物流网络模型具有较强的收敛性。双层规划网络模型的平均路径长度为28.14 km,明显小于单层规划网络模型平均路径长度(30.88 km)。同时,双层规划网络模型最优路径长度为24.53 km,较单层规划网络模型下降9.22%。所提出的仓储物流网络规划优化模型可以合理、最优地分配电力仓库物流系统的聚丙烯材料。研究结果可为电力仓库物流运输提供参考依据。

关键词：聚丙烯(PP) 物流网络仓储模型优化设计资源配置

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Investigation of Density Fluctuations with Different Toroidal Magnetic Field in KT-5B Tokamak

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Chinese Physics Letters 1991年第5期8卷 236-239页

作者： ZENG Lei CAO Jinxiang ZHAN Furu liu wandong CHANG Liyan YU Changxuan ZU Qinxin Department of Modern Physics University of Science and Technology of ChinaHelei 230026 nstitute of Physics Academia SinicaBeijinq 100080

Microturbulence density fluctuations with drift-wave characteristics in KT-5B tokamak were *** density fluctuation power spectrum S(k_(⊥))can be fitted into S(k_(⊥))∝k_(⊥)^(-α),in whichαis in inverse proportion to the toroidal magnetic field *** averaged frequency and width(FWHM)of the frequency spectrum are increasing functions of *** phase velocity from the statistical dispersion is larger for k_(⊥)<20cm^(-1) than that for k_(⊥)≥20cm^(-1).

关键词： Density spectrum turbulence

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INVESTIGATION OF LINEAR ION BERNSTEIN WAVE IN KT-5B TOKAMAK

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Chinese Physics Letters 1989年第5期6卷 201-204页

作者： liu wandong WEN Yizhi WAN Shude YU Changxuan Department of Modern Physics University of Science and Technology of ChinaHefeiAnhui

Linear ion Bernstein waves have been successfully excited in KT-5B tokamak by a toroidal current *** Bernstain waves were detected by two rf Langmuir probes and identified by their exciting region and their dispersion *** ion temperature profile in the tokamak has been obtained from the dispersion relation of ion Bernstein wave in agreement with the measuring by an electrostatic ion probe.

关键词： relation. dispersion electrostatic

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Oxide Coated Cathode Plasma Source of Linear Magnetized Plasma Device

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Plasma Science and Technology 2016年第9期18卷 918-923页

作者： HU Guanghai JIN Xiaoli YUAN Lin ZHANG Qiaofeng XIE Jinlin LI Hong liu wandong Department of Modern Physics University of Science and Technology of China Hefei 230026 China

Plasma source is the most important part of the laboratory plasma platform for fundamental plasma experimental research. Barium oxide coated cathode plasma source is well recognized as an effective technique due to its high electron emission current. An indirectly heated oxide coated cathode plasma source has been constructed on a linear magnetized plasma device. The electron emission current density can reach 2 A/cm2 to 6 A/cm2 in pulsed mode within pulse length 5-20 ms. A 10 cm diameter, 2 m long plasma column with density 10is m-3 to 1019 m3 and electron temperature Te --~ 3-7 eV is produced. The spatial uniformity of the emission ability is less than 4% and the discharge reproducibility is better than 97%. With a wide range of the plasma parameters, this kind of plasma source provides great flexibility for many basic plasma investigations. The detail of construction and initial characterization of oxide coated cathode are described in this paper.

关键词： oxide coated cathode plasma source magnetized plasma pulse discharge

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